In this paper,we define a new class of control functions through aggregate special functions.These class of control functions help us to stabilize and approximate a tri-additiveψ-functional inequality to get a better...In this paper,we define a new class of control functions through aggregate special functions.These class of control functions help us to stabilize and approximate a tri-additiveψ-functional inequality to get a better estimation for permuting tri-homomorphisms and permuting tri-derivations in unital C*-algebras and Banach algebras by the vector-valued alternative fixed point theorem.展开更多
背景:阿尔茨海默病患者存在严重的脑能量障碍,近年来基于酮体干预的脑能量拯救策略在阿尔茨海默病的治疗中越来越受到重视。目的:探讨β-羟基丁酸能否改善β淀粉样蛋白1-42(β-amyloid protein 1-42,Aβ_(1-42))诱导的小鼠海马神经元HT2...背景:阿尔茨海默病患者存在严重的脑能量障碍,近年来基于酮体干预的脑能量拯救策略在阿尔茨海默病的治疗中越来越受到重视。目的:探讨β-羟基丁酸能否改善β淀粉样蛋白1-42(β-amyloid protein 1-42,Aβ_(1-42))诱导的小鼠海马神经元HT22细胞能量障碍。方法:将HT22细胞分为4组,分别为对照组、β-羟基丁酸组、Aβ_(1-42)组、Aβ_(1-42)+β-羟基丁酸组。使用相应试剂盒检测HT22细胞的存活率、ATP水平、α-酮戊二酸脱氢酶活性、Na^(+)K^(+)-ATP酶活性、线粒体膜电位及活性氧水平。结果与结论:与对照组相比,Aβ_(1-42)组HT22细胞的存活率、ATP水平、α-酮戊二酸脱氢酶活性、Na^(+)K^(+)-ATP酶活性、线粒体膜电位均显著降低(P<0.05),活性氧水平显著升高(P<0.05)。与Aβ_(1-42)组相比,Aβ_(1-42)+β-羟基丁酸组HT22细胞的存活率、ATP水平、α-酮戊二酸脱氢酶活性、Na^(+)K^(+)-ATP酶活性、线粒体膜电位均显著升高(P<0.05),活性氧水平显著降低(P<0.05)。结果表明:β-羟基丁酸提高了线粒体生物能量功能和细胞存活率,最终改善了Aβ_(1-42)诱导的HT22细胞能量障碍。展开更多
目的通过研究度拉糖肽联合二甲双胍在初诊超重/肥胖2型糖尿病(type 2 diabetes mellitus,T2DM)患者治疗前后胰岛β细胞功能的变化情况,探讨其对胰岛β细胞功能的影响。方法选取2023年7—12月于百色市人民医院就诊的160例初诊超重/肥胖T...目的通过研究度拉糖肽联合二甲双胍在初诊超重/肥胖2型糖尿病(type 2 diabetes mellitus,T2DM)患者治疗前后胰岛β细胞功能的变化情况,探讨其对胰岛β细胞功能的影响。方法选取2023年7—12月于百色市人民医院就诊的160例初诊超重/肥胖T2DM患者。对照组口服二甲双胍缓释片、观察组使用二甲双胍缓释片联合度拉糖肽。分析治疗12周后两组患者体重、腰围、体重指数(body mass index,BMI)、空腹血糖、糖化血红蛋白(glycosylated hemoglobin A1c,HbA1c)、胰岛素抵抗指数(homeostasis model assessment-insulin resistance index,HOMA-IR)、胰岛素分泌指数(homeostasis model assessment ofβ-cell function index,HOMA-β)、葡萄糖目标范围时间(time in range,TIR)、甘油三酯、总胆固醇、低密度脂蛋白等指标的变化及药物不良反应发生率。结果治疗后,与对照组比较,观察组体重、BMI、FPG、HbA1c、甘油三酯、总胆固醇水平均更低,差异均有统计学意义(P均<0.05)。治疗后,与对照组比较,HOMA-β、HOMA-IR指数、TIR均更优,差异均有统计学意义(P均<0.05)。结论度拉糖肽联合二甲双胍较单用二甲双胍更利于初诊超重/肥胖T2DM患者减重、改善BMI,其降脂、降糖效果可能更优,更有助于改善胰岛β细胞功能。展开更多
The synthesis of functionalized rubber copolymers is a topic of great research interest.In this study,we present a novel approach for the direct construction ofα-functionalized 3,4-polyisoprene through polymerization...The synthesis of functionalized rubber copolymers is a topic of great research interest.In this study,we present a novel approach for the direct construction ofα-functionalized 3,4-polyisoprene through polymerization of polar monomers and isoprene monomer.Theα-functionalized 3,4-polyisoprene was successfully synthesized via in situ sequential polymerization using the iron-based catalytic system(Fe(acac)_(3)/IITP/AliBu_(3)),exhibiting high activity and resistance to polar monomers without requiring protection of polar groups.The structure ofα-functionalized 3,4-polyisoprene was confirmed by proton nuclear magnetic resonance spectroscopy(^(1)H-NMR)and two-dimensional diffusion-ordered spectroscopy(2D DOSY)spectra analysis.The introduction of polar groups,particularly hydroxyl groups,enhanced the hydrophilicity of the copolymer.This was evidenced by a decrease in the water contact angle from 106.9°to 96.4°with increasing hydroxyl content in the copolymer.展开更多
基金partially supported by the Natural Sciences and Engineering Research Council of Canada(2019-03907)。
文摘In this paper,we define a new class of control functions through aggregate special functions.These class of control functions help us to stabilize and approximate a tri-additiveψ-functional inequality to get a better estimation for permuting tri-homomorphisms and permuting tri-derivations in unital C*-algebras and Banach algebras by the vector-valued alternative fixed point theorem.
文摘背景:阿尔茨海默病患者存在严重的脑能量障碍,近年来基于酮体干预的脑能量拯救策略在阿尔茨海默病的治疗中越来越受到重视。目的:探讨β-羟基丁酸能否改善β淀粉样蛋白1-42(β-amyloid protein 1-42,Aβ_(1-42))诱导的小鼠海马神经元HT22细胞能量障碍。方法:将HT22细胞分为4组,分别为对照组、β-羟基丁酸组、Aβ_(1-42)组、Aβ_(1-42)+β-羟基丁酸组。使用相应试剂盒检测HT22细胞的存活率、ATP水平、α-酮戊二酸脱氢酶活性、Na^(+)K^(+)-ATP酶活性、线粒体膜电位及活性氧水平。结果与结论:与对照组相比,Aβ_(1-42)组HT22细胞的存活率、ATP水平、α-酮戊二酸脱氢酶活性、Na^(+)K^(+)-ATP酶活性、线粒体膜电位均显著降低(P<0.05),活性氧水平显著升高(P<0.05)。与Aβ_(1-42)组相比,Aβ_(1-42)+β-羟基丁酸组HT22细胞的存活率、ATP水平、α-酮戊二酸脱氢酶活性、Na^(+)K^(+)-ATP酶活性、线粒体膜电位均显著升高(P<0.05),活性氧水平显著降低(P<0.05)。结果表明:β-羟基丁酸提高了线粒体生物能量功能和细胞存活率,最终改善了Aβ_(1-42)诱导的HT22细胞能量障碍。
文摘目的通过研究度拉糖肽联合二甲双胍在初诊超重/肥胖2型糖尿病(type 2 diabetes mellitus,T2DM)患者治疗前后胰岛β细胞功能的变化情况,探讨其对胰岛β细胞功能的影响。方法选取2023年7—12月于百色市人民医院就诊的160例初诊超重/肥胖T2DM患者。对照组口服二甲双胍缓释片、观察组使用二甲双胍缓释片联合度拉糖肽。分析治疗12周后两组患者体重、腰围、体重指数(body mass index,BMI)、空腹血糖、糖化血红蛋白(glycosylated hemoglobin A1c,HbA1c)、胰岛素抵抗指数(homeostasis model assessment-insulin resistance index,HOMA-IR)、胰岛素分泌指数(homeostasis model assessment ofβ-cell function index,HOMA-β)、葡萄糖目标范围时间(time in range,TIR)、甘油三酯、总胆固醇、低密度脂蛋白等指标的变化及药物不良反应发生率。结果治疗后,与对照组比较,观察组体重、BMI、FPG、HbA1c、甘油三酯、总胆固醇水平均更低,差异均有统计学意义(P均<0.05)。治疗后,与对照组比较,HOMA-β、HOMA-IR指数、TIR均更优,差异均有统计学意义(P均<0.05)。结论度拉糖肽联合二甲双胍较单用二甲双胍更利于初诊超重/肥胖T2DM患者减重、改善BMI,其降脂、降糖效果可能更优,更有助于改善胰岛β细胞功能。
基金financially supported by the National Key R&D Program of China(No.2022YFB3704701)the National Key R&D Program of China(No.2022YFC2603502)+1 种基金Natural Science Foundation of Shandong Province(No.ZR2022QE271)the financial support from the Taishan Scholars Program(No.tsqn202211165)。
文摘The synthesis of functionalized rubber copolymers is a topic of great research interest.In this study,we present a novel approach for the direct construction ofα-functionalized 3,4-polyisoprene through polymerization of polar monomers and isoprene monomer.Theα-functionalized 3,4-polyisoprene was successfully synthesized via in situ sequential polymerization using the iron-based catalytic system(Fe(acac)_(3)/IITP/AliBu_(3)),exhibiting high activity and resistance to polar monomers without requiring protection of polar groups.The structure ofα-functionalized 3,4-polyisoprene was confirmed by proton nuclear magnetic resonance spectroscopy(^(1)H-NMR)and two-dimensional diffusion-ordered spectroscopy(2D DOSY)spectra analysis.The introduction of polar groups,particularly hydroxyl groups,enhanced the hydrophilicity of the copolymer.This was evidenced by a decrease in the water contact angle from 106.9°to 96.4°with increasing hydroxyl content in the copolymer.
