Quantum error correction is a technique that enhances a system’s ability to combat noise by encoding logical information into additional quantum bits,which plays a key role in building practical quantum computers.The...Quantum error correction is a technique that enhances a system’s ability to combat noise by encoding logical information into additional quantum bits,which plays a key role in building practical quantum computers.The XZZX surface code,with only one stabilizer generator on each face,demonstrates significant application potential under biased noise.However,the existing minimum weight perfect matching(MWPM)algorithm has high computational complexity and lacks flexibility in large-scale systems.Therefore,this paper proposes a decoding method that combines graph neural networks(GNN)with multi-classifiers,the syndrome is transformed into an undirected graph,and the features are aggregated by convolutional layers,providing a more efficient and accurate decoding strategy.In the experiments,we evaluated the performance of the XZZX code under different biased noise conditions(bias=1,20,200)and different code distances(d=3,5,7,9,11).The experimental results show that under low bias noise(bias=1),the GNN decoder achieves a threshold of 0.18386,an improvement of approximately 19.12%compared to the MWPM decoder.Under high bias noise(bias=200),the GNN decoder reaches a threshold of 0.40542,improving by approximately 20.76%,overcoming the limitations of the conventional decoder.They demonstrate that the GNN decoding method exhibits superior performance and has broad application potential in the error correction of XZZX code.展开更多
Background:Triple-negative breast cancer(TNBC)has long been a difficult therapeutic target to overcome because of its extreme aggressiveness,poor efficacy and rarity of available treatment regimens.To explore the anti...Background:Triple-negative breast cancer(TNBC)has long been a difficult therapeutic target to overcome because of its extreme aggressiveness,poor efficacy and rarity of available treatment regimens.To explore the anti-TNBC potential of Caulis Polygoni Multiflori(CPM),this investigation applied an integrated computational and experimental approach.Methods:Bioactive CPM compounds were investigated via screening of three TCM databases(TCMSP,TCMID,and HERB)using Bioavailability(OB≥30%)as inclusion criteria.TNBC targets were obtained from the online resources GeneCards,CTD,and OMIM network pharmacology analysis was used to determine common target(s),utilizing two PPI analysis tools–STRING and Cytoscape.Molecular docking assessed target-compound interactions by means of AutoDock Vina.In vitro studies conducted on MDA-MB-231 cells involved evaluating inhibitory effects via MTT,wound-healing assay,transwell,and qPCR techniques.Results:Six bioactive compounds were identified,with emodin(IC_(50) approximately 15μM)and chrysophanol(IC50 approximately 25μM)showing strong binding to TNBC targets(emodin-HSP90AB1:−9.42 kcal/mol;chrysophanol-SRC:−8.32 kcal/mol).Network analysis revealed 143 shared targets,with BCL2,EGFR and ESR1 as key nodes.Pathway analysis implicated PI3K-AKT signaling and apoptosis.In vitro,emodin and chrysophanol synergistically inhibited proliferation,migration and invasion,while downregulating BCL2,EGFR and ESR1 expression.Conclusion:To the best of our knowledge,this is the first report that describes the synergistic mechanisms of multiple compounds from the extract of CPM in TNBC with chrysophanol and emodin working as the main components by mediating oncogenic pathways.展开更多
BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents with depressive disorders and poses a major public health challenge.Rumination,a key cognitive feature of depression,includes different subtypes tha...BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents with depressive disorders and poses a major public health challenge.Rumination,a key cognitive feature of depression,includes different subtypes that may relate to NSSI through distinct psychological mechanisms.However,how these subtypes interact with specific NSSI behaviors remains unclear.AIM To examine associations between rumination subtypes and specific NSSI behaviors in adolescents.METHODS We conducted a cross-sectional study with 305 hospitalized adolescents diagnosed with depressive disorders.The subjects ranged from 12-18 years in age.Rumi-nation subtypes were assessed using the Ruminative Response Scale,and 12 NSSI behaviors were evaluated using a validated questionnaire.Network analysis was applied to explore symptom-level associations and identify central symptoms.RESULTS The network analysis revealed close connections between rumination subtypes and NSSI behaviors.Brooding was linked to behaviors such as hitting objects and burning.Scratching emerged as the most influential NSSI symptom.Symptomfocused rumination served as a key bridge connecting rumination and NSSI.CONCLUSION Symptom-focused rumination and scratching were identified as potential intervention targets.These findings highlight the psychological significance of specific cognitive-behavioral links in adolescent depression and suggest directions for tailored prevention and treatment.However,the cross-sectional,single-site design limits causal inference and generalizability.Future longitudinal and multi-center studies are needed to confirm causal pathways and verify the generalizability of the findings to broader adolescent populations.展开更多
Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY o...Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY on AD.Methods:The DNFB-induced mouse models of AD were established to investigate the therapeutic effects of WQY on AD.The symptoms of AD in the ears and backs of the mice were assessed,while inflammatory factors in the ear were quantified using quantitative real-time-polymerase chain reaction(qRT-PCR),and the percentages of CD4^(+)and CD8^(+)cells in the spleen were analyzed through flow cytometry.The compounds in WQY were identified using ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)analysis and the key targets and pathways of WQY to treat AD were predicted by network pharmacology.Subsequently,the key genes were tested and verified by qRT-PCR,and the potential active components and target proteins were verified by molecular docking.Results:WQY relieved the AD symptoms and histopathological injuries in the ear and back skin of mice with AD.Meanwhile,WQY significantly reduced the levels of inflammatory factors IL-6 and IL-1βin ear tissue,as well as the ratio of CD4^(+)/CD8^(+)cells in spleen.Additionally,a total of 142 compounds were identified from the water extract of WQY by UPLC-Orbitrap-MS/MS.39 key targets related to AD were screened out by network pharmacology methods.The KEGG analysis indicated that the effects of WQY were primarily mediated through pathways associated with Toll-like receptor signaling and T cell receptor signaling.Moreover,the results of qRT-PCR demonstrated that WQY significantly reduced the mRNA expressions of IL-4,IL-10,GATA3 and FOXP3,and molecular docking simulation verified that the active components of WQY had excellent binding abilities with IL-4,IL-10,GATA3 and FOXP3 proteins.Conclusion:The present study demonstrated that WQY effectively relieved AD symptoms in mice,decreased the inflammatory factors levels,regulated the balance of CD4^(+)and CD8^(+)cells,and the mechanism may be associated with the suppression of Th2 and Treg cell immune responses.展开更多
This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for ...This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels.展开更多
In order to make the information transmission more efficient and reliable in a digital communication channel with limited capacity, various encoding-decoding techniques have been proposed and widely applied in many br...In order to make the information transmission more efficient and reliable in a digital communication channel with limited capacity, various encoding-decoding techniques have been proposed and widely applied in many branches of the signal processing including digital communications, data compression,information encryption, etc. Recently, due to its promising application potentials in the networked systems(NSs), the analysis and synthesis issues of the NSs under various encoding-decoding schemes have stirred some research attention. However, because of the network-enhanced complexity caused by the limited network resources, it poses new challenges to the design of suitable encoding-decoding procedures to meet certain control or filtering performance for the NSs. In this survey paper, our aim is to present a comprehensive review of the encoding-decodingbased control and filtering problems for different types of NSs.First, some basic introduction with respect to the coding-decoding mechanism is presented in terms of its engineering insights,specific properties and theoretical formulations. Then, the recent representative research progress in the design of the encodingdecoding protocols for various control and filtering problems is discussed. Some possible further research topics are finally outlined for the encoding-decoding-based NSs.展开更多
Adaptive inverse control system can improve the performance of turbo decoding,and modeling turbo decoder is one of the most important technologies. A neural network model for the inverse model of turbo decoding is pro...Adaptive inverse control system can improve the performance of turbo decoding,and modeling turbo decoder is one of the most important technologies. A neural network model for the inverse model of turbo decoding is proposed in this paper. Compared with linear filter with its revi-sion,the general relationship between the input and output of the inverse model of turbo decoding system can be established exactly by Nonlinear Auto-Regressive eXogeneous input (NARX) filter. Combined with linear inverse system,it has simpler structure and costs less computation,thus can satisfy the demand of real-time turbo decoding. Simulation results show that neural network in-verse control system can improve the performance of turbo decoding further than other linear con-trol system.展开更多
Brain-machine interface (BMI) has been developed due to its possibility to cure severe body paralysis. This technology has been used to realize the direct control of prosthetic devices,such as robot arms,computer curs...Brain-machine interface (BMI) has been developed due to its possibility to cure severe body paralysis. This technology has been used to realize the direct control of prosthetic devices,such as robot arms,computer cursors,and paralyzed muscles. A variety of neural decoding algorithms have been designed to explore relationships between neural activities and movements of the limbs. In this paper,two novel neural decoding methods based on probabilistic neural network (PNN) in rats were introduced,the PNN decoder and the modified PNN (MPNN) decoder. In the ex-periment,rats were trained to obtain water by pressing a lever over a pressure threshold. Microelectrode array was implanted in the motor cortex to record neural activity,and pressure was recorded by a pressure sensor synchronously. After training,the pressure values were estimated from the neural signals by PNN and MPNN decoders. Their per-formances were evaluated by a correlation coefficient (CC) and a mean square error (MSE). The results show that the MPNN decoder,with a CC of 0.8657 and an MSE of 0.2563,outperformed the traditionally-used Wiener filter (WF) and Kalman filter (KF) decoders. It was also observed that the discretization level did not affect the MPNN performance,indicating that the MPNN decoder can handle different tasks in BMI system,including the detection of movement states and estimation of continuous kinematic parameters.展开更多
A network-coding-based multisource LDPC-coded cooperative MIMO scheme is proposed,where multiple sources transmit their messages to the destination with the assistance from a single relay.The relay cooperates with mul...A network-coding-based multisource LDPC-coded cooperative MIMO scheme is proposed,where multiple sources transmit their messages to the destination with the assistance from a single relay.The relay cooperates with multiple sources simultaneously via network-coding.It avoids the issues of imperfect frequency/timing synchronization and large transmission delay which may be introduced by frequency-division multiple access(FDMA)/code-division multiple access(CDMA)and time-division multiple access(TDMA)manners.The proposed joint″Min-Sum″iterative decoding is effectively carried out in the destination.Such a decoding algorithm agrees with the introduced equivalent joint Tanner graph which can be used to fully characterize LDPC codes employed by the sources and relay.Theoretical analysis and numerical simulation show that the proposed scheme with joint iterative decoding can achieve significant cooperation diversity gain.Furthermore,for the relay,compared with the cascade scheme,the proposed scheme has much lower complexity of LDPC-encoding and is easier to be implemented in the hardware with similar bit error rate(BER)performance.展开更多
Ocean underwater exploration is a part of oceanography that investigates the physical and biological conditions for scientific and commercial purposes. And video technology plays an important role and is extensively a...Ocean underwater exploration is a part of oceanography that investigates the physical and biological conditions for scientific and commercial purposes. And video technology plays an important role and is extensively applied for underwater environment observation. Different from the conventional methods, video technology explores the underwater ecosystem continuously and non-invasively. However, due to the scattering and attenuation of light transport in the water, complex noise distribution and lowlight condition cause challenges for underwater video applications including object detection and recognition. In this paper, we propose a new deep encoding-decoding convolutional architecture for underwater object recognition. It uses the deep encoding-decoding network for extracting the discriminative features from the noisy low-light underwater images. To create the deconvolutional layers for classification, we apply the deconvolution kernel with a matched feature map, instead of full connection, to solve the problem of dimension disaster and low accuracy. Moreover, we introduce data augmentation and transfer learning technologies to solve the problem of data starvation. For experiments, we investigated the public datasets with our proposed method and the state-of-the-art methods. The results show that our work achieves significant accuracy. This work provides new underwater technologies applied for ocean exploration.展开更多
This letter proposes a sliced-gated-convolutional neural network with belief propagation(SGCNN-BP) architecture for decoding long codes under correlated noise. The basic idea of SGCNNBP is using Neural Networks(NN) to...This letter proposes a sliced-gated-convolutional neural network with belief propagation(SGCNN-BP) architecture for decoding long codes under correlated noise. The basic idea of SGCNNBP is using Neural Networks(NN) to transform the correlated noise into white noise, setting up the optimal condition for a standard BP decoder that takes the output from the NN. A gate-controlled neuron is used to regulate information flow and an optional operation—slicing is adopted to reduce parameters and lower training complexity. Simulation results show that SGCNN-BP has much better performance(with the largest gap being 5dB improvement) than a single BP decoder and achieves a nearly 1dB improvement compared to Fully Convolutional Networks(FCN).展开更多
The parallel decoding method of a parallel concatenation of multiple codes is well known. In this paper, we present a new serial decoding method. The iterative gain in this method is always one. Therefore, this method...The parallel decoding method of a parallel concatenation of multiple codes is well known. In this paper, we present a new serial decoding method. The iterative gain in this method is always one. Therefore, this method does not need optimization of the iterative gain by using simulated annealing like the parallel decoding method. Though it is simpler than the parallel decoding method in calculation, it gives the same performance. We also use Pearl's propagation algorithm to show the appropriateness of the serial decoding method.展开更多
<div style="text-align:justify;"> Polar codes using successive-cancellation decoding always suffer from high latency for its serial nature. Fast simplified successive-cancellation decoding algorithm im...<div style="text-align:justify;"> Polar codes using successive-cancellation decoding always suffer from high latency for its serial nature. Fast simplified successive-cancellation decoding algorithm improves the situation in theoretically but not performs well as expected in practical for the workload of nodes identification and the existence of many short blocks. Meanwhile, Neural network (NN) based decoders have appeared as potential candidates to replace conventional decoders for polar codes. But the exponentially increasing training complexity with information bits is unacceptable which means it is only suitable for short codes. In this paper, we present an improvement that increases decoding efficiency without degrading the error-correction performance. The long polar codes are divided into several sub-blocks, some of which can be decoded adopting fast maximum likelihood decoding method and the remained parts are replaced by several short codes NN decoders. The result shows that time steps the proposed algorithm need only equal to 79.8% of fast simplified successive-cancellation decoders require. Moreover, it has up to 21.2 times faster than successive-cancellation decoding algorithm. More importantly, the proposed algorithm decreases the hardness when applying in some degree. </div>展开更多
Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the u...Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the use of virtual reality(VR)technology.VR has been demonstrated to be an effective treatment for pain associated with medical procedures,as well as for chronic pain conditions for which no effective treatment has been established.The precise mechanism by which the diversion from reality facilitated by VR contributes to the diminution of pain and anxiety has yet to be elucidated.However,the provision of positive images through VR-based visual stimulation may enhance the functionality of brain networks.The salience network is diminished,while the default mode network is enhanced.Additionally,the medial prefrontal cortex may establish a stronger connection with the default mode network,which could result in a reduction of pain and anxiety.Further research into the potential of VR technology to alleviate pain could lead to a reduction in the number of individuals who overdose on painkillers and contribute to positive change in the medical field.展开更多
<div style="text-align:justify;"> <p style="text-align:justify;background:white;"> <span style="font-size:10.0pt;font-family:" color:black;"="">This artic...<div style="text-align:justify;"> <p style="text-align:justify;background:white;"> <span style="font-size:10.0pt;font-family:" color:black;"="">This article has been retracted to straighten the academic record. In making this decision the Editorial Board follows COPE's </span><span><a href="http://publicationethics.org/files/retraction%20guidelines.pdf"><span style="font-size:10.0pt;font-family:;" "="">Retraction Guidelines</span></a></span><span style="font-size:10.0pt;font-family:" color:black;"="">. The aim is to promote the circulation of scientific research by offering an ideal research publication platform with due consideration of internationally accepted standards on publication ethics. The Editorial Board would like to extend its sincere apologies for any inconvenience this retraction may have caused.</span><span style="font-size:10.0pt;font-family:" color:black;"=""></span> </p> <p style="text-align:justify;background:white;"> <span style="font-size:10.0pt;font-family:" color:black;"="">Please see the </span><span><a href="https://www.scirp.org/journal/paperinformation.aspx?paperid=101825"><span style="font-size:10.0pt;font-family:;" "="">article page</span></a></span><span style="font-size:10.0pt;font-family:" color:black;"=""> for more details. </span><span><a href="https://www.scirp.org/pdf/opj_2020072814494052.pdf"><span style="font-size:10.0pt;font-family:;" "="">The full retraction notice</span></a></span><span style="font-size:10.0pt;font-family:" color:black;"=""> in PDF is preceding the original paper which is marked "RETRACTED". </span> </p> <br /> </div>展开更多
Combinatorial networks are widely applied in many practical scenarios. In this paper, we compute the closed-form probability expressions of successful decoding at a sink and at all sinks in the multicast scenario, in ...Combinatorial networks are widely applied in many practical scenarios. In this paper, we compute the closed-form probability expressions of successful decoding at a sink and at all sinks in the multicast scenario, in which one source sends messages to k destinations through m relays using random linear network coding over a Galois field. The formulation at a （all） sink（s） represents the impact of major parameters, i.e., the size of field, the number of relays （and sinks） and provides theoretical groundings to numerical results in the literature. Such condition maps to the receivers＇ capability to decode the original information and its mathematical characterization is helpful to design the coding. In addition, numerical results show that, under a fixed exact decoding probability, the required field size can be minimized.展开更多
Complex network models are frequently employed for simulating and studyingdiverse real-world complex systems.Among these models,scale-free networks typically exhibit greater fragility to malicious attacks.Consequently...Complex network models are frequently employed for simulating and studyingdiverse real-world complex systems.Among these models,scale-free networks typically exhibit greater fragility to malicious attacks.Consequently,enhancing the robustness of scale-free networks has become a pressing issue.To address this problem,this paper proposes a Multi-Granularity Integration Algorithm(MGIA),which aims to improve the robustness of scale-free networks while keeping the initial degree of each node unchanged,ensuring network connectivity and avoiding the generation of multiple edges.The algorithm generates a multi-granularity structure from the initial network to be optimized,then uses different optimization strategies to optimize the networks at various granular layers in this structure,and finally realizes the information exchange between different granular layers,thereby further enhancing the optimization effect.We propose new network refresh,crossover,and mutation operators to ensure that the optimized network satisfies the given constraints.Meanwhile,we propose new network similarity and network dissimilarity evaluation metrics to improve the effectiveness of the optimization operators in the algorithm.In the experiments,the MGIA enhances the robustness of the scale-free network by 67.6%.This improvement is approximately 17.2%higher than the optimization effects achieved by eight currently existing complex network robustness optimization algorithms.展开更多
Satellite edge computing has garnered significant attention from researchers;however,processing a large volume of tasks within multi-node satellite networks still poses considerable challenges.The sharp increase in us...Satellite edge computing has garnered significant attention from researchers;however,processing a large volume of tasks within multi-node satellite networks still poses considerable challenges.The sharp increase in user demand for latency-sensitive tasks has inevitably led to offloading bottlenecks and insufficient computational capacity on individual satellite edge servers,making it necessary to implement effective task offloading scheduling to enhance user experience.In this paper,we propose a priority-based task scheduling strategy based on a Software-Defined Network(SDN)framework for satellite-terrestrial integrated networks,which clarifies the execution order of tasks based on their priority.Subsequently,we apply a Dueling-Double Deep Q-Network(DDQN)algorithm enhanced with prioritized experience replay to derive a computation offloading strategy,improving the experience replay mechanism within the Dueling-DDQN framework.Next,we utilize the Deep Deterministic Policy Gradient(DDPG)algorithm to determine the optimal resource allocation strategy to reduce the processing latency of sub-tasks.Simulation results demonstrate that the proposed d3-DDPG algorithm outperforms other approaches,effectively reducing task processing latency and thus improving user experience and system efficiency.展开更多
基金supported by the Natural Science Foundation of Shandong Province,China(Grant No.ZR2021MF049)the Joint Fund of Natural Science Foundation of Shandong Province,China(Grant Nos.ZR2022LL.Z012 and ZR2021LLZ001)the Key Research and Development Program of Shandong Province,China(Grant No.2023CXGC010901).
文摘Quantum error correction is a technique that enhances a system’s ability to combat noise by encoding logical information into additional quantum bits,which plays a key role in building practical quantum computers.The XZZX surface code,with only one stabilizer generator on each face,demonstrates significant application potential under biased noise.However,the existing minimum weight perfect matching(MWPM)algorithm has high computational complexity and lacks flexibility in large-scale systems.Therefore,this paper proposes a decoding method that combines graph neural networks(GNN)with multi-classifiers,the syndrome is transformed into an undirected graph,and the features are aggregated by convolutional layers,providing a more efficient and accurate decoding strategy.In the experiments,we evaluated the performance of the XZZX code under different biased noise conditions(bias=1,20,200)and different code distances(d=3,5,7,9,11).The experimental results show that under low bias noise(bias=1),the GNN decoder achieves a threshold of 0.18386,an improvement of approximately 19.12%compared to the MWPM decoder.Under high bias noise(bias=200),the GNN decoder reaches a threshold of 0.40542,improving by approximately 20.76%,overcoming the limitations of the conventional decoder.They demonstrate that the GNN decoding method exhibits superior performance and has broad application potential in the error correction of XZZX code.
基金supported by 2022 Anhui University Research Project(grant numbers No.2022AH051162)2023 Anhui University Collaborative innovation project(grant numbers No.GXXT-2023-074)National Key Clinical Collaboration Project for Difficult and Complex Diseases(Ovarian Malignancies)Integrating Traditional Chinese and Western Medicine(grant numbers National Traditional Chinese Medicine Comprehensive Development Document(2024)No.3).
文摘Background:Triple-negative breast cancer(TNBC)has long been a difficult therapeutic target to overcome because of its extreme aggressiveness,poor efficacy and rarity of available treatment regimens.To explore the anti-TNBC potential of Caulis Polygoni Multiflori(CPM),this investigation applied an integrated computational and experimental approach.Methods:Bioactive CPM compounds were investigated via screening of three TCM databases(TCMSP,TCMID,and HERB)using Bioavailability(OB≥30%)as inclusion criteria.TNBC targets were obtained from the online resources GeneCards,CTD,and OMIM network pharmacology analysis was used to determine common target(s),utilizing two PPI analysis tools–STRING and Cytoscape.Molecular docking assessed target-compound interactions by means of AutoDock Vina.In vitro studies conducted on MDA-MB-231 cells involved evaluating inhibitory effects via MTT,wound-healing assay,transwell,and qPCR techniques.Results:Six bioactive compounds were identified,with emodin(IC_(50) approximately 15μM)and chrysophanol(IC50 approximately 25μM)showing strong binding to TNBC targets(emodin-HSP90AB1:−9.42 kcal/mol;chrysophanol-SRC:−8.32 kcal/mol).Network analysis revealed 143 shared targets,with BCL2,EGFR and ESR1 as key nodes.Pathway analysis implicated PI3K-AKT signaling and apoptosis.In vitro,emodin and chrysophanol synergistically inhibited proliferation,migration and invasion,while downregulating BCL2,EGFR and ESR1 expression.Conclusion:To the best of our knowledge,this is the first report that describes the synergistic mechanisms of multiple compounds from the extract of CPM in TNBC with chrysophanol and emodin working as the main components by mediating oncogenic pathways.
基金Supported by Key Research and Development Program of Shaanxi Province,China,No.2024SF-YBXM-078.
文摘BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents with depressive disorders and poses a major public health challenge.Rumination,a key cognitive feature of depression,includes different subtypes that may relate to NSSI through distinct psychological mechanisms.However,how these subtypes interact with specific NSSI behaviors remains unclear.AIM To examine associations between rumination subtypes and specific NSSI behaviors in adolescents.METHODS We conducted a cross-sectional study with 305 hospitalized adolescents diagnosed with depressive disorders.The subjects ranged from 12-18 years in age.Rumi-nation subtypes were assessed using the Ruminative Response Scale,and 12 NSSI behaviors were evaluated using a validated questionnaire.Network analysis was applied to explore symptom-level associations and identify central symptoms.RESULTS The network analysis revealed close connections between rumination subtypes and NSSI behaviors.Brooding was linked to behaviors such as hitting objects and burning.Scratching emerged as the most influential NSSI symptom.Symptomfocused rumination served as a key bridge connecting rumination and NSSI.CONCLUSION Symptom-focused rumination and scratching were identified as potential intervention targets.These findings highlight the psychological significance of specific cognitive-behavioral links in adolescent depression and suggest directions for tailored prevention and treatment.However,the cross-sectional,single-site design limits causal inference and generalizability.Future longitudinal and multi-center studies are needed to confirm causal pathways and verify the generalizability of the findings to broader adolescent populations.
基金supported by grants from the National Natural Science Foundation of China(82004252)the Project of Administration of Traditional Chinese Medicine of Guangdong Province(202405112017596500)the Basic and Applied Basic Research Foundation of Guangzhou Municipal Science and Technology Bureau(202102020533).
文摘Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY on AD.Methods:The DNFB-induced mouse models of AD were established to investigate the therapeutic effects of WQY on AD.The symptoms of AD in the ears and backs of the mice were assessed,while inflammatory factors in the ear were quantified using quantitative real-time-polymerase chain reaction(qRT-PCR),and the percentages of CD4^(+)and CD8^(+)cells in the spleen were analyzed through flow cytometry.The compounds in WQY were identified using ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)analysis and the key targets and pathways of WQY to treat AD were predicted by network pharmacology.Subsequently,the key genes were tested and verified by qRT-PCR,and the potential active components and target proteins were verified by molecular docking.Results:WQY relieved the AD symptoms and histopathological injuries in the ear and back skin of mice with AD.Meanwhile,WQY significantly reduced the levels of inflammatory factors IL-6 and IL-1βin ear tissue,as well as the ratio of CD4^(+)/CD8^(+)cells in spleen.Additionally,a total of 142 compounds were identified from the water extract of WQY by UPLC-Orbitrap-MS/MS.39 key targets related to AD were screened out by network pharmacology methods.The KEGG analysis indicated that the effects of WQY were primarily mediated through pathways associated with Toll-like receptor signaling and T cell receptor signaling.Moreover,the results of qRT-PCR demonstrated that WQY significantly reduced the mRNA expressions of IL-4,IL-10,GATA3 and FOXP3,and molecular docking simulation verified that the active components of WQY had excellent binding abilities with IL-4,IL-10,GATA3 and FOXP3 proteins.Conclusion:The present study demonstrated that WQY effectively relieved AD symptoms in mice,decreased the inflammatory factors levels,regulated the balance of CD4^(+)and CD8^(+)cells,and the mechanism may be associated with the suppression of Th2 and Treg cell immune responses.
基金supported by Istanbul Technical University(Project No.45698)supported through the“Young Researchers’Career Development Project-training of doctoral students”of the Croatian Science Foundation.
文摘This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels.
基金supported in part by the Royal Society of the UK,the Nationa Natural Science,Foundation of China(61329301,61374039)the Program for Capability Construction of Shanghai Provincial Universities(15550502500)the Alexander von Humboldt Foundation of Germany
文摘In order to make the information transmission more efficient and reliable in a digital communication channel with limited capacity, various encoding-decoding techniques have been proposed and widely applied in many branches of the signal processing including digital communications, data compression,information encryption, etc. Recently, due to its promising application potentials in the networked systems(NSs), the analysis and synthesis issues of the NSs under various encoding-decoding schemes have stirred some research attention. However, because of the network-enhanced complexity caused by the limited network resources, it poses new challenges to the design of suitable encoding-decoding procedures to meet certain control or filtering performance for the NSs. In this survey paper, our aim is to present a comprehensive review of the encoding-decodingbased control and filtering problems for different types of NSs.First, some basic introduction with respect to the coding-decoding mechanism is presented in terms of its engineering insights,specific properties and theoretical formulations. Then, the recent representative research progress in the design of the encodingdecoding protocols for various control and filtering problems is discussed. Some possible further research topics are finally outlined for the encoding-decoding-based NSs.
文摘Adaptive inverse control system can improve the performance of turbo decoding,and modeling turbo decoder is one of the most important technologies. A neural network model for the inverse model of turbo decoding is proposed in this paper. Compared with linear filter with its revi-sion,the general relationship between the input and output of the inverse model of turbo decoding system can be established exactly by Nonlinear Auto-Regressive eXogeneous input (NARX) filter. Combined with linear inverse system,it has simpler structure and costs less computation,thus can satisfy the demand of real-time turbo decoding. Simulation results show that neural network in-verse control system can improve the performance of turbo decoding further than other linear con-trol system.
基金Project supported by the National Natural Science Foundation of China (Nos. 30800287 and 60703038)the Natural Science Foundation of Zhejiang Province, China (No. Y2090707)
文摘Brain-machine interface (BMI) has been developed due to its possibility to cure severe body paralysis. This technology has been used to realize the direct control of prosthetic devices,such as robot arms,computer cursors,and paralyzed muscles. A variety of neural decoding algorithms have been designed to explore relationships between neural activities and movements of the limbs. In this paper,two novel neural decoding methods based on probabilistic neural network (PNN) in rats were introduced,the PNN decoder and the modified PNN (MPNN) decoder. In the ex-periment,rats were trained to obtain water by pressing a lever over a pressure threshold. Microelectrode array was implanted in the motor cortex to record neural activity,and pressure was recorded by a pressure sensor synchronously. After training,the pressure values were estimated from the neural signals by PNN and MPNN decoders. Their per-formances were evaluated by a correlation coefficient (CC) and a mean square error (MSE). The results show that the MPNN decoder,with a CC of 0.8657 and an MSE of 0.2563,outperformed the traditionally-used Wiener filter (WF) and Kalman filter (KF) decoders. It was also observed that the discretization level did not affect the MPNN performance,indicating that the MPNN decoder can handle different tasks in BMI system,including the detection of movement states and estimation of continuous kinematic parameters.
基金Supported by the Postdoctoral Science Foundation of China(2014M561694)the Science and Technology on Avionics Integration Laboratory and National Aeronautical Science Foundation of China(20105552)
文摘A network-coding-based multisource LDPC-coded cooperative MIMO scheme is proposed,where multiple sources transmit their messages to the destination with the assistance from a single relay.The relay cooperates with multiple sources simultaneously via network-coding.It avoids the issues of imperfect frequency/timing synchronization and large transmission delay which may be introduced by frequency-division multiple access(FDMA)/code-division multiple access(CDMA)and time-division multiple access(TDMA)manners.The proposed joint″Min-Sum″iterative decoding is effectively carried out in the destination.Such a decoding algorithm agrees with the introduced equivalent joint Tanner graph which can be used to fully characterize LDPC codes employed by the sources and relay.Theoretical analysis and numerical simulation show that the proposed scheme with joint iterative decoding can achieve significant cooperation diversity gain.Furthermore,for the relay,compared with the cascade scheme,the proposed scheme has much lower complexity of LDPC-encoding and is easier to be implemented in the hardware with similar bit error rate(BER)performance.
基金supported by the Jilin Science and Technology Development Plan Project (Nos. 20160209006GX, 20170309001GX and 20180201043GX)
文摘Ocean underwater exploration is a part of oceanography that investigates the physical and biological conditions for scientific and commercial purposes. And video technology plays an important role and is extensively applied for underwater environment observation. Different from the conventional methods, video technology explores the underwater ecosystem continuously and non-invasively. However, due to the scattering and attenuation of light transport in the water, complex noise distribution and lowlight condition cause challenges for underwater video applications including object detection and recognition. In this paper, we propose a new deep encoding-decoding convolutional architecture for underwater object recognition. It uses the deep encoding-decoding network for extracting the discriminative features from the noisy low-light underwater images. To create the deconvolutional layers for classification, we apply the deconvolution kernel with a matched feature map, instead of full connection, to solve the problem of dimension disaster and low accuracy. Moreover, we introduce data augmentation and transfer learning technologies to solve the problem of data starvation. For experiments, we investigated the public datasets with our proposed method and the state-of-the-art methods. The results show that our work achieves significant accuracy. This work provides new underwater technologies applied for ocean exploration.
基金supported by Beijing Natural Science Foundation (L202003)。
文摘This letter proposes a sliced-gated-convolutional neural network with belief propagation(SGCNN-BP) architecture for decoding long codes under correlated noise. The basic idea of SGCNNBP is using Neural Networks(NN) to transform the correlated noise into white noise, setting up the optimal condition for a standard BP decoder that takes the output from the NN. A gate-controlled neuron is used to regulate information flow and an optional operation—slicing is adopted to reduce parameters and lower training complexity. Simulation results show that SGCNN-BP has much better performance(with the largest gap being 5dB improvement) than a single BP decoder and achieves a nearly 1dB improvement compared to Fully Convolutional Networks(FCN).
文摘The parallel decoding method of a parallel concatenation of multiple codes is well known. In this paper, we present a new serial decoding method. The iterative gain in this method is always one. Therefore, this method does not need optimization of the iterative gain by using simulated annealing like the parallel decoding method. Though it is simpler than the parallel decoding method in calculation, it gives the same performance. We also use Pearl's propagation algorithm to show the appropriateness of the serial decoding method.
文摘<div style="text-align:justify;"> Polar codes using successive-cancellation decoding always suffer from high latency for its serial nature. Fast simplified successive-cancellation decoding algorithm improves the situation in theoretically but not performs well as expected in practical for the workload of nodes identification and the existence of many short blocks. Meanwhile, Neural network (NN) based decoders have appeared as potential candidates to replace conventional decoders for polar codes. But the exponentially increasing training complexity with information bits is unacceptable which means it is only suitable for short codes. In this paper, we present an improvement that increases decoding efficiency without degrading the error-correction performance. The long polar codes are divided into several sub-blocks, some of which can be decoded adopting fast maximum likelihood decoding method and the remained parts are replaced by several short codes NN decoders. The result shows that time steps the proposed algorithm need only equal to 79.8% of fast simplified successive-cancellation decoders require. Moreover, it has up to 21.2 times faster than successive-cancellation decoding algorithm. More importantly, the proposed algorithm decreases the hardness when applying in some degree. </div>
文摘Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the use of virtual reality(VR)technology.VR has been demonstrated to be an effective treatment for pain associated with medical procedures,as well as for chronic pain conditions for which no effective treatment has been established.The precise mechanism by which the diversion from reality facilitated by VR contributes to the diminution of pain and anxiety has yet to be elucidated.However,the provision of positive images through VR-based visual stimulation may enhance the functionality of brain networks.The salience network is diminished,while the default mode network is enhanced.Additionally,the medial prefrontal cortex may establish a stronger connection with the default mode network,which could result in a reduction of pain and anxiety.Further research into the potential of VR technology to alleviate pain could lead to a reduction in the number of individuals who overdose on painkillers and contribute to positive change in the medical field.
文摘<div style="text-align:justify;"> <p style="text-align:justify;background:white;"> <span style="font-size:10.0pt;font-family:" color:black;"="">This article has been retracted to straighten the academic record. In making this decision the Editorial Board follows COPE's </span><span><a href="http://publicationethics.org/files/retraction%20guidelines.pdf"><span style="font-size:10.0pt;font-family:;" "="">Retraction Guidelines</span></a></span><span style="font-size:10.0pt;font-family:" color:black;"="">. The aim is to promote the circulation of scientific research by offering an ideal research publication platform with due consideration of internationally accepted standards on publication ethics. The Editorial Board would like to extend its sincere apologies for any inconvenience this retraction may have caused.</span><span style="font-size:10.0pt;font-family:" color:black;"=""></span> </p> <p style="text-align:justify;background:white;"> <span style="font-size:10.0pt;font-family:" color:black;"="">Please see the </span><span><a href="https://www.scirp.org/journal/paperinformation.aspx?paperid=101825"><span style="font-size:10.0pt;font-family:;" "="">article page</span></a></span><span style="font-size:10.0pt;font-family:" color:black;"=""> for more details. </span><span><a href="https://www.scirp.org/pdf/opj_2020072814494052.pdf"><span style="font-size:10.0pt;font-family:;" "="">The full retraction notice</span></a></span><span style="font-size:10.0pt;font-family:" color:black;"=""> in PDF is preceding the original paper which is marked "RETRACTED". </span> </p> <br /> </div>
基金Supported by the National Natural Science Foundation of China(61271174,61301178)the Science and Technology Innovation Foundation of Xi’an(CXY1352WL28)
文摘Combinatorial networks are widely applied in many practical scenarios. In this paper, we compute the closed-form probability expressions of successful decoding at a sink and at all sinks in the multicast scenario, in which one source sends messages to k destinations through m relays using random linear network coding over a Galois field. The formulation at a （all） sink（s） represents the impact of major parameters, i.e., the size of field, the number of relays （and sinks） and provides theoretical groundings to numerical results in the literature. Such condition maps to the receivers＇ capability to decode the original information and its mathematical characterization is helpful to design the coding. In addition, numerical results show that, under a fixed exact decoding probability, the required field size can be minimized.
基金National Natural Science Foundation of China(11971211,12171388).
文摘Complex network models are frequently employed for simulating and studyingdiverse real-world complex systems.Among these models,scale-free networks typically exhibit greater fragility to malicious attacks.Consequently,enhancing the robustness of scale-free networks has become a pressing issue.To address this problem,this paper proposes a Multi-Granularity Integration Algorithm(MGIA),which aims to improve the robustness of scale-free networks while keeping the initial degree of each node unchanged,ensuring network connectivity and avoiding the generation of multiple edges.The algorithm generates a multi-granularity structure from the initial network to be optimized,then uses different optimization strategies to optimize the networks at various granular layers in this structure,and finally realizes the information exchange between different granular layers,thereby further enhancing the optimization effect.We propose new network refresh,crossover,and mutation operators to ensure that the optimized network satisfies the given constraints.Meanwhile,we propose new network similarity and network dissimilarity evaluation metrics to improve the effectiveness of the optimization operators in the algorithm.In the experiments,the MGIA enhances the robustness of the scale-free network by 67.6%.This improvement is approximately 17.2%higher than the optimization effects achieved by eight currently existing complex network robustness optimization algorithms.
文摘Satellite edge computing has garnered significant attention from researchers;however,processing a large volume of tasks within multi-node satellite networks still poses considerable challenges.The sharp increase in user demand for latency-sensitive tasks has inevitably led to offloading bottlenecks and insufficient computational capacity on individual satellite edge servers,making it necessary to implement effective task offloading scheduling to enhance user experience.In this paper,we propose a priority-based task scheduling strategy based on a Software-Defined Network(SDN)framework for satellite-terrestrial integrated networks,which clarifies the execution order of tasks based on their priority.Subsequently,we apply a Dueling-Double Deep Q-Network(DDQN)algorithm enhanced with prioritized experience replay to derive a computation offloading strategy,improving the experience replay mechanism within the Dueling-DDQN framework.Next,we utilize the Deep Deterministic Policy Gradient(DDPG)algorithm to determine the optimal resource allocation strategy to reduce the processing latency of sub-tasks.Simulation results demonstrate that the proposed d3-DDPG algorithm outperforms other approaches,effectively reducing task processing latency and thus improving user experience and system efficiency.
