To address the neglect of seismic performance in conventional double-girder bridge crane optimization,this paper introduces a time-history analysis-based seismic optimization methodology for crane structures.Using a 2...To address the neglect of seismic performance in conventional double-girder bridge crane optimization,this paper introduces a time-history analysis-based seismic optimization methodology for crane structures.Using a 25-t nuclear power crane as a case study,a bridge frame finite element model is established and validated through static analysis,confirming its accurate representation of the physical entity’s mechanical behavior.Furthermore,with bridge mass reduction as the objective and structural strength,stiffness,stability,and seismic mechanical performance as constraints,an optimization model is developed employing the Whale Optimization Algorithm(WOA).展开更多
Conformal truss-like lattice structures face significant manufacturability challenges in additive manufac-turing due to overhang angle limitations.To address this problem,we propose a novel angle-constrained optimizat...Conformal truss-like lattice structures face significant manufacturability challenges in additive manufac-turing due to overhang angle limitations.To address this problem,we propose a novel angle-constrained optimization method grounded in the global adjustment of nodal coordinates.First,a build direction is selected to minimize the number of violating struts.Then,an angular-constraint matrix is assembled from strut direction vectors,and analytical sensitivities with respect to nodal coordinates are derived to enable efficient constrained optimization under nonlinear angular inequality constraints.Numerical studies on two complex curved-surface lattices demonstrate that all overhang violations are eliminated while only minor changes are induced in global stiffness and strength.In particular,the maximum displacement of an ergonomic insole varies by only 2.87%after optimization.The results confirm the method’s versatility and engineering robustness,providing a practical approach for additive manufacturing-oriented lattice structure design.展开更多
Idiopathic pulmonary fibrosis(IPF)is a progressive lung disease and its incidence rate is rapidly rising.However,effective therapies for the treatment of IPF are still lacking.Phosphodiesterase 4(PDE4)inhibitors were ...Idiopathic pulmonary fibrosis(IPF)is a progressive lung disease and its incidence rate is rapidly rising.However,effective therapies for the treatment of IPF are still lacking.Phosphodiesterase 4(PDE4)inhibitors were reported to be potential anti-fibrotic agents.Herein,structure-based hit-to-lead optimization of natural isoaurostatin(8.98μmol/L)resulted in several potent inhibitors of PDE4 with half maximal inhibitory concentration(IC_(50))values ranging from 35 nmol/L to 126 nmol/L.Co-crystal structures revealed that isoaurostatin compounds exhibited different binding patterns from the classic PDE4 inhibitor rolipram and the analogues would favor to be Z configurations other than the corresponding E isomers.Finally,lead 2–9 showed remarkable in vitro/in vivo anti-fibrotic effects indicating its potential as a novel anti-IPF agent.展开更多
The beam pumping unit(BPU)remains the most stable and reliable equipment for crude oil lifting.Despite its simple four-link mechanism,the structural design of the BPU presents a constrained single-objective optimizati...The beam pumping unit(BPU)remains the most stable and reliable equipment for crude oil lifting.Despite its simple four-link mechanism,the structural design of the BPU presents a constrained single-objective optimization problem.Currently,a comprehensive framework for the structural design and optimization of compound balanced BPUs is lacking.Therefore,this study proposes a novel structural design scheme for BPUs,aiming to meet the practical needs of designers and operators by sequentially optimizing both the dynamic characteristics and balance properties of the BPUs.A dynamic model of compound balanced BPU was established based on D'Alembert's principle.The constraints for structural dimensions were formulated based on the actual operational requirements and design experience with BPUs.To optimize the structure,three algorithms were employed:the particle swarm optimization(PSO)algorithm,the genetic algorithm(GA),and the gray wolf optimization(GWO)algorithm.Each newly generated individuals are regulated by constraints to ensure the rationality of the outcomes.Furthermore,the integration of three algorithms ensures the increased likelihood of attaining the global optimal solution.The polished rod acceleration of the optimized structure is significantly reduced,and the dynamic characteristics of the up and down strokes are essentially symmetrical.Additionally,these three algorithms are also applied to the balance optimization of BPUs based on the measured dynamometer card.The calculation results demonstrate that the GWO-based optimization method exhibits excellent robustness in terms of structural optimization by enhancing the operational smoothness of the BPU,as well as in balance optimization by achieving energy conservation.By applying the optimization scheme proposed in this paper,the CYJW7-3-23HF type of BPU was designed,achieving a maximum polished rod acceleration of±0.675 m/s^(2) when operating at a stroke of 6 min^(−1).When deployed in two wells,the root-mean-square(RMS)torque was minimized,reaching values of 7.539 kN·m and 12.921 kN·m,respectively.The proposed design method not only contributes to the personalized customization but also improves the design efficiency of compound balanced BPUs.展开更多
The optimization of civil engineering structures is critical for enhancing structural performance and material efficiency in engineering applications.Structural optimization approaches seek to determine the optimal de...The optimization of civil engineering structures is critical for enhancing structural performance and material efficiency in engineering applications.Structural optimization approaches seek to determine the optimal design,by considering material performance,cost,and structural safety.The design approaches aim to reduce the built environment’s energy use and carbon emissions.This comprehensive review examines optimization techniques,including size,shape,topology,and multi-objective approaches,by integrating these methodologies.The trends and advancements that contribute to developing more efficient,cost-effective,and reliable structural designs were identified.The review also discusses emerging technologies,such as machine learning applications with different optimization techniques.Optimization of truss,frame,tensegrity,reinforced concrete,origami,pantographic,and adaptive structures are covered and discussed.Optimization techniques are explained,including metaheuristics,genetic algorithm,particle swarm,ant-colony,harmony search algorithm,and their applications with mentioned structure types.Linear and non-linear structures,including geometric and material nonlinearity,are distinguished.The role of optimization in active structures,structural design,seismic design,form-finding,and structural control is taken into account,and the most recent techniques and advancements are mentioned.展开更多
Transportation structures such as composite pavements and railway foundations typically consist of multi-layered media designed to withstand high bearing capacity.A theoretical understanding of load transfer mechanism...Transportation structures such as composite pavements and railway foundations typically consist of multi-layered media designed to withstand high bearing capacity.A theoretical understanding of load transfer mechanisms in these multi-layer composites is essential,as it offers intuitive insights into parametric influences and facilitates enhanced structural performance.This paper employs an improved transfer matrix method to address the limitations of existing theoretical approaches for analyzing multi-layer composite structures.By establishing a twodimensional composite pavement model,it investigates load transfer characteristics and validates the accuracy through finite element simulation.The proposed method offers a straightforward analytical approach for examining internal interactions between structural layers.Case studies indicate that the concrete surface layer is the main load-bearing layer for most vertical normal and shear stresses.The soil base layer reduces the overall mechanical response of the substructure,while horizontal actions increase the risk of interfacial slip and cracking.Structural optimization analysis demonstrates that increasing the thickness of the concrete surface layer,enhancing the thickness and stiffness of the soil base layer,or incorporating gradient layers can significantly mitigate these risks of interfacial slip and cracking.The findings of this study can guide the optimization design,parameter analysis,and damage prevention of multi-layer composite structures.展开更多
Green finance,as an important policy to promote high-quality economic development,has become a focus of attention in the academic and policy circles for its promotion of industrial structure optimization.Based on the ...Green finance,as an important policy to promote high-quality economic development,has become a focus of attention in the academic and policy circles for its promotion of industrial structure optimization.Based on the data of six provinces in Central China from 2010 to 2023,this paper constructs a comprehensive index of green finance development by using entropy value method and empirically analyses the impact of green finance on industrial structure optimization.The results show that the level of green finance development has a significant contribution to the optimization of the industrial structure in the central region.Accordingly,this study provides suggestions for deepening green finance reform and accelerating industrial transformation and upgrading.展开更多
Under the background of this era,green finance and the upgrading and optimization of industrial structure have become a hot research topic.The article focuses on Jiangsu Province,carefully explores the impact of green...Under the background of this era,green finance and the upgrading and optimization of industrial structure have become a hot research topic.The article focuses on Jiangsu Province,carefully explores the impact of green financial development on the upgrading and optimization of industrial structure and the real effect,collates and summarizes the theories of green finance and industrial structure at home and abroad,and carefully analyzes the development of green finance in Jiangsu Province,such as the gradual expansion of green credit scale,the characteristics of industrial structure,the change of the proportion of three industries,the development situation of emerging industries and so on.By means of econometrics,an empirical model covering Green Financial Development Indicators and industrial structure optimization indicators is established to do multiple linear regression analysis and stability test.The empirical results show that the development of green finance in Jiangsu plays an obvious positive role in the optimization and upgrading of industrial structure.Green finance is environmental protection,new energy and other green industries are given important financial support,which drives their scale expansion and technological innovation,and makes the industrial structure develop towards a higher level and a more reasonable direction.From this point of view,corresponding proposals are put forward to improve the policy incentive system,add green financial products,and strengthen the construction of green financial market.The purpose is to give better play to the advantages of green finance,accelerate the optimization and upgrading of industrial structure in Jiangsu,and provide theoretical basis and practical guidance for achieving green economic transformation and sustainable development.展开更多
Sandwich structures are widely favored for their lightweight,high strength and superior impact mitigation capabilities in blast mitigation and transportation safety applications.Their application in large-scale,high-e...Sandwich structures are widely favored for their lightweight,high strength and superior impact mitigation capabilities in blast mitigation and transportation safety applications.Their application in large-scale,high-energy rockfall protection remains limited due to their relatively low volumetric energy absorption efficiency and the complex fabrication processes of key energy-absorbing components.To address these limitations,this study proposes a novel sandwich structure incorporating mild steel tubes as core energy absorbers to efficiently mitigate highenergy rockfall impacts.A finite element model was developed in LS-DYNA to systematically investigate the deformation and energy absorption behaviors.Comprehensive parametric analyses were conducted to quantify the effects of key design variables,including tube wall thickness,tube spacing(number of tubes),and infill materials.The results demonstrate that increasing tube wall thickness significantly enhances ultimate energy absorption,with 12-mm-thick tubes absorbing 2.2 times more energy than 6-mm-thick tubes.Lateral constraints induced by adjacent tubes improve specific energy absorption per unit displacement by approximately 30%-45%.Furthermore,incorporating infill materials considerably enhances energy absorption,with aluminum foam infills achieving an 81%increase compared to empty tubes.Nevertheless,higher energy absorption capacity typically leads to greater peak impact forces,increasing the number of tubes offers a better balance between energy absorption and impact force,optimizing the structural performance.These findings provide valuable theoretical insights and practical guidelines for designing sandwich structures in civil and infrastructure engineering applications for effective rockfall protection.展开更多
The roller is one of the fundamental elements of ore belt conveyor systems since it supports,guides,and directs material on the belt.This component comprises a body(the external tube)that rotates around a fixed shaft ...The roller is one of the fundamental elements of ore belt conveyor systems since it supports,guides,and directs material on the belt.This component comprises a body(the external tube)that rotates around a fixed shaft supported by easels.The external tube and shaft of rollers used in ore conveyor belts are mostly made of steel,resulting in high mass,hindering maintenance and replacement.Aiming to achieve mass reduction,we conducted a structural optimization of a roller with a polymeric external tube(hereafter referred to as a polymeric roller),seeking the optimal values for two design parameters:the inner diameter of the external tube and the shaft diameter.The optimization was constrained by admissible values for maximum stress,maximum deflection and misalignment angle between the shaft and bearings.A finite element model was built in Ansys Workbench to obtain the structural response of the system.The roller considered is composed of an external tube made of high-density polyethylene(HDPE),bearing seats of polyamide 6(PA6),and a steel shaft.To characterize the polymeric materials(HDPE and PA6),stress relaxation tests were conducted,and the data on shear modulus variation over time were inserted into the model to calculate Prony series terms to account for viscoelastic effects.The roller optimization was performed using surrogate modeling based on radial basis functions,with the Globalized Bounded Nelder-Mead(GBNM)algorithm as the optimizer.Two optimization cases were conducted.In the first case,concerning the roller’s initial material settings,the designs found violated the constraints and could not reduce mass.In the second case,by using PA6 in both bearing seats and the tube,a design configuration was found that respected all constraints and reduced the roller mass by 15.5%,equivalent to 5.15 kg.This study is among the first to integrate experimentally obtained viscoelastic data into the surrogate-based optimization of polymeric rollers,combining methodological innovation with industrial relevance.展开更多
Based on the Fluent numerical simulation method,this study systematically analyzed the structural parameters of the spiral tube heat exchanger and the influence of the external baffle on its heat transfer performance....Based on the Fluent numerical simulation method,this study systematically analyzed the structural parameters of the spiral tube heat exchanger and the influence of the external baffle on its heat transfer performance.The results show that when the equivalent diameter of the spiral tube increased from 16.68 to 21.23 mm,its surface heat transfer coefficient decreased from 22,040 to 17,230 W/m^(2)⋅K,and the outlet air temperature dropped from 822.3 to 807.3 K.However,the pressure loss decreased from 2.692 to 0.958 kPa.which reveals the contradiction between the heat transfer efficiency and the flow resistance.By adding a baffle to enhance the turbulent disturbance,the wall heat flux density is increased by 21.17%,the surface heat transfer coefficient is increased by 12.1%,and the outlet temperature is optimized,which verifies the significant improvement of the heat transfer performance by the countercurrent design.Comprehensive research shows that the collaborative optimization of spiral tube equivalent diameter parameters and baffle flow control is the key to improve the comprehensive performance of heat exchanger.Theresearch results provide a theoretical basis for energy-saving design of industrial heat exchangers.展开更多
Energy shortage has become one of themost concerning issues in the world today,and improving energy utilization efficiency is a key area of research for experts and scholars worldwide.Small-diameter heat exchangers of...Energy shortage has become one of themost concerning issues in the world today,and improving energy utilization efficiency is a key area of research for experts and scholars worldwide.Small-diameter heat exchangers offer advantages such as reduced material usage,lower refrigerant charge,and compact structure.However,they also face challenges,including increased refrigerant pressure drop and smaller heat transfer area inside the tubes.This paper combines the advantages and disadvantages of both small and large-diameter tubes and proposes a combined-diameter heat exchanger,consisting of large and small diameters,for use in the indoor units of split-type air conditioners.There are relatively few studies in this area.In this paper,A theoretical and numerical computation method is employed to establish a theoretical-numerical calculation model,and its reliability is verified through experiments.Using this model,the optimal combined diameters and flow path design for a combined-diameter heat exchanger using R32 as the working fluid are derived.The results show that the heat transfer performance of all combined diameter configurations improves by 2.79%to 8.26%compared to the baseline design,with the coefficient of performance(COP)increasing from 4.15 to 4.27~4.5.These designs can save copper material,but at the cost of an increase in pressure drop by 66.86%to 131.84%.The scheme IIIH,using R32,is the optimal combined-diameter and flow path configuration that balances both heat transfer performance and economic cost.展开更多
Build-up panels for the commercial aircraft fuselage subjected to the axial compression load are studied by both experimental and theoretical methods.An integral panel is designed with the same overall size and weight...Build-up panels for the commercial aircraft fuselage subjected to the axial compression load are studied by both experimental and theoretical methods.An integral panel is designed with the same overall size and weight as the build-up structure,and finite element models（FEMs）of these two panels are established.Experimental results of build-up panels agree well with the FEM results with the nonliearity and the large deformation,so FEMs are validated.FEM calculation results of these two panels indicate that the failure mode of the integral panel is different from that of the build-up panel,and the failure load increases by 18.4% up to post-buckling.Furthermore,the integral structure is optimized by using the multi-island genetic algorithm and the sequential quadratic programming.Compared with the initial design,the optimal mass is reduced by 8.7% and the strength is unchanged.展开更多
A new exist-null combined model is proposed for the structural topology optimization. The model is applied to the topology optimization of the truss with stress constraints. Satisfactory computational result can be ob...A new exist-null combined model is proposed for the structural topology optimization. The model is applied to the topology optimization of the truss with stress constraints. Satisfactory computational result can be obtained with more rapid and more stable convergence as compared with the cross-sectional optimization. This work also shows that the presence of independent and continuous topological variable motivates the research of structural topology optimization.展开更多
Land use structure optimization(LUSO) is an important issue for land use planning. In order for land use planning to have reasonable flexibility, uncertain optimization should be applied for LUSO. In this paper, the r...Land use structure optimization(LUSO) is an important issue for land use planning. In order for land use planning to have reasonable flexibility, uncertain optimization should be applied for LUSO. In this paper, the researcher first expounded the uncertainties of LUSO. Based on this, an interval programming model was developed, of which interval variables were to hold land use uncertainties. To solve the model, a heuristics based on Genetic Algorithm was designed according to Pareto Optimum principle with a confidence interval under given significance level to represent LUSO result. Proposed method was applied to a real case of Yangzhou, an eastern city in China. The following conclusions were reached. 1) Different forms of uncertainties ranged from certainty to indeterminacy lay in the five steps of LUSO, indicating necessary need of comprehensive approach to quantify them. 2) With regards to trade-offs of conflicted objectives and preferences to uncertainties, our proposed model displayed good ability of making planning decision process transparent, therefore providing an effective tool for flexible land use planning compiling. 3) Under uncertain conditions, land use planning effectiveness can be primarily enhanced by flexible management with reserved space to percept and hold uncertainties in advance.展开更多
Sintering characteristics of common fluxes and sintering blending ores, such as mineralization capacity, liquid generation capacity, consolidation strength, were examined to master the behavior and effect of fluxes in...Sintering characteristics of common fluxes and sintering blending ores, such as mineralization capacity, liquid generation capacity, consolidation strength, were examined to master the behavior and effect of fluxes in sintering. Based on fundamental studies, sinter pot tests were carried out to obtain the principles of optimizing the sinter flux structure. The results showed that strong mineralization capacity, liquid phase generation capacity, and consolidation strength were obtained as sintering blending ores combined with the calcareous flux, while rela-tively poor sintering characteristics were obtained as sintering blending ores combined with the magnesian flux. High reactive quicklime should be used as much as possible in the sintering mixture. It reached better sintering results while quicklime was used instead of limestone and its appropriate proportion in the sintering mixture was around 4wt%. On the premise of ensuring the MgO content, the dolomite amount should be decreased, and the substitution of quicklime for dolomite caused better sintering results. The granularity of serpentine should be re-fined with a proper size smaller than 2 mm. The application of the divided addition method brought the best sintering performance with 30wt% of quicklime and 70wt% of fuel.展开更多
An aeroelastic two-level optimization methodology for preliminary design of wing struc- tures is presented, in which the parameters for structural layout and sizes are taken as design vari- ables in the first-level op...An aeroelastic two-level optimization methodology for preliminary design of wing struc- tures is presented, in which the parameters for structural layout and sizes are taken as design vari- ables in the first-level optimization, and robust constraints in conjunction with conventional aeroelastic constraints are considered in the second-level optimization. A low-order panel method is used for aerodynamic analysis in the first-level optimization, and a high-order panel method is employed in the second-level optimization. It is concluded that the design of the abovementioned structural parameters of a wing can be improved using the present method with high efficiency. An improvement is seen in aeroelastic performance of the wing obtained with the present method when compared to the initial wing. Since these optimized structures are obtained after consideration of aerodynamic and structural uncertainties, they are well suited to encounter these uncertainties when they occur in reality.展开更多
Cavitating jet is a promising drilling rate improvement technology in both the marine natural gas hydrate (NGH) fluidization exploitation method and the integrated radial jet drilling and completion method. In present...Cavitating jet is a promising drilling rate improvement technology in both the marine natural gas hydrate (NGH) fluidization exploitation method and the integrated radial jet drilling and completion method. In present study, we aim to improve the efficiency of jet erosion and extracting NGH. With a computational fluid dynamics (CFD) method, the pressure, velocity and cavitation field characteristics of organ-pipe cavitating jet (OPCJ) are analysed. The divergent angle, throat length, and divergent length of OPCJ nozzle are preferred to obtain stronger jet cavitation erosion effect. Laboratory experiments of gas hydrate-bearing sediments (GHBS) erosion by OPCJ and conical jet (CJ) are conducted to compare and validate the jet erosion performance. The impinging models of OPCJ and CJ are constructed to study the impact characteristics. Results show that the preferred values of divergent angle, throat length, and divergent length are 15°, 1d, and 3d, respectively, in present simulation conditions. For GHBS, the OPCJ possesses the advantages of high efficiency and low energy consumption. Moreover, the OPCJ has higher penetration efficiency, while showing equivalent penetration ability compared to CJ. During the impinging process, the OPCJ can induce stronger impact pressure and turbulence effect, and also shows stronger chambering effect and bottom cleaning ability compared to CJ. This study presents the erosion performance of OPCJ and CJ on GHBS, and provides preliminary insights on the potential field applications in NGH exploitation.展开更多
A large number of mathematical models were developed for supporting agricultural production structure optimization decisions; however, few of them can address various uncertainties existing in many factors （e.g., eco...A large number of mathematical models were developed for supporting agricultural production structure optimization decisions; however, few of them can address various uncertainties existing in many factors （e.g., eco-social benefit maximization, food security, employment stability and ecosystem balance）. In this study, an interval-probabilistic agricultural production structure optimization model （IPAPSOM） is formulated for tackling uncertainty presented as discrete intervals and/or probability distribution. The developed model improves upon the existing probabilistic programming and inexact optimization approaches. The IPAPSOM considers not only food security policy constraints, but also involves rural households’income increase and eco-environmental conversation, which can effectively reflect various interrelations among different aspects in an agricultural production structure optimization system. Moreover, it can also help examine the reliability of satisfying （or risk of violating） system constraints under uncertainty. The model is applied to a real case of long-term agricultural production structure optimization in Dancheng County, which is located in Henan Province of Central China as one of the major grain producing areas. Interval solutions associated with different risk levels of constraint violation are obtained. The results are useful for generating a range of decision alternatives under various system benefit conditions, and thus helping decision makers to identify the desired agricultural production structure optimization strategy under uncertainty.展开更多
Weight reduction has attracted much attention among ship designers and ship owners.In the present work,based on an improved bi-directional evolutionary structural optimization(BESO) method and surrogate model method,w...Weight reduction has attracted much attention among ship designers and ship owners.In the present work,based on an improved bi-directional evolutionary structural optimization(BESO) method and surrogate model method,we propose a hybrid optimization method for the structural design optimization of beam-plate structures,which covers three optimization levels:dimension optimization,topology optimization and section optimization.The objective of the proposed optimization method is to minimize the weight of design object under a group of constraints.The kernel optimization procedure(KOP) uses BESO to obtain the optimal topology from a ground structure.To deal with beam-plate structures,the traditional BESO method is improved by using cubic box as the unit cell instead of solid unit to construct periodic lattice structure.In the first optimization level,a series of ground structures are generated based on different dimensional parameter combinations,the KOP is performed to all the ground structures,the response surface model of optimal objective values and dimension parameters is created,and then the optimal dimension parameters can be obtained.In the second optimization level,the optimal topology is obtained by using the KOP according to the optimal dimension parameters.In the third optimization level,response surface method(RSM) is used to determine the section parameters.The proposed method is applied to a hatch cover structure design.The locations and shapes of all the structural members are determined from an oversized ground structure.The results show that the proposed method leads to a greater weight saving,compared with the original design and genetic algorithm(GA) based optimization results.展开更多
文摘To address the neglect of seismic performance in conventional double-girder bridge crane optimization,this paper introduces a time-history analysis-based seismic optimization methodology for crane structures.Using a 25-t nuclear power crane as a case study,a bridge frame finite element model is established and validated through static analysis,confirming its accurate representation of the physical entity’s mechanical behavior.Furthermore,with bridge mass reduction as the objective and structural strength,stiffness,stability,and seismic mechanical performance as constraints,an optimization model is developed employing the Whale Optimization Algorithm(WOA).
基金supported by the National Natural Science Foundation of China(Grant Nos.12432005 and 12472116)the Fundamental Research Funds for the Central Universities(DUTZD25240).
文摘Conformal truss-like lattice structures face significant manufacturability challenges in additive manufac-turing due to overhang angle limitations.To address this problem,we propose a novel angle-constrained optimization method grounded in the global adjustment of nodal coordinates.First,a build direction is selected to minimize the number of violating struts.Then,an angular-constraint matrix is assembled from strut direction vectors,and analytical sensitivities with respect to nodal coordinates are derived to enable efficient constrained optimization under nonlinear angular inequality constraints.Numerical studies on two complex curved-surface lattices demonstrate that all overhang violations are eliminated while only minor changes are induced in global stiffness and strength.In particular,the maximum displacement of an ergonomic insole varies by only 2.87%after optimization.The results confirm the method’s versatility and engineering robustness,providing a practical approach for additive manufacturing-oriented lattice structure design.
基金supported by the Natural Science Foundation of China(Nos.22277019,82150204,22307031,22377023,22077143,and 82003594)Key Project of Guangdong Natural Science Foundation(No.2016A030311033)+2 种基金Fundamental Research Funds for Hainan University(Nos.KYQD(ZR)-21031,KYQD(ZR)-21108,KYQD(ZR)-23003,and XTCX2022JKA01)Guangdong Provincial Key Laboratory of Construction Foundation(No.2023B1212060022)Science Foundation of Hainan Province(Nos.KJRC2023B10,824YXQN420,and 324MS018)。
文摘Idiopathic pulmonary fibrosis(IPF)is a progressive lung disease and its incidence rate is rapidly rising.However,effective therapies for the treatment of IPF are still lacking.Phosphodiesterase 4(PDE4)inhibitors were reported to be potential anti-fibrotic agents.Herein,structure-based hit-to-lead optimization of natural isoaurostatin(8.98μmol/L)resulted in several potent inhibitors of PDE4 with half maximal inhibitory concentration(IC_(50))values ranging from 35 nmol/L to 126 nmol/L.Co-crystal structures revealed that isoaurostatin compounds exhibited different binding patterns from the classic PDE4 inhibitor rolipram and the analogues would favor to be Z configurations other than the corresponding E isomers.Finally,lead 2–9 showed remarkable in vitro/in vivo anti-fibrotic effects indicating its potential as a novel anti-IPF agent.
基金supported by the Key Laboratory of Petroleum and Natural Gas Equipment,Ministry of Education(No.OGE202303-08)Engineering Technology Research Center for Industrial Internet of Things and Intelligent Sensing,Hubei Province(No.KXZ 202203).
文摘The beam pumping unit(BPU)remains the most stable and reliable equipment for crude oil lifting.Despite its simple four-link mechanism,the structural design of the BPU presents a constrained single-objective optimization problem.Currently,a comprehensive framework for the structural design and optimization of compound balanced BPUs is lacking.Therefore,this study proposes a novel structural design scheme for BPUs,aiming to meet the practical needs of designers and operators by sequentially optimizing both the dynamic characteristics and balance properties of the BPUs.A dynamic model of compound balanced BPU was established based on D'Alembert's principle.The constraints for structural dimensions were formulated based on the actual operational requirements and design experience with BPUs.To optimize the structure,three algorithms were employed:the particle swarm optimization(PSO)algorithm,the genetic algorithm(GA),and the gray wolf optimization(GWO)algorithm.Each newly generated individuals are regulated by constraints to ensure the rationality of the outcomes.Furthermore,the integration of three algorithms ensures the increased likelihood of attaining the global optimal solution.The polished rod acceleration of the optimized structure is significantly reduced,and the dynamic characteristics of the up and down strokes are essentially symmetrical.Additionally,these three algorithms are also applied to the balance optimization of BPUs based on the measured dynamometer card.The calculation results demonstrate that the GWO-based optimization method exhibits excellent robustness in terms of structural optimization by enhancing the operational smoothness of the BPU,as well as in balance optimization by achieving energy conservation.By applying the optimization scheme proposed in this paper,the CYJW7-3-23HF type of BPU was designed,achieving a maximum polished rod acceleration of±0.675 m/s^(2) when operating at a stroke of 6 min^(−1).When deployed in two wells,the root-mean-square(RMS)torque was minimized,reaching values of 7.539 kN·m and 12.921 kN·m,respectively.The proposed design method not only contributes to the personalized customization but also improves the design efficiency of compound balanced BPUs.
文摘The optimization of civil engineering structures is critical for enhancing structural performance and material efficiency in engineering applications.Structural optimization approaches seek to determine the optimal design,by considering material performance,cost,and structural safety.The design approaches aim to reduce the built environment’s energy use and carbon emissions.This comprehensive review examines optimization techniques,including size,shape,topology,and multi-objective approaches,by integrating these methodologies.The trends and advancements that contribute to developing more efficient,cost-effective,and reliable structural designs were identified.The review also discusses emerging technologies,such as machine learning applications with different optimization techniques.Optimization of truss,frame,tensegrity,reinforced concrete,origami,pantographic,and adaptive structures are covered and discussed.Optimization techniques are explained,including metaheuristics,genetic algorithm,particle swarm,ant-colony,harmony search algorithm,and their applications with mentioned structure types.Linear and non-linear structures,including geometric and material nonlinearity,are distinguished.The role of optimization in active structures,structural design,seismic design,form-finding,and structural control is taken into account,and the most recent techniques and advancements are mentioned.
基金supported by Fundamental Research Funds for the Central Universities(No.lzujbky-2024-05)Innovation Foundation of Provincial Education Department of Gansu(2024B-005)+2 种基金Scientific Department of Gansu(24CXGA083,24CXGA024,JK2024-28,JK2024-32 and 23CXJA0007)Industrial Support Plan Project of Provincial Education Department of Gansu(2025CYZC-003 and CYZC-2024-10)the Hunan Natural Science Foundation Science and Education Joint Fund Project(2022JJ60109).
文摘Transportation structures such as composite pavements and railway foundations typically consist of multi-layered media designed to withstand high bearing capacity.A theoretical understanding of load transfer mechanisms in these multi-layer composites is essential,as it offers intuitive insights into parametric influences and facilitates enhanced structural performance.This paper employs an improved transfer matrix method to address the limitations of existing theoretical approaches for analyzing multi-layer composite structures.By establishing a twodimensional composite pavement model,it investigates load transfer characteristics and validates the accuracy through finite element simulation.The proposed method offers a straightforward analytical approach for examining internal interactions between structural layers.Case studies indicate that the concrete surface layer is the main load-bearing layer for most vertical normal and shear stresses.The soil base layer reduces the overall mechanical response of the substructure,while horizontal actions increase the risk of interfacial slip and cracking.Structural optimization analysis demonstrates that increasing the thickness of the concrete surface layer,enhancing the thickness and stiffness of the soil base layer,or incorporating gradient layers can significantly mitigate these risks of interfacial slip and cracking.The findings of this study can guide the optimization design,parameter analysis,and damage prevention of multi-layer composite structures.
基金Project of Hunan Federation of Social Sciences,“Research on the Coupling Coordination Relationship between Green Finance and Industrial Structure Optimization in Hunan Province”(Project No.:XSP2023GLC027)。
文摘Green finance,as an important policy to promote high-quality economic development,has become a focus of attention in the academic and policy circles for its promotion of industrial structure optimization.Based on the data of six provinces in Central China from 2010 to 2023,this paper constructs a comprehensive index of green finance development by using entropy value method and empirically analyses the impact of green finance on industrial structure optimization.The results show that the level of green finance development has a significant contribution to the optimization of the industrial structure in the central region.Accordingly,this study provides suggestions for deepening green finance reform and accelerating industrial transformation and upgrading.
基金The Impact of Digital Economy on Green Development Efficiency.2025 Nanjing University of Science and Technology Zijin College Campus Level Scientific Research Project(Project No.:2025ZXSK0401011)。
文摘Under the background of this era,green finance and the upgrading and optimization of industrial structure have become a hot research topic.The article focuses on Jiangsu Province,carefully explores the impact of green financial development on the upgrading and optimization of industrial structure and the real effect,collates and summarizes the theories of green finance and industrial structure at home and abroad,and carefully analyzes the development of green finance in Jiangsu Province,such as the gradual expansion of green credit scale,the characteristics of industrial structure,the change of the proportion of three industries,the development situation of emerging industries and so on.By means of econometrics,an empirical model covering Green Financial Development Indicators and industrial structure optimization indicators is established to do multiple linear regression analysis and stability test.The empirical results show that the development of green finance in Jiangsu plays an obvious positive role in the optimization and upgrading of industrial structure.Green finance is environmental protection,new energy and other green industries are given important financial support,which drives their scale expansion and technological innovation,and makes the industrial structure develop towards a higher level and a more reasonable direction.From this point of view,corresponding proposals are put forward to improve the policy incentive system,add green financial products,and strengthen the construction of green financial market.The purpose is to give better play to the advantages of green finance,accelerate the optimization and upgrading of industrial structure in Jiangsu,and provide theoretical basis and practical guidance for achieving green economic transformation and sustainable development.
基金supported by the National Key R&D Program of China(Grant No.2019YFC1509703)the Tianjin Science and Technology Program Project(Grant No.23YFYSHZ00130)。
文摘Sandwich structures are widely favored for their lightweight,high strength and superior impact mitigation capabilities in blast mitigation and transportation safety applications.Their application in large-scale,high-energy rockfall protection remains limited due to their relatively low volumetric energy absorption efficiency and the complex fabrication processes of key energy-absorbing components.To address these limitations,this study proposes a novel sandwich structure incorporating mild steel tubes as core energy absorbers to efficiently mitigate highenergy rockfall impacts.A finite element model was developed in LS-DYNA to systematically investigate the deformation and energy absorption behaviors.Comprehensive parametric analyses were conducted to quantify the effects of key design variables,including tube wall thickness,tube spacing(number of tubes),and infill materials.The results demonstrate that increasing tube wall thickness significantly enhances ultimate energy absorption,with 12-mm-thick tubes absorbing 2.2 times more energy than 6-mm-thick tubes.Lateral constraints induced by adjacent tubes improve specific energy absorption per unit displacement by approximately 30%-45%.Furthermore,incorporating infill materials considerably enhances energy absorption,with aluminum foam infills achieving an 81%increase compared to empty tubes.Nevertheless,higher energy absorption capacity typically leads to greater peak impact forces,increasing the number of tubes offers a better balance between energy absorption and impact force,optimizing the structural performance.These findings provide valuable theoretical insights and practical guidelines for designing sandwich structures in civil and infrastructure engineering applications for effective rockfall protection.
基金funded by Vale S.A.company(www.vale.com)and the Institute of Technology Vale(ITV—www.itv.org),grant number SAP 4600048682.
文摘The roller is one of the fundamental elements of ore belt conveyor systems since it supports,guides,and directs material on the belt.This component comprises a body(the external tube)that rotates around a fixed shaft supported by easels.The external tube and shaft of rollers used in ore conveyor belts are mostly made of steel,resulting in high mass,hindering maintenance and replacement.Aiming to achieve mass reduction,we conducted a structural optimization of a roller with a polymeric external tube(hereafter referred to as a polymeric roller),seeking the optimal values for two design parameters:the inner diameter of the external tube and the shaft diameter.The optimization was constrained by admissible values for maximum stress,maximum deflection and misalignment angle between the shaft and bearings.A finite element model was built in Ansys Workbench to obtain the structural response of the system.The roller considered is composed of an external tube made of high-density polyethylene(HDPE),bearing seats of polyamide 6(PA6),and a steel shaft.To characterize the polymeric materials(HDPE and PA6),stress relaxation tests were conducted,and the data on shear modulus variation over time were inserted into the model to calculate Prony series terms to account for viscoelastic effects.The roller optimization was performed using surrogate modeling based on radial basis functions,with the Globalized Bounded Nelder-Mead(GBNM)algorithm as the optimizer.Two optimization cases were conducted.In the first case,concerning the roller’s initial material settings,the designs found violated the constraints and could not reduce mass.In the second case,by using PA6 in both bearing seats and the tube,a design configuration was found that respected all constraints and reduced the roller mass by 15.5%,equivalent to 5.15 kg.This study is among the first to integrate experimentally obtained viscoelastic data into the surrogate-based optimization of polymeric rollers,combining methodological innovation with industrial relevance.
基金supported by the Jing-Jin-Ji Regional Integrated Environmental Improvement-National Science and Technology Major Project(No.2024ZD1200400).
文摘Based on the Fluent numerical simulation method,this study systematically analyzed the structural parameters of the spiral tube heat exchanger and the influence of the external baffle on its heat transfer performance.The results show that when the equivalent diameter of the spiral tube increased from 16.68 to 21.23 mm,its surface heat transfer coefficient decreased from 22,040 to 17,230 W/m^(2)⋅K,and the outlet air temperature dropped from 822.3 to 807.3 K.However,the pressure loss decreased from 2.692 to 0.958 kPa.which reveals the contradiction between the heat transfer efficiency and the flow resistance.By adding a baffle to enhance the turbulent disturbance,the wall heat flux density is increased by 21.17%,the surface heat transfer coefficient is increased by 12.1%,and the outlet temperature is optimized,which verifies the significant improvement of the heat transfer performance by the countercurrent design.Comprehensive research shows that the collaborative optimization of spiral tube equivalent diameter parameters and baffle flow control is the key to improve the comprehensive performance of heat exchanger.Theresearch results provide a theoretical basis for energy-saving design of industrial heat exchangers.
基金supported by Supported by the Scientific Research Foundation for High-Level Talents of Zhoukou Normal University(ZKNUC2024018).
文摘Energy shortage has become one of themost concerning issues in the world today,and improving energy utilization efficiency is a key area of research for experts and scholars worldwide.Small-diameter heat exchangers offer advantages such as reduced material usage,lower refrigerant charge,and compact structure.However,they also face challenges,including increased refrigerant pressure drop and smaller heat transfer area inside the tubes.This paper combines the advantages and disadvantages of both small and large-diameter tubes and proposes a combined-diameter heat exchanger,consisting of large and small diameters,for use in the indoor units of split-type air conditioners.There are relatively few studies in this area.In this paper,A theoretical and numerical computation method is employed to establish a theoretical-numerical calculation model,and its reliability is verified through experiments.Using this model,the optimal combined diameters and flow path design for a combined-diameter heat exchanger using R32 as the working fluid are derived.The results show that the heat transfer performance of all combined diameter configurations improves by 2.79%to 8.26%compared to the baseline design,with the coefficient of performance(COP)increasing from 4.15 to 4.27~4.5.These designs can save copper material,but at the cost of an increase in pressure drop by 66.86%to 131.84%.The scheme IIIH,using R32,is the optimal combined-diameter and flow path configuration that balances both heat transfer performance and economic cost.
文摘Build-up panels for the commercial aircraft fuselage subjected to the axial compression load are studied by both experimental and theoretical methods.An integral panel is designed with the same overall size and weight as the build-up structure,and finite element models（FEMs）of these two panels are established.Experimental results of build-up panels agree well with the FEM results with the nonliearity and the large deformation,so FEMs are validated.FEM calculation results of these two panels indicate that the failure mode of the integral panel is different from that of the build-up panel,and the failure load increases by 18.4% up to post-buckling.Furthermore,the integral structure is optimized by using the multi-island genetic algorithm and the sequential quadratic programming.Compared with the initial design,the optimal mass is reduced by 8.7% and the strength is unchanged.
基金The project supported by the State Key Laboratory for Structural Analysis of Industrial Equipment,Dalian University of Technology.
文摘A new exist-null combined model is proposed for the structural topology optimization. The model is applied to the topology optimization of the truss with stress constraints. Satisfactory computational result can be obtained with more rapid and more stable convergence as compared with the cross-sectional optimization. This work also shows that the presence of independent and continuous topological variable motivates the research of structural topology optimization.
基金Under the auspices of National Natural Science Foundation of China(No.41401627,41471144)Foundation Research Project of Jiangsu Province(No.BK20140236)
文摘Land use structure optimization(LUSO) is an important issue for land use planning. In order for land use planning to have reasonable flexibility, uncertain optimization should be applied for LUSO. In this paper, the researcher first expounded the uncertainties of LUSO. Based on this, an interval programming model was developed, of which interval variables were to hold land use uncertainties. To solve the model, a heuristics based on Genetic Algorithm was designed according to Pareto Optimum principle with a confidence interval under given significance level to represent LUSO result. Proposed method was applied to a real case of Yangzhou, an eastern city in China. The following conclusions were reached. 1) Different forms of uncertainties ranged from certainty to indeterminacy lay in the five steps of LUSO, indicating necessary need of comprehensive approach to quantify them. 2) With regards to trade-offs of conflicted objectives and preferences to uncertainties, our proposed model displayed good ability of making planning decision process transparent, therefore providing an effective tool for flexible land use planning compiling. 3) Under uncertain conditions, land use planning effectiveness can be primarily enhanced by flexible management with reserved space to percept and hold uncertainties in advance.
文摘Sintering characteristics of common fluxes and sintering blending ores, such as mineralization capacity, liquid generation capacity, consolidation strength, were examined to master the behavior and effect of fluxes in sintering. Based on fundamental studies, sinter pot tests were carried out to obtain the principles of optimizing the sinter flux structure. The results showed that strong mineralization capacity, liquid phase generation capacity, and consolidation strength were obtained as sintering blending ores combined with the calcareous flux, while rela-tively poor sintering characteristics were obtained as sintering blending ores combined with the magnesian flux. High reactive quicklime should be used as much as possible in the sintering mixture. It reached better sintering results while quicklime was used instead of limestone and its appropriate proportion in the sintering mixture was around 4wt%. On the premise of ensuring the MgO content, the dolomite amount should be decreased, and the substitution of quicklime for dolomite caused better sintering results. The granularity of serpentine should be re-fined with a proper size smaller than 2 mm. The application of the divided addition method brought the best sintering performance with 30wt% of quicklime and 70wt% of fuel.
基金supported by the National Natural Science Foundation of China (No. 11172025 and No. 91116005)
文摘An aeroelastic two-level optimization methodology for preliminary design of wing struc- tures is presented, in which the parameters for structural layout and sizes are taken as design vari- ables in the first-level optimization, and robust constraints in conjunction with conventional aeroelastic constraints are considered in the second-level optimization. A low-order panel method is used for aerodynamic analysis in the first-level optimization, and a high-order panel method is employed in the second-level optimization. It is concluded that the design of the abovementioned structural parameters of a wing can be improved using the present method with high efficiency. An improvement is seen in aeroelastic performance of the wing obtained with the present method when compared to the initial wing. Since these optimized structures are obtained after consideration of aerodynamic and structural uncertainties, they are well suited to encounter these uncertainties when they occur in reality.
基金financially supported by National Natural Science Foundation of China(No.52174009 and No.51827804)Marine Economy Development Foundation of Guangdong Province(GDNRC[2022]44)“Technical Support for Stimulation and Testing of Gas Hydrate Reservoirs”.
文摘Cavitating jet is a promising drilling rate improvement technology in both the marine natural gas hydrate (NGH) fluidization exploitation method and the integrated radial jet drilling and completion method. In present study, we aim to improve the efficiency of jet erosion and extracting NGH. With a computational fluid dynamics (CFD) method, the pressure, velocity and cavitation field characteristics of organ-pipe cavitating jet (OPCJ) are analysed. The divergent angle, throat length, and divergent length of OPCJ nozzle are preferred to obtain stronger jet cavitation erosion effect. Laboratory experiments of gas hydrate-bearing sediments (GHBS) erosion by OPCJ and conical jet (CJ) are conducted to compare and validate the jet erosion performance. The impinging models of OPCJ and CJ are constructed to study the impact characteristics. Results show that the preferred values of divergent angle, throat length, and divergent length are 15°, 1d, and 3d, respectively, in present simulation conditions. For GHBS, the OPCJ possesses the advantages of high efficiency and low energy consumption. Moreover, the OPCJ has higher penetration efficiency, while showing equivalent penetration ability compared to CJ. During the impinging process, the OPCJ can induce stronger impact pressure and turbulence effect, and also shows stronger chambering effect and bottom cleaning ability compared to CJ. This study presents the erosion performance of OPCJ and CJ on GHBS, and provides preliminary insights on the potential field applications in NGH exploitation.
基金funded by the National Natural Science Foundation of China (41130748, 41101162)the Key Knowledge Innovation Project of Chinese Academy of Sciences (KZCX2-EW-304)
文摘A large number of mathematical models were developed for supporting agricultural production structure optimization decisions; however, few of them can address various uncertainties existing in many factors （e.g., eco-social benefit maximization, food security, employment stability and ecosystem balance）. In this study, an interval-probabilistic agricultural production structure optimization model （IPAPSOM） is formulated for tackling uncertainty presented as discrete intervals and/or probability distribution. The developed model improves upon the existing probabilistic programming and inexact optimization approaches. The IPAPSOM considers not only food security policy constraints, but also involves rural households’income increase and eco-environmental conversation, which can effectively reflect various interrelations among different aspects in an agricultural production structure optimization system. Moreover, it can also help examine the reliability of satisfying （or risk of violating） system constraints under uncertainty. The model is applied to a real case of long-term agricultural production structure optimization in Dancheng County, which is located in Henan Province of Central China as one of the major grain producing areas. Interval solutions associated with different risk levels of constraint violation are obtained. The results are useful for generating a range of decision alternatives under various system benefit conditions, and thus helping decision makers to identify the desired agricultural production structure optimization strategy under uncertainty.
基金the National Natural Science Foundation of China(No.51509033)
文摘Weight reduction has attracted much attention among ship designers and ship owners.In the present work,based on an improved bi-directional evolutionary structural optimization(BESO) method and surrogate model method,we propose a hybrid optimization method for the structural design optimization of beam-plate structures,which covers three optimization levels:dimension optimization,topology optimization and section optimization.The objective of the proposed optimization method is to minimize the weight of design object under a group of constraints.The kernel optimization procedure(KOP) uses BESO to obtain the optimal topology from a ground structure.To deal with beam-plate structures,the traditional BESO method is improved by using cubic box as the unit cell instead of solid unit to construct periodic lattice structure.In the first optimization level,a series of ground structures are generated based on different dimensional parameter combinations,the KOP is performed to all the ground structures,the response surface model of optimal objective values and dimension parameters is created,and then the optimal dimension parameters can be obtained.In the second optimization level,the optimal topology is obtained by using the KOP according to the optimal dimension parameters.In the third optimization level,response surface method(RSM) is used to determine the section parameters.The proposed method is applied to a hatch cover structure design.The locations and shapes of all the structural members are determined from an oversized ground structure.The results show that the proposed method leads to a greater weight saving,compared with the original design and genetic algorithm(GA) based optimization results.
