This article discusses the evolving real-world practice using nitazoxanide,nonsteroidal anti-inflammatory drugs(NSAIDs)and/or azithromycin(Kelleni’s protocol)to manage the evolving manifestations of severe acute resp...This article discusses the evolving real-world practice using nitazoxanide,nonsteroidal anti-inflammatory drugs(NSAIDs)and/or azithromycin(Kelleni’s protocol)to manage the evolving manifestations of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron EG.5.1,its descendant HV.1 as well as BA.2.86 and its descendant JN.1 subvariants in Egypt in 2024.These subvariants are well-known for their highly evolved immune-evasive properties and the manifestations include some peculiar manifestations as persistent cough besides high fever in young children as well as high fever,persistent severe cough,change of voice,loss of taste and smell,epigastric pain,nausea,vomiting,diarrhea,generalized malaise and marked bone aches in adults including the high-risk groups.It’s suggested that the ongoing SARS-CoV-2 evolution is continuing to mostly affect the high-risk groups of patients,to some of whom we’ve also successfully prescribed nitazoxanide and/or NSAIDs for post-exposure prophylaxis of all household contacts.We also continue to recommend starting the immune-modulatory antiviral Kelleni’s protocol as soon as possible in the course of infection and adjusting it in a personalized manner to be more aggressive from the beginning for the high risk patients,at least until the currently encountered surge of infections subsides.展开更多
Based on the nonlinear Mohr-Coulomb failure criterion and an associated flow rule,a kinematic admissible velocity field of failure mechanism of the 2-layer soil above a shallow horizontal strip anchor plate is constru...Based on the nonlinear Mohr-Coulomb failure criterion and an associated flow rule,a kinematic admissible velocity field of failure mechanism of the 2-layer soil above a shallow horizontal strip anchor plate is constructed.The ultimate pull-out force and its corresponding failure mechanism through the upper bound limit analysis according to a variation principle are deduced.When the 2-layer overlying soil is degraded into single-layer soil,the model of ultimate pullout force could also be degraded into the model of single-layer soil.And the comparison between results of single-layer soil variation method and those calculated by rigid limit analysis method proves the correctness of our method.Based on that,the influence of changes of geotechnical parameters on ultimate pullout forces and failure mechanism of a shallow horizontal strip anchor with the 2-layer soil above are analyzed.The results show that the ultimate pull-out force and failure mechanism of a shallow horizontal strip anchor with the 2-layer soil above are affected by the nonlinear geotechnical parameters greatly.Thus,it is very important to obtain the accurate geotechnical parameters of 2-layer soil for the evaluation of the ultimate pullout capacity of the anchor plate.展开更多
This study deals with Peak of electron density in F2-layer sensibility scale during quiet time on solar minimum. Peaks of electron density in F2-layer (NmF2) values at the quietest days are compared to those carried o...This study deals with Peak of electron density in F2-layer sensibility scale during quiet time on solar minimum. Peaks of electron density in F2-layer (NmF2) values at the quietest days are compared to those carried out from the two nearest days (previous and following of quietest day). The study uses International Reference Ionosphere (IRI) for ionosphere modeling. The located station is Ouagadougou, in West Africa. Solar minimum of phase 22 is considered in this study. Using three core principles of ionosphere modeling under IRI running conditions, the study enables to carry out Peak of electron density in F2-layer values during the quietest days of the characteristic months for the four different seasons. These parameters are compared to those of the previous and the following of the quietest days (the day before and following each quietest selected day) at the same hour. The knowledge of NmF2 values at the quietest days and at the two nearest days enables to calculate the relative error that can be made on this parameter. This calculation highlights insignificant relative errors. This means that NmF2 values at the two nearest days of each quietest day on solar minimum can be used for simulating the quietest days’ behavior. NmF2 values obtained by running IRI model have good correlation with those carried out by Thermosphere-Ionosphere-Electrodynamics-General Circulation Model (TIEGCM).展开更多
Broadcasting is a basic technique in Mobile ad-hoc network(MANET),and it refers to sending a packet from one node to every other node within the transmission range.Flooding is a type of broadcast where the received pa...Broadcasting is a basic technique in Mobile ad-hoc network(MANET),and it refers to sending a packet from one node to every other node within the transmission range.Flooding is a type of broadcast where the received packet is retransmitted once by every node.The naive flooding technique,floods the network with query messages,while the random walk technique operates by contacting the subsets of every node’s neighbors at each step,thereby restricting the search space.One of the key challenges in an ad-hoc network is the resource or content discovery problem which is about locating the queried resource.Many earlier works have mainly focused on the simulation-based analysis of flooding,and its variants under a wired network.Although,there have been some empirical studies in peer-to-peer(P2P)networks,the analytical results are still lacking,especially in the context of P2P systems running over MANET.In this paper,we describe how P2P resource discovery protocols perform badly over MANETs.To address the limitations,we propose a new protocol named ABRW(Address Broadcast Random Walk),which is a lightweight search approach,designed considering the underlay topology aimed to better suit the unstructured architecture.We provide the mathematical model,measuring the performance of our proposed search scheme with different widely popular benchmarked search techniques.Further,we also derive three relevant search performance metrics,i.e.,mean no.of steps needed to find a resource,the probability of finding a resource,and the mean no.of message overhead.We validated the analytical expressions through simulations.The simulation results closely matched with our analyticalmodel,justifying our findings.Our proposed search algorithm under such highly dynamic self-evolving networks performed better,as it reduced the search latency,decreased the overall message overhead,and still equally had a good success rate.展开更多
Most of the public key algorithms used in the exchange of information for power data transmission protocols are RSA. The core of the key part of this kind of algorithm system has not been announced. For the domestic s...Most of the public key algorithms used in the exchange of information for power data transmission protocols are RSA. The core of the key part of this kind of algorithm system has not been announced. For the domestic sensitive information data field, there are threats such as preset backdoors and security vulnerabilities. In response to the above problems, the article introduces a secure communication protocol based on the optimized Secret SM2 algorithm, which uses socket programming to achieve two-way encrypted communication between clients and services, and is able to complete the security protection of data encryption transmission, authentication, data tampering, etc., and proves through experiments that the security protocol is more secure than traditional methods, can effectively identify each other, carry out stable and controllable data encryption transmission, and has good applicability.展开更多
3D （Three-dimensional） Caco-2 spheroids closely recapitulating in vivo physiological organization of intestinal epithelial cells, provide an excellent in vitro model system to study their pathophysiology and their r...3D （Three-dimensional） Caco-2 spheroids closely recapitulating in vivo physiological organization of intestinal epithelial cells, provide an excellent in vitro model system to study their pathophysiology and their response to stressful stimuli. The objective of this technical note is to provide optimized in vitro experimental protocols for culturing 3D Caco-2 spheroids and for analyzing their cell growth features. An optimized 3D Caco-2 spheroid culturing technique based on a new configuration of the culture medium is provided A methodological approach to determine the distribution of the cell cycle phases in disaggregated Caco-2 spheroids by using cytofluorimetric analysis is also described. The optimized culturing protocol favors 3D Caco-2 spheroid differentiation process, as evaluated by the number of well-differentiated spheroids with a single hollow lumen. The cytofluorimetric analysis allows rapid collection of cell cycle phase data from high numbers of spheroid samples, thus, permitting to estimate their growth dynamics in a relatively short time. The optimized technical approaches described here can be applied in systematic manner to a variety of research activities utilizing 3D Caco-2 spheroids. Ease of use, time and economic saving advantages deriving from these protocols further highlight their potential.展开更多
The electronic system in a comprehensive shipboard has a extremely wide bandwidth. It supports synchronized and asynchronous data transmission, muhimedia correspondence, and videophone conferencing. In order to guaran...The electronic system in a comprehensive shipboard has a extremely wide bandwidth. It supports synchronized and asynchronous data transmission, muhimedia correspondence, and videophone conferencing. In order to guarantee the security and correspondent real time of the communication, choosing a multicast routing protocol based on different applications is a key problem in terms of the complexity of the system. A simulation model was first designed for existing multicast routing protocols in NS-2 and analysis was performed on their corresponding application environments. The experiments proved that PIM-DM based on the shortest-path tree protocol is suitable for communication in the field of comprehensive shipboard. Further work that is necessary is also discussed.展开更多
Ionosphere layer is the atmosphere region which reflects radio waves for telecommunication. The density in particles in this layer influences the quality of communication. This study deals with the effects of Total El...Ionosphere layer is the atmosphere region which reflects radio waves for telecommunication. The density in particles in this layer influences the quality of communication. This study deals with the effects of Total Electron Contents (TEC) on the critical frequency of radio waves in the F2-layer. Total Electron Contents parameter symbolizes electron bulk surface density in ionosphere layer. Above critical frequency value in F2 layer (foF2), radio waves pass through ionosphere. The knowledge of this value enables to calibrate transmission frequencies. In this study, we consider TEC effects on foF2 under quiet time conditions during the maximum and the minimum of solar cycle 22, at Ouagadougou station, in West Africa. The study also considers the effects of seasons and the hourly variability of TEC and foF2. This work shows winter anomaly on foF2 and TEC on minimum and maximum of solar cycle phase respectively. Running International Reference Ionosphere (IRI) model enables to carry out the effects of TEC on foF2 by use of their monthly average values. This leads to a new approach to calibrate radio transmitters.展开更多
The IEC60870-5-104 protocol lacks an integrated authentication mechanism during plaintext transmission, and is vulnerable to security threats, monitoring, tampering, or cutting off communication connections. In order ...The IEC60870-5-104 protocol lacks an integrated authentication mechanism during plaintext transmission, and is vulnerable to security threats, monitoring, tampering, or cutting off communication connections. In order to verify the security problems of 104 protocol, the 104 master-slave communication implemented DoS attacks, ARP spoofing and Ettercap packet filtering and other man-in-the-middle attacks. DoS attacks may damage the network functions of the 104 communication host, resulting in communication interruption. ARP spoofing damaged the data privacy of the 104 protocol, and Ettercap packet filtering cut off the communication connection between the master and the slave. In order to resist the man-in-the-middle attack, the AES and RSA hybrid encryption signature algorithm and the national secret SM2 elliptic curve algorithm are proposed. AES and RSA hybrid encryption increases the security strength of communication data and realizes identity authentication. The digital signature implemented by the SM2 algorithm can realize identity verification, ensure that the data has not been tampered with, and can ensure the integrity of the data. Both of them improve the communication security of the 104 protocol.展开更多
The current recommendation to avoid non-steroidal anti-inflammatory drugs(NSAIDs)in the management of dengue virus disease(DVD)is scientifically considered of very low to low certainty,despite being widely adopted wor...The current recommendation to avoid non-steroidal anti-inflammatory drugs(NSAIDs)in the management of dengue virus disease(DVD)is scientifically considered of very low to low certainty,despite being widely adopted worldwide.The same recommendation,initially made during the coronavirus disease 2019(COVID-19)pandemic,was subsequently proven incorrect.In this clinical report,we present evidence,for the first time globally,from a real-life practice that NSAIDs may actually be lifesaving in the early management of DVD as they have proved to be in COVID-19.Moreover,we propose that the personalized immunemodulatory Kelleni’s protocol,which includes nitazoxanide as a key component,can be safely and effectively used to manage various separate or concomitant viral infections and co-infections,including DVD.Importantly,this article contributes to the current medical knowledge in the global pursuit of a safe and effective broad-spectrum antiviral protocol that can be used to early manage multiple highly infectious viruses.However,it’s crucial that sufficiently powered controlled randomized clinical trials be conducted to thoroughly assess and evaluate the safety of NSAIDs in the early management of DVD as well as the efficacy of nitazoxanide with or without NSAIDs in its management.展开更多
BACKGROUND Lower respiratory tract viral infections are a major cause of mortality in children under five years old,leading to hundreds of thousands of fatalities annually.The highest risk is observed in infants under...BACKGROUND Lower respiratory tract viral infections are a major cause of mortality in children under five years old,leading to hundreds of thousands of fatalities annually.The highest risk is observed in infants under one year old,underscoring the critical need for safe and effective antiviral protocols.CASE SUMMARY A 9-month-old infant suffered from severe bronchiolitis as manifested by high fever(39°C),decreased appetite,tachypnea,wheezing,and oxygen desaturation(SpO284%on room air)and was effectively managed at home using Kelleni’s protocol,which includes age-adjusted dose of nitazoxanide(60 mg twice daily),ibuprofen and azithromycin,complemented by selective antihistaminic,antitussive and mucolytic immunomodulatory treatment.The fever resolved,wheezing became more prominent but without respiratory distress,and oxygen saturation gradually increased to 92%by day 10.Nitazoxanide exerts broad antiviral and immunomodulatory effects by enhancing host interferon responses and inhibiting viral replication,potentially attenuating airway inflammation and accelerating resolution of bronchiolitis.The nitazoxanide dose(60 mg twice daily for five days)was carefully adjusted based on the developmental expression and activity of the uridine diphosphate-glucuronosyltransferase 1A1 enzyme,responsible for its metabolism,ensuring safe age-appropriate administration.The infant’s clinical status steadily improved,and by day 14 the infant achieved full recovery with normalization of oxygen saturation(96%on room air).No adverse events occurred,and follow-up at day 28 confirmed sustained recovery.CONCLUSION To the best of my knowledge,this report presents,for the first time globally,a potential of nitazoxanide within Kelleni’s protocol to early manage infants younger than one year suffering from severe lower respiratory tract viral infection at home.Selective antitussive treatment,using agents such as low dose benproperine,was employed to mitigate troublesome cough and improve patient comfort without compromising respiratory function.Additionally,alpha amylase was used to facilitate pulmonary secretion clearance.The protocol aims to reduce morbidity and mortality from viral lower respiratory tract infections in this vulnerable population.展开更多
文摘This article discusses the evolving real-world practice using nitazoxanide,nonsteroidal anti-inflammatory drugs(NSAIDs)and/or azithromycin(Kelleni’s protocol)to manage the evolving manifestations of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron EG.5.1,its descendant HV.1 as well as BA.2.86 and its descendant JN.1 subvariants in Egypt in 2024.These subvariants are well-known for their highly evolved immune-evasive properties and the manifestations include some peculiar manifestations as persistent cough besides high fever in young children as well as high fever,persistent severe cough,change of voice,loss of taste and smell,epigastric pain,nausea,vomiting,diarrhea,generalized malaise and marked bone aches in adults including the high-risk groups.It’s suggested that the ongoing SARS-CoV-2 evolution is continuing to mostly affect the high-risk groups of patients,to some of whom we’ve also successfully prescribed nitazoxanide and/or NSAIDs for post-exposure prophylaxis of all household contacts.We also continue to recommend starting the immune-modulatory antiviral Kelleni’s protocol as soon as possible in the course of infection and adjusting it in a personalized manner to be more aggressive from the beginning for the high risk patients,at least until the currently encountered surge of infections subsides.
基金Project (51478477) supported by the National Natural Science Foundation of ChinaProject (2016CX012) supported by the Innovation-Driven Project of Central South University,ChinaProject (2014122006) supported by the Guizhou Provincial Department of Transportation Foundation,China
文摘Based on the nonlinear Mohr-Coulomb failure criterion and an associated flow rule,a kinematic admissible velocity field of failure mechanism of the 2-layer soil above a shallow horizontal strip anchor plate is constructed.The ultimate pull-out force and its corresponding failure mechanism through the upper bound limit analysis according to a variation principle are deduced.When the 2-layer overlying soil is degraded into single-layer soil,the model of ultimate pullout force could also be degraded into the model of single-layer soil.And the comparison between results of single-layer soil variation method and those calculated by rigid limit analysis method proves the correctness of our method.Based on that,the influence of changes of geotechnical parameters on ultimate pullout forces and failure mechanism of a shallow horizontal strip anchor with the 2-layer soil above are analyzed.The results show that the ultimate pull-out force and failure mechanism of a shallow horizontal strip anchor with the 2-layer soil above are affected by the nonlinear geotechnical parameters greatly.Thus,it is very important to obtain the accurate geotechnical parameters of 2-layer soil for the evaluation of the ultimate pullout capacity of the anchor plate.
文摘This study deals with Peak of electron density in F2-layer sensibility scale during quiet time on solar minimum. Peaks of electron density in F2-layer (NmF2) values at the quietest days are compared to those carried out from the two nearest days (previous and following of quietest day). The study uses International Reference Ionosphere (IRI) for ionosphere modeling. The located station is Ouagadougou, in West Africa. Solar minimum of phase 22 is considered in this study. Using three core principles of ionosphere modeling under IRI running conditions, the study enables to carry out Peak of electron density in F2-layer values during the quietest days of the characteristic months for the four different seasons. These parameters are compared to those of the previous and the following of the quietest days (the day before and following each quietest selected day) at the same hour. The knowledge of NmF2 values at the quietest days and at the two nearest days enables to calculate the relative error that can be made on this parameter. This calculation highlights insignificant relative errors. This means that NmF2 values at the two nearest days of each quietest day on solar minimum can be used for simulating the quietest days’ behavior. NmF2 values obtained by running IRI model have good correlation with those carried out by Thermosphere-Ionosphere-Electrodynamics-General Circulation Model (TIEGCM).
文摘Broadcasting is a basic technique in Mobile ad-hoc network(MANET),and it refers to sending a packet from one node to every other node within the transmission range.Flooding is a type of broadcast where the received packet is retransmitted once by every node.The naive flooding technique,floods the network with query messages,while the random walk technique operates by contacting the subsets of every node’s neighbors at each step,thereby restricting the search space.One of the key challenges in an ad-hoc network is the resource or content discovery problem which is about locating the queried resource.Many earlier works have mainly focused on the simulation-based analysis of flooding,and its variants under a wired network.Although,there have been some empirical studies in peer-to-peer(P2P)networks,the analytical results are still lacking,especially in the context of P2P systems running over MANET.In this paper,we describe how P2P resource discovery protocols perform badly over MANETs.To address the limitations,we propose a new protocol named ABRW(Address Broadcast Random Walk),which is a lightweight search approach,designed considering the underlay topology aimed to better suit the unstructured architecture.We provide the mathematical model,measuring the performance of our proposed search scheme with different widely popular benchmarked search techniques.Further,we also derive three relevant search performance metrics,i.e.,mean no.of steps needed to find a resource,the probability of finding a resource,and the mean no.of message overhead.We validated the analytical expressions through simulations.The simulation results closely matched with our analyticalmodel,justifying our findings.Our proposed search algorithm under such highly dynamic self-evolving networks performed better,as it reduced the search latency,decreased the overall message overhead,and still equally had a good success rate.
文摘Most of the public key algorithms used in the exchange of information for power data transmission protocols are RSA. The core of the key part of this kind of algorithm system has not been announced. For the domestic sensitive information data field, there are threats such as preset backdoors and security vulnerabilities. In response to the above problems, the article introduces a secure communication protocol based on the optimized Secret SM2 algorithm, which uses socket programming to achieve two-way encrypted communication between clients and services, and is able to complete the security protection of data encryption transmission, authentication, data tampering, etc., and proves through experiments that the security protocol is more secure than traditional methods, can effectively identify each other, carry out stable and controllable data encryption transmission, and has good applicability.
文摘3D （Three-dimensional） Caco-2 spheroids closely recapitulating in vivo physiological organization of intestinal epithelial cells, provide an excellent in vitro model system to study their pathophysiology and their response to stressful stimuli. The objective of this technical note is to provide optimized in vitro experimental protocols for culturing 3D Caco-2 spheroids and for analyzing their cell growth features. An optimized 3D Caco-2 spheroid culturing technique based on a new configuration of the culture medium is provided A methodological approach to determine the distribution of the cell cycle phases in disaggregated Caco-2 spheroids by using cytofluorimetric analysis is also described. The optimized culturing protocol favors 3D Caco-2 spheroid differentiation process, as evaluated by the number of well-differentiated spheroids with a single hollow lumen. The cytofluorimetric analysis allows rapid collection of cell cycle phase data from high numbers of spheroid samples, thus, permitting to estimate their growth dynamics in a relatively short time. The optimized technical approaches described here can be applied in systematic manner to a variety of research activities utilizing 3D Caco-2 spheroids. Ease of use, time and economic saving advantages deriving from these protocols further highlight their potential.
基金Supported by the Performance Simulation and Computation Complexity on Computer Network Foundation (No.F2004060)
文摘The electronic system in a comprehensive shipboard has a extremely wide bandwidth. It supports synchronized and asynchronous data transmission, muhimedia correspondence, and videophone conferencing. In order to guarantee the security and correspondent real time of the communication, choosing a multicast routing protocol based on different applications is a key problem in terms of the complexity of the system. A simulation model was first designed for existing multicast routing protocols in NS-2 and analysis was performed on their corresponding application environments. The experiments proved that PIM-DM based on the shortest-path tree protocol is suitable for communication in the field of comprehensive shipboard. Further work that is necessary is also discussed.
文摘Ionosphere layer is the atmosphere region which reflects radio waves for telecommunication. The density in particles in this layer influences the quality of communication. This study deals with the effects of Total Electron Contents (TEC) on the critical frequency of radio waves in the F2-layer. Total Electron Contents parameter symbolizes electron bulk surface density in ionosphere layer. Above critical frequency value in F2 layer (foF2), radio waves pass through ionosphere. The knowledge of this value enables to calibrate transmission frequencies. In this study, we consider TEC effects on foF2 under quiet time conditions during the maximum and the minimum of solar cycle 22, at Ouagadougou station, in West Africa. The study also considers the effects of seasons and the hourly variability of TEC and foF2. This work shows winter anomaly on foF2 and TEC on minimum and maximum of solar cycle phase respectively. Running International Reference Ionosphere (IRI) model enables to carry out the effects of TEC on foF2 by use of their monthly average values. This leads to a new approach to calibrate radio transmitters.
文摘The IEC60870-5-104 protocol lacks an integrated authentication mechanism during plaintext transmission, and is vulnerable to security threats, monitoring, tampering, or cutting off communication connections. In order to verify the security problems of 104 protocol, the 104 master-slave communication implemented DoS attacks, ARP spoofing and Ettercap packet filtering and other man-in-the-middle attacks. DoS attacks may damage the network functions of the 104 communication host, resulting in communication interruption. ARP spoofing damaged the data privacy of the 104 protocol, and Ettercap packet filtering cut off the communication connection between the master and the slave. In order to resist the man-in-the-middle attack, the AES and RSA hybrid encryption signature algorithm and the national secret SM2 elliptic curve algorithm are proposed. AES and RSA hybrid encryption increases the security strength of communication data and realizes identity authentication. The digital signature implemented by the SM2 algorithm can realize identity verification, ensure that the data has not been tampered with, and can ensure the integrity of the data. Both of them improve the communication security of the 104 protocol.
文摘The current recommendation to avoid non-steroidal anti-inflammatory drugs(NSAIDs)in the management of dengue virus disease(DVD)is scientifically considered of very low to low certainty,despite being widely adopted worldwide.The same recommendation,initially made during the coronavirus disease 2019(COVID-19)pandemic,was subsequently proven incorrect.In this clinical report,we present evidence,for the first time globally,from a real-life practice that NSAIDs may actually be lifesaving in the early management of DVD as they have proved to be in COVID-19.Moreover,we propose that the personalized immunemodulatory Kelleni’s protocol,which includes nitazoxanide as a key component,can be safely and effectively used to manage various separate or concomitant viral infections and co-infections,including DVD.Importantly,this article contributes to the current medical knowledge in the global pursuit of a safe and effective broad-spectrum antiviral protocol that can be used to early manage multiple highly infectious viruses.However,it’s crucial that sufficiently powered controlled randomized clinical trials be conducted to thoroughly assess and evaluate the safety of NSAIDs in the early management of DVD as well as the efficacy of nitazoxanide with or without NSAIDs in its management.
文摘BACKGROUND Lower respiratory tract viral infections are a major cause of mortality in children under five years old,leading to hundreds of thousands of fatalities annually.The highest risk is observed in infants under one year old,underscoring the critical need for safe and effective antiviral protocols.CASE SUMMARY A 9-month-old infant suffered from severe bronchiolitis as manifested by high fever(39°C),decreased appetite,tachypnea,wheezing,and oxygen desaturation(SpO284%on room air)and was effectively managed at home using Kelleni’s protocol,which includes age-adjusted dose of nitazoxanide(60 mg twice daily),ibuprofen and azithromycin,complemented by selective antihistaminic,antitussive and mucolytic immunomodulatory treatment.The fever resolved,wheezing became more prominent but without respiratory distress,and oxygen saturation gradually increased to 92%by day 10.Nitazoxanide exerts broad antiviral and immunomodulatory effects by enhancing host interferon responses and inhibiting viral replication,potentially attenuating airway inflammation and accelerating resolution of bronchiolitis.The nitazoxanide dose(60 mg twice daily for five days)was carefully adjusted based on the developmental expression and activity of the uridine diphosphate-glucuronosyltransferase 1A1 enzyme,responsible for its metabolism,ensuring safe age-appropriate administration.The infant’s clinical status steadily improved,and by day 14 the infant achieved full recovery with normalization of oxygen saturation(96%on room air).No adverse events occurred,and follow-up at day 28 confirmed sustained recovery.CONCLUSION To the best of my knowledge,this report presents,for the first time globally,a potential of nitazoxanide within Kelleni’s protocol to early manage infants younger than one year suffering from severe lower respiratory tract viral infection at home.Selective antitussive treatment,using agents such as low dose benproperine,was employed to mitigate troublesome cough and improve patient comfort without compromising respiratory function.Additionally,alpha amylase was used to facilitate pulmonary secretion clearance.The protocol aims to reduce morbidity and mortality from viral lower respiratory tract infections in this vulnerable population.
