From the dried roots and leaves of Tripterygium wilfordii^(1.2),a new diter- penoid triepoxide,16-hydroxytriptolide was isolated,and its structure and stereochemistry elucidated as 16-(S)-hydroxy-triptolide on the bas...From the dried roots and leaves of Tripterygium wilfordii^(1.2),a new diter- penoid triepoxide,16-hydroxytriptolide was isolated,and its structure and stereochemistry elucidated as 16-(S)-hydroxy-triptolide on the basis of spectral data(IR, MS, UV,~1HNMR,^(13)CNMR,2d-NMR,Selective Long-range DEPT)and x-ray crystallographic analysis.This compound showed definite antiinflammatory action,strong immunosuppressive and antifertile activities.In addition,a known compound,triptolide was also isolated and all the spectral signals of^1 HNMR and ^(13)CNMR were assigned.展开更多
目的探讨血清甲壳质酶蛋白40(chitinase protein 40,YKL-40)、Clara细胞蛋白16(Clara cell protein 16,CC16)对急性阑尾炎(acute appendicitis,AA)患儿手术切口感染的预测价值。方法河北北方学院附属第一医院小儿外科2021年10月至2023...目的探讨血清甲壳质酶蛋白40(chitinase protein 40,YKL-40)、Clara细胞蛋白16(Clara cell protein 16,CC16)对急性阑尾炎(acute appendicitis,AA)患儿手术切口感染的预测价值。方法河北北方学院附属第一医院小儿外科2021年10月至2023年10月收治的324例行腹腔镜手术的AA患儿,根据患儿腹腔镜手术30 d后的切口感染情况分为感染组(n=40)和未感染者组(n=284),ELISA测定血清YKL-40、CC16水平,多因素Logistic回归分析影响AA患儿发生手术切口感染的因素;采用受试者工作特征(ROC)曲线分析血清YKL-40、CC16对AA患儿发生手术切口感染的预测价值,Pearson法分析发生切口感染的AA患者血清YKL-40、CC16水平的相关性。结果感染组和未感染组患儿的身高、合并阑尾穿孔、体重、切口长度、腹腔引流管留置、切口探查、性别、年龄、疾病持续时间、白细胞计数、术前体温及术中出血量情况比较,差异无统计学意义(P>0.05);感染组较非感染组手术操作时间≥1 h的患儿比例及血清YKL-40水平增加,血清CC16水平降低(P<0.05);YKL-40是AA患儿发生手术切口感染的危险因素,CC16是保护因素(P<0.05);血清YKL-40、CC16及联合预测AA患儿发生手术切口感染的AUC为0.805、0.833、0.899,二者联合优于单独预测价值(Z=3.372、2.032,P=0.001、0.042);感染组患儿血清YKL-40、CC16水平呈负相关(r=-0.730,P<0.001)。结论AA患儿手术切口感染者较未感染者血清YKL-40水平升高、CC16水平降低,二者对AA患儿发生手术切口感染具有一定的预测价值。展开更多
文摘From the dried roots and leaves of Tripterygium wilfordii^(1.2),a new diter- penoid triepoxide,16-hydroxytriptolide was isolated,and its structure and stereochemistry elucidated as 16-(S)-hydroxy-triptolide on the basis of spectral data(IR, MS, UV,~1HNMR,^(13)CNMR,2d-NMR,Selective Long-range DEPT)and x-ray crystallographic analysis.This compound showed definite antiinflammatory action,strong immunosuppressive and antifertile activities.In addition,a known compound,triptolide was also isolated and all the spectral signals of^1 HNMR and ^(13)CNMR were assigned.
文摘目的探讨血清甲壳质酶蛋白40(chitinase protein 40,YKL-40)、Clara细胞蛋白16(Clara cell protein 16,CC16)对急性阑尾炎(acute appendicitis,AA)患儿手术切口感染的预测价值。方法河北北方学院附属第一医院小儿外科2021年10月至2023年10月收治的324例行腹腔镜手术的AA患儿,根据患儿腹腔镜手术30 d后的切口感染情况分为感染组(n=40)和未感染者组(n=284),ELISA测定血清YKL-40、CC16水平,多因素Logistic回归分析影响AA患儿发生手术切口感染的因素;采用受试者工作特征(ROC)曲线分析血清YKL-40、CC16对AA患儿发生手术切口感染的预测价值,Pearson法分析发生切口感染的AA患者血清YKL-40、CC16水平的相关性。结果感染组和未感染组患儿的身高、合并阑尾穿孔、体重、切口长度、腹腔引流管留置、切口探查、性别、年龄、疾病持续时间、白细胞计数、术前体温及术中出血量情况比较,差异无统计学意义(P>0.05);感染组较非感染组手术操作时间≥1 h的患儿比例及血清YKL-40水平增加,血清CC16水平降低(P<0.05);YKL-40是AA患儿发生手术切口感染的危险因素,CC16是保护因素(P<0.05);血清YKL-40、CC16及联合预测AA患儿发生手术切口感染的AUC为0.805、0.833、0.899,二者联合优于单独预测价值(Z=3.372、2.032,P=0.001、0.042);感染组患儿血清YKL-40、CC16水平呈负相关(r=-0.730,P<0.001)。结论AA患儿手术切口感染者较未感染者血清YKL-40水平升高、CC16水平降低,二者对AA患儿发生手术切口感染具有一定的预测价值。
