The rapid growth of distributed data-centric applications and AI workloads increases demand for low-latency,high-throughput communication,necessitating frequent and flexible updates to network routing configurations.H...The rapid growth of distributed data-centric applications and AI workloads increases demand for low-latency,high-throughput communication,necessitating frequent and flexible updates to network routing configurations.However,maintaining consistent forwarding states during these updates is challenging,particularly when rerouting multiple flows simultaneously.Existing approaches pay little attention to multi-flow update,where improper update sequences across data plane nodes may construct deadlock dependencies.Moreover,these methods typically involve excessive control-data plane interactions,incurring significant resource overhead and performance degradation.This paper presents P4LoF,an efficient loop-free update approach that enables the controller to reroute multiple flows through minimal interactions.P4LoF first utilizes a greedy-based algorithm to generate the shortest update dependency chain for the single-flow update.These chains are then dynamically merged into a dependency graph and resolved as a Shortest Common Super-sequence(SCS)problem to produce the update sequence of multi-flow update.To address deadlock dependencies in multi-flow updates,P4LoF builds a deadlock-fix forwarding model that leverages the flexible packet processing capabilities of the programmable data plane.Experimental results show that P4LoF reduces control-data plane interactions by at least 32.6%with modest overhead,while effectively guaranteeing loop-free consistency.展开更多
With the rise of remote collaboration,the demand for advanced storage and collaboration tools has rapidly increased.However,traditional collaboration tools primarily rely on access control,leaving data stored on cloud...With the rise of remote collaboration,the demand for advanced storage and collaboration tools has rapidly increased.However,traditional collaboration tools primarily rely on access control,leaving data stored on cloud servers vulnerable due to insufficient encryption.This paper introduces a novel mechanism that encrypts data in‘bundle’units,designed to meet the dual requirements of efficiency and security for frequently updated collaborative data.Each bundle includes updated information,allowing only the updated portions to be reencrypted when changes occur.The encryption method proposed in this paper addresses the inefficiencies of traditional encryption modes,such as Cipher Block Chaining(CBC)and Counter(CTR),which require decrypting and re-encrypting the entire dataset whenever updates occur.The proposed method leverages update-specific information embedded within data bundles and metadata that maps the relationship between these bundles and the plaintext data.By utilizing this information,the method accurately identifies the modified portions and applies algorithms to selectively re-encrypt only those sections.This approach significantly enhances the efficiency of data updates while maintaining high performance,particularly in large-scale data environments.To validate this approach,we conducted experiments measuring execution time as both the size of the modified data and the total dataset size varied.Results show that the proposed method significantly outperforms CBC and CTR modes in execution speed,with greater performance gains as data size increases.Additionally,our security evaluation confirms that this method provides robust protection against both passive and active attacks.展开更多
With the widespread adoption of hydraulic fracturing technology in oil and gas resource development,improving the accuracy and efficiency of fracturing simulations has become a critical research focus.This paper propo...With the widespread adoption of hydraulic fracturing technology in oil and gas resource development,improving the accuracy and efficiency of fracturing simulations has become a critical research focus.This paper proposes an improved fluid flow algorithm,aiming to enhance the computational efficiency of hydraulic fracturing simulations while ensuring computational accuracy.The algorithm optimizes the aperture law and iteration criteria,focusing on improving the domain volume and crack pressure update strategy,thereby enabling precise capture of dynamic borehole pressure variations during injection tests.The effectiveness of the algorithm is verified through three flow-solid coupling cases.The study also analyzes the effects of borehole size,domain volume,and crack pressure update strategy on fracturing behavior.Furthermore,the performance of the improved algorithm in terms of crack propagation rate,micro-crack formation,and fluid pressure distribution was further evaluated.The results indicate that while large-size boreholes delay crack initiation,the cracks propagate more rapidly once formed.Additionally,the optimized domain volume calculation and crack pressure update strategy significantly shorten the pressure propagation stage,promote crack propagation,and improve computational efficiency.展开更多
The Chinese Society of Clinical Oncology Non-small Cell Lung Cancer(CSCO NSCLC)guidelines were first published in 2016,ranking among the earliest-released guidelines within the CSCO series.In 2020 the CSCO published s...The Chinese Society of Clinical Oncology Non-small Cell Lung Cancer(CSCO NSCLC)guidelines were first published in 2016,ranking among the earliest-released guidelines within the CSCO series.In 2020 the CSCO published separate guidelines for NSCLC and small cell lung cancer(SCLC)for the first time to improve clinical usability.展开更多
As vehicular networks become increasingly pervasive,enhancing connectivity and reliability has emerged as a critical objective.Among the enabling technologies for advanced wireless communication,particularly those tar...As vehicular networks become increasingly pervasive,enhancing connectivity and reliability has emerged as a critical objective.Among the enabling technologies for advanced wireless communication,particularly those targeting low latency and high reliability,time synchronization is critical,especially in vehicular networks.However,due to the inherent mobility of vehicular environments,consistently exchanging synchronization packets with a fixed base station or access point is challenging.This issue is further exacerbated in signal shadowed areas such as urban canyons,tunnels,or large-scale indoor hallswhere other technologies,such as global navigation satellite system(GNSS),are unavailable.One-way synchronization techniques offer a feasible approach under such transient connectivity conditions.One-way schemes still suffer from long convergence times to reach the required synchronization accuracy in these circumstances.In this paper,we propose a WLAN-based multi-stage clock synchronization scheme(WMC)tailored for vehicular networks.The proposed method comprises an initial hard update stage to rapidly achieve synchronization,followed by a high-precision stable stage based on Maximum Likelihood Estimation(MLE).By implementing the scheme directly at the network driver,we address key limitations of hard update mechanisms.Our approach significantly reduces the initial period to collect high-quality samples and offset estimation time to reach sub-50μs accuracy,and subsequently transitions to a refined MLE-based synchronization stage,achieving stable accuracy at approximately 30μs.The windowed moving average stabilized(reaching 90%of the baseline)in approximately 35 s,which corresponds to just 5.1%of the baseline time accuracy.Finally,the impact of synchronization performance on the localization model was validated using the Simulation of Urban Mobility(SUMO).The results demonstrate that more accurate conditions for position estimation can be supported,with an improvement about 38.5%in the mean error.展开更多
Colorectal cancer(CRC)is the most frequently diagnosed malignancy of the digestive system and the second leading cause of cancer-related deaths worldwide(1).In China,CRC ranks as the second most common cancer with inc...Colorectal cancer(CRC)is the most frequently diagnosed malignancy of the digestive system and the second leading cause of cancer-related deaths worldwide(1).In China,CRC ranks as the second most common cancer with incidence and mortality rates continuing to rise(2).The Chinese Society of Clinical Oncology(CSCO)first introduced its guidelines in 2017,and since then,they have been updated annually to incorporate the latest clinical research findings,drug availability,and expert consensus(3-8).This article presents the key updates in the 2025 edition compared to the 2024 version.展开更多
We present a gain adaptive tuning method for fiber Raman amplifier(FRA) using two-stage neural networks(NNs) and double weights updates. After training the connection weights of two-stage NNs separately in training ph...We present a gain adaptive tuning method for fiber Raman amplifier(FRA) using two-stage neural networks(NNs) and double weights updates. After training the connection weights of two-stage NNs separately in training phase, the connection weights of the unified NN are updated again in verification phase according to error between the predicted and target gains to eliminate the inherent error of the NNs. The simulation results show that the mean of root mean square error(RMSE) and maximum error of gains are 0.131 d B and 0.281 d B, respectively. It shows that the method can realize adaptive adjustment function of FRA gain with high accuracy.展开更多
We combine the Fermi and Moran update rules in the spatial prisoner＇s dilemma and snowdrift games to investigate the behavior of collective cooperation among agents on the regular lattice. Large-scale simulations ind...We combine the Fermi and Moran update rules in the spatial prisoner＇s dilemma and snowdrift games to investigate the behavior of collective cooperation among agents on the regular lattice. Large-scale simulations indicate that, compared to the model with only one update rule, the the role of update dynamics should be paid more attention in cooperation behavior exhibits the richer phenomena, and the evolutionary game theory. Meanwhile, we also observe that the introduction of Moran rule, which needs to consider all neighbor＇s information, can markedly promote the aggregate cooperation level, that is, randomly selecting the neighbor proportional to its payoff to imitate will facilitate the cooperation among agents. Current results will contribute to further understand the cooperation dynamics and evolutionary behaviors within many biological, economic and social systems.展开更多
The authors will examine prediction of temperature daily profile using various modifications of BPTT （backpropagation through time algorithm） done by stochastic update in the artificial RCNN （recurrent neural netwo...The authors will examine prediction of temperature daily profile using various modifications of BPTT （backpropagation through time algorithm） done by stochastic update in the artificial RCNN （recurrent neural networks）. The general introduction was provided by Salvetti and Wilamowski in 1994 in order to improve probability of convergence and speed of convergence. This update method has also one another quality, its implementation is simple for arbitrary network topology. In stochastic update scenario, constant number of weights/neurons is randomly selected and updated. This is in contrast to classical ordered update, where always all weights/neurons are updated. Stochastic update is suitable to replace classical ordered update without any penalty on implementation complexity and with good chance without penalty on quality of convergence. They have provided first experiments with stochastic modification on BP （backpropagation algorithm） used for artificial FFNN （feed-forward neural network） in detail described in the article ＂Stochastic Weight Update in the Backpropagation Algorithm on Feed-Forward Neural Networks＂ presented on the conference IJCNN （International Joint Conference of Neural Networks） 2010 in Barcelona. The BPTT on RCNN uses the history of previous steps stored inside of the NN that can be used for prediction. They will describe exact implementation on the RCNN, and present experiment results on temperature prediction with recurrent neural network topology. The dataset used for temperature prediction consists of the measured temperature from the year 2000 till the end of February 2011. Dataset is split into two groups： training dataset, which is provided to network in learning phase, and testing dataset, which is unknown part of dataset to NN and used to test the ability of NN to predict the temperature and the ability of NN to generalize the model hidden in the temperature profile. The results show promising properties of stochastic weight update with toy-task data, and the higher complexity of the temperature daily profile prediction.展开更多
Aiming at the inaccessible problem of remote embedded devices update and maintenance, this paper presents a method using general packet radio service （GPRS） to achieve update based on the embedded real-time operatin...Aiming at the inaccessible problem of remote embedded devices update and maintenance, this paper presents a method using general packet radio service （GPRS） to achieve update based on the embedded real-time operating system （RTOS） μC/OS-Ⅱ. It introduces architecture of the system first. And then it uses LPC1768 chip as the central processing unit, SIM900A module for data transmission, and SST25VF016B to store the data. To ensure accuracy of the data transmis- sion, cyclic redundancy code （CRC） is adopted. The software uses fixed bootstrap and mutable update program, and thus the embedded devices can still normally start in case of update failure. Finally, high stability and extensive adaptability of the system are verified by experimental data.展开更多
Histopathologic diversity and several distinct histologic subtypes of hepatocellular carcinoma(HCC) are well-recognized. Recent advances in molecular pathology and growing knowledge about the biology associated with d...Histopathologic diversity and several distinct histologic subtypes of hepatocellular carcinoma(HCC) are well-recognized. Recent advances in molecular pathology and growing knowledge about the biology associated with distinct histologic features and immuno-profile in HCC allowed pathologists to update classifications. Improving sub-classification will allow for more clinically relevant diagnoses and may allow for stratification into biologically meaningful subgroups. Therefore, immuno-histochemical and molecular testing are not only diagnostically useful, but also are being incorporated as crucial components in predicting prognosis of the patients with HCC. Possibilities of targeted therapy are being explored in HCC, and it will be important for pathologists to provide any data that may be valuable from a theranostic perspective. Herein, we review and provide updates regarding the pathologic sub-classification of HCC.Pathologic diagnostic approach and the role of biomarkers as prognosticators are reviewed. Further, the histopathology of four particular subtypes of HCC:Steatohepatitic, clear cell, fibrolamellar and scirrhous-and their clinical relevance, and the recent consensus on combined HCC-cholangiocarcinoma is summarized. Finally, emerging novel biomarkers and new approaches to HCC stratification are reviewed.展开更多
An Extended Kalman Filter（EKF） is commonly used to fuse raw Global Navigation Satellite System（GNSS） measurements and Inertial Navigation System（INS） derived measurements. However, the Conventional EKF（CEKF） s...An Extended Kalman Filter（EKF） is commonly used to fuse raw Global Navigation Satellite System（GNSS） measurements and Inertial Navigation System（INS） derived measurements. However, the Conventional EKF（CEKF） suffers the problem for which the uncertainty of the statistical properties to dynamic and measurement models will degrade the performance.In this research, an Adaptive Interacting Multiple Model（AIMM） filter is developed to enhance performance. The soft-switching property of Interacting Multiple Model（IMM） algorithm allows the adaptation between two levels of process noise, namely lower and upper bounds of the process noise. In particular, the Sage adaptive filtering is applied to adapt the measurement covariance on line. In addition, a classified measurement update strategy is utilized, which updates the pseudorange and Doppler observations sequentially. A field experiment was conducted to validate the proposed algorithm, the pseudorange and Doppler observations from Global Positioning System（GPS） and Bei Dou Navigation Satellite System（BDS） were post-processed in differential mode.The results indicate that decimeter-level positioning accuracy is achievable with AIMM for GPS/INS and GPS/BDS/INS configurations, and the position accuracy is improved by 35.8%, 34.3% and 33.9% for north, east and height components, respectively, compared to the CEKF counterpartfor GPS/BDS/INS. Degraded performance for BDS/INS is obtained due to the lower precision of BDS pseudorange observations.展开更多
Vaccination is the main prophylactic measure to reduce the mortality caused by hepatitis B virus (HBV) infection in healthy subjects since the immune response to hepatitis B recombinant vaccination occurs in over 90% ...Vaccination is the main prophylactic measure to reduce the mortality caused by hepatitis B virus (HBV) infection in healthy subjects since the immune response to hepatitis B recombinant vaccination occurs in over 90% of general population. Individuals who develop an anti-HBs titer less than 10 mIU/mL after primary vaccination cycle are defined “no responders”. Many factors could cause a non response to the HBV vaccination, such as administration of the vaccine in buttocks, impaired vaccine storage conditions, drug abuse, smoking, infections and obesity. Moreover there are some diseases, like chronic kidney disease, human immunodeficiency virus infection, chronic liver disease, celiac disease, thalassaemia, type I diabetes mellitus, down’s syndrome and other forms of mental retardation that are characterized by a poorer response to HBV vaccination than healthy subjects. To date it is still unclear how to treat this group of patients at high risk of hepatitis B infection. Recent studies seem to indicate that the administration of HBV recombinant vaccine by the intradermal route is very effective and could represent a more useful strategy than intramuscular route. This review focuses on the use of anti hepatitis B vaccine by intradermal route as alternative to conventional intramuscular vaccine in all non responder patients. A comprehensive review of the literature using PubMed database, with appropriate terms, was undertaken for articles in English published since 1983. The literature search was undertaken in September 2013.展开更多
Cancer is a major public health issue in most of countries, including China. Accurate and valid information on cancer incidence, mortality, survival and relevant factors is irreplaceable for cancer prevention and cont...Cancer is a major public health issue in most of countries, including China. Accurate and valid information on cancer incidence, mortality, survival and relevant factors is irreplaceable for cancer prevention and control. Since the national program of cancer registry was launched by the Ministry of Health of China in 2008, the National Central Cancer Registry （NCCR） has been releasing the cancer incidence and mortality based on the data collected from cancer registries supported by the program. The cancer statistics provide current data from registered areas and aims to accurately reflect the cancer burden and epidemic in China. In 2014, the NCCR collected data for calendar year 2011 from 234 registries. After comprehensive quality＇ evaluation, data from 177 registries have been selected as sources of the reports reflecting cancer incidence and mortaliD, in the registration areas in 2011. These reports are the updated cancer statistics so far, covering much more registries and a hig population.展开更多
The year 2020 was welcomed and characterized with a report of pneumonia of unknown etiology,which occurred primarily in Wuhan City of Hubei Province of China.Between 31 December 2019 and 3 January 2020,a total of 44 c...The year 2020 was welcomed and characterized with a report of pneumonia of unknown etiology,which occurred primarily in Wuhan City of Hubei Province of China.Between 31 December 2019 and 3 January 2020,a total of 44 cases in human was reported to the World Health Organization(WHO)by the Chinese Health Authorities[1].By 3 February 2020,a total of 17391 cases have been confirmed globally with 2838 new cases(China:17238;2831 new cases and 361 deaths;Outside China:153 with 7 new cases and 1 death from 23 countries)[1].展开更多
基金supported by the National Key Research and Development Program of China under Grant 2022YFB2901501in part by the Science and Technology Innovation leading Talents Subsidy Project of Central Plains under Grant 244200510038.
文摘The rapid growth of distributed data-centric applications and AI workloads increases demand for low-latency,high-throughput communication,necessitating frequent and flexible updates to network routing configurations.However,maintaining consistent forwarding states during these updates is challenging,particularly when rerouting multiple flows simultaneously.Existing approaches pay little attention to multi-flow update,where improper update sequences across data plane nodes may construct deadlock dependencies.Moreover,these methods typically involve excessive control-data plane interactions,incurring significant resource overhead and performance degradation.This paper presents P4LoF,an efficient loop-free update approach that enables the controller to reroute multiple flows through minimal interactions.P4LoF first utilizes a greedy-based algorithm to generate the shortest update dependency chain for the single-flow update.These chains are then dynamically merged into a dependency graph and resolved as a Shortest Common Super-sequence(SCS)problem to produce the update sequence of multi-flow update.To address deadlock dependencies in multi-flow updates,P4LoF builds a deadlock-fix forwarding model that leverages the flexible packet processing capabilities of the programmable data plane.Experimental results show that P4LoF reduces control-data plane interactions by at least 32.6%with modest overhead,while effectively guaranteeing loop-free consistency.
基金supported by the Institute of Information&communications Technology Planning&Evaluation(IITP)grant funded by the Korea government(MSIT)(RS-2024-00399401,Development of Quantum-Safe Infrastructure Migration and Quantum Security Verification Technologies).
文摘With the rise of remote collaboration,the demand for advanced storage and collaboration tools has rapidly increased.However,traditional collaboration tools primarily rely on access control,leaving data stored on cloud servers vulnerable due to insufficient encryption.This paper introduces a novel mechanism that encrypts data in‘bundle’units,designed to meet the dual requirements of efficiency and security for frequently updated collaborative data.Each bundle includes updated information,allowing only the updated portions to be reencrypted when changes occur.The encryption method proposed in this paper addresses the inefficiencies of traditional encryption modes,such as Cipher Block Chaining(CBC)and Counter(CTR),which require decrypting and re-encrypting the entire dataset whenever updates occur.The proposed method leverages update-specific information embedded within data bundles and metadata that maps the relationship between these bundles and the plaintext data.By utilizing this information,the method accurately identifies the modified portions and applies algorithms to selectively re-encrypt only those sections.This approach significantly enhances the efficiency of data updates while maintaining high performance,particularly in large-scale data environments.To validate this approach,we conducted experiments measuring execution time as both the size of the modified data and the total dataset size varied.Results show that the proposed method significantly outperforms CBC and CTR modes in execution speed,with greater performance gains as data size increases.Additionally,our security evaluation confirms that this method provides robust protection against both passive and active attacks.
基金supported by the National Natural Science Foundation of China(Nos.52164001,52064006,52004072 and 52364004)the Science and Technology Support Project of Guizhou(Nos.[2020]4Y044,[2021]N404 and[2021]N511)+1 种基金the Guizhou Provincial Science and Technology Foundation(No.GCC[2022]005-1),Talents of Guizhou University(No.201901)the Special Research Funds of Guizhou University(Nos.201903,202011,and 202012).
文摘With the widespread adoption of hydraulic fracturing technology in oil and gas resource development,improving the accuracy and efficiency of fracturing simulations has become a critical research focus.This paper proposes an improved fluid flow algorithm,aiming to enhance the computational efficiency of hydraulic fracturing simulations while ensuring computational accuracy.The algorithm optimizes the aperture law and iteration criteria,focusing on improving the domain volume and crack pressure update strategy,thereby enabling precise capture of dynamic borehole pressure variations during injection tests.The effectiveness of the algorithm is verified through three flow-solid coupling cases.The study also analyzes the effects of borehole size,domain volume,and crack pressure update strategy on fracturing behavior.Furthermore,the performance of the improved algorithm in terms of crack propagation rate,micro-crack formation,and fluid pressure distribution was further evaluated.The results indicate that while large-size boreholes delay crack initiation,the cracks propagate more rapidly once formed.Additionally,the optimized domain volume calculation and crack pressure update strategy significantly shorten the pressure propagation stage,promote crack propagation,and improve computational efficiency.
文摘The Chinese Society of Clinical Oncology Non-small Cell Lung Cancer(CSCO NSCLC)guidelines were first published in 2016,ranking among the earliest-released guidelines within the CSCO series.In 2020 the CSCO published separate guidelines for NSCLC and small cell lung cancer(SCLC)for the first time to improve clinical usability.
基金supported by Korea Institute of Energy Technology Evaluation and Planning(KETEP)grant funded by the Korea government(MOTIE)(No.20224B10300090)supported by the MSIT(Ministry of Science and ICT),Republic of Korea,under the ITRC(Information Technology Research Center)support program(IITP-2025-RS-2021-II211835)supervised by the IITP(Institute of Information&Communications Technology Planning&Evaluation).
文摘As vehicular networks become increasingly pervasive,enhancing connectivity and reliability has emerged as a critical objective.Among the enabling technologies for advanced wireless communication,particularly those targeting low latency and high reliability,time synchronization is critical,especially in vehicular networks.However,due to the inherent mobility of vehicular environments,consistently exchanging synchronization packets with a fixed base station or access point is challenging.This issue is further exacerbated in signal shadowed areas such as urban canyons,tunnels,or large-scale indoor hallswhere other technologies,such as global navigation satellite system(GNSS),are unavailable.One-way synchronization techniques offer a feasible approach under such transient connectivity conditions.One-way schemes still suffer from long convergence times to reach the required synchronization accuracy in these circumstances.In this paper,we propose a WLAN-based multi-stage clock synchronization scheme(WMC)tailored for vehicular networks.The proposed method comprises an initial hard update stage to rapidly achieve synchronization,followed by a high-precision stable stage based on Maximum Likelihood Estimation(MLE).By implementing the scheme directly at the network driver,we address key limitations of hard update mechanisms.Our approach significantly reduces the initial period to collect high-quality samples and offset estimation time to reach sub-50μs accuracy,and subsequently transitions to a refined MLE-based synchronization stage,achieving stable accuracy at approximately 30μs.The windowed moving average stabilized(reaching 90%of the baseline)in approximately 35 s,which corresponds to just 5.1%of the baseline time accuracy.Finally,the impact of synchronization performance on the localization model was validated using the Simulation of Urban Mobility(SUMO).The results demonstrate that more accurate conditions for position estimation can be supported,with an improvement about 38.5%in the mean error.
基金supported by the National Natural Science Foundation of China(No.82373415)Beijing Xisike Clinical Oncology Research Foundation(No.Ytongshu2021/ms-0003)。
文摘Colorectal cancer(CRC)is the most frequently diagnosed malignancy of the digestive system and the second leading cause of cancer-related deaths worldwide(1).In China,CRC ranks as the second most common cancer with incidence and mortality rates continuing to rise(2).The Chinese Society of Clinical Oncology(CSCO)first introduced its guidelines in 2017,and since then,they have been updated annually to incorporate the latest clinical research findings,drug availability,and expert consensus(3-8).This article presents the key updates in the 2025 edition compared to the 2024 version.
基金supported by the Natural Science Research Project of Colleges and Universities in Anhui Province (No.KJ2021A0479)the Science Research Program of Anhui University of Finance and Economics (No.ACKYC22082)。
文摘We present a gain adaptive tuning method for fiber Raman amplifier(FRA) using two-stage neural networks(NNs) and double weights updates. After training the connection weights of two-stage NNs separately in training phase, the connection weights of the unified NN are updated again in verification phase according to error between the predicted and target gains to eliminate the inherent error of the NNs. The simulation results show that the mean of root mean square error(RMSE) and maximum error of gains are 0.131 d B and 0.281 d B, respectively. It shows that the method can realize adaptive adjustment function of FRA gain with high accuracy.
基金Supported by the National Natural Science Foundation of China under Grant No.60904063Tianjin Municipal Natural Science Foundation under Grant No.11JCYBJC06600+1 种基金the Development Fund of Science and Technology for the Higher Education in Tianjin under Grant No.20090813the 7th Overseas Training Project for the Young and Middle Teachers in Tianjin Municipal Universities
文摘We combine the Fermi and Moran update rules in the spatial prisoner＇s dilemma and snowdrift games to investigate the behavior of collective cooperation among agents on the regular lattice. Large-scale simulations indicate that, compared to the model with only one update rule, the the role of update dynamics should be paid more attention in cooperation behavior exhibits the richer phenomena, and the evolutionary game theory. Meanwhile, we also observe that the introduction of Moran rule, which needs to consider all neighbor＇s information, can markedly promote the aggregate cooperation level, that is, randomly selecting the neighbor proportional to its payoff to imitate will facilitate the cooperation among agents. Current results will contribute to further understand the cooperation dynamics and evolutionary behaviors within many biological, economic and social systems.
文摘The authors will examine prediction of temperature daily profile using various modifications of BPTT （backpropagation through time algorithm） done by stochastic update in the artificial RCNN （recurrent neural networks）. The general introduction was provided by Salvetti and Wilamowski in 1994 in order to improve probability of convergence and speed of convergence. This update method has also one another quality, its implementation is simple for arbitrary network topology. In stochastic update scenario, constant number of weights/neurons is randomly selected and updated. This is in contrast to classical ordered update, where always all weights/neurons are updated. Stochastic update is suitable to replace classical ordered update without any penalty on implementation complexity and with good chance without penalty on quality of convergence. They have provided first experiments with stochastic modification on BP （backpropagation algorithm） used for artificial FFNN （feed-forward neural network） in detail described in the article ＂Stochastic Weight Update in the Backpropagation Algorithm on Feed-Forward Neural Networks＂ presented on the conference IJCNN （International Joint Conference of Neural Networks） 2010 in Barcelona. The BPTT on RCNN uses the history of previous steps stored inside of the NN that can be used for prediction. They will describe exact implementation on the RCNN, and present experiment results on temperature prediction with recurrent neural network topology. The dataset used for temperature prediction consists of the measured temperature from the year 2000 till the end of February 2011. Dataset is split into two groups： training dataset, which is provided to network in learning phase, and testing dataset, which is unknown part of dataset to NN and used to test the ability of NN to predict the temperature and the ability of NN to generalize the model hidden in the temperature profile. The results show promising properties of stochastic weight update with toy-task data, and the higher complexity of the temperature daily profile prediction.
文摘Aiming at the inaccessible problem of remote embedded devices update and maintenance, this paper presents a method using general packet radio service （GPRS） to achieve update based on the embedded real-time operating system （RTOS） μC/OS-Ⅱ. It introduces architecture of the system first. And then it uses LPC1768 chip as the central processing unit, SIM900A module for data transmission, and SST25VF016B to store the data. To ensure accuracy of the data transmis- sion, cyclic redundancy code （CRC） is adopted. The software uses fixed bootstrap and mutable update program, and thus the embedded devices can still normally start in case of update failure. Finally, high stability and extensive adaptability of the system are verified by experimental data.
文摘Histopathologic diversity and several distinct histologic subtypes of hepatocellular carcinoma(HCC) are well-recognized. Recent advances in molecular pathology and growing knowledge about the biology associated with distinct histologic features and immuno-profile in HCC allowed pathologists to update classifications. Improving sub-classification will allow for more clinically relevant diagnoses and may allow for stratification into biologically meaningful subgroups. Therefore, immuno-histochemical and molecular testing are not only diagnostically useful, but also are being incorporated as crucial components in predicting prognosis of the patients with HCC. Possibilities of targeted therapy are being explored in HCC, and it will be important for pathologists to provide any data that may be valuable from a theranostic perspective. Herein, we review and provide updates regarding the pathologic sub-classification of HCC.Pathologic diagnostic approach and the role of biomarkers as prognosticators are reviewed. Further, the histopathology of four particular subtypes of HCC:Steatohepatitic, clear cell, fibrolamellar and scirrhous-and their clinical relevance, and the recent consensus on combined HCC-cholangiocarcinoma is summarized. Finally, emerging novel biomarkers and new approaches to HCC stratification are reviewed.
基金co-supported by the National Key Research and Development Program of China(No.2016YFC0803103)Beijing Advanced Innovation Center for Future Urban Design(No.UDC2016050100)Beijing Postdoctoral Research Foundation
文摘An Extended Kalman Filter（EKF） is commonly used to fuse raw Global Navigation Satellite System（GNSS） measurements and Inertial Navigation System（INS） derived measurements. However, the Conventional EKF（CEKF） suffers the problem for which the uncertainty of the statistical properties to dynamic and measurement models will degrade the performance.In this research, an Adaptive Interacting Multiple Model（AIMM） filter is developed to enhance performance. The soft-switching property of Interacting Multiple Model（IMM） algorithm allows the adaptation between two levels of process noise, namely lower and upper bounds of the process noise. In particular, the Sage adaptive filtering is applied to adapt the measurement covariance on line. In addition, a classified measurement update strategy is utilized, which updates the pseudorange and Doppler observations sequentially. A field experiment was conducted to validate the proposed algorithm, the pseudorange and Doppler observations from Global Positioning System（GPS） and Bei Dou Navigation Satellite System（BDS） were post-processed in differential mode.The results indicate that decimeter-level positioning accuracy is achievable with AIMM for GPS/INS and GPS/BDS/INS configurations, and the position accuracy is improved by 35.8%, 34.3% and 33.9% for north, east and height components, respectively, compared to the CEKF counterpartfor GPS/BDS/INS. Degraded performance for BDS/INS is obtained due to the lower precision of BDS pseudorange observations.
文摘Vaccination is the main prophylactic measure to reduce the mortality caused by hepatitis B virus (HBV) infection in healthy subjects since the immune response to hepatitis B recombinant vaccination occurs in over 90% of general population. Individuals who develop an anti-HBs titer less than 10 mIU/mL after primary vaccination cycle are defined “no responders”. Many factors could cause a non response to the HBV vaccination, such as administration of the vaccine in buttocks, impaired vaccine storage conditions, drug abuse, smoking, infections and obesity. Moreover there are some diseases, like chronic kidney disease, human immunodeficiency virus infection, chronic liver disease, celiac disease, thalassaemia, type I diabetes mellitus, down’s syndrome and other forms of mental retardation that are characterized by a poorer response to HBV vaccination than healthy subjects. To date it is still unclear how to treat this group of patients at high risk of hepatitis B infection. Recent studies seem to indicate that the administration of HBV recombinant vaccine by the intradermal route is very effective and could represent a more useful strategy than intramuscular route. This review focuses on the use of anti hepatitis B vaccine by intradermal route as alternative to conventional intramuscular vaccine in all non responder patients. A comprehensive review of the literature using PubMed database, with appropriate terms, was undertaken for articles in English published since 1983. The literature search was undertaken in September 2013.
文摘Cancer is a major public health issue in most of countries, including China. Accurate and valid information on cancer incidence, mortality, survival and relevant factors is irreplaceable for cancer prevention and control. Since the national program of cancer registry was launched by the Ministry of Health of China in 2008, the National Central Cancer Registry （NCCR） has been releasing the cancer incidence and mortality based on the data collected from cancer registries supported by the program. The cancer statistics provide current data from registered areas and aims to accurately reflect the cancer burden and epidemic in China. In 2014, the NCCR collected data for calendar year 2011 from 234 registries. After comprehensive quality＇ evaluation, data from 177 registries have been selected as sources of the reports reflecting cancer incidence and mortaliD, in the registration areas in 2011. These reports are the updated cancer statistics so far, covering much more registries and a hig population.
文摘The year 2020 was welcomed and characterized with a report of pneumonia of unknown etiology,which occurred primarily in Wuhan City of Hubei Province of China.Between 31 December 2019 and 3 January 2020,a total of 44 cases in human was reported to the World Health Organization(WHO)by the Chinese Health Authorities[1].By 3 February 2020,a total of 17391 cases have been confirmed globally with 2838 new cases(China:17238;2831 new cases and 361 deaths;Outside China:153 with 7 new cases and 1 death from 23 countries)[1].
