Objective：To investigate the influences of urapidil and nicardipine on rabbit sinus function, atrio-ventricular node function and hemodynamics. Methods：Thirty-two Angora＇ s rabbits were selected and randomly divide...Objective：To investigate the influences of urapidil and nicardipine on rabbit sinus function, atrio-ventricular node function and hemodynamics. Methods：Thirty-two Angora＇ s rabbits were selected and randomly divided into four groups. U1 group：urapidil 0.25 mg/kg; U2 group：urapidil 0.5 mg/kg; N1 group：nicardipine 10 μg/kg; N2 group： nicardipine 20 μg/kg. All these medicine were administrated within 30 seconds. Measurements were taken before and after the administration of urapidil or nicardipine for the following data： mean blood pressure（MAP）, heart rate（HR）, sino-atrial conduction time（SACT）, maximal sinoatrial recovery time（SNRTmax） corrected sinus node recovery time（CSNRT）, index of sinus node recovery time（SNRTI）, Wenckebach A-V conduction frequency （WB）, and P-R interval. Results：Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine. No significant changes could be found in the rest of the parameters. Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group（P 〈 0.01）; the MAP decreased（P 〈 0.01） and the HR increased drastically（P〈 0.01）. Conclusions：Neither urapidil（0.25 mg/kg, 0,5 mg/kg） nor nicardipine（10 μg/kg, 20 μg/kg） has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function. Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.展开更多
In this letter, a Function node-based Multiple Pairwise Keys Management (MPKMF) protocol for Wireless Sensor Networks (WSNs) is firstly designed, in which ordinary nodes and cluster head nodes are responsible for data...In this letter, a Function node-based Multiple Pairwise Keys Management (MPKMF) protocol for Wireless Sensor Networks (WSNs) is firstly designed, in which ordinary nodes and cluster head nodes are responsible for data collection and transmission, and function nodes are responsible for key management. There are more than one function nodes in the cluster consulting the key generation and other security decision-making. The function nodes are the second-class security center because of the characteristics of the distributed WSNs. Secondly, It is also described that the formation of function nodes and cluster heads under the control of the former, and five kinds of keys, i.e., individual key, pairwise keys, cluster key, management key, and group key. Finally, performance analysis and experiments show that, the protocol is superior in communication and energy consumption. The delay of establishing the cluster key meets the requirements, and a multiple pairwise key which adopts the coordinated security authentication scheme is provided.展开更多
In this paper we propose a collocation method for solving Lane-Emden type equation which is nonlinear or-dinary differential equation on the semi-infinite domain. This equation is categorized as singular initial value...In this paper we propose a collocation method for solving Lane-Emden type equation which is nonlinear or-dinary differential equation on the semi-infinite domain. This equation is categorized as singular initial value problems. We solve this equation by the generalized Laguerre polynomial collocation method based on Her-mite-Gauss nodes. This method solves the problem on the semi-infinite domain without truncating it to a fi-nite domain and transforming domain of the problem to a finite domain. In addition, this method reduces so-lution of the problem to solution of a system of algebraic equations.展开更多
Purpose: Brain functional networks (BFNs) has become important approach for diagnosis of some neurological or psychological disorders. Before estimating BFN, obtaining blood oxygen level dependent (BOLD) representativ...Purpose: Brain functional networks (BFNs) has become important approach for diagnosis of some neurological or psychological disorders. Before estimating BFN, obtaining blood oxygen level dependent (BOLD) representative signals from brain regions of interest (ROIs) is important. In the past decades, the common method is generally to take a ROI as a node, averaging all the voxel time series inside it to extract a representative signal. However, one node does not represent the entire information of this ROI, and averaging method often leads to signal cancellation and information loss. Inspired by this, we propose a novel model extraction method based on an assumption that a ROI can be represented by multiple nodes. Methods: In this paper, we first extract multiple nodes (the number is user-defined) from the ROI based on two traditional methods, including principal component analysis (PCA), and K-means (Clustering according to the spatial position of voxels). Then, canonical correlation analysis (CCA) was issued to construct BFNs by maximizing the correlation between the representative signals corresponding to the nodes in any two ROIs. Finally, to further verify the effectiveness of the proposed method, the estimated BFNs are applied to identify subjects with autism spectrum disorder (ASD) and mild cognitive impairment (MCI) from health controls (HCs). Results: Experimental results on two benchmark databases demonstrate that the proposed method outperforms the baseline method in the sense of classification performance. Conclusions: We propose a novel method for obtaining nodes of ROId based on the hypothesis that a ROI can be represented by multiple nodes, that is, to extract the node signals of ROIs with K-means or PCA. Then, CCA is used to construct BFNs.展开更多
A Coupling Magneto-Electro-Elastic(MEE)Node-based Smoothed Radial Point Interpolation Method(CM-NS-RPIM)was proposed to solve the free vibration and transient responses of Functionally Graded Magneto-Electro-Elastic(F...A Coupling Magneto-Electro-Elastic(MEE)Node-based Smoothed Radial Point Interpolation Method(CM-NS-RPIM)was proposed to solve the free vibration and transient responses of Functionally Graded Magneto-Electro-Elastic(FGMEE)structures.By introducing the modified Newmark method,the displacement,electrical potential and magnetic potential of the structures under transient mechanical loading were obtained.Based on G space theory and the weakened weak(W2)formulation,the equations of the multi-physics coupling problems were derived.Using triangular background elements,the free vibration and transient responses of three numerical examples were studied.Results proved that CM-NS-RPIM performed better than the standard FEM by reducing the overly-stiff of structures.Moreover,CM-NS-RPIM could reduce the number of nodes while guaranteeing the accuracy.Besides,triangular elements could be generated automatically even for complex geometries.Therefore,the effectiveness and validity of CM-NS-RPIM were demonstrated,which were valuable for the design of intelligence devices,such as energy harvesters and sensors.展开更多
As a key mode of transportation, urban metro networks have significantly enhanced urban traffic environments and travel efficiency, making the identification of critical stations within these networks increasingly ess...As a key mode of transportation, urban metro networks have significantly enhanced urban traffic environments and travel efficiency, making the identification of critical stations within these networks increasingly essential. This study presents a novel integrated topological-functional(ITF) algorithm for identifying critical nodes, combining topological metrics such as K-shell decomposition, node information entropy, and neighbor overlapping interaction with the functional attributes of passenger flow operations, while also considering the coupling effects between metro and bus networks. Using the Chengdu metro network as a case study, the effectiveness of the algorithm under different conditions is validated.The results indicate significant differences in passenger flow patterns between working and non-working days, leading to varying sets of critical nodes across these scenarios. Moreover, the ITF algorithm demonstrates a marked improvement in the accuracy of critical node identification compared to existing methods. This conclusion is supported by the analysis of changes in the overall network structure and relative global operational efficiency following targeted attacks on the identified critical nodes. The findings provide valuable insight into urban transportation planning, offering theoretical and practical guidance for improving metro network safety and resilience.展开更多
The gravest prognostic factor in early gastric cancer is lymph-node metastasis,with an incidence of about 10% overall. About two-thirds of early gastric cancer patients can be diagnosed as node-negative prior to treat...The gravest prognostic factor in early gastric cancer is lymph-node metastasis,with an incidence of about 10% overall. About two-thirds of early gastric cancer patients can be diagnosed as node-negative prior to treatment based on clinicpathological data. Thus, the tumor can be resected by endoscopic submucosal dissection. In the remaining third, surgical resection is necessary because of the possibility of nodal metastasis. Nevertheless, almost all patients can be cured by gastrectomy with D1+ lymph-node dissection. Laparoscopic or robotic gastrectomy has become widespread in East Asia because perioperative and oncological safety are similar to open surgery. However, after D1+ gastrectomy,functional symptoms may still result. Physicians must strive to minimize postgastrectomy symptoms and optimize long-term quality of life after this operation.Depending on the location and size of the primary lesion, preservation of the pylorus or cardia should be considered. In addition, the extent of lymph-node dissection can be individualized, and significant gastric-volume preservation can be achieved if sentinel node biopsy is used to distinguish node-negative patients.Though the surgical treatment for early gastric cancer may be less radical than in the past, the operative method itself seems to be still in transition.展开更多
Identifying influential nodes in complex networks is still an open issue. In this paper, a new comprehensive centrality mea- sure is proposed based on the Dempster-Shafer evidence theory. The existing measures of degr...Identifying influential nodes in complex networks is still an open issue. In this paper, a new comprehensive centrality mea- sure is proposed based on the Dempster-Shafer evidence theory. The existing measures of degree centrality, betweenness centra- lity and closeness centrality are taken into consideration in the proposed method. Numerical examples are used to illustrate the effectiveness of the proposed method.展开更多
BACKGROUND Lymphatic basin dissection is a sentinel node biopsy method that is specific for gastric cancer.In this method,the dyed lymphatic system is dissected en bloc,and sentinel nodes are identified at the back ta...BACKGROUND Lymphatic basin dissection is a sentinel node biopsy method that is specific for gastric cancer.In this method,the dyed lymphatic system is dissected en bloc,and sentinel nodes are identified at the back table(ex vivo).Even with lymphatic basin dissection,blood flow to the residual stomach can be preserved,and functionpreserving curative gastrectomy can be performed.The oncological safety of function-preserving curative gastrectomy combined with lymphatic basin dissection has not yet been fully investigated.We hypothesized that the oncological safety of sentinel node navigation surgery(SNNS)is not inferior to that of the guidelines.AIM To investigate the life prognosis of SNNS for gastric cancer in comparison with guidelines surgery.METHODS This was a retrospective cohort study.Patients were selected from gastric cancer patients who underwent sentinel node biopsy from April 1999 to March 2016.Patients from April 1999 to August 2008 were from the Department of Surgery II,Kanazawa University Hospital,and patients from August 2009 to March 2016 were from the Department of Surgical Oncology,Kanazawa Medical University Hospital.Patients who were diagnosed with gastric cancer,which was preoperatively diagnosed as superficial type(type 0),5 cm or less in length,clinical T1-2 and node negative,and underwent various gastrectomies guided by sentinel node navigation were retrospectively collected.The overall survival(OS)and relapsefree survival(RFS)of these patients(SNNS group)were investigated.Patients with gastric cancer of the same stage and who underwent guidelines gastrectomy with standard nodal dissection were also selected as the control group.RESULTS A total of 239 patients in the SNNS group and 423 patients in the control group were included.Pathological nodal metastasis was observed in 10.5%and 10.4%of the SNNS and control groups,respectively.The diagnostic abilities of sentinel node biopsy were 84%and 98.6%for sensitivity and accuracy,respectively.In the SNNS group,81.6%of patients underwent modified gastrectomy or functionpreserving curative gastrectomy with lymphatic basin dissection,in which the extent of nodal dissection was further reduced compared to the guidelines.The OS rate in the SNNS group was 96.8%at 5 years and was significantly better than 91.3%in the control group(P=0.0014).The RFS rates were equal in both groups.After propensity score matching,there were 231 patients in both groups,and the cumulative recurrence rate was 0.43%at 5 years in the SNNS group and 1.30%in the control group,which was not statistically different.CONCLUSION The oncological safety of patients who undergo gastrectomy guided by sentinel node navigation is not inferior to that of the guidelines surgery.展开更多
Combining Dual Reciprocity Method （DRM） with Hybrid Boundary Node Method （HBNM）, the Dual Reciprocity Hybrid Boundary Node Method （DRHBNM） is developed for three-dimensional linear elasticity problems with body ...Combining Dual Reciprocity Method （DRM） with Hybrid Boundary Node Method （HBNM）, the Dual Reciprocity Hybrid Boundary Node Method （DRHBNM） is developed for three-dimensional linear elasticity problems with body force. This method can be used to solve the elasticity problems with body force without domain integral, which is inevitable by HBNM. To demonstrate the versatility and the fast convergence of this method, some numerical examples of 3-D elasticity problems with body forces are examined. The computational results show that the present method is effective and can be widely applied in solving practical engineering problems.展开更多
AIM: To investigate and evaluate the change in healthrelated quality of life (HRQoL) by tumor node metastasis (TNM) staging system in patients with hepatocellular carcinoma (HCC). METHODS: A total of 140 patients diag...AIM: To investigate and evaluate the change in healthrelated quality of life (HRQoL) by tumor node metastasis (TNM) staging system in patients with hepatocellular carcinoma (HCC). METHODS: A total of 140 patients diagnosed with HCC between June 2008 and April 2009 in our department were enrolled to this study. One hundred and thirty-five (96.5%) patients had liver cirrhosis secondary to hepatitis B virus (HBV) infection, 73 (54.07%) of them being HBV DNA positive; the other etiologies of liver cirrhosis were alcoholic liver disease (1.4%), hepatitis C (1.4%) or cryptogenic (0.7%). All subjects were fully aware of their diagnosis and provided informed consent. HRQoL was assessed before treatment using the functional assessment of cancer therapy-hepatobiliary (FACT-Hep) questionnaire. Descriptive statistics were used to evaluate demographics and disease-specific characteristics of the patients. One-way analysis of variance and independent samples t tests were used to compare the overall FACT-Hep scores and clinically distinct TNM stages. Scores for all FACT-Hep items were analyzed by frequency analyses. The mean scores obtained from the FACT-Hep in different Child-Pugh classes were also evaluated. RESULTS: The mean FACT-Hep scores were reduced significantly from TNM StageⅠto Stage Ⅱ, Stage ⅢA, Stage ⅢB group (687 ± 39.69 vs 547 ± 42.57 vs 387 ± 51.24 vs 177 ± 71.44, P = 0.001). Regarding the physical and emotional well-being subscales, scores decreased gradually from Stage Ⅰ to Stage ⅢB (P = 0.002 vs Stage Ⅰ; P = 0.032 vs Stage Ⅱ; P = 0.033 vs Stage ⅢA). Mean FACT-Hep scores varied by Child-Pugh class, especially in the subscales of physical well-being, functional well-being and the hepatobiliary cancer (P = 0.001 vs Stage I; P = 0.036 vs Stage Ⅱ; P = 0.032 vs Stage ⅢA). For the social and family well-being subscale, only Stage ⅢB scores were significantly lower as compared with Stage Ⅰ scores (P = 0.035). For the subscales of functional well-being and hepatobiliary cancer, there were significant differences for Stages ⅡΙ, ⅢA and ⅢB (P = 0.002vs StageⅠ). CONCLUSION: HRQoL of patients with HCC worsens gradually with progression of TNM stages. The most impaired subscales of HRQoL, as measured by FACT-Hep, were physical and emotional well-being.展开更多
In this paper,we enumerate the set of Motzkin trees with n edges according to the number of leaves,the number of vertices adjacent to a leaf,the number of protected nodes,the number of(protected)branch nodes,and the n...In this paper,we enumerate the set of Motzkin trees with n edges according to the number of leaves,the number of vertices adjacent to a leaf,the number of protected nodes,the number of(protected)branch nodes,and the number of(protected)lonely nodes.Explicit formulae as well as generating functions are obtained.We also find that,as n goes to infinity,the proportion of protected branch nodes and protected lonely nodes among all vertices of Motzkin trees with n edges approaches 4/27 and 2/9.展开更多
Abstract:Fog computing provides quality of service for cloud infrastructure.As the data computation intensifies,edge computing becomes difficult.Therefore,mobile fog computing is used for reducing traffic and the time...Abstract:Fog computing provides quality of service for cloud infrastructure.As the data computation intensifies,edge computing becomes difficult.Therefore,mobile fog computing is used for reducing traffic and the time for data computation in the network.In previous studies,software-defined networking(SDN)and network functions virtualization(NFV)were used separately in edge computing.Current industrial and academic research is tackling to integrate SDN and NFV in different environments to address the challenges in performance,reliability,and scalability.SDN/NFV is still in development.The traditional Internet of things(IoT)data analysis system is only based on a linear and time-variant system that needs an IoT data system with a high-precision model.This paper proposes a combined architecture of SDN and NFV on an edge node server for IoT devices to reduce the computational complexity in cloud-based fog computing.SDN provides a generalization structure of the forwarding plane,which is separated from the control plane.Meanwhile,NFV concentrates on virtualization by combining the forwarding model with virtual network functions(VNFs)as a single or chain of VNFs,which leads to interoperability and consistency.The orchestrator layer in the proposed software-defined NFV is responsible for handling real-time tasks by using an edge node server through the SDN controller via four actions:task creation,modification,operation,and completion.Our proposed architecture is simulated on the EstiNet simulator,and total time delay,reliability,and satisfaction are used as evaluation parameters.The simulation results are compared with the results of existing architectures,such as software-defined unified virtual monitoring function and ASTP,to analyze the performance of the proposed architecture.The analysis results indicate that our proposed architecture achieves better performance in terms of total time delay(1800 s for 200 IoT devices),reliability(90%),and satisfaction(90%).展开更多
In this paper,general interpolating isogeometric boundary node method(IIBNM)and isogeometric boundary element method(IBEM)based on parameter space are proposed for 2D elasticity problems.In both methods,the integral c...In this paper,general interpolating isogeometric boundary node method(IIBNM)and isogeometric boundary element method(IBEM)based on parameter space are proposed for 2D elasticity problems.In both methods,the integral cells and elements are defined in parameter space,which can reproduce the geometry exactly at all the stages.In IIBNM,the improved interpolating moving leastsquare method(IIMLS)is applied for field approximation and the shape functions have the delta function property.The Lagrangian basis functions are used for field approximation in IBEM.Thus,the boundary conditions can be imposed directly in both methods.The shape functions are defined in 1D parameter space and no curve length needs to be computed.Besides,most methods for the treatment of the singular integrals in the boundary element method can be applied in IIBNM and IBEM directly.Numerical examples have demonstrated the accuracy of the proposed methods.展开更多
In this paper,we study the computative structure of computable function-a structure of computative tree,and,by analysis on it,got the most general algorithm and model for computation on computable functions.
文摘Objective：To investigate the influences of urapidil and nicardipine on rabbit sinus function, atrio-ventricular node function and hemodynamics. Methods：Thirty-two Angora＇ s rabbits were selected and randomly divided into four groups. U1 group：urapidil 0.25 mg/kg; U2 group：urapidil 0.5 mg/kg; N1 group：nicardipine 10 μg/kg; N2 group： nicardipine 20 μg/kg. All these medicine were administrated within 30 seconds. Measurements were taken before and after the administration of urapidil or nicardipine for the following data： mean blood pressure（MAP）, heart rate（HR）, sino-atrial conduction time（SACT）, maximal sinoatrial recovery time（SNRTmax） corrected sinus node recovery time（CSNRT）, index of sinus node recovery time（SNRTI）, Wenckebach A-V conduction frequency （WB）, and P-R interval. Results：Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine. No significant changes could be found in the rest of the parameters. Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group（P 〈 0.01）; the MAP decreased（P 〈 0.01） and the HR increased drastically（P〈 0.01）. Conclusions：Neither urapidil（0.25 mg/kg, 0,5 mg/kg） nor nicardipine（10 μg/kg, 20 μg/kg） has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function. Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.
基金Supported by the National Natural Science Foundation of China (No. 60475012)
文摘In this letter, a Function node-based Multiple Pairwise Keys Management (MPKMF) protocol for Wireless Sensor Networks (WSNs) is firstly designed, in which ordinary nodes and cluster head nodes are responsible for data collection and transmission, and function nodes are responsible for key management. There are more than one function nodes in the cluster consulting the key generation and other security decision-making. The function nodes are the second-class security center because of the characteristics of the distributed WSNs. Secondly, It is also described that the formation of function nodes and cluster heads under the control of the former, and five kinds of keys, i.e., individual key, pairwise keys, cluster key, management key, and group key. Finally, performance analysis and experiments show that, the protocol is superior in communication and energy consumption. The delay of establishing the cluster key meets the requirements, and a multiple pairwise key which adopts the coordinated security authentication scheme is provided.
文摘In this paper we propose a collocation method for solving Lane-Emden type equation which is nonlinear or-dinary differential equation on the semi-infinite domain. This equation is categorized as singular initial value problems. We solve this equation by the generalized Laguerre polynomial collocation method based on Her-mite-Gauss nodes. This method solves the problem on the semi-infinite domain without truncating it to a fi-nite domain and transforming domain of the problem to a finite domain. In addition, this method reduces so-lution of the problem to solution of a system of algebraic equations.
文摘Purpose: Brain functional networks (BFNs) has become important approach for diagnosis of some neurological or psychological disorders. Before estimating BFN, obtaining blood oxygen level dependent (BOLD) representative signals from brain regions of interest (ROIs) is important. In the past decades, the common method is generally to take a ROI as a node, averaging all the voxel time series inside it to extract a representative signal. However, one node does not represent the entire information of this ROI, and averaging method often leads to signal cancellation and information loss. Inspired by this, we propose a novel model extraction method based on an assumption that a ROI can be represented by multiple nodes. Methods: In this paper, we first extract multiple nodes (the number is user-defined) from the ROI based on two traditional methods, including principal component analysis (PCA), and K-means (Clustering according to the spatial position of voxels). Then, canonical correlation analysis (CCA) was issued to construct BFNs by maximizing the correlation between the representative signals corresponding to the nodes in any two ROIs. Finally, to further verify the effectiveness of the proposed method, the estimated BFNs are applied to identify subjects with autism spectrum disorder (ASD) and mild cognitive impairment (MCI) from health controls (HCs). Results: Experimental results on two benchmark databases demonstrate that the proposed method outperforms the baseline method in the sense of classification performance. Conclusions: We propose a novel method for obtaining nodes of ROId based on the hypothesis that a ROI can be represented by multiple nodes, that is, to extract the node signals of ROIs with K-means or PCA. Then, CCA is used to construct BFNs.
基金co-supported by the National Key R&D Program of China(Nos.2018YFF01012401-05)the National Natural Science Foundation of China(No.51975243)+2 种基金Jilin Provincial Department of Education(No.JJKH20180084KJ),Chinathe Fundamental Research Funds for the Central Universities and Jilin Provincial Department of Science&Technology Fund Project,China(Nos.20170101043JC and 20180520072JH)Graduate Innovation Fund of Jilin University,China(No.101832018C184).
文摘A Coupling Magneto-Electro-Elastic(MEE)Node-based Smoothed Radial Point Interpolation Method(CM-NS-RPIM)was proposed to solve the free vibration and transient responses of Functionally Graded Magneto-Electro-Elastic(FGMEE)structures.By introducing the modified Newmark method,the displacement,electrical potential and magnetic potential of the structures under transient mechanical loading were obtained.Based on G space theory and the weakened weak(W2)formulation,the equations of the multi-physics coupling problems were derived.Using triangular background elements,the free vibration and transient responses of three numerical examples were studied.Results proved that CM-NS-RPIM performed better than the standard FEM by reducing the overly-stiff of structures.Moreover,CM-NS-RPIM could reduce the number of nodes while guaranteeing the accuracy.Besides,triangular elements could be generated automatically even for complex geometries.Therefore,the effectiveness and validity of CM-NS-RPIM were demonstrated,which were valuable for the design of intelligence devices,such as energy harvesters and sensors.
基金Project supported by the National Natural Science Foundation of China (Grant No. 71971150)the Project of Research Center for System Sciences and Enterprise Development (Grant No. Xq16B05)the Fundamental Research Funds for the Central Universities of China (Grant No. SXYPY202313)。
文摘As a key mode of transportation, urban metro networks have significantly enhanced urban traffic environments and travel efficiency, making the identification of critical stations within these networks increasingly essential. This study presents a novel integrated topological-functional(ITF) algorithm for identifying critical nodes, combining topological metrics such as K-shell decomposition, node information entropy, and neighbor overlapping interaction with the functional attributes of passenger flow operations, while also considering the coupling effects between metro and bus networks. Using the Chengdu metro network as a case study, the effectiveness of the algorithm under different conditions is validated.The results indicate significant differences in passenger flow patterns between working and non-working days, leading to varying sets of critical nodes across these scenarios. Moreover, the ITF algorithm demonstrates a marked improvement in the accuracy of critical node identification compared to existing methods. This conclusion is supported by the analysis of changes in the overall network structure and relative global operational efficiency following targeted attacks on the identified critical nodes. The findings provide valuable insight into urban transportation planning, offering theoretical and practical guidance for improving metro network safety and resilience.
文摘The gravest prognostic factor in early gastric cancer is lymph-node metastasis,with an incidence of about 10% overall. About two-thirds of early gastric cancer patients can be diagnosed as node-negative prior to treatment based on clinicpathological data. Thus, the tumor can be resected by endoscopic submucosal dissection. In the remaining third, surgical resection is necessary because of the possibility of nodal metastasis. Nevertheless, almost all patients can be cured by gastrectomy with D1+ lymph-node dissection. Laparoscopic or robotic gastrectomy has become widespread in East Asia because perioperative and oncological safety are similar to open surgery. However, after D1+ gastrectomy,functional symptoms may still result. Physicians must strive to minimize postgastrectomy symptoms and optimize long-term quality of life after this operation.Depending on the location and size of the primary lesion, preservation of the pylorus or cardia should be considered. In addition, the extent of lymph-node dissection can be individualized, and significant gastric-volume preservation can be achieved if sentinel node biopsy is used to distinguish node-negative patients.Though the surgical treatment for early gastric cancer may be less radical than in the past, the operative method itself seems to be still in transition.
基金supported by the National Natural Science Foundation of China(61174022)the National High Technology Research and Development Program of China(863 Program)(2013AA013801)+2 种基金the Open Funding Project of State Key Laboratory of Virtual Reality Technology and Systems,Beihang University(BUAA-VR-14KF-02)the General Research Program of the Science Supported by Sichuan Provincial Department of Education(14ZB0322)the Fundamental Research Funds for the Central Universities(XDJK2014D008)
文摘Identifying influential nodes in complex networks is still an open issue. In this paper, a new comprehensive centrality mea- sure is proposed based on the Dempster-Shafer evidence theory. The existing measures of degree centrality, betweenness centra- lity and closeness centrality are taken into consideration in the proposed method. Numerical examples are used to illustrate the effectiveness of the proposed method.
基金This study was approved by the ethics committee of Kanazawa University Hospital and Kanazawa Medical University(Trial Number R093,M288)ICG mapping was approved by the ethics committee of Kanazawa Medical University(Trial NumberM404).
文摘BACKGROUND Lymphatic basin dissection is a sentinel node biopsy method that is specific for gastric cancer.In this method,the dyed lymphatic system is dissected en bloc,and sentinel nodes are identified at the back table(ex vivo).Even with lymphatic basin dissection,blood flow to the residual stomach can be preserved,and functionpreserving curative gastrectomy can be performed.The oncological safety of function-preserving curative gastrectomy combined with lymphatic basin dissection has not yet been fully investigated.We hypothesized that the oncological safety of sentinel node navigation surgery(SNNS)is not inferior to that of the guidelines.AIM To investigate the life prognosis of SNNS for gastric cancer in comparison with guidelines surgery.METHODS This was a retrospective cohort study.Patients were selected from gastric cancer patients who underwent sentinel node biopsy from April 1999 to March 2016.Patients from April 1999 to August 2008 were from the Department of Surgery II,Kanazawa University Hospital,and patients from August 2009 to March 2016 were from the Department of Surgical Oncology,Kanazawa Medical University Hospital.Patients who were diagnosed with gastric cancer,which was preoperatively diagnosed as superficial type(type 0),5 cm or less in length,clinical T1-2 and node negative,and underwent various gastrectomies guided by sentinel node navigation were retrospectively collected.The overall survival(OS)and relapsefree survival(RFS)of these patients(SNNS group)were investigated.Patients with gastric cancer of the same stage and who underwent guidelines gastrectomy with standard nodal dissection were also selected as the control group.RESULTS A total of 239 patients in the SNNS group and 423 patients in the control group were included.Pathological nodal metastasis was observed in 10.5%and 10.4%of the SNNS and control groups,respectively.The diagnostic abilities of sentinel node biopsy were 84%and 98.6%for sensitivity and accuracy,respectively.In the SNNS group,81.6%of patients underwent modified gastrectomy or functionpreserving curative gastrectomy with lymphatic basin dissection,in which the extent of nodal dissection was further reduced compared to the guidelines.The OS rate in the SNNS group was 96.8%at 5 years and was significantly better than 91.3%in the control group(P=0.0014).The RFS rates were equal in both groups.After propensity score matching,there were 231 patients in both groups,and the cumulative recurrence rate was 0.43%at 5 years in the SNNS group and 1.30%in the control group,which was not statistically different.CONCLUSION The oncological safety of patients who undergo gastrectomy guided by sentinel node navigation is not inferior to that of the guidelines surgery.
文摘Combining Dual Reciprocity Method （DRM） with Hybrid Boundary Node Method （HBNM）, the Dual Reciprocity Hybrid Boundary Node Method （DRHBNM） is developed for three-dimensional linear elasticity problems with body force. This method can be used to solve the elasticity problems with body force without domain integral, which is inevitable by HBNM. To demonstrate the versatility and the fast convergence of this method, some numerical examples of 3-D elasticity problems with body forces are examined. The computational results show that the present method is effective and can be widely applied in solving practical engineering problems.
基金Supported by Grants from the E-Institute of Shanghai Municipal Education Commission, No. E03008Shanghai Municipal Health Bureau of Traditional Chinese Medicine Research Project Fund 2010-2011, No. 2010L052B
文摘AIM: To investigate and evaluate the change in healthrelated quality of life (HRQoL) by tumor node metastasis (TNM) staging system in patients with hepatocellular carcinoma (HCC). METHODS: A total of 140 patients diagnosed with HCC between June 2008 and April 2009 in our department were enrolled to this study. One hundred and thirty-five (96.5%) patients had liver cirrhosis secondary to hepatitis B virus (HBV) infection, 73 (54.07%) of them being HBV DNA positive; the other etiologies of liver cirrhosis were alcoholic liver disease (1.4%), hepatitis C (1.4%) or cryptogenic (0.7%). All subjects were fully aware of their diagnosis and provided informed consent. HRQoL was assessed before treatment using the functional assessment of cancer therapy-hepatobiliary (FACT-Hep) questionnaire. Descriptive statistics were used to evaluate demographics and disease-specific characteristics of the patients. One-way analysis of variance and independent samples t tests were used to compare the overall FACT-Hep scores and clinically distinct TNM stages. Scores for all FACT-Hep items were analyzed by frequency analyses. The mean scores obtained from the FACT-Hep in different Child-Pugh classes were also evaluated. RESULTS: The mean FACT-Hep scores were reduced significantly from TNM StageⅠto Stage Ⅱ, Stage ⅢA, Stage ⅢB group (687 ± 39.69 vs 547 ± 42.57 vs 387 ± 51.24 vs 177 ± 71.44, P = 0.001). Regarding the physical and emotional well-being subscales, scores decreased gradually from Stage Ⅰ to Stage ⅢB (P = 0.002 vs Stage Ⅰ; P = 0.032 vs Stage Ⅱ; P = 0.033 vs Stage ⅢA). Mean FACT-Hep scores varied by Child-Pugh class, especially in the subscales of physical well-being, functional well-being and the hepatobiliary cancer (P = 0.001 vs Stage I; P = 0.036 vs Stage Ⅱ; P = 0.032 vs Stage ⅢA). For the social and family well-being subscale, only Stage ⅢB scores were significantly lower as compared with Stage Ⅰ scores (P = 0.035). For the subscales of functional well-being and hepatobiliary cancer, there were significant differences for Stages ⅡΙ, ⅢA and ⅢB (P = 0.002vs StageⅠ). CONCLUSION: HRQoL of patients with HCC worsens gradually with progression of TNM stages. The most impaired subscales of HRQoL, as measured by FACT-Hep, were physical and emotional well-being.
基金Supported by the National Natural Science Foundation of China(Grant No.11861045)Gansu Province Science Foundation for Youths(Grant No.20JR10RA187)the Hongliu Foundation of First-Class Disciplines of Lanzhou University of Technology,China。
文摘In this paper,we enumerate the set of Motzkin trees with n edges according to the number of leaves,the number of vertices adjacent to a leaf,the number of protected nodes,the number of(protected)branch nodes,and the number of(protected)lonely nodes.Explicit formulae as well as generating functions are obtained.We also find that,as n goes to infinity,the proportion of protected branch nodes and protected lonely nodes among all vertices of Motzkin trees with n edges approaches 4/27 and 2/9.
文摘Abstract:Fog computing provides quality of service for cloud infrastructure.As the data computation intensifies,edge computing becomes difficult.Therefore,mobile fog computing is used for reducing traffic and the time for data computation in the network.In previous studies,software-defined networking(SDN)and network functions virtualization(NFV)were used separately in edge computing.Current industrial and academic research is tackling to integrate SDN and NFV in different environments to address the challenges in performance,reliability,and scalability.SDN/NFV is still in development.The traditional Internet of things(IoT)data analysis system is only based on a linear and time-variant system that needs an IoT data system with a high-precision model.This paper proposes a combined architecture of SDN and NFV on an edge node server for IoT devices to reduce the computational complexity in cloud-based fog computing.SDN provides a generalization structure of the forwarding plane,which is separated from the control plane.Meanwhile,NFV concentrates on virtualization by combining the forwarding model with virtual network functions(VNFs)as a single or chain of VNFs,which leads to interoperability and consistency.The orchestrator layer in the proposed software-defined NFV is responsible for handling real-time tasks by using an edge node server through the SDN controller via four actions:task creation,modification,operation,and completion.Our proposed architecture is simulated on the EstiNet simulator,and total time delay,reliability,and satisfaction are used as evaluation parameters.The simulation results are compared with the results of existing architectures,such as software-defined unified virtual monitoring function and ASTP,to analyze the performance of the proposed architecture.The analysis results indicate that our proposed architecture achieves better performance in terms of total time delay(1800 s for 200 IoT devices),reliability(90%),and satisfaction(90%).
基金The research for this paper was supported by(1)the National Natural Science Foundation of China(Grants Nos.51708429,51708428)the Open Projects Foundation(Grant No.2017-04-GF)of State Key Laboratory for Health and Safety of Bridge Structures+1 种基金Wuhan Institute of Technology Science Found(Grant No.K201734)the science and technology projects of Wuhan Urban and Rural Construction Bureau(Grants Nos.201831,201919).
文摘In this paper,general interpolating isogeometric boundary node method(IIBNM)and isogeometric boundary element method(IBEM)based on parameter space are proposed for 2D elasticity problems.In both methods,the integral cells and elements are defined in parameter space,which can reproduce the geometry exactly at all the stages.In IIBNM,the improved interpolating moving leastsquare method(IIMLS)is applied for field approximation and the shape functions have the delta function property.The Lagrangian basis functions are used for field approximation in IBEM.Thus,the boundary conditions can be imposed directly in both methods.The shape functions are defined in 1D parameter space and no curve length needs to be computed.Besides,most methods for the treatment of the singular integrals in the boundary element method can be applied in IIBNM and IBEM directly.Numerical examples have demonstrated the accuracy of the proposed methods.
基金supported by National Natural Science Foundation of China.
文摘In this paper,we study the computative structure of computable function-a structure of computative tree,and,by analysis on it,got the most general algorithm and model for computation on computable functions.
