Mantle cell lymphoma(MCL)is recognized as one of the most genetically heterogeneous diseases,with high instability at the genomic level.MCL is common in males with a male-to-female ratio of about 2:1,and its incidence...Mantle cell lymphoma(MCL)is recognized as one of the most genetically heterogeneous diseases,with high instability at the genomic level.MCL is common in males with a male-to-female ratio of about 2:1,and its incidence accounts for 3%e10%of adult non-Hodgkin lymphoma cases.The evolutionary dynamics of MCL clones at the single-cell level remain largely unclear.Our research suggests that MCL may arise from multiple cells within the abnormal microenvironment of the entire hematopoietic lineage,particularly from initiating cells.These initiating cells predominantly consist of CD19^(-)/IgM^(-) subclones and exhibit a disrupted malignant clonal differentiation of pre-B cells along the tumor immunity evolution tree.展开更多
基金funded by the Chongqing Medical Scientific Research Project(Joint Project of Chongqing Health Commission and Science and Technology Bureau,China)(No.2023GGXM006,2024ZDXM026,2024MSXM115)the Key Research Project from Science and Technology Department of Sichuan Province,China(No.2019YFS0301)+3 种基金the Chongqing Key Municipal Public Health Specialty Construction Project(China)the Key Research Project from Chongqing Medical and Pharmaceutical Vocational Education Group(China)(No.CQZJ202329)the Incubation Project of the First Affiliated Hospital of Chongqing Medical and Pharmaceutical College(China)(No.2022-2023ZD04,2022-2023ZD03,2022-2023MS04,2022-2023MS03,2022-2023MS010)the Science and Technology Research Program of Chongqing Education Commission(China)(No.KJQN202302811).
文摘Mantle cell lymphoma(MCL)is recognized as one of the most genetically heterogeneous diseases,with high instability at the genomic level.MCL is common in males with a male-to-female ratio of about 2:1,and its incidence accounts for 3%e10%of adult non-Hodgkin lymphoma cases.The evolutionary dynamics of MCL clones at the single-cell level remain largely unclear.Our research suggests that MCL may arise from multiple cells within the abnormal microenvironment of the entire hematopoietic lineage,particularly from initiating cells.These initiating cells predominantly consist of CD19^(-)/IgM^(-) subclones and exhibit a disrupted malignant clonal differentiation of pre-B cells along the tumor immunity evolution tree.
