武汉地铁某线路四期电动客车在无人驾驶模式下频繁出现牵引受阻故障,信号系统可正常输出目标点与速度码,但列车无法输出牵引力。通过分析车辆运行数据和电路逻辑,确定故障原因为车载控制器(vehicle on board computer,VOBC)有效端切换时...武汉地铁某线路四期电动客车在无人驾驶模式下频繁出现牵引受阻故障,信号系统可正常输出目标点与速度码,但列车无法输出牵引力。通过分析车辆运行数据和电路逻辑,确定故障原因为车载控制器(vehicle on board computer,VOBC)有效端切换时,车辆无人驾驶模式逻辑失效,导致列车进入无控车模式,从而无法输出有效牵引力。该问题可通过增加“或”逻辑扩展信号条件提高冗余性,或者通过简化无人驾驶判断条件来避免逻辑失效。经综合判断,简化无人驾驶判断条件的方法稳定性高、操作难度小,为最优解决方案,可为无人驾驶模式下牵引系统的逻辑优化提供重要依据。展开更多
An effective quality control system is the key to ensuring the quality, safety and efficacy of traditional Chinese medicines(TCMs). However, the current quality standard research lacks top-level design and systematic ...An effective quality control system is the key to ensuring the quality, safety and efficacy of traditional Chinese medicines(TCMs). However, the current quality standard research lacks top-level design and systematic design,mostly based on specific technologies or evaluation methods. To resolve the challenges and questions of quality control of TCMs, a brand-new quality standard system, named "iVarious", was proposed. The system comprises eight elements in a modular format. Meaning of every element was specifically illustrated via corresponding research instances. Furthermore, frankincense study was taken as an example for demonstrating standards and research process, based on the "i Various" system. This system highlighted a holistic strategy for effectiveness,security, integrity and systematization of quality and safety control standards of TCMs. The establishment of"i Various" integrates multi-disciplinary technologies and progressive methods, basis elements and key points of standard construction. The system provides a novel idea and technological demonstration for regulation establishment of TCMs quality standards.展开更多
贵阳轨道交通3号线一期工程全长43.03 km,起于花溪区桐木岭,止于乌当区洛湾,共计29座车站和28个区间。介绍了贵阳地铁3号线列车网络控制及监控系统(Train Control and Monitoring System,TCMS)的结构和功能,阐述了系统的总线型式、网络...贵阳轨道交通3号线一期工程全长43.03 km,起于花溪区桐木岭,止于乌当区洛湾,共计29座车站和28个区间。介绍了贵阳地铁3号线列车网络控制及监控系统(Train Control and Monitoring System,TCMS)的结构和功能,阐述了系统的总线型式、网络架构、设备组成及主要功能。展开更多
Human monoamine oxidase B(hMAO-B)has emerged as a pivotal therapeutic target for Parkinson's disease.Due to adverse effects and shortage of commercial drugs,there is a need for novel,highly selective,and reversibl...Human monoamine oxidase B(hMAO-B)has emerged as a pivotal therapeutic target for Parkinson's disease.Due to adverse effects and shortage of commercial drugs,there is a need for novel,highly selective,and reversible hMAO-B inhibitors with good blood-brain barrier permeability.In this study,a high-throughput at-line nanofractionation screening platform was established with extracts from Chuanxiong Rhizoma,which resulted in the discovery of 75 active compounds,including phenolic acids,volatile oils,and phthalides,two of which were highly selective novel natural phthalide hMAO-B inhibitors that were potent,selective,reversible and had good blood‒brain permeability.Molecular docking and molecular dynamics simulations elucidated the inhibition mechanism.Sedanolide(IC_(50)=103 nmol/L;SI=645)and neocnidilide(IC_(50)=131 nmol/L;SI=207)demonstrated their excellent potential as hMAO-B inhibitors.They offset the limitations of deactivating enzymes associated with irreversible hMAO-B inhibitors such as rasagiline.In SH-SY5Y cell assays,sedanolide(EC_(50)=0.962μmol/L)and neocnidilide(EC_(50)=1.161μmol/L)exhibited significant neuroprotective effects,comparable to the positive drugs rasagiline(EC_(50)=0.896μmol/L)and safinamide(EC_(50)=1.079μmol/L).These findings underscore the potential of sedanolide as a novel natural hMAO-B inhibitor that warrants further development as a promising drug candidate.展开更多
文摘武汉地铁某线路四期电动客车在无人驾驶模式下频繁出现牵引受阻故障,信号系统可正常输出目标点与速度码,但列车无法输出牵引力。通过分析车辆运行数据和电路逻辑,确定故障原因为车载控制器(vehicle on board computer,VOBC)有效端切换时,车辆无人驾驶模式逻辑失效,导致列车进入无控车模式,从而无法输出有效牵引力。该问题可通过增加“或”逻辑扩展信号条件提高冗余性,或者通过简化无人驾驶判断条件来避免逻辑失效。经综合判断,简化无人驾驶判断条件的方法稳定性高、操作难度小,为最优解决方案,可为无人驾驶模式下牵引系统的逻辑优化提供重要依据。
基金financial support from National Major Scientific and Technological Special Project for "Significant New Drugs Development" (2014ZX09304307-002)Youth Development Research Foundation of NIFDC (2013WA8)the National Natural Foundation of China (81303214)
文摘An effective quality control system is the key to ensuring the quality, safety and efficacy of traditional Chinese medicines(TCMs). However, the current quality standard research lacks top-level design and systematic design,mostly based on specific technologies or evaluation methods. To resolve the challenges and questions of quality control of TCMs, a brand-new quality standard system, named "iVarious", was proposed. The system comprises eight elements in a modular format. Meaning of every element was specifically illustrated via corresponding research instances. Furthermore, frankincense study was taken as an example for demonstrating standards and research process, based on the "i Various" system. This system highlighted a holistic strategy for effectiveness,security, integrity and systematization of quality and safety control standards of TCMs. The establishment of"i Various" integrates multi-disciplinary technologies and progressive methods, basis elements and key points of standard construction. The system provides a novel idea and technological demonstration for regulation establishment of TCMs quality standards.
文摘贵阳轨道交通3号线一期工程全长43.03 km,起于花溪区桐木岭,止于乌当区洛湾,共计29座车站和28个区间。介绍了贵阳地铁3号线列车网络控制及监控系统(Train Control and Monitoring System,TCMS)的结构和功能,阐述了系统的总线型式、网络架构、设备组成及主要功能。
基金This work was supported by grants from the National Natural Science Foundation of China(82073806,82304437,82204342,82373835,82173781)The China Postdoctoral Science Foundation(2022M721355,China)the Fundamental Research Funds for the Central Universities(21623343,China).
文摘Human monoamine oxidase B(hMAO-B)has emerged as a pivotal therapeutic target for Parkinson's disease.Due to adverse effects and shortage of commercial drugs,there is a need for novel,highly selective,and reversible hMAO-B inhibitors with good blood-brain barrier permeability.In this study,a high-throughput at-line nanofractionation screening platform was established with extracts from Chuanxiong Rhizoma,which resulted in the discovery of 75 active compounds,including phenolic acids,volatile oils,and phthalides,two of which were highly selective novel natural phthalide hMAO-B inhibitors that were potent,selective,reversible and had good blood‒brain permeability.Molecular docking and molecular dynamics simulations elucidated the inhibition mechanism.Sedanolide(IC_(50)=103 nmol/L;SI=645)and neocnidilide(IC_(50)=131 nmol/L;SI=207)demonstrated their excellent potential as hMAO-B inhibitors.They offset the limitations of deactivating enzymes associated with irreversible hMAO-B inhibitors such as rasagiline.In SH-SY5Y cell assays,sedanolide(EC_(50)=0.962μmol/L)and neocnidilide(EC_(50)=1.161μmol/L)exhibited significant neuroprotective effects,comparable to the positive drugs rasagiline(EC_(50)=0.896μmol/L)and safinamide(EC_(50)=1.079μmol/L).These findings underscore the potential of sedanolide as a novel natural hMAO-B inhibitor that warrants further development as a promising drug candidate.
