Respiratory monitoring is increasingly used in clinical and healthcare practices to diagnose chronic cardio-pulmonary functional diseases during various routine activities.Wearable medical devices have realized the po...Respiratory monitoring is increasingly used in clinical and healthcare practices to diagnose chronic cardio-pulmonary functional diseases during various routine activities.Wearable medical devices have realized the possibilities of ubiquitous respiratory monitoring,however,relatively little attention is paid to accuracy and reliability.In previous study,a wearable respiration biofeedback system was designed.In this work,three kinds of signals were mixed to extract respiratory rate,i.e.,respiration inductive plethysmography(RIP),3D-acceleration and ECG.In-situ experiments with twelve subjects indicate that the method significantly improves the accuracy and reliability over a dynamic range of respiration rate.It is possible to derive respiration rate from three signals within mean absolute percentage error 4.37%of a reference gold standard.Similarly studies derive respiratory rate from single-lead ECG within mean absolute percentage error 17%of a reference gold standard.展开更多
The acceleration grid power supply(AGPS) is a crucial part of the Negative-ion Neutral Beam Injection system in the China Fusion Engineering Test Reactor,which includes a 3-phase passive(diode) rectifier.To diagnose a...The acceleration grid power supply(AGPS) is a crucial part of the Negative-ion Neutral Beam Injection system in the China Fusion Engineering Test Reactor,which includes a 3-phase passive(diode) rectifier.To diagnose and localize faults in the rectifier,this paper proposes a frequencydomain analysis-based fault diagnosis algorithm for the rectifier in AGPS.First,time-domain expressions and spectral characteristics of the output voltage of the TPTL-NPC inverter-based power supply are analyzed.Then,frequency-domain analysis-based fault diagnosis and frequency-domain analysis-based sub-fault diagnosis algorithms are proposed to diagnose open circuit(OC) faults of diode(s),which benefit from the analysis of harmonics magnitude and phase-angle of the output voltage.Only a fundamental period is needed to diagnose and localize exact faults,and a strong Variable-duration Fault Detection Method is proposed to identify acceptable ripple from OC faults.Detailed simulations and experimental results demonstrate the effectiveness,quickness,and robustness of the proposed algorithms,and the diagnosis algorithms proposed in this article provide a significant method for the fault diagnosis of other rectifiers and converters.展开更多
Many analytical methods have been adopted to estimate the slope stability by providing various stability numbers,e.g.static safety of factor(static FoS)or the critical seismic acceleration coefficient,while little att...Many analytical methods have been adopted to estimate the slope stability by providing various stability numbers,e.g.static safety of factor(static FoS)or the critical seismic acceleration coefficient,while little attention has been given to the relationship between the slope stability numbers and the critical seismic acceleration coefficient.This study aims to investigate the relationship between the static FoS and the critical seismic acceleration coefficient of soil slopes in the framework of the upper-bound limit analysis.Based on the 3D rotational failure mechanism,the critical seismic acceleration coefficient using the pseudo-static method and the static FoS using the strength reduction technique are first determined.Then,the relationship between the static FoS and the critical seismic acceleration coefficient is presented under considering the slope angleβ,the frictional angleφ,and the dimensionless coefficients B/H and c/γH.Finally,a fitting formula between the static FoS and the critical seismic acceleration coefficient is proposed and validated by analytical and numerical results.展开更多
This study explores the influence of infill patterns on machine acceleration prediction in the realm of three-dimensional(3D)printing,particularly focusing on extrusion technology.Our primary objective was to develop ...This study explores the influence of infill patterns on machine acceleration prediction in the realm of three-dimensional(3D)printing,particularly focusing on extrusion technology.Our primary objective was to develop a long short-term memory(LSTM)network capable of assessing this impact.We conducted an extensive analysis involving 12 distinct infill patterns,collecting time-series data to examine their effects on the acceleration of the printer’s bed.The LSTM network was trained using acceleration data from the adaptive cubic infill pattern,while the Archimedean chords infill pattern provided data for evaluating the network’s prediction accuracy.This involved utilizing offline time-series acceleration data as the training and testing datasets for the LSTM model.Specifically,the LSTM model was devised to predict the acceleration of a fused deposition modeling(FDM)printer using data from the adaptive cubic infill pattern.Rigorous testing yielded a root mean square error(RMSE)of 0.007144,reflecting the model’s precision.Further refinement and testing of the LSTM model were conducted using acceleration data from the Archimedean chords infill pattern,resulting in an RMSE of 0.007328.Notably,the developed LSTM model demonstrated superior performance compared to an optimized recurrent neural network(RNN)in predicting machine acceleration data.The empirical findings highlight that the adaptive cubic infill pattern considerably influences the dimensional accuracy of parts printed using FDM technology.展开更多
The effects of accelerated photooxidation on the molecular weight and thermal and mechanical properties of Cast PHBV and PHBV/Cloisite 30B(3 wt%)bionanocomposites are investigated herein.Through size exclusion chromat...The effects of accelerated photooxidation on the molecular weight and thermal and mechanical properties of Cast PHBV and PHBV/Cloisite 30B(3 wt%)bionanocomposites are investigated herein.Through size exclusion chromatography(SEC)analysis,a significant decrease in both weight and number average molecular weights was observed for all irradiated samples over time,resulting from the chain scission mechanism.Differential scanning calorimetry(DSC)data indicated a decrease in degree of crystallinity and melting temperature after UV exposure,with the appearance of double melting peaks related to the changes in the crystal structure of PHBV.Thermal stability,tensile and thermo-mechanical properties were also reduced consecutively in photooxidation,being more pronounced for Cast PHBV.This study shows that the incorporation of Cloisite 30B in PHBV provides a better resistance to photooxidation in comparison with the neat polymer.展开更多
Objective To investigate whether the antioxidation and the regulation on the Extracellular Regulated Protein Kinases （ERK） signaling pathway are involved in the protective effects of blueberry on central nervous sys...Objective To investigate whether the antioxidation and the regulation on the Extracellular Regulated Protein Kinases （ERK） signaling pathway are involved in the protective effects of blueberry on central nervous system. Methods 30 Senescence-accelerated mice prone 8 （SAMP8） mice were divided into three groups and treated with normal diet, blueberry extracts （200 mg/kg.bw/day） and cyaniding-3-O-galactoside （Cy-3-GAL） （50 mg/kg.bw/day） from blueberry for 8 weeks. 10 SAMR1 mice were set as control group. The capacity of spatial memory was assessed by Passive avoidance task and Morris water maze. Histological analyses on hippocampus were completed. Malondialdehyde （MDA） levels, Superoxide Dismutase （SOD） activity and the expression of ERK were detected. Results Both Cy-3-GAL and blueberry extracts were shown effective functions to relieve cellular injury, improve hippocampal neurons survival and inhibit the pyramidal cell layer damage. Cy-3-GAL and blueberry extracts also increased SOD activity and reduced MDA content in brain tissues and plasma, and increased hippocampal phosphorylated ERK （p-ERK） expression in SAMP8 mice. Further more, the passive avoidance task test showed that both the latency time and the number of errors were improved by Cy-3-GAL treatment, and the Morris Water Maze test showed significant decreases of latency were detected by Cy-3-GAL and blueberry extracts treatment on day 4. Conclusion Blueberry extracts may reverse the declines of cognitive and behavioral function in the ageing process through several pathways, including enhancing the capacity of antioxidation, altering stress signaling. Cy-3-GAL may be an important active ingredient for these biological effects.展开更多
Optical coherence tomography(OCT)imaging technology has significant advantages in in situ and noninvasive monitoring of biological tissues.However,it still faces the following challenges:including data processing spee...Optical coherence tomography(OCT)imaging technology has significant advantages in in situ and noninvasive monitoring of biological tissues.However,it still faces the following challenges:including data processing speed,image quality,and improvements in three-dimensional(3D)visualization effects.OCT technology,especially functional imaging techniques like optical coherence tomography angiography(OCTA),requires a long acquisition time and a large data size.Despite the substantial increase in the acquisition speed of swept source optical coherence tomography(SS-OCT),it still poses significant challenges for data processing.Additionally,during in situ acquisition,image artifacts resulting from interface reflections or strong reflections from biological tissues and culturing containers present obstacles to data visualization and further analysis.Firstly,a customized frequency domainfilter with anti-banding suppression parameters was designed to suppress artifact noises.Then,this study proposed a graphics processing unit(GPU)-based real-time data processing pipeline for SS-OCT,achieving a measured line-process rate of 800 kHz for 3D fast and high-quality data visualization.Furthermore,a GPU-based realtime data processing for CC-OCTA was integrated to acquire dynamic information.Moreover,a vascular-like network chip was prepared using extrusion-based 3D printing and sacrificial materials,with sacrificial material being printed at the desired vascular network locations and then removed to form the vascular-like network.OCTA imaging technology was used to monitor the progression of sacrificial material removal and vascular-like network formation.Therefore,GPU-based OCT enables real-time processing and visualization with artifact suppression,making it particularly suitable for in situ noninvasive longitudinal monitoring of 3D bioprinting tissue and vascular-like networks in microfluidic chips.展开更多
The acquisition of secondary chromosomal aberrations in chronic myeloid leukemia (CML) patients with Philadelphia chromosome-positive (Ph+) karyotype signifies clonal evolution associated with the progression of the d...The acquisition of secondary chromosomal aberrations in chronic myeloid leukemia (CML) patients with Philadelphia chromosome-positive (Ph+) karyotype signifies clonal evolution associated with the progression of the disease to its accelerated or blastic phase. Therefore, these aberrations have clinical and biological significance. T(3;12)(q26;p13), which is a recurrent chromosomal aberration observed in myeloid malignancies, is typically associated with dysplasia of megakaryocytes, multilineage involvement, short duration of any blastic phase, and extremely poor prognosis. We have identified a recurrent reciprocal translocation between chromosomes 3 and 12 with different breakpoint at bands 3q21 in the malignant cells from a 28-year-old man. The patient was initially diagnosed as having Ph+ CML in the chronic phase. The t(3;12)(q21;p13) translocation occurred 4 years after the patient was first diagnosed with CML while undergoing tyrosine kinase inhibitor therapy. We confirmed the t(3;12)(q21;p13) translocation via fluorescence in situ hybridization assay by using whole-chromosome paint probes for chromosomes 3 and 12. Our findings demonstrate that, similar to other recurrent translocations involving 3q26 such as t(3;3) and t(3;21), the t(3;12)(q21;p13) translocation is implicated not only in myelodysplastic syndrome and acute myeloid leukemia but also in the progression of CML. These findings extend the disease spectrum of this cytogenetic aberration.展开更多
In this paper, we construct rotating charged hairy black hole in(2+1) dimensions for infinitesimal black hole charge and rotation parameters. Then we consider this black hole as particle accelerator and calculate the ...In this paper, we construct rotating charged hairy black hole in(2+1) dimensions for infinitesimal black hole charge and rotation parameters. Then we consider this black hole as particle accelerator and calculate the centerof-mass energy of two colliding test particles near the rotating charged hairy black hole in(2+1) dimensions. As we expected, the center-of-mass energy has infinite value.展开更多
To find the distribution patterns of dynamic amplification coefficients for dams subjected to earthquake, 3D seismic responses of concrete-faced rockfill dams with different heights and different shapes of river valle...To find the distribution patterns of dynamic amplification coefficients for dams subjected to earthquake, 3D seismic responses of concrete-faced rockfill dams with different heights and different shapes of river valley were analyzed by using the equivalent-linear model. Statistical analysis was also made to the seismic coefficient, and an empirical formula for calculating the maximum acceleration was provided. The results indicate that under the condition of the same dam height and the same base acceleration excitations, with the increase of the river valley width, the position of the maximum acceleration on the axis of the top of the dam moves from the center to the riversides symmetrically. For the narrow valleys, the maximum acceleration occurs in the middle of the axis at the top of the dam; for wide valleys the maximum acceleration appears near the riversides. The result negates the application of 2D dynamical computation for wide valleys, and shows that for the seismic response of high concrete-faced rockfill dams, the seismic coefficient along the axis should be given, except for that along the dam height. Seismic stability analysis of rockfill dams using pseudo-static method can be modified according to the formula.展开更多
The loss of Baryonic Matter through Black Holes from our spatial 3-D Universe into its 4th dimension as Dark Matter, is used along with the Conservation of Angular Momentum Principle to prove theoretically the acceler...The loss of Baryonic Matter through Black Holes from our spatial 3-D Universe into its 4th dimension as Dark Matter, is used along with the Conservation of Angular Momentum Principle to prove theoretically the accelerated expansion of the 3-D Universe, as has already been confirmed experimentally being awarded the 2011 Nobel Prize in Physics. Theoretical calculations can estimate further to indicate the true nature of the acceleration;that the outward acceleration is due to the rotation of the Universe caused by Dark Energy from the Void, that the acceleration is non-linear, initially increasing from zero for the short period of about a Million years at a constant rate, and then leveling off non-linearly over extended time before the outward acceleration begins to decrease in a non-linear fashion until it is matched by the gravitational attraction of the matter content of 4D Space and the virtual matter in 3-D Vacuum Space. m = m(4D) + m(Virtual). The rotation of our 3D Universe will become constant once all 3D matter has entered 4D space. As the 3-D Universe tries to expand further it will be pulled inward by its gravitational attraction and will then keep on oscillating about a final radius r<sub>f</sub> while it also keeps on oscillating at right angles to the radius r<sub>f</sub> around final angular velocity ω<sub>f</sub>, until it becomes part of the 4-D Universe. The constant value of the Angular Momentum of our Universe is L = .展开更多
Designing highly effective cathodic catalysts that can efficiently generate H_(2)O_(2)in situ and promptly convert it to hydroxyl radicals(·OH)poses a significant challenge within the heterogeneous electro-Fenton...Designing highly effective cathodic catalysts that can efficiently generate H_(2)O_(2)in situ and promptly convert it to hydroxyl radicals(·OH)poses a significant challenge within the heterogeneous electro-Fenton(EF)systems.Herein,we fabricate a bifunctional core-shell catalyst featuring Co^(0)species encapsulated within N,P-codoped carbon shells through a hydrothermal-pyrolysis strategy,utilizing bamboo shoots as biomass-derived precursors.Density functional theory(DFT)calculations elucidate that the protonation of pyridinic nitrogen modifies the adsorption energy of the OOH*intermediate,positioning it optimally at the peak(3.81 eV)on the twoelectron oxygen reduction reaction(2e-ORR)volcano plot,thereby significantly boosting H_(2)O_(2)production.Moreover,the Co^(0)species embedded within the catalyst function as electron donors,catalyzing the activation of H_(2)O_(2)to produce·OH by efficiently facilitating the transfer of electrons to Fe^(3+).Consequently,the synthesized catalyst exhibits a minimum electron transfer number of 2.06 and a maximum H_(2)O_(2)selectivity of 97.4%.Moreover,the degradation for the methylene blue solution exceeds 95%within 15 min,with only an 11.3%reduction in degradation efficiency after 180 min of continuous operation(9 cycles).This bifunctional catalyst design provides valuable insights that can accelerate the development of EF-based degradation systems.展开更多
运用最先进的小型加速加载设备MMLS3(1/3model mobile load simulator)对常见的用于上、中面层的4种改性沥青混合料进行了高温稳定性试验,提出了适合中国的MMLS3室内加速加载的各项试验参数.通过研究改性沥青混合料的实际抗车辙性能,得...运用最先进的小型加速加载设备MMLS3(1/3model mobile load simulator)对常见的用于上、中面层的4种改性沥青混合料进行了高温稳定性试验,提出了适合中国的MMLS3室内加速加载的各项试验参数.通过研究改性沥青混合料的实际抗车辙性能,得出沥青混合料高温稳定性能的优劣顺序为:SBS橡胶复合改性SMA-13,SBS改性AC-20C,SBS改性AC-13C,SBS橡胶复合改性OGFC-13,岩沥青改性AC-20C.由于OGFC-13的大空隙结构,必然要在某种程度上牺牲其强度、抗剪切性能及耐久性,不建议在重交通的高速公路上使用其作为表面层.高温重载或超限地区应加强中面层的优化设计.MMLS3加载试验及常规动稳定度试验在衡量空隙率差距小的沥青混合料时,两者试验结果具有较好的一致性;而对于不同沥青混合料,当其空隙率差距大时,应根据需要选择合适的试验或评价方法.展开更多
基金Project(2012M510207)supported by the China Postdoctoral Science FoundationProjects(60932001,61072031)supported by the National Natural Science Foundation of China+2 种基金Project(2012AA02A604)supported by the National High Technology Research and Development Program of ChinaProject(2013ZX03005013)supported by the Next Generation Communication Technology Major Project of National Science and Technology,ChinaProject supported by the"One-hundred Talent"and the"Low-cost Healthcare"Programs of Chinese Academy of Sciences
文摘Respiratory monitoring is increasingly used in clinical and healthcare practices to diagnose chronic cardio-pulmonary functional diseases during various routine activities.Wearable medical devices have realized the possibilities of ubiquitous respiratory monitoring,however,relatively little attention is paid to accuracy and reliability.In previous study,a wearable respiration biofeedback system was designed.In this work,three kinds of signals were mixed to extract respiratory rate,i.e.,respiration inductive plethysmography(RIP),3D-acceleration and ECG.In-situ experiments with twelve subjects indicate that the method significantly improves the accuracy and reliability over a dynamic range of respiration rate.It is possible to derive respiration rate from three signals within mean absolute percentage error 4.37%of a reference gold standard.Similarly studies derive respiratory rate from single-lead ECG within mean absolute percentage error 17%of a reference gold standard.
基金supported by the National Key R&D Program of China(No.2017YFE0300104)National Natural Science Foundation of China(No.51821005)
文摘The acceleration grid power supply(AGPS) is a crucial part of the Negative-ion Neutral Beam Injection system in the China Fusion Engineering Test Reactor,which includes a 3-phase passive(diode) rectifier.To diagnose and localize faults in the rectifier,this paper proposes a frequencydomain analysis-based fault diagnosis algorithm for the rectifier in AGPS.First,time-domain expressions and spectral characteristics of the output voltage of the TPTL-NPC inverter-based power supply are analyzed.Then,frequency-domain analysis-based fault diagnosis and frequency-domain analysis-based sub-fault diagnosis algorithms are proposed to diagnose open circuit(OC) faults of diode(s),which benefit from the analysis of harmonics magnitude and phase-angle of the output voltage.Only a fundamental period is needed to diagnose and localize exact faults,and a strong Variable-duration Fault Detection Method is proposed to identify acceptable ripple from OC faults.Detailed simulations and experimental results demonstrate the effectiveness,quickness,and robustness of the proposed algorithms,and the diagnosis algorithms proposed in this article provide a significant method for the fault diagnosis of other rectifiers and converters.
基金Project(2017YFB1201204)supported by the National Key R&D Program of ChinaProject(1053320190957)supported by the Fundamental Research Funds for the Central Universities,China。
文摘Many analytical methods have been adopted to estimate the slope stability by providing various stability numbers,e.g.static safety of factor(static FoS)or the critical seismic acceleration coefficient,while little attention has been given to the relationship between the slope stability numbers and the critical seismic acceleration coefficient.This study aims to investigate the relationship between the static FoS and the critical seismic acceleration coefficient of soil slopes in the framework of the upper-bound limit analysis.Based on the 3D rotational failure mechanism,the critical seismic acceleration coefficient using the pseudo-static method and the static FoS using the strength reduction technique are first determined.Then,the relationship between the static FoS and the critical seismic acceleration coefficient is presented under considering the slope angleβ,the frictional angleφ,and the dimensionless coefficients B/H and c/γH.Finally,a fitting formula between the static FoS and the critical seismic acceleration coefficient is proposed and validated by analytical and numerical results.
文摘This study explores the influence of infill patterns on machine acceleration prediction in the realm of three-dimensional(3D)printing,particularly focusing on extrusion technology.Our primary objective was to develop a long short-term memory(LSTM)network capable of assessing this impact.We conducted an extensive analysis involving 12 distinct infill patterns,collecting time-series data to examine their effects on the acceleration of the printer’s bed.The LSTM network was trained using acceleration data from the adaptive cubic infill pattern,while the Archimedean chords infill pattern provided data for evaluating the network’s prediction accuracy.This involved utilizing offline time-series acceleration data as the training and testing datasets for the LSTM model.Specifically,the LSTM model was devised to predict the acceleration of a fused deposition modeling(FDM)printer using data from the adaptive cubic infill pattern.Rigorous testing yielded a root mean square error(RMSE)of 0.007144,reflecting the model’s precision.Further refinement and testing of the LSTM model were conducted using acceleration data from the Archimedean chords infill pattern,resulting in an RMSE of 0.007328.Notably,the developed LSTM model demonstrated superior performance compared to an optimized recurrent neural network(RNN)in predicting machine acceleration data.The empirical findings highlight that the adaptive cubic infill pattern considerably influences the dimensional accuracy of parts printed using FDM technology.
文摘The effects of accelerated photooxidation on the molecular weight and thermal and mechanical properties of Cast PHBV and PHBV/Cloisite 30B(3 wt%)bionanocomposites are investigated herein.Through size exclusion chromatography(SEC)analysis,a significant decrease in both weight and number average molecular weights was observed for all irradiated samples over time,resulting from the chain scission mechanism.Differential scanning calorimetry(DSC)data indicated a decrease in degree of crystallinity and melting temperature after UV exposure,with the appearance of double melting peaks related to the changes in the crystal structure of PHBV.Thermal stability,tensile and thermo-mechanical properties were also reduced consecutively in photooxidation,being more pronounced for Cast PHBV.This study shows that the incorporation of Cloisite 30B in PHBV provides a better resistance to photooxidation in comparison with the neat polymer.
基金supported by the grant of National Natural Science Foundation of Tianjin(09JCYBJC12900)
文摘Objective To investigate whether the antioxidation and the regulation on the Extracellular Regulated Protein Kinases （ERK） signaling pathway are involved in the protective effects of blueberry on central nervous system. Methods 30 Senescence-accelerated mice prone 8 （SAMP8） mice were divided into three groups and treated with normal diet, blueberry extracts （200 mg/kg.bw/day） and cyaniding-3-O-galactoside （Cy-3-GAL） （50 mg/kg.bw/day） from blueberry for 8 weeks. 10 SAMR1 mice were set as control group. The capacity of spatial memory was assessed by Passive avoidance task and Morris water maze. Histological analyses on hippocampus were completed. Malondialdehyde （MDA） levels, Superoxide Dismutase （SOD） activity and the expression of ERK were detected. Results Both Cy-3-GAL and blueberry extracts were shown effective functions to relieve cellular injury, improve hippocampal neurons survival and inhibit the pyramidal cell layer damage. Cy-3-GAL and blueberry extracts also increased SOD activity and reduced MDA content in brain tissues and plasma, and increased hippocampal phosphorylated ERK （p-ERK） expression in SAMP8 mice. Further more, the passive avoidance task test showed that both the latency time and the number of errors were improved by Cy-3-GAL treatment, and the Morris Water Maze test showed significant decreases of latency were detected by Cy-3-GAL and blueberry extracts treatment on day 4. Conclusion Blueberry extracts may reverse the declines of cognitive and behavioral function in the ageing process through several pathways, including enhancing the capacity of antioxidation, altering stress signaling. Cy-3-GAL may be an important active ingredient for these biological effects.
基金supported by the National Key Research and Development Program of China(Nos.2022YFA1104600 and 2022YFA1200208)National Natural Science Foundation of China(No.31927801)Key Research and Development Foundation of Zhejiang Province(No.2022C01123).
文摘Optical coherence tomography(OCT)imaging technology has significant advantages in in situ and noninvasive monitoring of biological tissues.However,it still faces the following challenges:including data processing speed,image quality,and improvements in three-dimensional(3D)visualization effects.OCT technology,especially functional imaging techniques like optical coherence tomography angiography(OCTA),requires a long acquisition time and a large data size.Despite the substantial increase in the acquisition speed of swept source optical coherence tomography(SS-OCT),it still poses significant challenges for data processing.Additionally,during in situ acquisition,image artifacts resulting from interface reflections or strong reflections from biological tissues and culturing containers present obstacles to data visualization and further analysis.Firstly,a customized frequency domainfilter with anti-banding suppression parameters was designed to suppress artifact noises.Then,this study proposed a graphics processing unit(GPU)-based real-time data processing pipeline for SS-OCT,achieving a measured line-process rate of 800 kHz for 3D fast and high-quality data visualization.Furthermore,a GPU-based realtime data processing for CC-OCTA was integrated to acquire dynamic information.Moreover,a vascular-like network chip was prepared using extrusion-based 3D printing and sacrificial materials,with sacrificial material being printed at the desired vascular network locations and then removed to form the vascular-like network.OCTA imaging technology was used to monitor the progression of sacrificial material removal and vascular-like network formation.Therefore,GPU-based OCT enables real-time processing and visualization with artifact suppression,making it particularly suitable for in situ noninvasive longitudinal monitoring of 3D bioprinting tissue and vascular-like networks in microfluidic chips.
文摘The acquisition of secondary chromosomal aberrations in chronic myeloid leukemia (CML) patients with Philadelphia chromosome-positive (Ph+) karyotype signifies clonal evolution associated with the progression of the disease to its accelerated or blastic phase. Therefore, these aberrations have clinical and biological significance. T(3;12)(q26;p13), which is a recurrent chromosomal aberration observed in myeloid malignancies, is typically associated with dysplasia of megakaryocytes, multilineage involvement, short duration of any blastic phase, and extremely poor prognosis. We have identified a recurrent reciprocal translocation between chromosomes 3 and 12 with different breakpoint at bands 3q21 in the malignant cells from a 28-year-old man. The patient was initially diagnosed as having Ph+ CML in the chronic phase. The t(3;12)(q21;p13) translocation occurred 4 years after the patient was first diagnosed with CML while undergoing tyrosine kinase inhibitor therapy. We confirmed the t(3;12)(q21;p13) translocation via fluorescence in situ hybridization assay by using whole-chromosome paint probes for chromosomes 3 and 12. Our findings demonstrate that, similar to other recurrent translocations involving 3q26 such as t(3;3) and t(3;21), the t(3;12)(q21;p13) translocation is implicated not only in myelodysplastic syndrome and acute myeloid leukemia but also in the progression of CML. These findings extend the disease spectrum of this cytogenetic aberration.
文摘In this paper, we construct rotating charged hairy black hole in(2+1) dimensions for infinitesimal black hole charge and rotation parameters. Then we consider this black hole as particle accelerator and calculate the centerof-mass energy of two colliding test particles near the rotating charged hairy black hole in(2+1) dimensions. As we expected, the center-of-mass energy has infinite value.
基金Project(90815024) supported by the National Natural Science Foundation of China
文摘To find the distribution patterns of dynamic amplification coefficients for dams subjected to earthquake, 3D seismic responses of concrete-faced rockfill dams with different heights and different shapes of river valley were analyzed by using the equivalent-linear model. Statistical analysis was also made to the seismic coefficient, and an empirical formula for calculating the maximum acceleration was provided. The results indicate that under the condition of the same dam height and the same base acceleration excitations, with the increase of the river valley width, the position of the maximum acceleration on the axis of the top of the dam moves from the center to the riversides symmetrically. For the narrow valleys, the maximum acceleration occurs in the middle of the axis at the top of the dam; for wide valleys the maximum acceleration appears near the riversides. The result negates the application of 2D dynamical computation for wide valleys, and shows that for the seismic response of high concrete-faced rockfill dams, the seismic coefficient along the axis should be given, except for that along the dam height. Seismic stability analysis of rockfill dams using pseudo-static method can be modified according to the formula.
文摘The loss of Baryonic Matter through Black Holes from our spatial 3-D Universe into its 4th dimension as Dark Matter, is used along with the Conservation of Angular Momentum Principle to prove theoretically the accelerated expansion of the 3-D Universe, as has already been confirmed experimentally being awarded the 2011 Nobel Prize in Physics. Theoretical calculations can estimate further to indicate the true nature of the acceleration;that the outward acceleration is due to the rotation of the Universe caused by Dark Energy from the Void, that the acceleration is non-linear, initially increasing from zero for the short period of about a Million years at a constant rate, and then leveling off non-linearly over extended time before the outward acceleration begins to decrease in a non-linear fashion until it is matched by the gravitational attraction of the matter content of 4D Space and the virtual matter in 3-D Vacuum Space. m = m(4D) + m(Virtual). The rotation of our 3D Universe will become constant once all 3D matter has entered 4D space. As the 3-D Universe tries to expand further it will be pulled inward by its gravitational attraction and will then keep on oscillating about a final radius r<sub>f</sub> while it also keeps on oscillating at right angles to the radius r<sub>f</sub> around final angular velocity ω<sub>f</sub>, until it becomes part of the 4-D Universe. The constant value of the Angular Momentum of our Universe is L = .
基金financially supported by the National Natural Science Foundation of China(Nos.52402249 and 52302288)the China Postdoctoral Science Foundation(No.2021M690930)+1 种基金the Key Scientific Research Project of Henan Province Higher Education of China(Nos.23A430005 and 24A430023)Songshan Lake Materials Laboratory(SLAB)grant(No.260842082)
文摘Designing highly effective cathodic catalysts that can efficiently generate H_(2)O_(2)in situ and promptly convert it to hydroxyl radicals(·OH)poses a significant challenge within the heterogeneous electro-Fenton(EF)systems.Herein,we fabricate a bifunctional core-shell catalyst featuring Co^(0)species encapsulated within N,P-codoped carbon shells through a hydrothermal-pyrolysis strategy,utilizing bamboo shoots as biomass-derived precursors.Density functional theory(DFT)calculations elucidate that the protonation of pyridinic nitrogen modifies the adsorption energy of the OOH*intermediate,positioning it optimally at the peak(3.81 eV)on the twoelectron oxygen reduction reaction(2e-ORR)volcano plot,thereby significantly boosting H_(2)O_(2)production.Moreover,the Co^(0)species embedded within the catalyst function as electron donors,catalyzing the activation of H_(2)O_(2)to produce·OH by efficiently facilitating the transfer of electrons to Fe^(3+).Consequently,the synthesized catalyst exhibits a minimum electron transfer number of 2.06 and a maximum H_(2)O_(2)selectivity of 97.4%.Moreover,the degradation for the methylene blue solution exceeds 95%within 15 min,with only an 11.3%reduction in degradation efficiency after 180 min of continuous operation(9 cycles).This bifunctional catalyst design provides valuable insights that can accelerate the development of EF-based degradation systems.
文摘运用最先进的小型加速加载设备MMLS3(1/3model mobile load simulator)对常见的用于上、中面层的4种改性沥青混合料进行了高温稳定性试验,提出了适合中国的MMLS3室内加速加载的各项试验参数.通过研究改性沥青混合料的实际抗车辙性能,得出沥青混合料高温稳定性能的优劣顺序为:SBS橡胶复合改性SMA-13,SBS改性AC-20C,SBS改性AC-13C,SBS橡胶复合改性OGFC-13,岩沥青改性AC-20C.由于OGFC-13的大空隙结构,必然要在某种程度上牺牲其强度、抗剪切性能及耐久性,不建议在重交通的高速公路上使用其作为表面层.高温重载或超限地区应加强中面层的优化设计.MMLS3加载试验及常规动稳定度试验在衡量空隙率差距小的沥青混合料时,两者试验结果具有较好的一致性;而对于不同沥青混合料,当其空隙率差距大时,应根据需要选择合适的试验或评价方法.
