期刊文献+
共找到2,884篇文章
< 1 2 145 >
每页显示 20 50 100
Automatic gating and riser system design and defect control for K4169 superalloy guide blade casting based on parametric 3D modeling-simulation integrated system
1
作者 Le-chuan Li Ya-jun Yin +4 位作者 Bing-zheng Fan Guo-yan Shui Xiao-yuan Ji Jian-xin Zhou Lei Jin 《China Foundry》 2026年第1期20-30,共11页
Automation and intelligence have become the primary trends in the design of investment casting processes.However,the design of gating and riser systems still lacks precise quantitative evaluation criteria.Numerical si... Automation and intelligence have become the primary trends in the design of investment casting processes.However,the design of gating and riser systems still lacks precise quantitative evaluation criteria.Numerical simulation plays a significant role in quantitatively evaluating current processes and making targeted improvements,but its limitations lie in the inability to dynamically reflect the formation outcomes of castings under varying process conditions,making real-time adjustments to gating and riser designs challenging.In this study,an automated design model for gating and riser systems based on integrated parametric 3D modeling-simulation framework is proposed,which enhances the flexibility and usability of evaluating the casting process by simulation.Firstly,geometric feature extraction technology is employed to obtain the geometric information of the target casting.Based on this information,an automated design framework for gating and riser systems is established,incorporating multiple structural parameters for real-time process control.Subsequently,the simulation results for various structural parameters are analyzed,and the influence of these parameters on casting formation is thoroughly investigated.Finally,the optimal design scheme is generated and validated through experimental verification.Simulation analysis and experimental results show that using a larger gate neck(24 mm in side length) and external risers promotes a more uniform temperature distribution and a more stable flow state,effectively eliminating shrinkage cavities and enhancing process yield by 15%. 展开更多
关键词 numerical simulation automatic design investment casting parametric 3d modeling gating and riser system
在线阅读 下载PDF
Computer Simulation and Experimental Approach in the Investigation of Deformation and Fracture of TPMS Structures Manufactured by 3D Printing
2
作者 Nataliya Kazantseva Nikolai Saharov +2 位作者 Denis Davydov Nikola iPopov Maxim Il’inikh 《Computers, Materials & Continua》 2026年第4期578-595,共18页
Because of the developed surface of the Triply PeriodicMinimumSurface(TPMS)structures,polylactide(PLA)products with a TPMS structure are thought to be promising bio soluble implants with the potential for targeted dru... Because of the developed surface of the Triply PeriodicMinimumSurface(TPMS)structures,polylactide(PLA)products with a TPMS structure are thought to be promising bio soluble implants with the potential for targeted drug delivery.For implants,mechanical properties are key performance characteristics,so understanding the deformation and failure mechanisms is essential for selecting the appropriate implant structure.The deformation and fracture processes in PLA samples with different interior architectures have been studied through computer simulation and experimental research.Two TPMS topologies,the Schwarz Diamond and Gyroid architectures,were used for the sample construction by 3D printing.ANSYS software was utilized to simulate compressive deformation.It was found that under the same load,the vonMises stresses in the Gyroid structure are higher than those in the Schwartz Diamond structure,which was associated with the different orientations of the cells in the studied structures in relation to the direction of the loading axis.The deformation process occurs in the local regions of the studied TPMS structures.Maximum von Mises stresses were observed in the vertical parts of the structures oriented along the load direction.It was found that,unlike the Gyroid,the Schwartz Diamond structure contains a frame that forms unique stiffening ribs,which ensures the redistribution of the load under the vertical loading direction.An analysis of the mechanical characteristics of PLA samples with the Schwartz Diamond and Gyroid structures produced by the Fused Deposition Modeling(FDM)method was correlated with computer simulation.The Schwarz Diamond-type structure was shown to have a higher absorption energy than the Gyroid one.A study of the fracture in PLA samples with various cell sizes revealed a particular feature related to the samples’periodic surface topology and the 3D printing process.Scanning electron microscopic(SEM)studies of the samples deformed by compression showed thatwith an increase in the density of the samples,the failure mechanism changes from ductile to quasi-brittle due to the complex participation of both cell deformation and fiber deformation. 展开更多
关键词 Computer simulation TPMS structure dEFORMATION FRACTURE SEM 3d printing
在线阅读 下载PDF
Construction and Simulation of Global Land Surface Microwave Emissivity Atlas Using FY-3D Satellite Data
3
作者 Yonghong LIU Fuzhong WENG +5 位作者 Fei TANG Yang HAN Qingyang LIU Rui LI Yongming XU Jun YANG 《Advances in Atmospheric Sciences》 2026年第4期805-826,共22页
The Microwave Land Surface Emissivity(MLSE)atlas and instantaneous simulation of all-sky/all-surface MLSE are important prerequisites for satellite data assimilation.A ten-day/month synthesized FengYun-3D MLSE atlas(N... The Microwave Land Surface Emissivity(MLSE)atlas and instantaneous simulation of all-sky/all-surface MLSE are important prerequisites for satellite data assimilation.A ten-day/month synthesized FengYun-3D MLSE atlas(New_FY3D)was constructed by the two global MLSE daily product datasets,clear-sky(FY-3D1)and clear/cloudy(FY-3D2),which were retrieved from the same FY-3D MicroWave Radiation Imager(MWRI)Level-1 brightness temperature(BT)data from 2021 to 2022,respectively.Then,a set of global MLSE label samples based on the New_FY3D,including 14 surface geophysical parameters,was obtained for an instantaneous global MLSE simulation at a 0.10°spatial resolution by adopting the extreme gradient boosting(XGBoost)machine learning method.Finally,the FengYun-3F(FY-3F)MWRI-II BT simulations using the Advanced Radiative Transfer Modeling System(ARMS)based on the above different MLSE products were evaluated.The results show that the New_FY3D atlas performs well,and the BT simulation at the top of atmosphere is better than that of FY-3D1,FY-3D2,and the international mainstream TELSEM2(Version 2.0 for a Tool to Estimate Land Surface Emissivities in the Microwaves)atlas.Surface roughness,vegetation coverage,land cover type,and snow cover are vital parameters for MLSE simulation.The XGBoost model can accurately simulate all-sky/all-surface MLSE instantaneously over the frequency range 10.65–89.0 GHz.The average simulation determination coefficients(R^(2))under clear-sky and cloud-sky conditions are 0.925 and 0.901,respectively,and the average root-mean-square errors(RMSEs)are 0.018 and 0.021,respectively.Large simulation errors occur in permanent wetland,ice and snow,and urban and built-up areas.With a standard deviation of 6.6 K,the BT simulation based on an XGBoost simulated MLSE is better than those based on New_FY3D and TELSEM2. 展开更多
关键词 microwave land surface emissivity FY-3d all-sky/all-surface XGBoost brightness temperature simulation
在线阅读 下载PDF
茯苓不同药用部位中β-(1→3)-D-葡聚糖的组成及含量比较研究
4
作者 杨晨曦 王伟伟 +5 位作者 冯伟红 刘晓谦 张永欣 毛慧静 王智民 闫利华 《中国中药杂志》 北大核心 2026年第2期456-471,共16页
茯苓是我国大宗常用中药材,多个部位可入药,常见的有茯苓皮、赤茯苓、白茯苓、茯神等,多糖是其主要药效物质。明确茯苓不同药用部位中多糖的组成和含量差异,可为茯苓类药材及饮片的产地加工及临床用药提供参考依据。该研究采用高效凝胶... 茯苓是我国大宗常用中药材,多个部位可入药,常见的有茯苓皮、赤茯苓、白茯苓、茯神等,多糖是其主要药效物质。明确茯苓不同药用部位中多糖的组成和含量差异,可为茯苓类药材及饮片的产地加工及临床用药提供参考依据。该研究采用高效凝胶渗透色谱(HPGPC)、核磁共振光谱(NMR)等对茯苓菌核不同部位碱溶性多糖的相对分子质量分布、化学组成进行定性比较。结果表明,赤茯苓及茯苓皮中碱溶性多糖的组成与白茯苓中完全一致,均为β-(1→3)-D-葡聚糖,相对分子质量分布范围较接近,在9.13×10^(4)~1.04×10^(5)。基于2025年版《中国药典》茯苓中β-(1→3)-D-葡聚糖的含量测定法,对其供试品溶液的制备方法进行优化。首先,增加了除盐步骤,可使供试品色谱图中仅呈现待测物葡萄糖的色谱峰,降低了分离难度。其次,该试验首次发现,酸性条件下,茯苓β-(1→3)-D-葡聚糖水解为葡萄糖的过程中,同时伴随着少量5-羟甲基糠醛副产物的生成。酸水解反应条件越剧烈,5-羟甲基糠醛的生成量越大,因此,结合单因素试验和响应面试验考察结果,将酸水解时间由6 h缩短为1.5 h,提升了分析效率。经验证,优化后的方法简便、稳定且重复性、准确性良好。采用优化后的含量测定方法评价了茯苓菌核不同部位及茯苓类饮片中β-(1→3)-D-葡聚糖含量。结果表明,茯苓不同部位药材中β-(1→3)-D-葡聚糖的含量大小依次为白茯苓、茯神、赤茯苓、茯苓皮。市售茯苓饮片中,色白、质坚的饮片中β-(1→3)-D-葡聚糖含量高于色深、质地松泡的饮片。 展开更多
关键词 茯苓 药用部位 β-(13)-d-葡聚糖 含量测定 响应面法 5-羟甲基糠醛
原文传递
早产儿血清25羟维生素D3、血红素氧合酶-1及NLR与视网膜病变相关性
5
作者 唐朋伟 刘梅 +5 位作者 薛相丽 付阿营 刘彦娣 高升 顾双全 王淑云 《皖南医学院学报》 2026年第1期50-54,共5页
目的:探究早产儿血清25羟维生素D3[25(OH)D3]、血红素氧合酶-1(HO-1)及中性粒细胞与淋巴细胞比率(NLR)与视网膜病变(ROP)相关性。方法:选取2021年6月~2024年6月在太和县人民医院出生的早产儿作为研究组,根据早产儿有无ROP分为ROP组和非... 目的:探究早产儿血清25羟维生素D3[25(OH)D3]、血红素氧合酶-1(HO-1)及中性粒细胞与淋巴细胞比率(NLR)与视网膜病变(ROP)相关性。方法:选取2021年6月~2024年6月在太和县人民医院出生的早产儿作为研究组,根据早产儿有无ROP分为ROP组和非ROP组,比较两组患儿的血清25(OH)D3、HO-1及NLR,通过Logistic回归分析筛选早产儿发生ROP的影响因素,以Medcal软件绘制血清25(OH)D3、HO-1及NLR评估早产儿发生ROP的ROC曲线。结果:ROP组和非ROP组早产儿胎龄分别以28~33^(+6)周和34~36^(+6)周为主(P<0.001)。ROP组早产儿血清25(OH)D3、HO-1水平低于非ROP组(P<0.001),NLR水平高于非ROP组(P<0.001);多因素Logistic回归分析显示,胎龄28~33^(+6)、胎龄34~36^(+6)、血清25(OH)D3和HO-1水平升高,早产儿发生ROP的风险降低(P<0.01);NLR水平升高,早产儿发生ROP的风险升高(P<0.001);血清25(OH)D3、HO-1、胎龄及NLR联合预测早产儿发生ROP的AUC为0.969,灵敏度和特异度分别为98.08%、82.63%。结论:ROP患儿血清25(OH)D3、HO-1、胎龄及NLR与早产儿发生ROP有关,ROP患儿血清25(OH)D3、HO-1、胎龄及NLR联合能够提升ROP疾病的诊断效能。 展开更多
关键词 早产儿 25羟维生素d3 血红素氧合酶-1 视网膜病变
暂未订购
Carbon Footprint and Economic Analysis of LNG-fueled Fishing Vessel Using Real Engine Performance Simulation
6
作者 Momir Sjerić Maja Perčić +1 位作者 Ivana Jovanović Nikola Vladimir 《哈尔滨工程大学学报(英文版)》 2026年第1期259-276,共18页
Analysis of the environmental and economic performance of fishing vessels has received limited attention compared with other ship types despite their notable contribution to global greenhouse gas(GHG)emissions.This st... Analysis of the environmental and economic performance of fishing vessels has received limited attention compared with other ship types despite their notable contribution to global greenhouse gas(GHG)emissions.This study evaluates the carbon footprint(CF)and economic viability of a liquefied natural gas(LNG)-fueled fishing vessel,using real engine operation simulations to provide precise and dynamic evaluation of fuel consumption and GHG emissions.Operational profiles are obtained through the utilization of onboard monitoring systems,whereas engine performance is simulated using the 1D/0D AVL Boost^(TM)model.Life cycle assessment(LCA)is conducted to quantify the environmental impact,whereas life cycle cost assessment(LCCA)is performed to analyze the profitability of LNG as an alternative fuel.The potential impact of the future fuel price uncertainties is addressed using Monte Carlo simulations.The LCA findings indicate that LNG has the potential to reduce the CF of the vessel by 14%to 16%,in comparison to a diesel power system configuration that serves as the baseline scenario.The LCCA results further indicate that the total cost of an LNG-powered ship is lower by 9.5%-13.8%,depending on the share of LNG and pilot fuels.This finding highlights the potential of LNG to produce considerable environmental benefits while addressing economic challenges under diverse operational and fuel price conditions. 展开更多
关键词 1d/0d simulation Carbon footprint Fishing vessels Life cycle assessment Life cycle cost assessment Liquefied natural gas
在线阅读 下载PDF
Design and analysis of a flip-chip architecture for SAW-DQD strong coupling
7
作者 Yi-Bo Wang Xiang-Xiang Song +1 位作者 Zhuo-Zhi Zhang Guo-Ping Guo 《Chinese Physics B》 2026年第2期461-468,共8页
Surface acoustic wave(SAW)resonators offer distinct advantages for coupling to semiconductor qubits,including low loss,high stability,and compatibility with magnetic fields.However,the integration of SAW resonators wi... Surface acoustic wave(SAW)resonators offer distinct advantages for coupling to semiconductor qubits,including low loss,high stability,and compatibility with magnetic fields.However,the integration of SAW resonators with double quantum dots(DQDs)that host charge and spin qubits remains largely unexplored.In this work,we propose a flip-chip architecture that enables three-dimensional integration of a semiconductor DQD with a SAW resonator.Taking experimental feasibility into account,we estimate the coupling strength between a DQD and a SAW resonator.The results suggest that the strong coupling regime can be reached in our design.This study provides theoretical insight and practical guidance for experimental exploration of phonon–electron coupling in hybrid SAW-DQD quantum systems. 展开更多
关键词 surface acoustic wave resonator double quantum dot 3d integration strong coupling
原文传递
T_(1)-3D BRAVO序列与T_(1)WI、T_(2)WI、FLAIR常规序列在发育性静脉畸形诊断中的应用价值比较
8
作者 刘志方 桂国华 徐廉俊 《影像研究与医学应用》 2026年第1期82-85,共4页
目的:比较T_(1)-3D BRAVO序列与T_(1)WI、T_(2)WI、液体衰减反转恢复(FLAIR)常规序列在发育性静脉畸形(DVA)诊断中的应用价值。方法:选取2024年7月—2025年7月韶关市中医院收治的50例DVA患者作为研究对象,所有患者均行MRI常规序列与T_(1... 目的:比较T_(1)-3D BRAVO序列与T_(1)WI、T_(2)WI、液体衰减反转恢复(FLAIR)常规序列在发育性静脉畸形(DVA)诊断中的应用价值。方法:选取2024年7月—2025年7月韶关市中医院收治的50例DVA患者作为研究对象,所有患者均行MRI常规序列与T_(1)-3D BRABO序列检查。比较T_(1)-3D BRAVO序列与常规序列的可见性、病变与周围组织的界限、病变的血流信号、诊断的准确率。结果:T_(1)-3D BRAVO序列诊断的灵敏度、特异度、准确率均高于T_(1)WI、T_(2)WI、FLAIR序列,差异有统计学意义(P<0.05)。T_(1)-3D BRAVO序列在病变显示效果、病变形态呈现、病变位置准确性、病变大小测量准确性、病变与邻近结构关系等可见性方面均优于T_(1)WI、T_(2)WI、FLAIR序列,差异有统计学意义(P<0.05)。T_(1)-3D BRAVO序列在病变与正常组织的分界清晰度、病变边缘形态清晰度、病变边缘锐利度、病变与脑血管结构的区分度等方面均优于T_(1)WI、T_(2)WI、FLAIR序列,差异有统计学意义(P<0.05)。T_(1)-3D BRAVO序列在血流信号的识别能力、静脉回流的显示能力、血流信号诊断辅助作用等方面均优于T_(1)WI、T_(2)WI、FLAIR序列,差异有统计学意义(P<0.05)。结论:T_(1)-3D BRAVO序列诊断DVA的准确性更高,其可见性更强,能够清晰显示病灶与周围组织的界限及血流信号。 展开更多
关键词 T_(1)-3d BRAVO序列 T_(1)WI T_(2)WI FLAIR序列 发育性静脉畸形
暂未订购
Numerical Simulation of the Mass Movement Process of the 2018 Sedongpu Glacial Debris Flow by Using the Fluid-Solid Coupling Method 被引量:2
9
作者 Xing-Yu Long Yu-Xiang Hu +1 位作者 Bin-Rui Gan Jia-Wen Zhou 《Journal of Earth Science》 SCIE CAS CSCD 2024年第2期583-596,共14页
In the context of global warming and intensified human activities,glacier instability in plateau regions has increased,and glacier debris flows have become active,which poses a significant threat to the lives and prop... In the context of global warming and intensified human activities,glacier instability in plateau regions has increased,and glacier debris flows have become active,which poses a significant threat to the lives and property of people and socioeconomic development.The mass movement process of glacier debris flows is extremely complex,so this paper uses the 2018 Sedongpu glacier debris flow event on the Qinghai-Tibet Plateau as an example and applies a numerical simulation method to invert the whole process of mass movement.In view of the interaction between phases in the process of motion,we use the fluid-solid coupling method to describe the mass movement.The granular-flow model and drift-flux model are employed in FLOW3D software to study the mass movement process of glacier debris flows and explore their dynamic characteristics.The results indicate that the glacier debris flow lasted for 700 s,and the movement process was roughly divided into four stages,including initiation,scraping,surging and deposition;the depositional characteristics calculated by the fluid-solid coupling model are consistent with the actual survey results and have good reliability;strong erosion occurs during the mass movement,the clear volume amplification effect,and the first wave climbs 17.8 m across the slope.The fluid-solid coupling method can better simulate glacier debris flows in plateau regions,which is helpful for the study of the mechanism and dynamic characteristics of such disasters. 展开更多
关键词 glacial debris flow Qinghai-Tibet Plateau fluid-solid coupling FLOW3d mass movement depositional characteristics dISASTERS engineering geology
原文传递
Using 3D TCAD Simulation to Study Charge Collection of a p-n Junction in a 0.18μm Bulk Process
10
作者 梁斌 陈书明 刘必慰 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2008年第9期1692-1697,共6页
Single event transient of a real p-n junction in a 0.18μm bulk process is studied by 3D TCAD simulation. The impact of voltage, temperature, substrate concentration, and LET on SET is studied. Our simulation results ... Single event transient of a real p-n junction in a 0.18μm bulk process is studied by 3D TCAD simulation. The impact of voltage, temperature, substrate concentration, and LET on SET is studied. Our simulation results demonstrate that biases in the range 1.62 to 1.98V influence DSET current shape greatly and total collected charge weakly. Peak current and charge collection within 2ns decreases as temperature increases,and temperature has a stronger influence on SET currents than on total charge. Typical variation of substrate concentration in modern VDSM processes has a negligible effect on SEEs. Both peak current and total collection charge increases as LET increases. 展开更多
关键词 charge collection p-n junction very deep sub-micro 3d device simulation RAdIATION
在线阅读 下载PDF
黑逍遥散对APP/PS1小鼠神经炎症及NLRP3/Caspase-1/GSDMD信号通路的影响 被引量:4
11
作者 周君 李明成 +3 位作者 吕育洁 孟志鹏 胡韵韵 王虎平 《中国实验方剂学杂志》 北大核心 2025年第9期124-133,共10页
目的:观察黑逍遥散对阿尔茨海默病模型小鼠学习记忆能力的影响,并从核苷酸结合寡聚化结构域样受体3(NLRP3)/胱天蛋白酶-1(Caspase-1)/Gasdermin家族蛋白D(GSDMD)信号通路介导的神经炎症反应探讨其作用机制。方法:将SPF级4月龄APP/PS1小... 目的:观察黑逍遥散对阿尔茨海默病模型小鼠学习记忆能力的影响,并从核苷酸结合寡聚化结构域样受体3(NLRP3)/胱天蛋白酶-1(Caspase-1)/Gasdermin家族蛋白D(GSDMD)信号通路介导的神经炎症反应探讨其作用机制。方法:将SPF级4月龄APP/PS1小鼠随机分为模型组、MCC950组及黑逍遥散高、中、低剂量组,另将C57BL/6J小鼠作为空白组。适应性喂养7 d后,对各组小鼠分别进行干预,黑逍遥散高、中、低剂量组分别灌胃给药对应剂量药液(25.79、12.90、6.45 g·kg^(-1)·d^(-1)),MCC950组腹腔注射给药(10 mg·kg^(-1)·2 d^(-1)),空白组给予等体积生理盐水灌胃。干预90 d后用Y迷宫和Morris水迷宫试验测试学习记忆能力,苏木素-伊红(HE)染色观察海马神经元结构改变,免疫组化检测海马CA3区淀粉样蛋白前体(APP)表达水平,酶联免疫吸附测定法(ELISA)检测海马组织白细胞介素(IL)-10、IL-18、IL-1β表达水平,蛋白免疫印迹法(Western blot)检测海马组织NLRP3、Caspase-1、GSDMD、GSDMD-N蛋白表达,免疫荧光检测GSDMD-N和离子钙结合衔接分子-1(Iba-1)的共定位表达。结果:①Y迷宫实验结果显示,与空白组比较,模型组自发交替率显著减少(P<0.01);与模型组比较,黑逍遥散高、低剂量组自发交替率显著增加(P<0.01)。②Morris水迷宫实验结果显示,在1~4 d的定位航行测试中,随着训练时间的延长,各组逃避潜伏期时间均缩短。第4天,与空白组比较,模型组逃避潜伏期明显升高(P<0.05);与模型组比较,MCC950组和黑逍遥散低剂量组逃避潜伏期明显缩短(P<0.05)。在空间探索实验中,与空白组比较,模型组跨越平台位置的次数显著降低(P<0.01);与模型组比较,黑逍遥散低剂量组跨越平台次数明显增高(P<0.05)。③HE染色显示,模型组海马CA3区细胞损伤,排列松散且不规则、肿胀、边界不清,细胞核固缩、深染;MCC950与黑逍遥散各剂量组均能不同程度地改善APP/PS1海马CA3区细胞的损伤。④免疫组化结果表明,与空白组比较,模型组海马CA3区APP表达显著增多(P<0.01),MCC950和黑逍遥散高、中、低剂量组能降低APP/PS1海马CA3区APP的表达水平(P<0.01)。⑤ELISA检测结果表明,模型组海马IL-18、IL-1β水平显著升高,IL-10水平显著降低(P<0.01);与模型组比较,MCC950组和黑逍遥散中、低剂量组海马IL-18水平显著降低(P<0.01),MCC950组及黑逍遥散高、中、低剂量组海马IL-1β水平显著降低(P<0.01),MCC950组和黑逍遥散中、低剂量组海马IL-10水平升高(P<0.05,P<0.01)。⑥Western blot检测结果显示,与空白组比较,模型组海马NLRP3、Caspase-1、GSDMD、GSDMD-N蛋白表达显著升高(P<0.01);与模型组比较,各给药组海马NLRP3、Caspase-1含量减少(P<0.05,P<0.01),黑逍遥散高、中、低剂量组海马GSDMD含量减少(P<0.05,P<0.01),黑逍遥散中、低剂量组海马GSDMD-N含量减少(P<0.05,P<0.01)。⑦免疫荧光检测结果显示,与空白组比较,模型组海马区GSDMD-N与Iba-1共表达增加(P<0.01);与模型组比较,各给药组海马区GSDMD-N与Iba-1共表达减少(P<0.01)。结论:黑逍遥散可能通过调控NLRP3/Caspase-1/GSDMD信号通路影响炎症因子的释放,进而缓解神经炎症,改善海马组织病理学改变和学习记忆障碍以治疗阿尔茨海默病。 展开更多
关键词 阿尔茨海默病 黑逍遥散 神经炎症 核苷酸结合寡聚化结构域样受体3(NLRP3)/胱天蛋白酶-1(Caspase-1)/Gasdermin家族蛋白d(GSdMd)信号通路 实验研究
原文传递
Highly efficient contact detection strategy of 3D discontinuous deformation analysis in continuous-discontinuous simulation
12
作者 Jingyu Kang Xiaodong Fu +5 位作者 Qian Sheng Xing Wang Haifeng Ding Xuehan Zhao Tian Xi Shangwei Jiang 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第11期6977-6992,共16页
Contact detection is the most time-consuming stage in 3D discontinuous deformation analysis(3D-DDA)computation.Improving the efficiency of 3D-DDA is beneficial for its application in large-scale computing.In this stud... Contact detection is the most time-consuming stage in 3D discontinuous deformation analysis(3D-DDA)computation.Improving the efficiency of 3D-DDA is beneficial for its application in large-scale computing.In this study,aiming at the continuous-discontinuous simulation of 3D-DDA,a highly efficient contact detection strategy is proposed.Firstly,the global direct search(GDS)method is integrated into the 3D-DDA framework to address intricate contact scenarios.Subsequently,all geometric elements,including blocks,faces,edges,and vertices are divided into searchable and unsearchable parts.Contacts between unsearchable geometric elements would be directly inherited,while only searchable geometric elements are involved in contact detection.This strategy significantly reduces the number of geometric elements involved in contact detection,thereby markedly enhancing the computation efficiency.Several examples are adopted to demonstrate the accuracy and efficiency of the improved 3D-DDA method.The rock pillars with different mesh sizes are simulated under self-weight.The deformation and stress are consistent with the analytical results,and the smaller the mesh size,the higher the accuracy.The maximum speedup ratio is 38.46 for this case.Furthermore,the Brazilian splitting test on the discs with different flaws is conducted.The results show that the failure pattern of the samples is consistent with the results obtained by other methods and experiments,and the maximum speedup ratio is 266.73.Finally,a large-scale impact test is performed,and approximately 3.2 times enhanced efficiency is obtained.The proposed contact detection strategy significantly improves efficiency when the rock has not completely failed,which is more suitable for continuous-discontinuous simulation. 展开更多
关键词 3d discontinuous deformation analysis Contact detection Computation efficiency Continuous-discontinuous simulation FRACTURE
在线阅读 下载PDF
Magneto-Electro-Elastic 3D Coupling in Free Vibrations of Layered Plates
13
作者 Salvatore Brischetto Domenico Cesare Tommaso Mondino 《Computers, Materials & Continua》 2025年第12期4491-4518,共28页
A three-dimensional(3D)analytical formulation is proposed to put together magnetic,electric and elastic fields to analyze the vibration modes of simply-supported layered piezo-electro-magnetic plates.The present 3D mo... A three-dimensional(3D)analytical formulation is proposed to put together magnetic,electric and elastic fields to analyze the vibration modes of simply-supported layered piezo-electro-magnetic plates.The present 3D model allows analyses for layered smart plates in both open-circuit and closed-circuit configurations.The secondorder differential equations written in the mixed curvilinear reference system govern the magneto-electro-elastic free vibration problem for multilayered plates.This set consists of the 3D equations of motion and the 3D divergence equations for the magnetic induction and electric displacement.Navier harmonic forms in the planar directions and the exponential matrix method in the transversal direction of the plate are applied to solve the second-order differential equations in terms of displacements.For these reasons,simply-supported boundary conditions are considered.Imposition of interlaminar continuity conditions on primary variables(displacements,magnetic potential,electric potential),and some secondary variables(transverse normal and transverse shear stresses,transverse normal magnetic induction/electric displacement)allows the implementation of the layer-wise approach.Assessments for both load boundary configurations are proposed in the results section to validate the present 3D approach.3D electro-elastic and 3D magneto-elastic coupling validations are performed separately considering different models from the open literature.A new benchmark involving a full magneto-electro-elastic coupling for multilayered plates is presented considering both load boundary configurations for different thickness ratios.For this benchmark,circular frequency values and related vibration modes through the transverse direction in terms of displacements,magnetic and electric potential,transverse normal magnetic induction/electric displacement are shown to visualize the magneto-electroelastic coupling and material and thickness layer effects.The present formulation has been entirely implemented in an academic Matlab(R2024a)code developed by the authors.In this paper,for the first time,the second-order differential equations governing the magneto-electro-elastic problem for the free vibration analysis of plates has been solved considering the mixed mode of harmonic forms and exponential matrix.The exponential matrix permits computing the secondary variable of the problem(stresses,electric displacement components and magnetic induction components)exactly,directly from constitutive and geometrical equations.In addition,the very simple and elegant formulation permits having a code with very low computational costs.The present manuscript aims to fill the void in open literature regarding reference 3D solutions for the free vibration analysis of magneto-electro-elastic plates. 展开更多
关键词 3d analytical formulation multilayered smart plates free vibration analyses vibration modes magnetoelectro-elastic coupling exponential matrix method layer wise approach
在线阅读 下载PDF
D-阿洛酮糖-3-差向异构酶交联聚集体的制备及其性质分析
14
作者 邱荣慧 李子翼 +3 位作者 李娇 王德培 曾艳 孙媛霞 《食品工业科技》 北大核心 2026年第7期169-177,共9页
本研究旨在利用交联酶聚集体(cross-linked enzyme aggregates,CLEAs)技术固定化瘤胃球菌来源的D-阿洛酮糖-3-差向异构酶(D-allulose-3-epimerase from Ruminococcus sp.,RDAE)。选择聚乙二醇PEG4000作为沉淀剂、葡聚糖醛作为交联剂,通... 本研究旨在利用交联酶聚集体(cross-linked enzyme aggregates,CLEAs)技术固定化瘤胃球菌来源的D-阿洛酮糖-3-差向异构酶(D-allulose-3-epimerase from Ruminococcus sp.,RDAE)。选择聚乙二醇PEG4000作为沉淀剂、葡聚糖醛作为交联剂,通过优化沉淀剂用量、交联剂用量与交联时间制备交联聚集体RDAE-CLEAs。比较游离酶RDAE与固定化酶RDAE-CLEAs的酶学性质差异,并采用扫描电镜、红外光谱和分子动力学模拟分析固定化前后酶的结构变化。在不添加稳定剂的条件下,研究采用终质量分数36%(w/v)PEG4000与终浓度2.73 mg/mL葡聚糖醛交联反应4 h制备的RDAE-CLEAs酶活保留率达到55.88%。与游离酶相比,固定化酶在pH6.0~7.5和30~55℃下的环境耐受性显著提升(P<0.05),重复使用10次后仍能保持59.77%的初始活性。结构分析显示RDAE在交联过程中发生了明显的构象变化,酶蛋白四聚体结构中的亚基结合紧密程度降低。本研究获得了重复使用性能良好的RDAE-CLEAs,揭示了RDAE表面赖氨酸残基不仅为共价交联提供有效位点,还在维持酶蛋白四聚体刚性结构中发挥关键作用。基于四聚体刚性结构对RDAE热稳定性的重要影响,在避免破坏酶蛋白表面赖氨酸残基基础上开发新的交联策略对提高RDAE-CLEAs应用潜力具有积极意义。 展开更多
关键词 d-阿洛酮糖-3-差向异构酶 无载体固定化 交联酶聚集体 酶学性质 分子模拟
在线阅读 下载PDF
基于NLRP3/Gasdermin D/Caspase-1/Interleukin-1β焦亡通路探讨盐酸青藤碱对佐剂性关节炎大鼠的保护作用
15
作者 徐豫湘 田英 +2 位作者 许潜 葛子靖 姚璐莎 《中国临床药理学与治疗学》 北大核心 2025年第9期1174-1181,共8页
目的:探讨盐酸青藤碱(sinomenine,SIN)对佐剂性关节炎大鼠(adjuvant arthritis,AA)的保护作用及机制。方法:将60只大鼠随机分成6组,每组10只:Con组(正常大鼠)、AA组(AA大鼠模型)、L-SIN组(AA大鼠经灌胃100 mg/kg的SIN)、M-SIN组(AA大鼠... 目的:探讨盐酸青藤碱(sinomenine,SIN)对佐剂性关节炎大鼠(adjuvant arthritis,AA)的保护作用及机制。方法:将60只大鼠随机分成6组,每组10只:Con组(正常大鼠)、AA组(AA大鼠模型)、L-SIN组(AA大鼠经灌胃100 mg/kg的SIN)、M-SIN组(AA大鼠经灌胃200 mg/kg的SIN)、H-SIN组(AA大鼠经灌胃400 mg/kg的SIN)、ACG组(阳性药物组:AA大鼠灌胃万通筋骨片150 mg/kg)。评估关节炎症状。HE染色观察大鼠右踝关节组织的病理变化。检测滑膜组织中的炎症因子水平和氧化应激相关指标。Western blot检测NLRP3/Gasdermin D/Caspase-1/Interleukin-1β焦亡通路相关的蛋白表达水平。结果:与Con组比较,AA组关节肿胀程度、关节炎指数、炎症因子、氧化应激水平和NLRP3、GSDMD、Caspase-1、IL-1β蛋白表达水平显著增加(P<0.05)。与AA组比较,SIN治疗组随着治疗剂量的增加,关节肿胀程度、关节炎指数、炎症因子、氧化应激水平和NLRP3、GSDMD、Caspase-1、IL-1β蛋白表达水平显著降低(P<0.05)。与AA组和L-SIN组比较,ACG组的关节肿胀程度、关节炎指数、炎症因子、氧化应激水平和NLRP3、GSDMD、Caspase-1、IL-1β蛋白表达水平显著降低(P<0.05)。与H-SIN组比较,ACG组的关节肿胀程度、关节炎指数、炎症因子、氧化应激水平和NLRP3、GSDMD、Caspase-1、IL-1β蛋白表达水平显著增加(P<0.05)。结论:SIN能够缓解AA大鼠的炎症损伤,并降低炎症因子和氧化应激水平,从而发挥对AA大鼠的保护作用,其机制可能是基于NLRP3/Gasdermin D/Caspase-1/Interleukin-1β焦亡通路来实现。 展开更多
关键词 盐酸青藤碱 佐剂性关节炎 类风湿关节炎 NLRP3/Gasdermin d/Caspase-1/Interleukin-1β 焦亡
暂未订购
长链非编码RNA VPS9D1-AS1调控miR-532-3p/WEE1轴对卵巢癌细胞增殖、凋亡及上皮间质转化的影响
16
作者 刘宏伟 王雅红 +2 位作者 周齐 闫亚男 王颖欣 《中国优生与遗传杂志》 2025年第5期1025-1032,共8页
目的探究长链非编码RNA VPS9D1反义RNA1(lncRNA VPS9D1-AS1)靶向调控微小RNA-532-3p/丝氨酸/苏氨酸蛋白激酶1(miR-532-3p/WEE1)信号轴对卵巢癌细胞增殖、凋亡及上皮间质转化(EMT)的影响。方法将SKOV3细胞分为Control组、si-NC组、si-VPS... 目的探究长链非编码RNA VPS9D1反义RNA1(lncRNA VPS9D1-AS1)靶向调控微小RNA-532-3p/丝氨酸/苏氨酸蛋白激酶1(miR-532-3p/WEE1)信号轴对卵巢癌细胞增殖、凋亡及上皮间质转化(EMT)的影响。方法将SKOV3细胞分为Control组、si-NC组、si-VPS9D1-AS1组、si-VPS9D1-AS1+anti-NC组、si-VPS9D1-AS1+anti-miR-532-3p组;以qRT-PCR法检测组织与细胞中lncRNA VPS9D1-AS1、miR-532-3p水平;以双荧光素酶实验检测lncRNA VPS9D1-AS1、WEE1分别与miR-532-3p靶向关系;以Edu、流式细胞术分别检测细胞增殖、凋亡;以Western blot法检测细胞增殖、凋亡、EMT相关蛋白及WEE1表达情况;以裸鼠移植瘤验证lncRNA VPS9D1-AS1对卵巢癌移植瘤生长及miR-532-3p/WEE1轴的影响。结果在卵巢癌组织及SKOV3细胞中lncRNA VPS9D1-AS1高表达,miR-532-3p低表达。lncRNA VPS9D1-AS1、WEE1与miR-532-3p之间存在靶向结合位点。si-VPS9D1-AS1组较si-NC组Edu阳性率和lncRNA VPS9D1-AS1水平及WEE1、Ki67、Bcl-2、N-cadherin、Vimentin表达降低,细胞凋亡率和miR-532-3p水平及p21、Bax、E-cadherin表达升高(P<0.05);以沉默miR-532-3p可部分逆转沉默VPS9D1-AS1对SKOV3细胞恶性表型的改善作用;裸鼠移植瘤实验显示,si-VPS9D1-AS1组较si-NC组裸鼠移植瘤生长缓慢,lncRNA VPS9D1-AS1水平及WEE1表达降低,miR-532-3p水平升高(P<0.05)。结论lncRNA VPS9D1-AS1可通过调控miR-532-3p/WEE1轴参与卵巢癌细胞增殖、凋亡、EMT过程。 展开更多
关键词 长链非编码RNA VPS9d1反义RNA1 微小RNA-532-3p 蛋白激酶WEE1 卵巢癌 上皮间质转化
原文传递
几丁质酶3样蛋白1联合半乳糖凝集素-3与25-羟维生素D构建多囊卵巢综合征孕妇不良妊娠结局的列线图预测模型
17
作者 李岩华 刘长爱 刘永艳 《中国妇幼保健》 2025年第23期4277-4281,共5页
目的联合应用几丁质酶3样蛋白1(CHI3L1)、半乳糖凝集素-3(Gal-3)、25-羟维生素D[25-(OH)D]构建多囊卵巢综合征(PCOS)孕妇不良妊娠结局的列线图预测模型,为临床提供参考。方法选取2022年3月—2023年5月在天津市东丽医院诊断和治疗的104例... 目的联合应用几丁质酶3样蛋白1(CHI3L1)、半乳糖凝集素-3(Gal-3)、25-羟维生素D[25-(OH)D]构建多囊卵巢综合征(PCOS)孕妇不良妊娠结局的列线图预测模型,为临床提供参考。方法选取2022年3月—2023年5月在天津市东丽医院诊断和治疗的104例PCOS孕妇为PCOS组,同期在天津市东丽医院建档并且产检的52例健康孕妇为对照组。采用酶联免疫吸附法检测两组孕妇血清CHI3L1水平,采用化学发光免疫分析法检测两组孕妇血清Gal-3、25-(OH)D水平。收集PCOS组孕妇的临床资料,随访至孕妇分娩结束,按照妊娠结局分为良好组(73例)和不良组(31例)。采用Pearson相关性分析法分析CHI3L1、Gal-3、25-(OH)D的线性关联;采用多因素Cox比例风险回归模型筛选不良妊娠结局的独立影响因素,使用R语言构建列线图预测模型,绘制受试者工作特征(ROC)曲线,计算曲线下面积(AUC),验证预测模型的准确性。结果对照组孕妇血清CHI3L1水平为(24.94±3.11)pg/ml,血清Gal-3水平为(1.41±0.46)ng/ml,血清25-(OH)D水平为(38.71±4.19)nmol/L;PCOS组孕妇血清CHI3L1水平为(107.52±19.37)pg/ml,血清Gal-3水平为(4.58±1.13)ng/ml,血清25-(OH)D水平为(30.28±5.40)nmol/L。PCOS组孕妇血清CHI3L1、Gal-3水平均高于对照组,血清25-(OH)D水平低于对照组,差异均有统计学意义(t=48.367,17.918,13.690,均P<0.05)。Pearson相关性分析显示:PCOS孕妇血清CHI3L1与Gal-3呈正相关(r=0.847,P<0.05),血清CHI3L1与25-(OH)D呈负相关(r=-0.819,P<0.05),血清Gal-3与25-(OH)D呈负相关(r=-0.826,P<0.05)。妊娠结局良好的PCOS孕妇血清CHI3L1水平为(94.04±17.86)pg/ml,血清Gal-3水平为(4.09±0.98)ng/ml,血清25-(OH)D水平为(32.02±3.93)nmol/L;妊娠结局不良的PCOS孕妇血清CHI3L1水平为(139.26±22.93)pg/ml,血清Gal-3水平为(5.74±1.49)ng/ml,血清25-(OH)D水平为(26.19±4.81)nmol/L。妊娠结局不良的PCOS孕妇血清CHI3L1、Gal-3水平均高于妊娠结局良好的PCOS孕妇,血清25-(OH)D水平低于妊娠结局良好的PCOS孕妇(t=26.743,4.928,11.486,均P<0.05)。妊娠结局不良的PCOS孕妇血清睾酮水平、黄体生成素(LH)/卵泡刺激素(FSH)比值均高于妊娠结局良好的PCOS孕妇(均P<0.05)。多因素Cox比例风险回归模型分析显示:CHI3L1、Gal-3、25-(OH)D、睾酮、LH/FSH比值均是PCOS孕妇不良妊娠结局的独立影响因素(均P<0.05)。使用R语言绘制列线图预测模型,使用Bootstrap内部重复抽样法验证模型的区分度,一致性指数(C-index)为0.938,接近理想曲线,说明模型具有较高的校准能力。通过ROC曲线对该模型进行验证,AUC为0.926,说明预测模型预测不良妊娠结局的准确性较高。决策曲线分析证实:该预测模型能够获得较好的净获益,在预测不良妊娠结局方面具有良好的临床效用。结论PCOS孕妇血清CHI3L1、Gal-3水平升高,血清25-(OH)D水平降低,并且与不良妊娠结局相关。联合CHI3L1、Gal-3、25-(OH)D、睾酮、LH/FSH比值构建的列线图预测模型预测PCOS孕妇不良妊娠结局具有较高的临床应用价值。 展开更多
关键词 几丁质酶3样蛋白1 半乳糖凝集素-3 25-羟维生素d 多囊卵巢综合征 不良妊娠结局 列线图预测模型
原文传递
不同严重程度急性呼吸窘迫征患者血清1,25-二羟维生素D3水平的变化及其与预后的关系分析
18
作者 江帆 张娟 +1 位作者 邓林 阳键 《临床内科杂志》 2025年第9期732-737,共6页
目的探讨不同严重程度急性呼吸窘迫征(ARDS)患者血清1,25-二羟维生素D3[1,25-(OH)_(2)D_(3)]水平变化及其与预后的关系。方法将150例ARDS患者根据氧合指数分为轻度组(200 mm Hg<氧合指数≤300 mm Hg,54例)、中度组(100 mm Hg<氧... 目的探讨不同严重程度急性呼吸窘迫征(ARDS)患者血清1,25-二羟维生素D3[1,25-(OH)_(2)D_(3)]水平变化及其与预后的关系。方法将150例ARDS患者根据氧合指数分为轻度组(200 mm Hg<氧合指数≤300 mm Hg,54例)、中度组(100 mm Hg<氧合指数≤200 mm Hg,50例)、重度组(氧合指数≤100 mm Hg,46例)。根据预后情况再将其分为预后良好组(98例)与预后不良组(52例)。收集所有患者的一般资料、临床资料及实验室检查指标并分组进行比较。采用多元线性回归分析不同严重程度组ARDS患者1,25-(OH)_(2)D_(3)与炎症反应指标的相关性。采用多因素logistic回归分析评估影响ARDS患者预后的相关因素。采用共线性诊断检验自变量间的共线性。采用cox比例风险模型调整混杂变量后,分析1,25-(OH)_(2)D_(3)与炎症反应指标对ARDS患者预后的交互作用。采用logistic回归模型结合限制性立方样条模型(RCS)评估1,25-(OH)_(2)D_(3)和不同严重程度的ARDS患者预后的剂量-反应关系。结果轻度组、中度组、重度组患者1,25-(OH)_(2)D_(3)水平依次降低,急性生理和慢性疾病(APACHEⅡ)评分、脓毒症相关器官衰竭(SOFA)评分、降钙素原(PCT)、N末端B型脑钠肽前体(NT-proBNP)、C反应蛋白(CRP)、WBC计数、碱性成纤维细胞生长因子2(FGF2)、肿瘤坏死因子-α(TNF-α)、IL-6、IL-1β水平均依次升高(P<0.05)。多元线性回归分析结果显示,调整了相关因素后不同严重程度组ARDS患者TNF-α、IL-6、IL-1β均与1,25-(OH)_(2)D_(3)呈独立负相关(P<0.05)。预后不良组患者氧合指数及1,25-(OH)_(2)D_(3)水平均低于预后良好组,APACHEⅡ评分、SOFA评分、PCT、NT-proBNP、CRP、WBC计数、FGF2、TNF-α、IL-6、IL-1β水平均高于预后良好组(P<0.05)。多因素logistic回归分析结果显示,APACHEⅡ评分、氧合指数、FGF2、PCT、NT-proBNP、SOFA评分、1,25-(OH)_(2)D_(3)、TNF-α、IL-6、IL-1β均是影响ARDS患者预后的独立因素(P<0.05)。共线性诊断检验结果提示变量之间相互独立,不存在共线性。交互作用分析结果显示,相加及相乘模型中,1,25-(OH)_(2)D_(3)与TNF-α、IL-6、IL-1β对ARDS患者预后的影响均存在交互作用。RCS模型分析结果显示,1,25-(OH)_(2)D_(3)水平与轻度组、中度组、重度组ARDS患者预后不良发生风险均呈非线性相关(P_(非线性)=0.046、0.042、0.048)。结论血清1,25-(OH)_(2)D_(3)水平能够用来判断ARDS患者的病情严重程度,且1,25-(OH)_(2)D_(3)对ARDS患者预后具有一定的预测价值。 展开更多
关键词 急性呼吸窘迫征 1 25-二羟维生素d3 预后 相关性
暂未订购
AI辅助压缩感知在颅内血管壁3D T1WI成像中的应用
19
作者 张月青 赵元宾 +8 位作者 张瑞 周鑫 苗成鹏 谭桂蓉 段云云 隋滨滨 董健 柴丽 丁金立 《北京生物医学工程》 2025年第5期496-502,共7页
目的探索人工智能辅助压缩感知(artificial intelligence-assisted compressed sensing,ACS)技术加速颅内血管壁高分辨率三维T1加权黑血成像(three-dimensional T1-weighted black blood imaging,3D T1_HRVWI)的可行性,并与临床常规采... 目的探索人工智能辅助压缩感知(artificial intelligence-assisted compressed sensing,ACS)技术加速颅内血管壁高分辨率三维T1加权黑血成像(three-dimensional T1-weighted black blood imaging,3D T1_HRVWI)的可行性,并与临床常规采用的并行采集技术(parallel imaging,PI)进行对比分析。方法前瞻性纳入47例脑血管疾病患者,行ACS加速(实验组)和PI加速(对照组)的3D T1_HRVWI扫描。客观比较ACS组和PI组的序列扫描时长、图像中血管壁的信噪比以及相对于血管腔的对比噪声比,主观评估两组图像总体质量、颅内血管显示情况及病灶诊断价值,并进行统计分析。结果相较于PI 3D T1_HRVWI,ACS 3D T1_HRVWI的扫描时长缩短43%;ACS 3D T1_HRVWI图像中颈内动脉、基底动脉、椎动脉、大脑前动脉、大脑中动脉、大脑后动脉血管壁的信噪比均显著升高(P<0.001);两组图像的总体质量评分和颅内血管的显示评分均未见显著差异(P>0.05);两组图像的病灶诊断价值相当(P>0.05)。结论ACS技术实现了3D T1_HRVWI序列更快的采集速度,同时保持了较好的成像质量,为开发兼顾扫描效率与诊断精度的脑血管影像扫描方案提供了循证依据,在脑血管疾病的精准诊断中展现出重要价值。 展开更多
关键词 颅内血管壁成像 高分辨率3d T1加权黑血成像 脑血管疾病 人工智能辅助压缩感知技术 磁共振成像
暂未订购
GnRHa联合维生素D3对特发性中枢性性早熟女童血清25(OH)D、IGF-1及身高的影响
20
作者 杨玲 揭旭辉 +4 位作者 段春蓉 胡小英 赵小燕 朱美红 江志华 《现代诊断与治疗》 2025年第23期3480-3482,共3页
目的评估维生素D3联合长效促性腺激素释放激素类似物(GnRHa)治疗特发性中枢性性早熟女童的临床疗效及其对25-羟维生素D[25(OH)D]和胰岛素样生长因子-1(IGF-1)水平的影响。方法采用前瞻性随机对照设计,将2023年1至2024年12月在医院确诊... 目的评估维生素D3联合长效促性腺激素释放激素类似物(GnRHa)治疗特发性中枢性性早熟女童的临床疗效及其对25-羟维生素D[25(OH)D]和胰岛素样生长因子-1(IGF-1)水平的影响。方法采用前瞻性随机对照设计,将2023年1至2024年12月在医院确诊的50例特发性中枢性性早熟女童分为对照组和观察组,各25例。对照组单用GnRHa治疗,观察组在此基础上口服维生素D3,比较两组治疗效果、血清IGF-1、25(OH)D水平及身高。结果观察组总有效率高于对照组(χ^(2)=4.153,P=0.042);治疗6个月后,治疗6个月后,观察组IGF-1浓度低于对照组,25(OH)D水平高于对照组,平均身高高于对照组(t=2.349,P=0.023)。结论维生素D3联合GnRHa治疗特发性中枢性性早熟女童可有效提高整体疗效,下调IGF-1水平,提高25(OH)D水平,改善患儿身高增长情况。 展开更多
关键词 中枢性性早熟 维生素d3 促性腺激素释放激素类似物 25-羟维生素d 胰岛素样生长因子-1
暂未订购
上一页 1 2 145 下一页 到第
使用帮助 返回顶部