目的探究MR 3D CUBE与常规磁共振成像(MRI)在膝关节前交叉韧带损伤中的应用价值。方法选取2022年1月至2024年4月本院收治的136例膝关节前交叉韧带损伤患者,根据患者损伤程度分为Ⅰ级、Ⅱ级和Ⅲ级;患者均进行MR 3D CUBE与常规MRI检查;Ka...目的探究MR 3D CUBE与常规磁共振成像(MRI)在膝关节前交叉韧带损伤中的应用价值。方法选取2022年1月至2024年4月本院收治的136例膝关节前交叉韧带损伤患者,根据患者损伤程度分为Ⅰ级、Ⅱ级和Ⅲ级;患者均进行MR 3D CUBE与常规MRI检查;Kappa检验分析MR 3D CUBE、常规MRI与关节镜诊断的一致性;以关节镜检查结果为金标准,采用四格表分析MR 3D CUBE与常规MRI对膝关节前交叉韧带不同损伤分级的诊断价值;膝关节前交叉韧带损伤治疗效果的影响因素采用Logistic回归分析。结果MR 3D CUBE、常规MRI与关节镜诊断的一致性较好(Kappa=0.664、0.832,P<0.05)。MR 3D CUBE在诊断膝关节前交叉韧带损伤Ⅰ级时准确度为91.91%,Ⅱ级时准确度为91.18%,Ⅲ级时准确度为94.85%;常规MRI在诊断膝关节前交叉韧带损伤Ⅰ级时准确度为85.29%,Ⅱ级时准确度为83.09%,Ⅲ级时准确度为87.50%,MR 3D CUBE在诊断膝关节前交叉韧带损伤Ⅲ级时准确度显著高于常规MRI(P<0.05)。不良组和良好组病程和既往损伤比较有差异(P<0.05)。多因素Logistic回归分析得知,病程和既往损伤是影响膝关节前交叉韧带损伤患者治疗效果的危险因素(P<0.05)。结论MR 3D CUBE与常规MRI均能诊断膝关节前交叉韧带损伤,但MR 3D CUBE诊断效能高于常规MRI,可在临床应用。展开更多
目的:研究MRI 3D CUBE T_(2)序列检查在踝关节外伤患者韧带损伤诊断中的价值。方法:选择2020年4月—2023年4月于白银市第一人民医院就诊的226例踝关节外伤拟行手术术前患者作为研究对象,按照不同检查方式将患者分为观察组(n=126)与对照...目的:研究MRI 3D CUBE T_(2)序列检查在踝关节外伤患者韧带损伤诊断中的价值。方法:选择2020年4月—2023年4月于白银市第一人民医院就诊的226例踝关节外伤拟行手术术前患者作为研究对象,按照不同检查方式将患者分为观察组(n=126)与对照组(n=100)。观察组采用MRI 3D CUBE T_(2)序列检查,对照组采取常规MRI检查。比较两组患侧、健侧距腓前韧带测量结果、诊断效能。结果:两组患侧、健侧距腓前韧带宽度及厚度比较,差异无统计学意义(P>0.05)。观察组Ⅰ级踝关节外伤患者韧带损伤诊断准确度、敏感度、特异度、阳性预测值、阴性预测值高于对照组,Ⅱ级患者准确度、敏感度、阴性预测值高于对照组,Ⅲ级患者准确度、特异度、阳性预测值高于对照组,差异有统计学意义(P<0.05)。结论:MRI 3D CUBE T_(2)序列检查踝关节外伤患者韧带损伤诊断效能高于常规MRI检查,可作为治疗效果评价及康复治疗的重要依据。展开更多
Instead of the energy-intensive Haber-Bosch process,the researchers proposed a way to produce ammonia using water and nitrogen as feedstock,powered by electricity,without polluting the environment.Nevertheless,how to ...Instead of the energy-intensive Haber-Bosch process,the researchers proposed a way to produce ammonia using water and nitrogen as feedstock,powered by electricity,without polluting the environment.Nevertheless,how to design efficient electrocatalyst for electrocatalytic nitrogen reduction reaction(NRR)is still urgent and challenging.Herein,a strategy is proposed to adjust the morphology and surface electronic structure of electrocatalyst by optimizing material synthesis method.LiNbO3(lithium niobate,LN)cubes with oxygen-rich vacancy and regular morphology were synthesized by hydrothermal synthesis and followed molten salt calcination process,which were used for electrocatalytic NRR under mild conditions.Compared with LN nanoparticles synthesized by solid phase reaction,LN cubes exhibit better NRR performance,with the highest ammonia yield rate(13.74μg.h^(-1).mg^(-1))at the best potential of-0.45V(vs.reversible hydrogen electrode,RHE)and the best Faradaic efficiency(85.43%)at-0.4 V.Moreover,LN cubes electrocatalyst also demonstrates high stability in 7 cycles and 18 h current-time tests.Further investigation of the reaction mechanism confirmed that the structure of oxygen vacancy could adjust the electronic structure of the electrocatalyst,which was conducive to the adsorption and activation of N_(2) molecule and also increased the ECSA of electrocatalyst,thus providing more active sites for the NRR process.展开更多
目的:探讨MRI 3D CUBE T2序列检查在踝关节外侧韧带损伤诊断中的应用价值。方法:选取2022年1月至2024年2月本院收治的81例疑似踝关节外侧韧带损伤患者,回顾性分析其临床资料,均接受MRI常规二维序列及MRI 3D CUBE T2序列扫描,以关节镜检...目的:探讨MRI 3D CUBE T2序列检查在踝关节外侧韧带损伤诊断中的应用价值。方法:选取2022年1月至2024年2月本院收治的81例疑似踝关节外侧韧带损伤患者,回顾性分析其临床资料,均接受MRI常规二维序列及MRI 3D CUBE T2序列扫描,以关节镜检查结果为金标准,计算两种检查方式的图像质量及诊断效能。结果:本组81例疑似患者,经关节镜检查证实阳性53例,阴性28例。以关节镜检查结果为金标准,MRI 3D CUBE T2序列检查对踝关节外侧韧带损伤的诊断敏感度、特异性、准确度、阳性预测值、阴性预测值及正确指数均高于常规二维序列,假阳性率、假阴性率低于常规二维序列(P<0.05)。一致性分析发现,MRI 3D CUBE T2序列检查结果与关节镜检查结果之间的一致性Kappa值为0.744,一致性处于较高水平,高于常规二维序列的Kappa值0.572。3D CUBE T2序列扫描图像的边缘清晰度评分高于常规二维序列,运动伪影及模糊程度评分低于常规二维序列(P<0.05)。结论:MRI 3D CUBE T2序列扫描可清晰显示踝关节外侧韧带损伤形态学改变,图像清晰,可有效提高诊断效能,减少漏诊、误诊发生,为临床诊疗提供客观的影像学依据。展开更多
采用简单的一步溶剂热法合成了In_(2)O_(3)立方体,并利用X-射线衍射(X-ray diffraction,XRD)、扫描电子显微镜(Scanning electron microscopy,SEM)、透射电子显微镜(Transmission electron microscopy,TEM)、X射线光电子能谱(X-ray phot...采用简单的一步溶剂热法合成了In_(2)O_(3)立方体,并利用X-射线衍射(X-ray diffraction,XRD)、扫描电子显微镜(Scanning electron microscopy,SEM)、透射电子显微镜(Transmission electron microscopy,TEM)、X射线光电子能谱(X-ray photoelectron spectra,XPS)和N2吸附-脱附技术对该In_(2)O_(3)立方体的结构及形貌进行了表征。制备的In_(2)O_(3)立方体尺寸范围在1~5μm。将In_(2)O_(3)立方体制成传感器,测试其对甲苯、丙酮、氯苯、苯、乙醇、二甲苯、甲醇、异丙醇和二氧化氮(NO_(2))气体的气敏性能。结果表明,在最佳工作温度92℃时,In_(2)O_(3)传感器对NO_(2)有良好的气体选择性及灵敏度,对10×10^(-6) NO_(2)气体的响应值为187.7,最低检出限为0.6×10^(-6)。基于In_(2)O_(3)立方体的传感器具有良好的稳定性、重现性和抗湿性,有望实现在实际的复杂环境中对痕量NO_(2)气体的低温检测。展开更多
Objective: to investigate whether MR 3D-FSE Cube sequence imaging is superior to traditional 2 D-FSE sequence imaging in the diagnosis of space occupying lesions in saddle area. Methods: From January 2018 to January 2...Objective: to investigate whether MR 3D-FSE Cube sequence imaging is superior to traditional 2 D-FSE sequence imaging in the diagnosis of space occupying lesions in saddle area. Methods: From January 2018 to January 2020, data of 106 patients with space-occupying lesions in saddle area confirmed by surgery and pathology were collected, Routine 2 D-FSE sequence and 3 D-FSE Cube sequence scans were performed in all patients before operation. Analysis of MRI images by two radiologists over 10 years of service, and the two sequences were independently diagnosed, based on surgical and pathological findings, the diagnostic results were statistically analyzed. Results: according to conventional 2 D-FSE sequence images and 3 D-FSE Cube sequence images, the diagnostic accuracy was 70.7%(75/106) and 84.9%(90/106), difference was statistically significant (P<0.05). Conclusion: MR 3D-FSE Cube sequence imaging is superior to traditional 2 D-FSE in the qualitative diagnosis of space occupying lesions in saddle area, it is worth popularizing in clinical application.展开更多
目的·探讨泛素连接酶E3C(ubiquitin protein ligase E3C,UBE3C)对卵巢癌SKOV3细胞增殖、侵袭能力的影响。方法·Western blotting法检测UBE3C蛋白在不同卵巢癌细胞株和正常卵巢上皮细胞中的表达。选择卵巢癌SKOV3细胞株转染si-...目的·探讨泛素连接酶E3C(ubiquitin protein ligase E3C,UBE3C)对卵巢癌SKOV3细胞增殖、侵袭能力的影响。方法·Western blotting法检测UBE3C蛋白在不同卵巢癌细胞株和正常卵巢上皮细胞中的表达。选择卵巢癌SKOV3细胞株转染si-UBE3C下调UBE3C表达,转染ex-UBE3C质粒上调UBE3C表达。CCK-8法、平板克隆实验检测细胞增殖能力的变化,细胞划痕、Transwell侵袭实验检测细胞迁移、侵袭能力的变化,并检测增殖、转移相关蛋白β-catenin、c-Myc的表达。结果·UBE3C在卵巢癌细胞株中的表达显著高于正常卵巢上皮细胞。si-UBE3C转染SKOV3细胞沉默UBE3C表达,细胞增殖能力下降,迁移及侵袭能力减弱,β-catenin、c-Myc蛋白表达下调。ex-UBE3C转染后UBE3C过表达,SKOV3细胞增殖、迁移、侵袭能力增强,且β-catenin、c-Myc蛋白表达水平升高。结论·UBE3C可能通过上调β-catenin及c-Myc蛋白表达,增强卵巢癌SKOV3细胞的增殖、侵袭能力。展开更多
文摘目的探究MR 3D CUBE与常规磁共振成像(MRI)在膝关节前交叉韧带损伤中的应用价值。方法选取2022年1月至2024年4月本院收治的136例膝关节前交叉韧带损伤患者,根据患者损伤程度分为Ⅰ级、Ⅱ级和Ⅲ级;患者均进行MR 3D CUBE与常规MRI检查;Kappa检验分析MR 3D CUBE、常规MRI与关节镜诊断的一致性;以关节镜检查结果为金标准,采用四格表分析MR 3D CUBE与常规MRI对膝关节前交叉韧带不同损伤分级的诊断价值;膝关节前交叉韧带损伤治疗效果的影响因素采用Logistic回归分析。结果MR 3D CUBE、常规MRI与关节镜诊断的一致性较好(Kappa=0.664、0.832,P<0.05)。MR 3D CUBE在诊断膝关节前交叉韧带损伤Ⅰ级时准确度为91.91%,Ⅱ级时准确度为91.18%,Ⅲ级时准确度为94.85%;常规MRI在诊断膝关节前交叉韧带损伤Ⅰ级时准确度为85.29%,Ⅱ级时准确度为83.09%,Ⅲ级时准确度为87.50%,MR 3D CUBE在诊断膝关节前交叉韧带损伤Ⅲ级时准确度显著高于常规MRI(P<0.05)。不良组和良好组病程和既往损伤比较有差异(P<0.05)。多因素Logistic回归分析得知,病程和既往损伤是影响膝关节前交叉韧带损伤患者治疗效果的危险因素(P<0.05)。结论MR 3D CUBE与常规MRI均能诊断膝关节前交叉韧带损伤,但MR 3D CUBE诊断效能高于常规MRI,可在临床应用。
文摘目的:研究MRI 3D CUBE T_(2)序列检查在踝关节外伤患者韧带损伤诊断中的价值。方法:选择2020年4月—2023年4月于白银市第一人民医院就诊的226例踝关节外伤拟行手术术前患者作为研究对象,按照不同检查方式将患者分为观察组(n=126)与对照组(n=100)。观察组采用MRI 3D CUBE T_(2)序列检查,对照组采取常规MRI检查。比较两组患侧、健侧距腓前韧带测量结果、诊断效能。结果:两组患侧、健侧距腓前韧带宽度及厚度比较,差异无统计学意义(P>0.05)。观察组Ⅰ级踝关节外伤患者韧带损伤诊断准确度、敏感度、特异度、阳性预测值、阴性预测值高于对照组,Ⅱ级患者准确度、敏感度、阴性预测值高于对照组,Ⅲ级患者准确度、特异度、阳性预测值高于对照组,差异有统计学意义(P<0.05)。结论:MRI 3D CUBE T_(2)序列检查踝关节外伤患者韧带损伤诊断效能高于常规MRI检查,可作为治疗效果评价及康复治疗的重要依据。
基金the financial support from the National Natural Science Foundation of China(22075196,21878204)Key Research and Development Program of Shanxi Province(International Cooperation,201903D421073)Research Project Supported by Shanxi Scholarship Council of China(2022-050).
文摘Instead of the energy-intensive Haber-Bosch process,the researchers proposed a way to produce ammonia using water and nitrogen as feedstock,powered by electricity,without polluting the environment.Nevertheless,how to design efficient electrocatalyst for electrocatalytic nitrogen reduction reaction(NRR)is still urgent and challenging.Herein,a strategy is proposed to adjust the morphology and surface electronic structure of electrocatalyst by optimizing material synthesis method.LiNbO3(lithium niobate,LN)cubes with oxygen-rich vacancy and regular morphology were synthesized by hydrothermal synthesis and followed molten salt calcination process,which were used for electrocatalytic NRR under mild conditions.Compared with LN nanoparticles synthesized by solid phase reaction,LN cubes exhibit better NRR performance,with the highest ammonia yield rate(13.74μg.h^(-1).mg^(-1))at the best potential of-0.45V(vs.reversible hydrogen electrode,RHE)and the best Faradaic efficiency(85.43%)at-0.4 V.Moreover,LN cubes electrocatalyst also demonstrates high stability in 7 cycles and 18 h current-time tests.Further investigation of the reaction mechanism confirmed that the structure of oxygen vacancy could adjust the electronic structure of the electrocatalyst,which was conducive to the adsorption and activation of N_(2) molecule and also increased the ECSA of electrocatalyst,thus providing more active sites for the NRR process.
文摘目的:探讨MRI 3D CUBE T2序列检查在踝关节外侧韧带损伤诊断中的应用价值。方法:选取2022年1月至2024年2月本院收治的81例疑似踝关节外侧韧带损伤患者,回顾性分析其临床资料,均接受MRI常规二维序列及MRI 3D CUBE T2序列扫描,以关节镜检查结果为金标准,计算两种检查方式的图像质量及诊断效能。结果:本组81例疑似患者,经关节镜检查证实阳性53例,阴性28例。以关节镜检查结果为金标准,MRI 3D CUBE T2序列检查对踝关节外侧韧带损伤的诊断敏感度、特异性、准确度、阳性预测值、阴性预测值及正确指数均高于常规二维序列,假阳性率、假阴性率低于常规二维序列(P<0.05)。一致性分析发现,MRI 3D CUBE T2序列检查结果与关节镜检查结果之间的一致性Kappa值为0.744,一致性处于较高水平,高于常规二维序列的Kappa值0.572。3D CUBE T2序列扫描图像的边缘清晰度评分高于常规二维序列,运动伪影及模糊程度评分低于常规二维序列(P<0.05)。结论:MRI 3D CUBE T2序列扫描可清晰显示踝关节外侧韧带损伤形态学改变,图像清晰,可有效提高诊断效能,减少漏诊、误诊发生,为临床诊疗提供客观的影像学依据。
文摘采用简单的一步溶剂热法合成了In_(2)O_(3)立方体,并利用X-射线衍射(X-ray diffraction,XRD)、扫描电子显微镜(Scanning electron microscopy,SEM)、透射电子显微镜(Transmission electron microscopy,TEM)、X射线光电子能谱(X-ray photoelectron spectra,XPS)和N2吸附-脱附技术对该In_(2)O_(3)立方体的结构及形貌进行了表征。制备的In_(2)O_(3)立方体尺寸范围在1~5μm。将In_(2)O_(3)立方体制成传感器,测试其对甲苯、丙酮、氯苯、苯、乙醇、二甲苯、甲醇、异丙醇和二氧化氮(NO_(2))气体的气敏性能。结果表明,在最佳工作温度92℃时,In_(2)O_(3)传感器对NO_(2)有良好的气体选择性及灵敏度,对10×10^(-6) NO_(2)气体的响应值为187.7,最低检出限为0.6×10^(-6)。基于In_(2)O_(3)立方体的传感器具有良好的稳定性、重现性和抗湿性,有望实现在实际的复杂环境中对痕量NO_(2)气体的低温检测。
文摘Objective: to investigate whether MR 3D-FSE Cube sequence imaging is superior to traditional 2 D-FSE sequence imaging in the diagnosis of space occupying lesions in saddle area. Methods: From January 2018 to January 2020, data of 106 patients with space-occupying lesions in saddle area confirmed by surgery and pathology were collected, Routine 2 D-FSE sequence and 3 D-FSE Cube sequence scans were performed in all patients before operation. Analysis of MRI images by two radiologists over 10 years of service, and the two sequences were independently diagnosed, based on surgical and pathological findings, the diagnostic results were statistically analyzed. Results: according to conventional 2 D-FSE sequence images and 3 D-FSE Cube sequence images, the diagnostic accuracy was 70.7%(75/106) and 84.9%(90/106), difference was statistically significant (P<0.05). Conclusion: MR 3D-FSE Cube sequence imaging is superior to traditional 2 D-FSE in the qualitative diagnosis of space occupying lesions in saddle area, it is worth popularizing in clinical application.
文摘目的·探讨泛素连接酶E3C(ubiquitin protein ligase E3C,UBE3C)对卵巢癌SKOV3细胞增殖、侵袭能力的影响。方法·Western blotting法检测UBE3C蛋白在不同卵巢癌细胞株和正常卵巢上皮细胞中的表达。选择卵巢癌SKOV3细胞株转染si-UBE3C下调UBE3C表达,转染ex-UBE3C质粒上调UBE3C表达。CCK-8法、平板克隆实验检测细胞增殖能力的变化,细胞划痕、Transwell侵袭实验检测细胞迁移、侵袭能力的变化,并检测增殖、转移相关蛋白β-catenin、c-Myc的表达。结果·UBE3C在卵巢癌细胞株中的表达显著高于正常卵巢上皮细胞。si-UBE3C转染SKOV3细胞沉默UBE3C表达,细胞增殖能力下降,迁移及侵袭能力减弱,β-catenin、c-Myc蛋白表达下调。ex-UBE3C转染后UBE3C过表达,SKOV3细胞增殖、迁移、侵袭能力增强,且β-catenin、c-Myc蛋白表达水平升高。结论·UBE3C可能通过上调β-catenin及c-Myc蛋白表达,增强卵巢癌SKOV3细胞的增殖、侵袭能力。
