Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal function.In a healthy spinal cord,microglia are accou...Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal function.In a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal regeneration.In this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor cells.Despite a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive research.This review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.展开更多
目的:基于SEER数据库的宫颈癌患者影响因素分析,分析影响宫颈癌预后的相关因素,为宫颈癌患者预后恢复及治疗提供科学参考依据。方法:利用SEER数据库初步筛查宫颈癌相关数据,从中下载所有符合研究的宫颈癌患者的不同病理分型的数据,选用...目的:基于SEER数据库的宫颈癌患者影响因素分析,分析影响宫颈癌预后的相关因素,为宫颈癌患者预后恢复及治疗提供科学参考依据。方法:利用SEER数据库初步筛查宫颈癌相关数据,从中下载所有符合研究的宫颈癌患者的不同病理分型的数据,选用第八期T,N,M分期对数据的T,N,M分期进行整理,标准化,筛选,筛选条件为患者第八期T,N,M分期明确,有符合要求的观察结局,如死亡或存活。通过筛查出的患者的不同病理分型的数据,运用SPSS26.0统计软件进行统计描述,采用Kaplan-Meier法。描绘生存曲线并估计患者的生存率,死亡率。生存时间分布的组间比较采用Log-Rank检验,对分析结果中P α = 0.05,以P Objective: Study on the prognostic risk model of cervical cancer patients based on SEER database, analyze the relevant factors affecting the prognosis of cervical cancer, and provide scientific reference for the prognosis recovery and treatment of cervical cancer patients. Methods: The SEER database was used to preliminarily screen the data related to cervical cancer, download the data of different pathological types of cervical cancer patients in line with the study, and select the eighth stage T, N, M to sort out, standardize and screen the T, N and M stages of the data. The screening conditions were that the eighth stage T, N and M stages of patients were clear, and there were satisfactory observed outcomes, such as death or survival. Through the data of different pathological types of patients screened, spss26 0 statistical software for statistical description, using Kaplan Meier method. Draw the survival curve and estimate the survival rate and mortality of patients. The inter group comparison of survival time distribution adopts log rank test to conduct multi factor Cox analysis on the variables with statistical significance of P α = 0.05, P < 0.05. Result: (1) Kaplan Meier univariate analysis: different pathological stages of T stage, N stage and M stage have an impact on the survival of patients, which is statistically significant (P < 0.05), and can affect the survival of patients to varying degrees. (2) Cox multivariate analysis: T stage, N stage and M stage were independent prognostic factors affecting the survival time of patients. Conclusion: Different T, N and M pathological stages of different cervical cancer patients can affect the prognosis of cervical cancer patients to varying degrees. They have a significant impact on the mortality and survival rate of cervical cancer patients, and can provide relevant basis for the development and improvement of the treatment scheme of cervical cancer.展开更多
BACKGROUND Hepatitis B cirrhosis(HBC)is a chronic disease characterized by irreversible diffuse liver damage and aggravated by intestinal microbial imbalance and metabolic dysfunction.Although the relationship between...BACKGROUND Hepatitis B cirrhosis(HBC)is a chronic disease characterized by irreversible diffuse liver damage and aggravated by intestinal microbial imbalance and metabolic dysfunction.Although the relationship between certain single probiotics and HBC has been explored,the impact of the complex ready-to-eat Lactobacillus paracasei N1115(LP N1115)supplement on patients with HBC has not been determined.AIM To compare the changes in the microbiota,inflammatory factor levels,and liver function before and after probiotic treatment in HBC patients.METHODS This study included 160 HBC patients diagnosed at the General Hospital of Ningxia Medical University between October 2018 and December 2020.Patients were randomly divided into an intervention group that received LP N1115 supplementation and routine treatment and a control group that received routine treatment only.Fecal samples were collected at the onset and conclusion of the 12-wk intervention period.The structure of the intestinal microbiota and the levels of serological indicators,such as liver function and inflammatory factors,were assessed.RESULTS Following LP N1115 intervention,the intestinal microbial diversity significantly increased in the intervention group(P<0.05),and the structure of the intestinal microbiota was characterized by an increase in the proportions of probiotic microbes and a reduction in harmful bacteria.Additionally,the intervention group demonstrated notable improvements in liver function indices and significantly lower levels of inflammatory factors(P<0.05).CONCLUSION LP N1115 is a promising treatment for ameliorating intestinal microbial imbalance in HBC patients by modulating the structure of the intestinal microbiota,improving liver function,and reducing inflammatory factor levels.展开更多
RNA contains diverse post-transcriptional modifications,and its catabolic breakdown yields numerous modified nucleosides requiring correct processing,but the mechanisms remain unknown.Here,we demonstrate that three RN...RNA contains diverse post-transcriptional modifications,and its catabolic breakdown yields numerous modified nucleosides requiring correct processing,but the mechanisms remain unknown.Here,we demonstrate that three RNA-derived modified adenosines,N6-methyladenosine(m6A),N6,N6-dimethyladenosine(m6,6A),and N6-isopentenyladenosine(i6A),are sequentially metabolized into inosine monophosphate(IMP)to mitigate their intrinsic cytotoxicity.展开更多
Phytoplankton play a crucial role in maintaining the health of river ecosystems,and their communities are closely linked to river hydrodynamics.In inland waterways,disturbances generated by ship propellers alter flow ...Phytoplankton play a crucial role in maintaining the health of river ecosystems,and their communities are closely linked to river hydrodynamics.In inland waterways,disturbances generated by ship propellers alter flow dynamics and may affect phytoplankton communities.To clarify it,phytoplankton communities in the Zhenjiang section of the Beijing-Hangzhou Grand Canal(BHGC)in China,the world's longest canal,were studied and compared them with its undisturbed tributaries.The results revealed major alternations in seasonal patterns of phytoplankton communities in the BHGC,shifting the peak of phytoplankton density from spring to autumn and the lowest diversity from summer to autumn.Ship disturbances increased water turbidity and created optimal N/P ratios,which provided Cyanobacteria with a competitive advantage in autumn.The proliferation of Cyanobacteria resulted in a phytoplankton density in the BHGC,exceeding that in the tributaries by more than tenfold,accompanied by a decrease in diversity to its lowest level.Due to habitat alterations,functional groups emerged that are resilient to strong disturbances and high turbidity.The findings add to the understanding of the impact of ship traffic on river ecosystems.展开更多
Aiming at problems such as large errors and low efficiency in manual counting of drill pipes during drilling depth measurement,an intelligent detection and counting method for the small targets at the end of drill pip...Aiming at problems such as large errors and low efficiency in manual counting of drill pipes during drilling depth measurement,an intelligent detection and counting method for the small targets at the end of drill pipes based on the improved YOLO11n is proposed.This method realizes the high-precision detection of targets at drill pipe ends in the image by optimizing the target detection model,and combines a post-processing correction mechanism to improve the drill pipe counting accuracy.In order to alleviate the low-precision problem of YOLO11n algorithm for small target recognition in the complex underground background,the YOLO11n algorithm is improved.First,the key module C3k2 in the backbone network was improved,and Poly Kernel Inception(PKI)Block was introduced to replace Bottleneck in it to fully integrate the target context information and the model’s capability of feature extraction;Second,within the model’s neck network,a new feature fusion pyramid ISOP(Improved Small Object Pyramid)is proposed,SPDConv is introduced to strengthen the P2 feature,and CSP and OmniKernel are combined to integrate multi-scale features;Finally,the default loss function is substituted with Powerful-IoU(PIoU)to solve the anchor box expansion problem.On the self-built dataset,experimental verification was conducted.The findings showed that the Recall rose by 6.4%,mAP@0.5 increased by 4.5%,and mAP@0.5:0.95 improved by 6%compared with the baseline model,effectively solving the issues of false detection and missed detection problems in small target detection task.Meanwhile,we conducted counting tests on drilling videos from 5 different scenarios,achieving an average accuracy of 97.3%,which meets the accuracy needs for drill pipe recognition and counting in coal mine drilling sites.The research findings offer theoretical basis and technical backing for promoting the intelligent development of coal mine gas extraction drilling sites.展开更多
文摘Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal function.In a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal regeneration.In this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor cells.Despite a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive research.This review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.
文摘目的:基于SEER数据库的宫颈癌患者影响因素分析,分析影响宫颈癌预后的相关因素,为宫颈癌患者预后恢复及治疗提供科学参考依据。方法:利用SEER数据库初步筛查宫颈癌相关数据,从中下载所有符合研究的宫颈癌患者的不同病理分型的数据,选用第八期T,N,M分期对数据的T,N,M分期进行整理,标准化,筛选,筛选条件为患者第八期T,N,M分期明确,有符合要求的观察结局,如死亡或存活。通过筛查出的患者的不同病理分型的数据,运用SPSS26.0统计软件进行统计描述,采用Kaplan-Meier法。描绘生存曲线并估计患者的生存率,死亡率。生存时间分布的组间比较采用Log-Rank检验,对分析结果中P α = 0.05,以P Objective: Study on the prognostic risk model of cervical cancer patients based on SEER database, analyze the relevant factors affecting the prognosis of cervical cancer, and provide scientific reference for the prognosis recovery and treatment of cervical cancer patients. Methods: The SEER database was used to preliminarily screen the data related to cervical cancer, download the data of different pathological types of cervical cancer patients in line with the study, and select the eighth stage T, N, M to sort out, standardize and screen the T, N and M stages of the data. The screening conditions were that the eighth stage T, N and M stages of patients were clear, and there were satisfactory observed outcomes, such as death or survival. Through the data of different pathological types of patients screened, spss26 0 statistical software for statistical description, using Kaplan Meier method. Draw the survival curve and estimate the survival rate and mortality of patients. The inter group comparison of survival time distribution adopts log rank test to conduct multi factor Cox analysis on the variables with statistical significance of P α = 0.05, P < 0.05. Result: (1) Kaplan Meier univariate analysis: different pathological stages of T stage, N stage and M stage have an impact on the survival of patients, which is statistically significant (P < 0.05), and can affect the survival of patients to varying degrees. (2) Cox multivariate analysis: T stage, N stage and M stage were independent prognostic factors affecting the survival time of patients. Conclusion: Different T, N and M pathological stages of different cervical cancer patients can affect the prognosis of cervical cancer patients to varying degrees. They have a significant impact on the mortality and survival rate of cervical cancer patients, and can provide relevant basis for the development and improvement of the treatment scheme of cervical cancer.
基金Supported by The Health System Research Project of Ningxia Hui Autonomous Region of China,No.2022-NWKY-061.
文摘BACKGROUND Hepatitis B cirrhosis(HBC)is a chronic disease characterized by irreversible diffuse liver damage and aggravated by intestinal microbial imbalance and metabolic dysfunction.Although the relationship between certain single probiotics and HBC has been explored,the impact of the complex ready-to-eat Lactobacillus paracasei N1115(LP N1115)supplement on patients with HBC has not been determined.AIM To compare the changes in the microbiota,inflammatory factor levels,and liver function before and after probiotic treatment in HBC patients.METHODS This study included 160 HBC patients diagnosed at the General Hospital of Ningxia Medical University between October 2018 and December 2020.Patients were randomly divided into an intervention group that received LP N1115 supplementation and routine treatment and a control group that received routine treatment only.Fecal samples were collected at the onset and conclusion of the 12-wk intervention period.The structure of the intestinal microbiota and the levels of serological indicators,such as liver function and inflammatory factors,were assessed.RESULTS Following LP N1115 intervention,the intestinal microbial diversity significantly increased in the intervention group(P<0.05),and the structure of the intestinal microbiota was characterized by an increase in the proportions of probiotic microbes and a reduction in harmful bacteria.Additionally,the intervention group demonstrated notable improvements in liver function indices and significantly lower levels of inflammatory factors(P<0.05).CONCLUSION LP N1115 is a promising treatment for ameliorating intestinal microbial imbalance in HBC patients by modulating the structure of the intestinal microbiota,improving liver function,and reducing inflammatory factor levels.
文摘RNA contains diverse post-transcriptional modifications,and its catabolic breakdown yields numerous modified nucleosides requiring correct processing,but the mechanisms remain unknown.Here,we demonstrate that three RNA-derived modified adenosines,N6-methyladenosine(m6A),N6,N6-dimethyladenosine(m6,6A),and N6-isopentenyladenosine(i6A),are sequentially metabolized into inosine monophosphate(IMP)to mitigate their intrinsic cytotoxicity.
基金Jiangsu Provincial Carbon-peak and Carbonneutralization Technology Innovation Project,Grant/Award Number:BK20220041National Natural Science Foundation of China,Grant/Award Numbers:42477073,42277060。
文摘Phytoplankton play a crucial role in maintaining the health of river ecosystems,and their communities are closely linked to river hydrodynamics.In inland waterways,disturbances generated by ship propellers alter flow dynamics and may affect phytoplankton communities.To clarify it,phytoplankton communities in the Zhenjiang section of the Beijing-Hangzhou Grand Canal(BHGC)in China,the world's longest canal,were studied and compared them with its undisturbed tributaries.The results revealed major alternations in seasonal patterns of phytoplankton communities in the BHGC,shifting the peak of phytoplankton density from spring to autumn and the lowest diversity from summer to autumn.Ship disturbances increased water turbidity and created optimal N/P ratios,which provided Cyanobacteria with a competitive advantage in autumn.The proliferation of Cyanobacteria resulted in a phytoplankton density in the BHGC,exceeding that in the tributaries by more than tenfold,accompanied by a decrease in diversity to its lowest level.Due to habitat alterations,functional groups emerged that are resilient to strong disturbances and high turbidity.The findings add to the understanding of the impact of ship traffic on river ecosystems.
基金Henan Province University Science and Technology Innovation Team Support Program Project(22IRTSTHN005)..
文摘Aiming at problems such as large errors and low efficiency in manual counting of drill pipes during drilling depth measurement,an intelligent detection and counting method for the small targets at the end of drill pipes based on the improved YOLO11n is proposed.This method realizes the high-precision detection of targets at drill pipe ends in the image by optimizing the target detection model,and combines a post-processing correction mechanism to improve the drill pipe counting accuracy.In order to alleviate the low-precision problem of YOLO11n algorithm for small target recognition in the complex underground background,the YOLO11n algorithm is improved.First,the key module C3k2 in the backbone network was improved,and Poly Kernel Inception(PKI)Block was introduced to replace Bottleneck in it to fully integrate the target context information and the model’s capability of feature extraction;Second,within the model’s neck network,a new feature fusion pyramid ISOP(Improved Small Object Pyramid)is proposed,SPDConv is introduced to strengthen the P2 feature,and CSP and OmniKernel are combined to integrate multi-scale features;Finally,the default loss function is substituted with Powerful-IoU(PIoU)to solve the anchor box expansion problem.On the self-built dataset,experimental verification was conducted.The findings showed that the Recall rose by 6.4%,mAP@0.5 increased by 4.5%,and mAP@0.5:0.95 improved by 6%compared with the baseline model,effectively solving the issues of false detection and missed detection problems in small target detection task.Meanwhile,we conducted counting tests on drilling videos from 5 different scenarios,achieving an average accuracy of 97.3%,which meets the accuracy needs for drill pipe recognition and counting in coal mine drilling sites.The research findings offer theoretical basis and technical backing for promoting the intelligent development of coal mine gas extraction drilling sites.
