人类ether-à-go-go相关基因(human ether-à-go-go related gene,hERG)亚家族H成员2(KCNH2)所编码的快速激活延迟整流钾离子通道,是许多药物心脏毒性的靶标。药物诱导性长QT间期综合征(drug-induced long QT syndrome,diLQTS)...人类ether-à-go-go相关基因(human ether-à-go-go related gene,hERG)亚家族H成员2(KCNH2)所编码的快速激活延迟整流钾离子通道,是许多药物心脏毒性的靶标。药物诱导性长QT间期综合征(drug-induced long QT syndrome,diLQTS)是由各类抗心律失常药、抗生素、抗组胺药、抗精神病药和血管扩张药等一个或多个脱靶相互作用而诱导的QT间期延长的病理状态。男性校正后的QT间期(QTc)>450 ms、女性QTc>460 ms是diLQTS心电图的临床表征之一。这种获得性长QT间期综合征容易诱发尖端扭转型室性心动过速,继而进展为心室颤动甚至心脏性猝死。本文从化学结构、心电图学、生物学、电生理学和分子生物学这几方面,综述hERG在diLQTS发生发展中的作用。展开更多
Rare earth elements (REEs) are beneficial in developing modern technologies, especially electronics. Their extractions from natural deposits and their recycling require chemical processes that should be monitored rega...Rare earth elements (REEs) are beneficial in developing modern technologies, especially electronics. Their extractions from natural deposits and their recycling require chemical processes that should be monitored regarding efficiency and environmental sustainability. The purpose of this study is to develop impedimetric sensors for the sensitive detection of the rare earth elements La and Ce by modifying a platinum electrode with four isosorbide-based oligo (ether sulfone)s. These oligomers, functionalized with different end groups (hydroxyl, fluor, amine, maleimide), were obtained with satisfactory yields, starting from isosorbide and bis (4-fuorophenyl) sulphone monomers. The resulting oligomers were characterized by NMR, DSC, and ATG analysis. The dihydroxy-oligo (ether sulfone) modified sensor showed the highest analytical performance compared to the other oligomers. The detection limit is 10−9 M for La and 3 × 10−9 M for Ce which is lower than that of most of the published electrochemical sensors.展开更多
文摘人类ether-à-go-go相关基因(human ether-à-go-go related gene,hERG)亚家族H成员2(KCNH2)所编码的快速激活延迟整流钾离子通道,是许多药物心脏毒性的靶标。药物诱导性长QT间期综合征(drug-induced long QT syndrome,diLQTS)是由各类抗心律失常药、抗生素、抗组胺药、抗精神病药和血管扩张药等一个或多个脱靶相互作用而诱导的QT间期延长的病理状态。男性校正后的QT间期(QTc)>450 ms、女性QTc>460 ms是diLQTS心电图的临床表征之一。这种获得性长QT间期综合征容易诱发尖端扭转型室性心动过速,继而进展为心室颤动甚至心脏性猝死。本文从化学结构、心电图学、生物学、电生理学和分子生物学这几方面,综述hERG在diLQTS发生发展中的作用。
文摘Rare earth elements (REEs) are beneficial in developing modern technologies, especially electronics. Their extractions from natural deposits and their recycling require chemical processes that should be monitored regarding efficiency and environmental sustainability. The purpose of this study is to develop impedimetric sensors for the sensitive detection of the rare earth elements La and Ce by modifying a platinum electrode with four isosorbide-based oligo (ether sulfone)s. These oligomers, functionalized with different end groups (hydroxyl, fluor, amine, maleimide), were obtained with satisfactory yields, starting from isosorbide and bis (4-fuorophenyl) sulphone monomers. The resulting oligomers were characterized by NMR, DSC, and ATG analysis. The dihydroxy-oligo (ether sulfone) modified sensor showed the highest analytical performance compared to the other oligomers. The detection limit is 10−9 M for La and 3 × 10−9 M for Ce which is lower than that of most of the published electrochemical sensors.
