OBJECTIVE: To investigate the effects of warming moxibustion Tianshu(ST 25, bilateral) and Qihai(CV6) in patients with diarrhea-dominant irritable bowel syndrome(D-IBS) by assessing predominant factors, and determinin...OBJECTIVE: To investigate the effects of warming moxibustion Tianshu(ST 25, bilateral) and Qihai(CV6) in patients with diarrhea-dominant irritable bowel syndrome(D-IBS) by assessing predominant factors, and determining the best factor combinations and their interactions. To identify the optimal quantity of warming moxibustion Tianshu(ST 25, bilateral) and Qihai(CV 6) to achieve optimal efficacy.METHODS: An L9(3~4) orthogonal design was applied to 233 confirmed subjects based on the three most influential factors and the three most frequently used levels. Nine programs were designed.Subjects were assigned to four subgroups according to age and gender; each subject underwent one of the nine programs randomly. We selected Tianshu(ST 25, bilateral) and Qihai(CV 6). The scores of symptoms and the IBS Quality of Life(IBS-QOL) were evaluated after the final treatment.RESULTS: After treatment, clinical symptoms of all patients were significantly improved(P = 0.001).Quality of life also improved significantly(P < 0.05).For all the participants, frequency was the dominating factor regarding symptoms(P = 0.01). Duration was the dominating factor for quality of life(P =0.0001). The best combination for improving symptoms in 30-40-year-old male and female patients was two courses of 10 min each once a day, and for41-50-year-old male and female patients it was three courses of 10 min(males) or 30 min(females)twice a day. The best combination for quality of life was three courses of 20 min once a day. No interaction was found between frequency and course, or frequency and duration.CONCLUSION: Warming moxibustion Tianshu(ST25, bilateral) and Qihai(CV 6) is a promising therapy for D-IBS. To acquire optimal efficacy, the three main factors(duration, frequency and treatment course) of the warming moxibustion should reach a specific quantity and be combined appropriately.展开更多
目的:研究麻子仁增液汤联合针刺天枢穴治疗脑卒中后便秘临床疗效。方法:选取2022年3月至2024年5月期间本院收治的102例脑卒中后便秘患者作为研究对象,采用随机数字表法分为对照组和观察组,各51例。对照组采用针刺天枢穴治疗;观察组在对...目的:研究麻子仁增液汤联合针刺天枢穴治疗脑卒中后便秘临床疗效。方法:选取2022年3月至2024年5月期间本院收治的102例脑卒中后便秘患者作为研究对象,采用随机数字表法分为对照组和观察组,各51例。对照组采用针刺天枢穴治疗;观察组在对照组的基础上服用麻子仁增液汤治疗。分析比较两组的疗效、中医证候积分、血清学指标(胃动素、5-羟色胺)及生活质量。结果:观察组的治疗有效率明显高于对照组(P<0.05)。治疗后,两组的主症、兼症、总分、5-羟色胺水平、便秘患者生活质量量表(Patient assessment of constipation quality of life,PAC-QOL)评分均比治疗前明显下降,且观察组明显低于对照组(P<0.05);两组的胃动素水平比治疗前明显上升;且观察组明显高于对照组(P<0.05)。结论:麻子仁增液汤联合针刺天枢穴可改善脑卒中后便秘患者症状,提高临床疗效,改善胃动素、5-羟色胺含量,提高生活质量。展开更多
基金Supported by the National Basic Research Program of China(973 Program):Research on Basic Theory and Regularity of Moxibustion(No.2009CB522900)the National Natural Science Foundation of China:Involvement of Sigma-1 Receptor in Analgesic of Moxibustion on Chronic Visceral Hyperalgesia in Irritable bowel syndrome(IBS)-like Rats(No.81303031)+3 种基金the National Natural Science Foundation of China:Study on the Mechanism of Moxibustion Effect on Reconstruction of Post Infectious(PI)-IBS Intestinal Homeostasis via Intestinal Microbiota-Mucosal Immunity(No.81503656)Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function:Effect of Needle Warming Moxibustion on Clinical Effect and Psychological Condition for Female D-IBS(No.14DZ2260500)Shanghai Municipal Commission of Health and Family Planning:Observation on the Curative Effect and Ovarian Hormone Levels as Well as Psychological Condition of Female D-IBS Patients in Child-bearing Stage by Acupuncture&Moxibustion(No.20164Y0151)the Shanghai Sailing Program:and the Mechanism of Central Response in the Treatment of Diarrhea-predominate Irritable Bowel Syndrome by Moxibustion(No.15YF1411200)
文摘OBJECTIVE: To investigate the effects of warming moxibustion Tianshu(ST 25, bilateral) and Qihai(CV6) in patients with diarrhea-dominant irritable bowel syndrome(D-IBS) by assessing predominant factors, and determining the best factor combinations and their interactions. To identify the optimal quantity of warming moxibustion Tianshu(ST 25, bilateral) and Qihai(CV 6) to achieve optimal efficacy.METHODS: An L9(3~4) orthogonal design was applied to 233 confirmed subjects based on the three most influential factors and the three most frequently used levels. Nine programs were designed.Subjects were assigned to four subgroups according to age and gender; each subject underwent one of the nine programs randomly. We selected Tianshu(ST 25, bilateral) and Qihai(CV 6). The scores of symptoms and the IBS Quality of Life(IBS-QOL) were evaluated after the final treatment.RESULTS: After treatment, clinical symptoms of all patients were significantly improved(P = 0.001).Quality of life also improved significantly(P < 0.05).For all the participants, frequency was the dominating factor regarding symptoms(P = 0.01). Duration was the dominating factor for quality of life(P =0.0001). The best combination for improving symptoms in 30-40-year-old male and female patients was two courses of 10 min each once a day, and for41-50-year-old male and female patients it was three courses of 10 min(males) or 30 min(females)twice a day. The best combination for quality of life was three courses of 20 min once a day. No interaction was found between frequency and course, or frequency and duration.CONCLUSION: Warming moxibustion Tianshu(ST25, bilateral) and Qihai(CV 6) is a promising therapy for D-IBS. To acquire optimal efficacy, the three main factors(duration, frequency and treatment course) of the warming moxibustion should reach a specific quantity and be combined appropriately.
文摘目的:研究麻子仁增液汤联合针刺天枢穴治疗脑卒中后便秘临床疗效。方法:选取2022年3月至2024年5月期间本院收治的102例脑卒中后便秘患者作为研究对象,采用随机数字表法分为对照组和观察组,各51例。对照组采用针刺天枢穴治疗;观察组在对照组的基础上服用麻子仁增液汤治疗。分析比较两组的疗效、中医证候积分、血清学指标(胃动素、5-羟色胺)及生活质量。结果:观察组的治疗有效率明显高于对照组(P<0.05)。治疗后,两组的主症、兼症、总分、5-羟色胺水平、便秘患者生活质量量表(Patient assessment of constipation quality of life,PAC-QOL)评分均比治疗前明显下降,且观察组明显低于对照组(P<0.05);两组的胃动素水平比治疗前明显上升;且观察组明显高于对照组(P<0.05)。结论:麻子仁增液汤联合针刺天枢穴可改善脑卒中后便秘患者症状,提高临床疗效,改善胃动素、5-羟色胺含量,提高生活质量。
