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P4LoF: Scheduling Loop-Free Multi-Flow Updates in Programmable Networks
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作者 Jiqiang Xia Qi Zhan +2 位作者 Le Tian Yuxiang Hu Jianhua Peng 《Computers, Materials & Continua》 2026年第1期1236-1254,共19页
The rapid growth of distributed data-centric applications and AI workloads increases demand for low-latency,high-throughput communication,necessitating frequent and flexible updates to network routing configurations.H... The rapid growth of distributed data-centric applications and AI workloads increases demand for low-latency,high-throughput communication,necessitating frequent and flexible updates to network routing configurations.However,maintaining consistent forwarding states during these updates is challenging,particularly when rerouting multiple flows simultaneously.Existing approaches pay little attention to multi-flow update,where improper update sequences across data plane nodes may construct deadlock dependencies.Moreover,these methods typically involve excessive control-data plane interactions,incurring significant resource overhead and performance degradation.This paper presents P4LoF,an efficient loop-free update approach that enables the controller to reroute multiple flows through minimal interactions.P4LoF first utilizes a greedy-based algorithm to generate the shortest update dependency chain for the single-flow update.These chains are then dynamically merged into a dependency graph and resolved as a Shortest Common Super-sequence(SCS)problem to produce the update sequence of multi-flow update.To address deadlock dependencies in multi-flow updates,P4LoF builds a deadlock-fix forwarding model that leverages the flexible packet processing capabilities of the programmable data plane.Experimental results show that P4LoF reduces control-data plane interactions by at least 32.6%with modest overhead,while effectively guaranteeing loop-free consistency. 展开更多
关键词 network management update consistency programmable data plane P4
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4D printing of reprocessable thiocyanate covalent adaptable networks with reconfigurable shape memory ability
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作者 Ting Xu Kexiang Chen +7 位作者 Zhiyuan He Chuanzhen Zhang Xiaoyu Li Ziyan Zhang Wenbo Fan Zhishen Ge Chenhui Cui Yanfeng Zhang 《Chinese Chemical Letters》 2026年第2期505-511,共7页
Shape memory polymers used in 4D printing only had one permanent shape after molding,which limited their applications in requiring multiple reconstructions and multifunctional shapes.Furthermore,the inherent stability... Shape memory polymers used in 4D printing only had one permanent shape after molding,which limited their applications in requiring multiple reconstructions and multifunctional shapes.Furthermore,the inherent stability of the triazine ring structure within cyanate ester(CE)crosslinked networks after molding posed significant challenges for both recycling,repairing,and degradation of resin.To address these obstacles,dynamic thiocyanate ester(TCE)bonds and photocurable group were incorporated into CE,obtaining the recyclable and 3D printable CE covalent adaptable networks(CANs),denoted as PTCE1.5.This material exhibits a Young's modulus of 810 MPa and a tensile strength of 50.8 MPa.Notably,damaged printed PTCE1.5 objects can be readily repaired through reprinting and interface rejoining by thermal treatment.Leveraging the solid-state plasticity,PTCE1.5 also demonstrated attractive shape memory ability and permanent shape reconfigurability,enabling its reconfigurable 4D printing.The printed PTCE1.5 hinges and a main body were assembled into a deployable and retractable satellite model,validating its potential application as a controllable component in the aerospace field.Moreover,printed PTCE1.5 can be fully degraded into thiol-modified intermediate products.Overall,this material not only enriches the application range of CE resin,but also provides a reliable approach to addressing environmental issue. 展开更多
关键词 4D Printing Dynamic thiocyanate ester bonds Covalent adaptable networks Cyanate ester resin Shape memory
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中空骨料对轻质MgO-MgAl_(2)O_(4)-C耐火材料力学性能的影响
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作者 黄科 殷超凡 +6 位作者 王黎 于仁红 董宾宾 臧云飞 梁艳晨 李满仓 秦峰 《耐火材料》 北大核心 2025年第1期38-44,共7页
为了有效降低内衬材料的热量损失,保持钢液温度稳定,以高纯电熔镁砂、自制镁铝尖晶石中空骨料、α-Al_(2)O_(3)微粉、镁铝尖晶石粉、Si粉、Al粉和鳞片石墨为主要原料,以热固性酚醛树脂为结合剂,经1 200℃和1 400℃埋碳热处理制备了MgO-M... 为了有效降低内衬材料的热量损失,保持钢液温度稳定,以高纯电熔镁砂、自制镁铝尖晶石中空骨料、α-Al_(2)O_(3)微粉、镁铝尖晶石粉、Si粉、Al粉和鳞片石墨为主要原料,以热固性酚醛树脂为结合剂,经1 200℃和1 400℃埋碳热处理制备了MgO-MgAl_(2)O_(4)-C耐火材料。探究了自制镁铝尖晶石中空骨料加入量(加入质量分数分别为0、3%、6%、9%)对轻质MgO-MgAl_(2)O_(4)-C耐火材料力学性能的影响。结果表明:经1 200℃热处理后试样中有SiC和AlN产生,升温至1 400℃时生成了片状MgAlON。随着镁铝尖晶石中空骨料加入量的增加,试样的显气孔率上升,体积密度下降。当热处理温度为1 400℃时,加入6%(w)镁铝尖晶石中空骨料试样的常温抗折强度和耐压强度均达到最大值,分别为14.8 MPa和121 MPa,抗折强度保持率高达80%。中空骨料的引入改变了应力分布方向,形成了不同的耗散机制,实现了对材料的增强增韧。 展开更多
关键词 MgO-MgAl_(2)O_(4)-c耐火材料 中空骨料 MgAl_(2)O_(4) 力学性能
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废旧锂电有价元素提取热处理炉用SiC-Si_(3)N_(4)-C质耐侵蚀材料研究
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作者 姜悦纳 叶欣健 +6 位作者 陶天一 杨梦瑶 林凡凯 郑晓洪 孙振华 吴小文 黄朝晖 《耐火材料》 北大核心 2025年第3期224-228,共5页
回收废旧锂电池有价元素常用火法结合湿法冶金回收工艺,为提高回收工艺中热处理炉衬材料的耐腐蚀性能,以用后铁水包砖细颗粒(1~0.5、≤0.5 mm)、碳化硅(2~1、1~0.5、<0.5 mm)、氮化硅(<0.045 mm)和石墨为原料,将用后铁水包砖细颗... 回收废旧锂电池有价元素常用火法结合湿法冶金回收工艺,为提高回收工艺中热处理炉衬材料的耐腐蚀性能,以用后铁水包砖细颗粒(1~0.5、≤0.5 mm)、碳化硅(2~1、1~0.5、<0.5 mm)、氮化硅(<0.045 mm)和石墨为原料,将用后铁水包砖细颗粒替代同等粒度的氮化硅经800~1400℃保温3 h制备SiC-Si_(3)N_(4)-C复相耐火材料。研究了用后铁水包砖细颗粒加入量(加入质量分数分别为0、12.12%、26.25%、36.38%和48.5%)和热处理温度(800、1000、1200、1400℃)对复相耐火材料性能的影响。结果表明:1)随着用后铁水包砖细颗粒加入量的增加,试样体积密度变化较小,显气孔率呈现出逐渐减小的趋势,常温耐压强度和常温抗折强度先减小后增大;2)随着热处理温度的增加,试样体积密度先增加后减小,显气孔率呈现出逐渐减小的趋势,常温耐压强度和常温抗折强度增加;3)当热处理温度为1400℃,用后铁水包砖细颗粒全部取代碳化硅细颗粒时,试样综合性能最佳,其体积密度、显气孔率、常温耐压强度和常温抗折强度分别为2.37 g·cm^(-3)、14.3%、31.6 MPa和9.0 MPa,且1000℃抗废旧锂电池破碎料侵蚀性能良好。 展开更多
关键词 废旧锂电池回收 热处理 SiC-Si_(3)N_(4)-c 用后铁水包砖 抗侵蚀性能
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Fuzzy Neural Network Model of 4-CBA Concentration for Industrial Purified Terephthalic Acid Oxidation Process 被引量:7
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作者 刘瑞兰 苏宏业 +3 位作者 牟盛静 贾涛 陈渭泉 褚健 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2004年第2期234-239,共6页
A fuzzy neural network (FNN) model is developed to predict the 4-CBA concentration of the oxidation unit in purified terephthalic acid process. Several technologies are used to deal with the process data before modeli... A fuzzy neural network (FNN) model is developed to predict the 4-CBA concentration of the oxidation unit in purified terephthalic acid process. Several technologies are used to deal with the process data before modeling.First,a set of preliminary input variables is selected according to prior knowledge and experience. Secondly,a method based on the maximum correlation coefficient is proposed to detect the dead time between the process variables and response variables. Finally, the fuzzy curve method is used to reduce the unimportant input variables.The simulation results based on industrial data show that the relative error range of the FNN model is narrower than that of the American Oil Company (AMOCO) model. Furthermore, the FNN model can predict the trend of the 4-CBA concentration more accurately. 展开更多
关键词 purified terephthalic acid 4-carboxybenzaldchydc fuzzy neural network soft sensor input variables selection fuzzy curve dead time detection
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4-CBA Soft Sensor Based on Fuzzy CMAC Neural Networks 被引量:1
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作者 杜文莉 钱锋 +1 位作者 刘漫丹 张凯 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2005年第3期437-440,共4页
Soft sensor is attractive in dealing with online product quality measurement by virtue of other easily measured variables. In AMOCO PTA (purified terephthalic acid) production process, the unavailability of real-time ... Soft sensor is attractive in dealing with online product quality measurement by virtue of other easily measured variables. In AMOCO PTA (purified terephthalic acid) production process, the unavailability of real-time measurement of 4-CBA makes it impossible for timely adjustment and thereby influences the product quality and the plant economy benefit. In this paper, a kind of FCMAC (fuzzy cerebellar model articulation controller) method is presented to solve the online measurement problem. Different from the conventional CMAC (cerebellar model articulation controller) networks, which has inferior smoothing ability because of its table look-up based technology. Integrating fuzzy model into CMAC networks, it becomes more accurate in functional mapping without weakening its generalization ability. Numerical example and industrial application results show the method proposed here is satisfactory and feasible. 展开更多
关键词 fuzzy CMAC networks 4-carboxybenzaldehyde (4-cBA) purified terephthalic acid plant soft sensor
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Krüppel样因子4通过PI3K/Akt信号通路抑制心包间质细胞的增殖与表型转化
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作者 叶超 李芹 +3 位作者 潘佳君 宁小平 韩林 刘晓红 《海军军医大学学报》 北大核心 2026年第1期67-76,共10页
目的通过微阵列分析识别过表达Krüppel样因子4(KLF4)的心包间质细胞(PIC)中mRNA和环状RNA(circRNA)的表达谱,探讨KLF4在心包纤维化中的潜在调节机制。方法使用携带KLF4基因的腺病毒(Ad.KLF4)或携带增强型绿色荧光蛋白基因的腺病毒(... 目的通过微阵列分析识别过表达Krüppel样因子4(KLF4)的心包间质细胞(PIC)中mRNA和环状RNA(circRNA)的表达谱,探讨KLF4在心包纤维化中的潜在调节机制。方法使用携带KLF4基因的腺病毒(Ad.KLF4)或携带增强型绿色荧光蛋白基因的腺病毒(Ad.EGFP)感染PIC。通过微阵列分析识别差异表达的mRNA和circRNA。利用基因本体(GO)、京都基因与基因组百科全书(KEGG)进行基因功能和信号通路富集分析。采用CCK-8和蛋白质印迹法评估KLF4对PIC增殖和表型转化的影响,并描绘circRNA-miRNA-mRNA调控网络。结果与感染Ad.EGFP的PIC相比,在感染Ad.KLF4的PIC中识别出6197个差异表达的mRNA、393个差异表达的circRNA。GO分析显示,差异表达mRNA主要富集于细胞增殖与分化相关的生物学过程。KEGG通路富集分析提示差异表达mRNA与PI3K/Akt信号通路相关。蛋白质印迹法和CCK-8实验确认KLF4能够抑制TGF-β1诱导的细胞增殖和表型转化,这一作用可能通过PI3K/Akt信号通路实现。生物信息学分析发现,富集于PI3K/Akt通路的circRNA宿主基因包括溶血磷脂酸受体3(LPAR3)、血小板反应蛋白1(THBS1)和蛋白磷酸酶2催化亚基α(PPP2CA),并据此构建KLF4调控的PI3K/Akt通路相关circRNA-miRNA-mRNA网络。结论KLF4可能通过调节PI3K/Akt信号通路相关的circRNA-miRNA-mRNA网络抑制PIC的增殖和表型转化,为抗纤维化治疗提供了新靶点。 展开更多
关键词 Krüppel样因子4 心包间质细胞 调控网络 细胞增殖 表型转化
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Research on Predicting the Nephrotoxicity Mechanism of Lianqiao-4 Based on Network Pharmacology and Molecular Docking
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作者 Qingchun Bai Gala Bai Huan Wang 《Journal of Clinical and Nursing Research》 2025年第5期89-99,共11页
Objective:To predict the nephrotoxicity mechanism of Lianqiao-4 through network pharmacology and molecular docking methods.Methods:The main chemical components of Lianqiao(Forsythia suspensa),Bistortae rhizoma,Ophiopo... Objective:To predict the nephrotoxicity mechanism of Lianqiao-4 through network pharmacology and molecular docking methods.Methods:The main chemical components of Lianqiao(Forsythia suspensa),Bistortae rhizoma,Ophiopogonis radix,and Clematidis radix et rhizoma,as well as nephrotoxicity-related targets,were screened through databases such as TCMSP,Swiss Target Prediction,GeneCards,and ETCM.Venny 2.1.0 was used to identify the main components of Lianqiao-4 and nephrotoxicity targets.The STRING platform and David database were utilized to construct a protein-protein interaction(PPI)network diagram,while gene function(GO)enrichment analysis and KEGG pathway analysis were conducted.The“Lianqiao-4 active ingredients-nephrotoxicity targets-signaling pathways”network model was constructed using Cytoscape 3.9.1 software.Results:Network pharmacology and molecular docking analysis revealed that the core active ingredients responsible for the nephrotoxicity mechanism of Mongolian medicine Lianqiao-4 include steroidal saponins such as ophiopogonin A,flavonoids like kaempferol and quercetin,steroidal compounds such asβ-sitosterol and sitosterol,and other key regulatory targets including STAT3,ABCG2,HSP90AA1,MMP9,PTGS2,and EGFR.Major pathways involved include lipid and atherosclerosis,chemical carcinogenesis-DNA adducts,and arachidonic acid metabolism.Conclusion:Mongolian medicine Lianqiao-4 exerts its therapeutic effect on nephrotoxicity through multiple components,targets,and pathways,pending experimental verification. 展开更多
关键词 network pharmacology Molecular docking Lianqiao-4 NEPHROTOXICITY
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血清VEGF-C及FSH联合HE4对子宫肌瘤术后复发的预测价值
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作者 简锋 常艳 《浙江创伤外科》 2025年第8期1563-1566,共4页
目的 分析血清血管内皮生长因子(VEGF)-C、卵泡刺激素(FSH)联合人附睾蛋白4(HE4)对子宫肌瘤术后复发的预测。方法 回顾性分析2023年1月至2024年5月本院接受子宫肌瘤剔除术的95例子宫肌瘤患者的临床资料作为观察组,其中术后12个月有11例... 目的 分析血清血管内皮生长因子(VEGF)-C、卵泡刺激素(FSH)联合人附睾蛋白4(HE4)对子宫肌瘤术后复发的预测。方法 回顾性分析2023年1月至2024年5月本院接受子宫肌瘤剔除术的95例子宫肌瘤患者的临床资料作为观察组,其中术后12个月有11例复发、84例未复发,并选择本院同期接诊的90例健康体检女性的临床资料作为对照组。比较观察组、对照组及观察组复发与未复发患者血清VEGF-C、FSH、HE4水平,分析子宫肌瘤术后复发的危险因素及血清VEGF-C、FSH、HE4及联合检测对子宫肌瘤术后复发的预测价值。结果 观察组血清VEGF-C、FSH、HE4均高于对照组(P<0.05);观察组复发患者血清VEGF-C、FSH、HE4均高于未复发患者(P<0.05);多因素Logistic回归分析显示,肌瘤直径、肌瘤数量、血清VEGF-C、FSH、HE4均是子宫肌瘤术后复发的危险因素(P<0.05);经受试者工作曲线(ROC)分析显示,联合检测预测术后复发的AUC、敏感度、特异度分别为0.924、81.80%、97.60%,均高于各血清指标的单独检测。结论 联合检测血清VEGFC、FSH、HE4对子宫肌瘤术后复发有着较好的预测价值,临床上应予以密切关注。 展开更多
关键词 子宫肌瘤 腹腔镜 血管内皮生长因子-c 卵泡刺激素 人附睾蛋白4 预测价值
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Research on SiC-Si_(3)N_(4)-C Corrosion-resistant Materials for Heat Treatment Furnaces Used for Extraction of Valuable Elements from Spent Lithium-ion Batteries
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作者 JIANG Yuena YE Xinjian +6 位作者 TAO Tianyi YANG Mengyao LIN Fankai ZHENG Xiaohong SUN Zhenhua WU Xiaowen HUANG Zhaohui 《China's Refractories》 2025年第4期15-19,共5页
The pyrometallurgy combined with hydrometallurgy process is commonly used for recovering valuable elements from spent lithium-ion batteries.To improve the corrosion resistance of heat treatment furnace lining material... The pyrometallurgy combined with hydrometallurgy process is commonly used for recovering valuable elements from spent lithium-ion batteries.To improve the corrosion resistance of heat treatment furnace lining materials in this process,SiC-Si_(3)N_(4)-C composite refractories were prepared by heat-treating at 800-1400℃ for 3 h,using fine particles of spent iron ladle bricks(1-0.5 and<0.5 mm),silicon carbide(2-1,1-0.5,and<0.5 mm),silicon nitride(<0.045 mm),and graphite as raw materials.The fine particles of spent iron ladle bricks were used to replace silicon nitride with the same particle size.The effects of the spent iron ladle brick fine particles additions(0,12.12%,26.25%,36.38%and 48.5%,by mass)and the heat treatment temperatures(800,1000,1200 and 1400℃)on the properties of the composite refractories were studied.The results show that:(1)with the<1 mm spent iron ladle brick fine particles addition increasing,the bulk density of the samples changes slightly,the apparent porosity gradually decreases,the cold modulus of rupture(CMOR)increases,and the cold compressive strength(CCS)first decreases,then increases and finally decreases slightly;(2)with the heat treatment temperature rising,the bulk density of the samples first increases and then decreases,the apparent porosity gradually decreases,and the CCS and the CMOR increase;(3)when the temperature is 1400℃ and the spent iron ladle brick fine particles completely replace the silicon nitride fine particles with the same particle size,the sample exhibits the best comprehensive performance,with the bulk density of 2.37 g·cm^(-3),apparent porosity of 14.3%,CCS of 31.6 MPa,and CMOR of 9.0 MPa,and it has a good resistance to the corrosion of crushed spent lithium-ion battery materials at 1000℃. 展开更多
关键词 spent lithium-ion battery recycling heat treatment SiC-Si_(3)N_(4)-c spent iron ladle bricks corrosion resistance
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血清cMyBP-C、MyO、Foxo4水平在急性心肌梗死患者PCI术后的水平及与MACE发生的相关性分析
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作者 陈海萍 《四川生理科学杂志》 2025年第1期149-152,共4页
目的:探讨急性心肌梗死(Acute myocardial infarction,AMI)患者经皮冠状动脉介入术(Percutaneous coronary intervention,PCI)术后血清心肌肌球蛋白结合蛋白-C(Myocardial myosin binding protein-C,cMyBP-C)、肌红蛋白(Myoglobin,MyO)... 目的:探讨急性心肌梗死(Acute myocardial infarction,AMI)患者经皮冠状动脉介入术(Percutaneous coronary intervention,PCI)术后血清心肌肌球蛋白结合蛋白-C(Myocardial myosin binding protein-C,cMyBP-C)、肌红蛋白(Myoglobin,MyO)、转录因子叉头框蛋白4(Fork head box O4,Foxo4)水平变化及其对主要不良心血管事件(Major adverse cardiovascular events,MACE)发生的预测价值。方法:选取2021年1月至2023年1月于本院接受PCI治疗的104例AMI患者进行回顾性分析。依据术后6 m是否发生MACE将患者分为发生组和未发生组。分析比较两组的血清cMyBP-C、MyO、Foxo4水平及临床资料。分析PCI术后MACE发生的影响因素。评价术后1m血清cMyBP-C、MyO、Foxo4水平对MACE发生的预测价值。结果:术后15 d、术后1m,发生组的血清cMyBP-C、MyO、Foxo4水平均明显高于未发生组(P<0.05)。Killip分级及术后1m血清cMyBP-C、MyO、Foxo4水平均为MACE发生的独立危险因素(P<0.05)。cMyBP-C、MyO、Foxo4联合检测预测MACE发生的AUC明显大于单项指标预测(P<0.05)。结论:AMI患者PCI术后血清cMyBP-C、MyO、Foxo4水平升高与MACE发生密切相关,联合检测其水平对PCI术后6 m MACE发生具有一定预测价值。 展开更多
关键词 急性心肌梗死 经皮冠状动脉介入术 心肌肌球蛋白结合蛋白-c 肌红蛋白 转录因子叉头框蛋白4
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Simulation and optimization for synthetic technology of 2-chloro-4,6-dinitroresorcinol based on back-propagation neural network
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作者 史瑞欣 Huang Yudong 《High Technology Letters》 EI CAS 2007年第3期283-286,共4页
Back-propagation neural network was applied to predict and optimize the synthetic technology of 2-chloro-4,6-dinitroresorcinol. A model was established based on back-propagation neural network using the experimental d... Back-propagation neural network was applied to predict and optimize the synthetic technology of 2-chloro-4,6-dinitroresorcinol. A model was established based on back-propagation neural network using the experimental data of homogeneous design as the training sample set and the technological parameters were optimized by it. The optimal technological parameters are as follows: the reaction time is 4h, the reaction temperature is 80℃, the molar ratio of NaOH to 4,6-dinitro-1,2,3-trichlorobenzene is 5.5:1, the molar ratio of methanol to 4,6-dinitro-1,2,3- trichlorobenzene is 11:1, and the molar ratio of water to 4,6-dinitro-1,2,3-trichlorobenzene is 70:1. Under the optimal conditions, three groups of experiments were performed and the average yield of 2-chloro-4,6-dinitroresorcinol is 96.64%, the absolute error of it with the predicted value is -1.07%. 展开更多
关键词 2-chlom-4 6-dinitroresorcinol synthetic technology OPTIMIZATION back-propagation neural network model constructing
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An Auto-configuration 4M Group Management using Wireless Sensor Networks for Reconfigurable Manufacturing System
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作者 Suk-Keun Cha Jeong-Hoon Lee +4 位作者 Joon Jae Yoo Jung Hoon Kang Han Gyu Kim Dong Hoon Kim Jun Yeob Song 《Journal of Measurement Science and Instrumentation》 CAS 2010年第S1期192-198,共7页
The first tier of automotive manufacturers has faced to pressures about move,modify,updating tasks for manufacturing resources in production processes from demand response of production order sequence for motor compan... The first tier of automotive manufacturers has faced to pressures about move,modify,updating tasks for manufacturing resources in production processes from demand response of production order sequence for motor company and process innovation purpose for productivity. For meets this requirements,it has to require absolutely lead time to re-wiring of physical interface for production equipment,needs for change existing program and test over again.For prepare this constraints,it needs studying an auto-configuration functions that build for both visibility and flexibility based on the 4M(Man,Machine,Material, Method)group management which is supports from WSN (Wireless Sensor Network)of the open embedded device called M2M(Machine to Machine)and major functions of middleware including point manager for real-time device communication,real-time data management,Standard API (Application Program Interface)and application template management.To be application system to RMS (Reconfigurable Manufacturing System)for rapidly response from various orders and model from motor company that is beginning to establishing the mapping of manufacturing resources of 4M using WSN. 展开更多
关键词 Auto-configuration Wireless Sensor network RECONFIGURABLE Production resoureces of 4M TINYOS Machien to Machine MIDDLEWARE Application Template Manager
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血清腱糖蛋白-C和多种肝纤维化指数诊断慢性乙型肝炎患者肝纤维化效能研究
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作者 黄炎芳 李远 +1 位作者 李政 黎坚 《实用肝脏病杂志》 2026年第2期187-190,共4页
目的探讨血清腱糖蛋白-C(TN-C)及γ-谷氨酰转肽酶/血小板比值(GPR)、天冬氨酸氨基转移酶/血小板比率指数(APRI)、非酒精性脂肪性肝病肝纤维化评分(NFS)、纤维化4因子指数(FIB-4)和S指数诊断慢性乙型肝炎(CHB)患者肝纤维化的价值。方法2... 目的探讨血清腱糖蛋白-C(TN-C)及γ-谷氨酰转肽酶/血小板比值(GPR)、天冬氨酸氨基转移酶/血小板比率指数(APRI)、非酒精性脂肪性肝病肝纤维化评分(NFS)、纤维化4因子指数(FIB-4)和S指数诊断慢性乙型肝炎(CHB)患者肝纤维化的价值。方法2021年1月~2024年12月我院诊治的163例CHB患者,均接受经皮肝穿刺活检,常规检测血清和血液指标,计算各指数,采用ELISA法检测血清TN-C水平。应用Logistic回归分析影响进展性肝纤维化发生的因素,应用受试者工作特征曲线(ROC)评估血清TN-C和各指数诊断CHB患者发生进展性肝纤维化的效能。结果在163例CHB患者中,经肝组织病理学检查诊断无肝纤维化50例,显著性肝纤维化52例和进展性肝纤维化48例;进展期肝纤维化组血清TN-C、GPR、APRI、NFS、FIB-4和S指数分别为(62.4±9.1)ng/mL、(0.6±0.2)、(1.0±0.3)、(-0.3±0.1)、(3.1±0.7)和(1.2±0.2),均显著高于显著性肝纤维化组[分别为(37.5±5.2)ng/mL、(0.2±0.1)、(0.7±0.2)、(-1.0±0.4)、(0.8±0.2)和(0.4±0.1),P<0.05];多因素分析显示血清TN-C及GPR、APRI、NFS、FIB-4和S指数升高均为影响CHB患者发生进展性肝纤维化的独立危险因素(P<0.05);血清TN-C联合GPR、APRI、NFS、FIB-4和S指数诊断CHB患者发生进展性肝纤维化的AUC为0.915,其灵敏度为98.4%,但特异度仅为61.8%。结论血清TN-C水平联合多种指数评估CHB患者进展性肝纤维化有一定的临床应用价值。 展开更多
关键词 慢性乙型肝炎 肝纤维化 腱糖蛋白-c γ-谷氨酰转肽酶/血小板比值 天冬氨酸氨基转移酶/血小板比率指数 非酒精性脂肪性肝病肝纤维化评分 纤维化4因子指数 S指数 诊断
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An Auto-Configuration of 4M Group Management Using Wireless Sensor Networks
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作者 Suk-Keun Cha Jeong-Hoon Lee +4 位作者 Han Gyu Kim Joon Jae Yoo Jung Hoon Kang Dong Hoon Kim Jun Yeob Song 《Wireless Sensor Network》 2010年第5期402-410,共9页
The first tier of automotive manufacturers has faced to pressures about move, modify, updating tasks for manufacturing resources in production processes from demand response of production order sequence for motor comp... The first tier of automotive manufacturers has faced to pressures about move, modify, updating tasks for manufacturing resources in production processes from demand response of production order sequence for motor company and process innovation purpose for productivity. For meets this requirements, it has to require absolutely lead time to re-wiring of physical interface for production equipment, needs for change existing program and test over again. For prepare this constraints, it needs studying an auto-configuration functions that build for both visibility and flexibility based on the 4M (Man, Machine, Material, Method) group management which is supports from WSN (Wireless Sensor Network) of the open embedded device called M2M (Machine to Machine) and major functions of middleware including point manager for real-time device communication, real-time data management, Standard API (Application Program Interface) and application template management. To be application system to RMS (Reconfigurable Manufacturing System) for rapidly response from various orders and model from motor company that is beginning to establishing the mapping of manufacturing resources of 4M using WSN. 展开更多
关键词 Auto-configuration Wireless Sensor network RECONFIGURABLE Production Resoureces of 4M TINYOS Machien to MACHINE MIDDLEWARE Application TEMPLATE MANAGER
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3,3'-芳基(烷基)二(4-氨基香豆素)和1,4-二氢吡啶并[3,2-c][5,6-c]双香豆素类衍生物的有效合成 被引量:8
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作者 王道林 吴健莹 +2 位作者 董哲 吴丹 王永阳 《有机化学》 SCIE CAS CSCD 北大核心 2015年第1期200-206,共7页
在KHSO4作用下,以4-氨基香豆素和醛为基础原料,通过反应条件的有效控制,成功制备了一系列3,3′-芳基(烷基)二(4-氨基香豆素)和1,4-二氢吡啶并[3,2-c][5,6-c]双香豆素类化合物.该反应操作简单、条件温和、收率良好.产物结构经NMR,IR及元... 在KHSO4作用下,以4-氨基香豆素和醛为基础原料,通过反应条件的有效控制,成功制备了一系列3,3′-芳基(烷基)二(4-氨基香豆素)和1,4-二氢吡啶并[3,2-c][5,6-c]双香豆素类化合物.该反应操作简单、条件温和、收率良好.产物结构经NMR,IR及元素分析数据得以证实. 展开更多
关键词 4-氨基香豆素 3 3′-芳基(烷基)二(4-氨基香豆素) 1 4-二氢吡啶并[3 2-c][5 6-c]双香豆素 KHSO4 合成
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C1-C4烷烃预混层流燃烧与着火特性研究 被引量:16
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作者 胡二江 黄佐华 +2 位作者 姜雪 李倩倩 章心怡 《工程热物理学报》 EI CAS CSCD 北大核心 2013年第3期558-562,共5页
本文利用定容燃烧弹和激波管测量了C1-C4低碳烷烃燃料(甲烷、乙烷、丙烷和正丁烷)在不同压力和温度下的预混层流燃烧速度和着火延迟期,并利用Chemkin软件对预混层流燃烧和着火过程进行了模拟计算和化学反应动力学分析。实验结果和计算... 本文利用定容燃烧弹和激波管测量了C1-C4低碳烷烃燃料(甲烷、乙烷、丙烷和正丁烷)在不同压力和温度下的预混层流燃烧速度和着火延迟期,并利用Chemkin软件对预混层流燃烧和着火过程进行了模拟计算和化学反应动力学分析。实验结果和计算结果均表明,在相同工况下,四种烷烃的层流燃烧速度值分别为:甲烷最小,乙烷最快,丙烷和正丁烷相差不大并介于甲烷和乙烷之间;四种烷烃的着火延迟期分别为:甲烷最大,乙烷最快,丙烷和正丁烷相差不大并介于甲烷和乙烷之间。随着当量比的增加,甲烷混合气的马克斯坦长度增大,而乙烷、丙烷和正丁烷的减小。通过化学反应动力学分析和敏感性分析解释了上述现象。 展开更多
关键词 C1-c4低碳烷烃 层流燃烧速度 着火延迟期 化学反应动力学
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超硬薄膜β-C_3N_4的制备和表征 被引量:4
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作者 张永平 顾有松 +4 位作者 常香荣 田中卓 时东霞 张秀芳 袁磊 《功能材料》 EI CAS CSCD 北大核心 2000年第2期172-174,共3页
本文采用微波等离子体化学气相沉积 (MPCVD)法 ,用高纯氮气 (99.999% )和甲烷 (99.9% )作反应气体 ,在单晶硅和多晶铂基片上沉积 β -C3N4薄膜。X射线能谱 (EDX)分析了这种晶态C -N膜的化学成分 ,对不同样品的分析结果表明 ,N/C原子比在... 本文采用微波等离子体化学气相沉积 (MPCVD)法 ,用高纯氮气 (99.999% )和甲烷 (99.9% )作反应气体 ,在单晶硅和多晶铂基片上沉积 β -C3N4薄膜。X射线能谱 (EDX)分析了这种晶态C -N膜的化学成分 ,对不同样品的分析结果表明 ,N/C原子比在 1.1~ 2 .0范围内。X射线衍射结构分析结果与计算的α -和 β -C3N4单相X射线的峰位和强度相比较 ,说明它是α -和 β -C3N4的混合物。FT -IR和Raman谱支持C -N共价键的存在。薄膜的体弹性模量达到 349GPa。 展开更多
关键词 β-c3N4 超硬薄膜 MPCVD 制备 表征
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茂金属配合物 [(eat^5-C_5H_4R)Mo(CO)_3]_2(R:SiMe_3,Si_2Me_5)的电子结构研究 被引量:12
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作者 邝代治 冯泳兰 +3 位作者 许金生 王剑秋 张复兴 周秀中 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 北大核心 2003年第1期59-63,共5页
运用G98W ,采用Lanl2dz基组 ,对茂金属配合物 [(eat5 C5H4R)Mo(CO) 3 ]2 (R :SiMe3 ,Si2 Me5)进行从头算研究 ,探讨配合物结构单元的稳定性、分子轨道能量、原子净电荷布居规律 ,以及一些前沿分子轨道的组成特征等 ,结果表明 ,标题配合... 运用G98W ,采用Lanl2dz基组 ,对茂金属配合物 [(eat5 C5H4R)Mo(CO) 3 ]2 (R :SiMe3 ,Si2 Me5)进行从头算研究 ,探讨配合物结构单元的稳定性、分子轨道能量、原子净电荷布居规律 ,以及一些前沿分子轨道的组成特征等 ,结果表明 ,标题配合物结构在能量上是稳定的 ,作为结构单元而存在 . 展开更多
关键词 茂金属配合物 [(eat^5-c5H4R)Mo(CO)3]2 从头计算 电子结构
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真核细胞表达质粒pCMV4增强hCGβ-C3d3DNA疫苗的表达效率和免疫效力 被引量:4
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作者 赵欣荣 李大金 +1 位作者 蔡立荣 孙晓溪 《中国免疫学杂志》 CAS CSCD 北大核心 2004年第4期228-230,共3页
目的 :比较以pCMV4和pcDNA3为载体的hCGβ C3d3DNA疫苗的表达效率和免疫效力。 方法 :分别构建pcD NA3 hCGβ C3d3、pCMV4 hCGβ C3d3真核细胞表达质粒 ,并转染真核细胞瞬时表达系统COS 7细胞 ,以分析体外表达效率。抽提与纯化pcDNA3、... 目的 :比较以pCMV4和pcDNA3为载体的hCGβ C3d3DNA疫苗的表达效率和免疫效力。 方法 :分别构建pcD NA3 hCGβ C3d3、pCMV4 hCGβ C3d3真核细胞表达质粒 ,并转染真核细胞瞬时表达系统COS 7细胞 ,以分析体外表达效率。抽提与纯化pcDNA3、pcDNA3 hCGβ C3d3、pCMV4 hCGβ C3d3质粒。对 6周龄BLAB C小鼠行DNA免疫。于末次免疫后 6周采血 ,用间接ELISA分析实验动物外周血抗hCGβ抗体效价。 结果 :对COS 7体外表达效率分析 ,由pCMV4介导的hCGβ C3d3表达效率明显高于pcDNA3。动物DNA免疫结果 ,pCMV4 hCGβ C3d3刺激动物机体产生的免疫应答强度及免疫效果显著高于pcDNA3 hCGβ C3d3。 结论 :pCMV4真核表达质粒hCGβ C3d3体外表达效率及动物DNA免疫效力均显著高于pcDNA3真核表达质粒。 展开更多
关键词 pCMV4-hCGβ-c3d3 pcDNA3-hCGβ-c3d3 表达效率 免疫效力 DNA免疫
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