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Multi-dimensional Simulation of Phase Change by a 0D-2D Model Coupling via Stefan Condition
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作者 Adrien Drouillet Romain Le Tellier +2 位作者 Raphaël Loubère Mathieu Peybernes Louis Viot 《Communications on Applied Mathematics and Computation》 2023年第2期853-884,共32页
Considering phase changes associated with a high-temperature molten material cooled down from the outside,this work presents an improvement of the modelling and the numerical simulation of such processes for an applic... Considering phase changes associated with a high-temperature molten material cooled down from the outside,this work presents an improvement of the modelling and the numerical simulation of such processes for an application pertaining to the safety of light water nuclear reactors.Postulating a core meltdown accident,the behaviour of the core melt(aka corium)into a steel vessel is of tremendous importance when evaluating the vessel integrity.Evaluating correctly the heat fluxes requires the numerical simulation of the interaction between the liquid material and its solid counterpart which forms during the solidification process,but also may melt back.To simulate this configuration,encoun-tered in various industrial applications,one considers a bi-phase model constituted by a liquid phase in contact and interaction with its solid phase.The liquid phase may solidify in presence of low energetic source,while the solid phase may melt due to an intense heat flux from the high-temperature liquid.In the frame of the in-house legacy code,several simplifying assumptions(0D multi-layer discretization,instantaneous heat transfer via a quadratic temperature profile in solids)are made for the modelling of such phase changes.In the present work,these shortcomings are illustrated and further overcome by solving a 2D heat conduction model in the solid by a mixed Raviart-Thomas finite element method coupled to the liquid phase due to heat and mass exchanges through Stefan condition.The liquid phase is modeled with a 0D multi-layer approach.The 0D-liquid and 2D-solid mod-els are coupled by a Stefan like phase change interface model.Several sanity checks are performed to assess the validity of the approach on 1D and 2D academical configurations for which exact or reference solutions are available.Then more advanced situations(genu-ine multi-dimensional phase changes and an"industrial-like scenario")are simulated to verify the appropriate behavior of the obtained coupled simulation scheme. 展开更多
关键词 simulation of phase change FUSION SOLIdIFICATION 0d multi-layer model 2d heat conduction model Model coupling
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Simulation of the Hydrodynamic Functioning of the Cavally River Using a Coupled 1D-2D Model in the Ity Area (Zouan-Hounien in Côte d’Ivoire)
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作者 Affoué Berthe Yao Kouao Armand Anoh +2 位作者 Loukou Alexis Brou Menouan Wilfried Goli Lazare Kouakou Kouassi 《Open Journal of Modern Hydrology》 2021年第4期75-84,共10页
In recent years, the Cavally River has been subject to multiple activities, <span style="font-family:;" "="">including the construction of diversion channels and a bridge that makes it v... In recent years, the Cavally River has been subject to multiple activities, <span style="font-family:;" "="">including the construction of diversion channels and a bridge that makes it vulnerable to flooding. In order to assess the impact of these hydraulic structures on the <span>river hydrodynamic functioning, a 1D-2D model was realized. The</span> implementation of the 1D-2D model consisted </span><span style="font-family:;" "="">of </span><span style="font-family:;" "="">first </span><span style="font-family:;" "="">running</span><span style="font-family:;" "=""> </span><span style="font-family:;" "="">the 1D model, then the 2D model, and finally in coupling them. The 1D-2D model was designed with <span>the 1988 flood hydrograph, a Manning’s coefficient of 0.052 m<sup>1/3</sup>/s for the </span>minor bed and 0.06 m<sup>1/3</sup>/s for the major bed. The results of the hydraulic model show that the velocities are almost identical to those of the Cavally in natural operation. The values of the velocities are included between 0.4 m/s and 1.3 m/s at the level of the minor bed of the river and between 0.06 m/s and 0.71 m/s at the level of the floodplains. The average water level for flood propagation is 262.37 ± 0.44 m before construction of the structures and 262.23 ± <span>0.85 m after construction of the structures. The 0.41 m reduction in water</span> level due to the diversion canal and bridge is negligible compared to the total fluctuations of the Cavally River, which vary from 6 to 7 m over the year.</span> 展开更多
关键词 Ity Mines 1d-2d Modeling FLOOdING Cavally River Côte d’Ivoire
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异柠檬酸脱氢酶1突变介导D-2-羟基戊二酸代谢重编程在肿瘤免疫调控中的作用及相关药物研发进展
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作者 杨全军 柏丁源 +2 位作者 周雨萱 白露 郭澄 《上海交通大学学报(医学版)》 北大核心 2025年第9期1239-1248,共10页
异柠檬酸脱氢酶1(isocitrate dehydrogenase 1,IDH1)突变可异常产生致癌代谢物D-2-羟基戊二酸(D-2-hydroxyglutarate,D2HG),进而重塑肿瘤免疫微环境,近年来已成为肿瘤代谢-免疫交互研究的关键靶点。D2HG通过竞争性抑制内源性α-酮戊二... 异柠檬酸脱氢酶1(isocitrate dehydrogenase 1,IDH1)突变可异常产生致癌代谢物D-2-羟基戊二酸(D-2-hydroxyglutarate,D2HG),进而重塑肿瘤免疫微环境,近年来已成为肿瘤代谢-免疫交互研究的关键靶点。D2HG通过竞争性抑制内源性α-酮戊二酸依赖性双加氧酶,引发DNA组蛋白过甲基化与细胞分化阻滞,从而促进肿瘤的发生、发展、转移,并促使肿瘤产生耐药性。同时,D2HG抑制T细胞功能,促进髓系细胞扩增以及巨噬细胞极化,削弱免疫监视能力,形成免疫抑制状态,对免疫治疗响应产生影响。在胶质瘤、急性髓系白血病、胆管癌等多种肿瘤中,IDH1呈现出异质性和不同的预后特征。目前,针对IDH1突变的小分子抑制剂,如艾伏尼布(ivosidenib)、沃拉西尼布(vorasidenib)等,能够通过降低D2HG水平,部分逆转免疫抑制,在临床试验中显示出一定的疗效。然而,这些抑制剂存在疗效差异、耐药性及安全性等问题。IDH1抑制剂联合治疗旨在协同逆转代谢-表观遗传-免疫三重抑制网络,增强抗肿瘤药理效应,因而受到广泛关注。该文综述了IDH1突变介导D2HG代谢的肿瘤免疫调控网络,并全面综述了相关药物研发进展,希冀为肿瘤防治提供参考和思路。 展开更多
关键词 异柠檬酸脱氢酶1(IdH1) d-2-羟基戊二酸(d2HG) 免疫调控 艾伏尼布 沃拉西尼布 代谢重编程
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(4d+1)-正则图中的2d-因子 被引量:1
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作者 龙和平 《山东大学学报(理学版)》 CAS CSCD 北大核心 2002年第4期295-297,共3页
设d是一个正整数 ,G是一个 (4d +1 ) -正则图 .证明了若图G不含d +4条割边 ,则G有2d 因子 .进而说明上述结果是最好的 .
关键词 (4d+1)-正则图 2d-因子 割边 顶点集 边集 k-正则支撑子图 连通分支 无环图
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Fine-scale damage assessment of urban flooding based on the 1D/2D coupled hydrodynamic model 被引量:1
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作者 Boliang Dong Junqiang Xia +1 位作者 Qijie Li Xiaojie Wang 《River》 2023年第4期403-420,共18页
Due to the high population density and economic property in urban environments,urban flooding can result in substantial economic losses.However,accurate urban flood modeling and assessing the associated damages are ch... Due to the high population density and economic property in urban environments,urban flooding can result in substantial economic losses.However,accurate urban flood modeling and assessing the associated damages are challenging due to complex urban layouts and rugged topography.Furthermore,the rapid development of urban underground spaces has introduced additional complexities.To address the demanding need for accurate flood modeling and damage assessment in cities,a fine-scale flood damage assessment method was proposed in this study,based on the 1D/2D coupled hydrodynamic model,which can not only assess the flood damage on the ground surface but also evaluate the flood loss in underground spaces.Taking the Gangxi drainage area in Wuhan City,China as a case,this study extensively discussed the flood inundation processes on the ground surface as well as in the buildings and underground spaces,under different rainfall scenarios with the return period ranging from 2 to 200 years.Based on the high spatial-temporal hydrodynamic simulations,the flood damage degrees were evaluated for the buildings and underground spaces with different industry types.The results indicated that the inundation of buildings and underground spaces in densely built cities cannot be neglected in urban flood modeling.Buildings with public service attributes can have a higher flood damage degree,as compared with other types of buildings and underground spaces. 展开更多
关键词 1d/2d coupled modeling flood damage assessment underground spaces urban flooding
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An Implicit Coupled 1D/2D Model for Unsteady Subcritical Flow in Channel Networks and Embayment
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作者 GENG Yan-fen WANG Zhi-li 《China Ocean Engineering》 SCIE EI CSCD 2020年第1期110-118,共9页
In this study, 1D and 2D shallow-water models were coupled to simulate unsteady flow in channel networks and embayment. The 1D model solved the 1D shallow-water equations (St. Venant) using the Preissmann box method a... In this study, 1D and 2D shallow-water models were coupled to simulate unsteady flow in channel networks and embayment. The 1D model solved the 1D shallow-water equations (St. Venant) using the Preissmann box method and targeted long narrow reaches of the river networks, while the 2D model targeted broad channels and embayment and solved the 2D shallow-water equations using a semi-implicit scheme applied to an unstructured grid of triangular cells. The 1D and 2D models were solved simultaneously by building a matrix for the free surface elevation at every 1D junction and 2D cell center. Velocities were then computed explicitly based on the results at the previous time step and the updated water level. The originality of the scheme arose from a novel coupling method. The results showed that the coupled 1D/2D model produced identical results as the full 2D model in classical to benchmark problems with considerable savings in computational effort. Application of the model to the Pearl River Estuary in southern China showed that complex patterns of tidal wave propagation could be efficiently modeled. 展开更多
关键词 1d river network model 2d unstructured model full coupling model Pearl River delta
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Multi-scale simulation model of air system based on cross-dimensional data transmission method 被引量:3
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作者 Lei WANG Junkui MAO +2 位作者 Song WEI Longfei WANG Jin PAN 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2023年第5期157-174,共18页
The Secondary Air System(SAS)plays an important role in the safe operation and performance of aeroengines.The traditional 1D-3D coupling method loses information when used for secondary air systems,which affects the c... The Secondary Air System(SAS)plays an important role in the safe operation and performance of aeroengines.The traditional 1D-3D coupling method loses information when used for secondary air systems,which affects the calculation accuracy.In this paper,a Cross-dimensional Data Transmission method(CDT)from 3D to 1D is proposed by introducing flow field uniformity into the data transmission.First,a uniformity index was established to quantify the flow field parameter distribution characteristics,and a uniformity index prediction model based on the locally weighted regression method(Lowess)was established to quickly obtain the flow field information.Then,an information selection criterion in 3D to 1D data transmission was established based on the Spearman rank correlation coefficient between the uniformity index and the accuracy of coupling calculation,and the calculation method was automatically determined according to the established criterion.Finally,a modified function was obtained by fitting the ratio of the 3D mass-average parameters to the analytical solution,which are then used to modify the selected parameters at the 1D-3D interface.Taking a typical disk cavity air system as an example,the results show that the calculation accuracy of the CDT method is greatly improved by a relative 53.88%compared with the traditional 1D-3D coupling method.Furthermore,the CDT method achieves a speedup of 2 to 3 orders of magnitude compared to the 3D calculation. 展开更多
关键词 Air system data transmission disk cavity Multi-scale simulation 1d-3d coupling
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2D-3D registration for 3D analysis of lower limb alignment in a weight-bearing condition 被引量:2
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作者 SHIM Eungjune KIM Youngjun +3 位作者 LEE Deukhee LEE Byung Hoon WOO Sungkyung LEE Kunwoo 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2018年第1期59-70,共12页
X-ray imaging is the conventional method for diagnosing the orthopedic condition of a patient. Computerized Tomography(CT) scanning is another diagnostic method that provides patient’s 3D anatomical information. Howe... X-ray imaging is the conventional method for diagnosing the orthopedic condition of a patient. Computerized Tomography(CT) scanning is another diagnostic method that provides patient’s 3D anatomical information. However, both methods have limitations when diagnosing the whole leg; X-ray imaging does not provide 3D information, and normal CT scanning cannot be performed with a standing posture. Obtaining 3D data regarding the whole leg in a standing posture is clinically important because it enables 3D analysis in the weight bearing condition.Based on these clinical needs, a hardware-based bi-plane X-ray imaging system has been developed; it uses two orthogonal X-ray images. However, such methods have not been made available in general clinics because of the hight cost. Therefore, we proposed a widely adaptive method for 2 D X-ray image and 3D CT scan data. By this method, it is possible to threedimensionally analyze the whole leg in standing posture. The optimal position that generates the most similar image is the captured X-ray image. The algorithm verifies the similarity using the performance of the proposed method by simulation-based experiments. Then, we analyzed the internal-external rotation angle of the femur using real patient data. Approximately 10.55 degrees of internal rotations were found relative to the defined anterior-posterior direction. In this paper, we present a useful registration method using the conventional X-ray image and 3D CT scan data to analyze the whole leg in the weight-bearing condition. 展开更多
关键词 2d-3d registration 3d analysis X-RAY CT simulated annealing
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Evaluation of Fast Flood Diffusion through a Drainage Channel: A Flood Disaster Case Study of Japan’s Kinugawa River, September 10, 2015
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作者 Kazuaki Ohtsuki Yasuo Nihei 《Journal of Water Resource and Protection》 2017年第9期1063-1081,共19页
On September 10, 2015, unprecedented flood was occurred in Kinugawa River basin located on eastern Japan. It inundated 40 km2 of flood plain in Joso city, Ibaraki Prefecture, and more than 4000 people there called for... On September 10, 2015, unprecedented flood was occurred in Kinugawa River basin located on eastern Japan. It inundated 40 km2 of flood plain in Joso city, Ibaraki Prefecture, and more than 4000 people there called for help despite supposedly having sufficient time to evacuate. Some said that small initial flood before main severe flood arrived made them make a mistake in deciding whether to evacuate or stay there, despite having to actually evacuate in reality. This study focused on flood behaviour in this area, in particular, the effect of a small drainage channel lying on the flood plain which caused fast flood diffusion in case of occurring huge overflowing. Field investigations starting on time of the disaster with high-resolution positioning system were conducted to obtain spatial maps of flood depth and height. For appropriate modelling of the effect of small channel, we applied simulation model coupling 1-dimensional (1D) and 2-dimensional (2D) hydraulic scheme on the field and compared results from the 1D/2D coupled model and model without 1D scheme. The models provided information that the flood could reach 4 hours earlier to the city central of Joso city comparing in case of model without 1D scheme. The water depth rose irregularly and it was more confusing and difficult for the victims to make appropriate evacuation act. 展开更多
关键词 FLOOd dIFFUSION 1- and 2-dimensional couplEd FLOOd simulation CHANNEL Kinugawa RIVER
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An optimized time-adaptive aerothermal coupling calculation method for aerothermal analysis of disc cavity system
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作者 Shuai BI Junkui MAO +1 位作者 Lei WANG Feng HAN 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2024年第9期164-177,共14页
In order to further achieve the balance between the calculation accuracy and efficiency of the transient analysis of the aero-engine disc cavity system,an Optimized Time-adaptive Aerother-mal Coupling calculation(OTAC... In order to further achieve the balance between the calculation accuracy and efficiency of the transient analysis of the aero-engine disc cavity system,an Optimized Time-adaptive Aerother-mal Coupling calculation(OTAC)method has been proposed.It combines one-dimensional tran-sient calculation of air system,Conventional Sequence Staggered(CSS)method,Time-adaptive Aerothermal Coupling calculation(TAC)method and differential evolution optimization algorithm to obtain an efficient and high-precision aerothermal coupling calculation method of air system.Considering both the heat conduction in the solid domain and the flow in the fluid domain as unsteady states in the OTAC,the interaction of fluid-solid information within a single coupling time step size was implemented based on the CSS method.Furthermore,the coupling time step size was automatically adjusted with the number of iterations by using the Proportional-Integral-Deri vative(PID)controller.Results show that when compared with the traditional loosely coupling method with a fixed time step size,the computational accuracy and efficiency of the OTAC method are improved by 8.9%and 30%,respectively.Compared with the tight coupling calculation,the OTAC method can achieve a speedup of 1 to 2 orders of magnitude,while the calculation error is maintained within 6.1%. 展开更多
关键词 Air system 1d-3d coupling Conjugate heat transfer Transient calculation Adaptive time step size
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2D Coupled 3D:A New Numerical Model for Dual - Structured - Aquifer System
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作者 Chen Chongxi Fang Shuzhen Lin Min(Faculty of Environmental Science and Geotechnique,China University of Geosciehces, Wuhan 430074) 《Journal of Earth Science》 SCIE CAS CSCD 1995年第1期114-117,共4页
This paper points out that a successful numerical simulation is to construct a correct conceptional model which is very dose to the natural condition. A new model, two dimensional coupled three dimensional model (2D -... This paper points out that a successful numerical simulation is to construct a correct conceptional model which is very dose to the natural condition. A new model, two dimensional coupled three dimensional model (2D -3D ) is presented in the Present paper,which is the most suitable one for the dual - structured - aquifer system. An example of Wenyinghu area is shown.By using the 2D-3D model, a satisfied result of the simulated area is achieved. 展开更多
关键词 numerical simulation conceptional model two dimensional coupled threedimensional model (2d - 3d ) dual - structured- aquifer system Wenyinghu area.
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Pressure Effects on Spectra of Tunable Laser Crystal GSGG: Cr^3+ IV: Pressure—Induced Shifts of R1 Line, R2 Line, and U Band at 300 K
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作者 MADong-Ping ZHANGJi-Ping 《Communications in Theoretical Physics》 SCIE CAS CSCD 2003年第5期621-630,共10页
By means of both a theory for pressure-induced shifts (PS) of energy spectra and a theory for shifts of energy spectra due to electron-phonon interaction (EPI), the 'pure electronic' PS and the PS due to EPI o... By means of both a theory for pressure-induced shifts (PS) of energy spectra and a theory for shifts of energy spectra due to electron-phonon interaction (EPI), the 'pure electronic' PS and the PS due to EPI of R<SUB>1</SUB> line, R<SUB>2</SUB> line, and U band of GSGG:Cr<SUP>3+</SUP> at 300 K have been calculated, respectively. The calculated results are in good agreement with all the experimental data. Their physical origins have also been explained. It is found that the mixing-degree of and base-wavefunctions in the wavefunctions of R<SUB>1</SUB> level of GSGG:Cr<SUP>3+</SUP> at 300 K is remarkable under normal pressure, and the mixing-degree rapidly decreases with increasing pressure. The change of the mixing-degree with pressure plays a key role not only for the 'pure electronic' PS of R<SUB>1</SUB> line and R<SUB>2</SUB> line but also the PS of R<SUB>1</SUB> line and R<SUB>2</SUB> line due to EPI. The pressure-dependent behaviors of the 'pure electronic' PS of R<SUB>1</SUB> line (or R<SUB>2</SUB> line) and the PS of R<SUB>1</SUB> line (or R<SUB>2</SUB> line) due to EPI are quite different. It is the combined effect of them that gives rise to the total PS of R<SUB>1</SUB> line (or R<SUB>2</SUB> line). In the range of about 15 kbar ~ 45 kbar, the mergence and/or order-reversal between levels and levels take place, which cause the fluctuation of the rate of PS for with pressure. At 300 K, both the temperature-dependent contribution to R<SUB>1</SUB> line (or R<SUB>2</SUB> line or U band) from EPI and the temperature-independent one are important. 展开更多
关键词 high-pressure effect spin-orbit interaction electron-phonon interaction d orbital coupling between t(2)(2)(3T(1))e(4)T(2) and t(2)(32)E tunable laser crystal
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新型真空灭弧室1/2线圈纵磁结构设计与仿真 被引量:5
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作者 孙鹏 邵淑文 《真空》 CAS 北大核心 2010年第3期48-51,共4页
为了提高真空断路器的开断性能,本文设计一种新型1/2匝真空灭弧室线圈式纵向磁场触头结构,并对其纵向磁场分布特性进行分析。利用有限元方法建立三维结构模型并仿真,在电流分别处于峰值和电流过零时,得出静触头表面、开距中心平面和动... 为了提高真空断路器的开断性能,本文设计一种新型1/2匝真空灭弧室线圈式纵向磁场触头结构,并对其纵向磁场分布特性进行分析。利用有限元方法建立三维结构模型并仿真,在电流分别处于峰值和电流过零时,得出静触头表面、开距中心平面和动触头表面上的纵向磁场分布以及纵向磁场的滞后时间;纵向磁场在触头表面与开距中间平面比较均匀,纵向磁场在静触头面的最大值为0.782 T,纵向磁场在动触头面的最大值为0.442 T,滞后时间为0.897 ms,导体电阻为28.25μΩ;新型结构新型触头结构具有较强的纵向磁场,电流过零后的剩余磁场小、滞后时间短,且温升较小。 展开更多
关键词 真空灭弧室 1/2线圈 结构设计 三维磁场 仿真
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Pressure Effects on Spectra of Tunable Laser Crystal GSGG:Cr3+ III: Pressure-Induced Shift of R1 Line at 70 K
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作者 MADong-Ping ZHANGJi-Ping 《Communications in Theoretical Physics》 SCIE CAS CSCD 2003年第4期493-500,共8页
By means of both a theory for pressure-induced shifts (PS) of energy spectra and a theory for shifts of energy spectra due to electron-phonon interaction (EPI), the 'pure electronic' PS and the PS due to EPI o... By means of both a theory for pressure-induced shifts (PS) of energy spectra and a theory for shifts of energy spectra due to electron-phonon interaction (EPI), the 'pure electronic' PS and the PS due to EPI of R<SUB>1</SUB> line of GSGG:Cr<SUP>3+</SUP> at 70 K have been calculated, respectively. Their physical origins have been revealed. It is found that the admixture of and base-wavefunctions in the wavefunctions of R<SUB>1</SUB> level of GSGG:Cr<SUP>3+</SUP> at 70 K is remarkable under the normal pressure, and the degree of the admixture rapidly decreases with increasing pressure. The change of the degree of the admixture with the pressure plays a key role for not only the pure electronic PS of R<SUB>1</SUB> line but also the PS of R<SUB>1</SUB> line due to EPI. The detailed calculations and analyses show that the pressure-dependent behaviors of the pure electronic PS of R<SUB>1</SUB> line and the PS of R<SUB>1</SUB> line due to EPI are quite different. It is the combined effect of them that gives rise to the total PS of R<SUB>1</SUB> line, which has satisfactorily explained the experimental data (including a reversal of PS of R<SUB>1</SUB> line). In contributions to PS of R<SUB>1</SUB> line due to EPI at 70 K, the temperature-independent contribution is much larger than the temperature-dependent contribution. The former results from the interaction between the zero-point vibration of the lattice and localized electronic state. 展开更多
关键词 high-pressure effect spin-orbit interaction electron-phonon interaction d orbital coupling between t(2)(2)(T-3(1))e(4)T(2) and t(2)(3)(2)E tunable laser crystal
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A deterministic distributed modeling approach of Mediterranean water-cycle assessment,application in the Var catchment,France
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作者 Siyuan Chang Zhengmiao Li +2 位作者 Xinyi Lian Philippe Gourbesville Qiang Ma 《River》 2025年第3期297-310,共14页
Characterized by special morphologic,geographic,hydrologic,and societal behaviors,the water resources management of the Mediterranean catchment often shows a higher level of complexity including security issues of wat... Characterized by special morphologic,geographic,hydrologic,and societal behaviors,the water resources management of the Mediterranean catchment often shows a higher level of complexity including security issues of water supply,inundation risks,and environment management under the perspective of climate change.To have a comprehensive understanding of the Mediterranean water-cycle system,a deterministic distributed hydrologic modeling approach has been developed and presented in this study based on an application in the Var catchment(2800 km^(2))located at the French Mediterranean region.A 1D and 2D coupled model of MIKE SHE and MIKE 11 has been set up under a series of hypotheses to represent the whole hydrologic and hydrodynamic processes including rainfall-runoff,snow-melting,channel flow,overland flow,and the water exchange between land surface and unsaturated/saturated zones.The developed model was first calibrated with 4 years daily records from 2008 to 2011,then to be validated and further run within hourly time interval to produce detailed representation of the catchment water-cycle from 2012 to 2014.The deterministic distributed modeling approach presented in this study is able to represent its complicated water-cycle and used for supporting the decision‐making process of the water resources management of the catchment. 展开更多
关键词 1d/2d coupled model distributed hydrological model flood management Mediterranean catchment
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Three-dimensional(3D)printing-assisted freeze-casting of processed pyritum-dopedβ-tricalcium phosphate biomimetic scaffold with angiogenesis and bone regeneration capability
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作者 Chenxu WEI Zongan LI +9 位作者 Xiaoyun LIANG Yuwei ZHAO Xingyu ZHU Haibing HUA Guobao CHEN Kunming QIN Zhipeng CHEN Changcan SHI Feng ZHANG Weidong LI 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 2025年第9期863-880,共18页
Bone repair remains an important target in tissue engineering,making the development of bioactive scaffolds for effective bone defect repair a critical objective.In this study,β-tricalcium phosphate(β-TCP)scaffolds ... Bone repair remains an important target in tissue engineering,making the development of bioactive scaffolds for effective bone defect repair a critical objective.In this study,β-tricalcium phosphate(β-TCP)scaffolds incorporated with processed pyritum decoction(PPD)were fabricated using three-dimensional(3D)printing-assisted freeze-casting.The produced composite scaffolds were evaluated for their mechanical strength,physicochemical properties,biocompatibility,in vitro proangiogenic activity,and in vivo efficacy in repairing rabbit femoral defects.They not only demonstrated excellent physicochemical properties,enhanced mechanical strength,and good biosafety but also significantly promoted the proliferation,migration,and aggregation of pro-angiogenic human umbilical vein endothelial cells(HUVECs).In vivo studies revealed that all scaffold groups facilitated osteogenesis at the bone defect site,with theβ-TCP scaffolds loaded with PPD markedly enhancing the expression of neurogenic locus Notch homolog protein 1(Notch1),vascular endothelial growth factor(VEGF),bone morphogenetic protein-2(BMP-2),and osteopontin(OPN).Overall,the scaffolds developed in this study exhibited strong angiogenic and osteogenic capabilities both in vitro and in vivo.The incorporation of PPD notably promoted the angiogenic-osteogenic coupling,thereby accelerating bone repair,which suggests that PPD is a promising material for bone repair and that the PPD/β-TCP scaffolds hold great potential as a bone graft alternative. 展开更多
关键词 Bone defect Processed pyritum Three-dimensional(3d)printing-assisted freeze-casting ANGIOGENESIS Bone regeneration VEGF-Notch1-BMP-2-OPN coupling
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A Coupled Experiment with LICOM2 as the Ocean Component of CESM1 被引量:5
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作者 林鹏飞 刘海龙 +6 位作者 薛巍 李慧岷 姜金荣 宋米荣 宋毅 王夫常 张明华 《Journal of Meteorological Research》 SCIE CSCD 2016年第1期76-92,共17页
In the present study, the LASG/IAP Climate system Ocean Model version 2 (LICOM2) was implemented to replace the original ocean component in the Community Earth System Model version 1.0.4 (CESM1) to form a new coup... In the present study, the LASG/IAP Climate system Ocean Model version 2 (LICOM2) was implemented to replace the original ocean component in the Community Earth System Model version 1.0.4 (CESM1) to form a new coupled model referred to as CESMI+LICOM2. The simulation results from a 300-yr prein- dustrial experiment by using this model were evaluated against both observations and the Flexible Global Ocean-Atmosphere-Land System Model with grid-atmospheric model version 2 (FGOALS-g2). It was found that CESMI+LICOM2 simulates well the mean features of the ocean, sea ice, and atmosphere, relative to models used in the Coupled Model Intercomparison Experiment (CMIP5), when compared with obser- vations. The spatial distribution of SST bias in CESMI+LICOM2 is similar to that in the Community Climate System Model version 4 (CCSM4). The simulated climate variabilities, such as ENSO and Pacific decadal oscillation, are also reasonably simulated when compared with observations. The successful implementation of LICOM2 in the CESM1 framework greatly enhances the capability of LICOM2 in conducting high-resolution simulations and model tuning. Compared with FGOALS-g2, the simulations of both SST and Atlantic meridional overturning circulation are significantly improved in CESMI^LICOM2. The former can be mainly attributed to the atmospheric model, and the latter to the improvement in the parameterization of diapycnal mixing. The study provides a base to further improve the present version of LICOM and its functionalities in the coupled model FGOALS at both low and high resolutions. 展开更多
关键词 LICOM2 CESM1 simulation climate system coupled model
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A COUPLED 1-D AND 2-D CHANNEL NETWORK MATHEMATICAL MODEL USED FOR FLOW CALCULATIONS IN THE MIDDLE REACHES OF THE YANGTZE RIVER 被引量:5
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作者 HAN Dong FANG Hong-wei BAIJing HE Guo-jian 《Journal of Hydrodynamics》 SCIE EI CSCD 2011年第4期521-526,共6页
A coupled one-dimensional (1-D) and two-dimensional (2-D) channel network mathematical model is proposed for flow calculations at nodes in a channel network system in this article. For the 1-D model, the finite di... A coupled one-dimensional (1-D) and two-dimensional (2-D) channel network mathematical model is proposed for flow calculations at nodes in a channel network system in this article. For the 1-D model, the finite difference method is used to discretize the Saint-Venant equations in all channels of a looped network. The Alternating Direction Implicit (ADI) method is adopted for the 2-D model at the nodes. In the coupled model, the 1-D model provides a good approximation with small computational effort, while the 2-D model is applied for complex topography to achieve a high accuracy. An Artificial Neural Network (ANN.) method is used for the data exchange and the connectivity between the 1-D and 2-D models. The coupled model is applied to the Jingjiang-Dongting Lake region, to simulate the tremendous looped channel network system, and the results are compared with field data. The good agreement shows that the coupled hydraulic model is more effective than the conventional 1-D model. 展开更多
关键词 coupled 1-d and 2-d model looped channel network system Alternating driection Implicit (AdI) Jingjiang-dongting Lake region
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Mathematical model for flood routing in Jingjiang River and Dongting Lake network 被引量:6
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作者 Zuo-tao XIE Fang-li YANG Xiao-li FU 《Water Science and Engineering》 EI CAS 2012年第3期259-268,共10页
The main stream of the Yangtze River, Dongting Lake, and the river network in the Jingjiang reach of the Yangtze River constitute a complex water system. This paper develops a one-dimensional (l-D) mathematical mode... The main stream of the Yangtze River, Dongting Lake, and the river network in the Jingjiang reach of the Yangtze River constitute a complex water system. This paper develops a one-dimensional (l-D) mathematical model for flood routing in the river network Of the Jingjiang River and Dongting Lake using the explicit finite volume method. Based on observed data during the flood periods in 1996 and 1998, the model was calibrated and validated, and the results show that the model is effective and has high accuracy. In addition, the one-dimensional mathematical model for the river network and the horizontal two-dimensional (2-D) mathematical model for the Jingjiang flood diversion area were coupled to simulate the flood process in the Jingjiang River, Dongting Lake, and the Jingjiang flood diversion area. The calculated results of the coupled model are consistent with the practical processes. Meanwhile, the results show that the flood diversion has significant effects on the decrease of the peak water level at the Shashi and Chenjiawan hydrological stations near the flood diversion gates, and the effect is more obvious in the downstream than in the upstream. 展开更多
关键词 Jingjiang River dongting Lake Jing/iang flood diversion area flood routing rivernetworks 1-d and 2-d coupled model
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17aα—D-高炔雌二醇-3-乙酯联合γ射线照射对不同品系小鼠的抑瘤作用 被引量:5
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作者 王月英 王小春 +8 位作者 吴红英 李德冠 张恒 宋娜玲 褚丽萍 路璐 杜丽清 王彦 孟爱民 《国际放射医学核医学杂志》 2012年第2期97-100,共4页
目的对比观察17a α—D-高炔雌二醇-3-乙酯(DHEA)对不同品系小鼠肺腺癌的抑瘤作用及探讨合用^137Cs γ射线照射是否具有抑瘤增效作用。方法将LA795肺腺癌细胞用生理盐水稀释为浓度约3.5×10^7/ml瘤细胞,接种于近交系IRM-1和IR... 目的对比观察17a α—D-高炔雌二醇-3-乙酯(DHEA)对不同品系小鼠肺腺癌的抑瘤作用及探讨合用^137Cs γ射线照射是否具有抑瘤增效作用。方法将LA795肺腺癌细胞用生理盐水稀释为浓度约3.5×10^7/ml瘤细胞,接种于近交系IRM-1和IRM-2小鼠腋下,0.2ml/只,24h后分别将IRM-1和IRM-2荷瘤小鼠随机分为8组:对照组、单照组、DHEA(低、中、高剂量)组和DHEA(低、中、高剂量)联合照射组。DHEA组与DHEA联合照射组采取腹腔给药,每日1次,连续7d。其中,DHEA联合照射组于给药的第4日进行全身1Gy照射,每日1次,连续5d。观察DHEA联合γ射线照射对小鼠肺腺癌的抑瘤效果及对相关免疫学指标的影响。结果DHEA低、中、高剂量组对IRM-1荷瘤小鼠的抑瘤率分别为38.05%、49.33%和48.18%,与对照组比较差异有统计学意义(担3.417,4.929和4.889,P均〈0.01),联合^137Cs γ射线照射后的抑瘤率分别为56.98%、64.44%和62.72%,与对照组比较差异有统计学意义(t=5.475,5.770和6.165,P均〈0.01)。DHEA低、中、高剂量组对IRM-2小鼠的抑瘤率分别为42.73%、70.91%和67.73%,其中,中、高剂量组与对照组比较差异有统计学意义(t=3.239和3.062,P均〈0.01),联合^137Cs γ射线照射后的抑瘤率分别为63.63%、75.00%和68.64%,与对照组比较差异有统计学意义(t=2.834,3.426和3.156,P分别为〈0.05,〈0.01和〈0.01)。结论DHEA对不同品系小鼠肺腺癌细胞均有抑制作用,联合γ射线照射后的抑瘤疗效比单纯DHEA组更为明显。 展开更多
关键词 Γ射线 肺肿瘤 17a dd-高炔雌二醇-3-乙酯 IRM-1小鼠 IRM-2小鼠
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