OBJECTIVE: To investigate the effects of needling the Shu, Yuan, and Mu acupoints on serum uric acid(SUA), xanthine oxidase(XOD), and alkaline phosphatase(ALP) levels and the kidney index in a rat model of gout and hy...OBJECTIVE: To investigate the effects of needling the Shu, Yuan, and Mu acupoints on serum uric acid(SUA), xanthine oxidase(XOD), and alkaline phosphatase(ALP) levels and the kidney index in a rat model of gout and hyperuricemia.METHODS: Fifty rats were randomly divided into five groups: blank, model, Shu-acupoint, Yuan-acupoint, and Mu-acupoint groups. A rat model of hyperuricemia was developed by intragastric administration of adenine and ethambutol. This experiment last for 90 d in total. Treatment groups underwent 3 courses of acupuncture. Each course involved a total of 10 interventions(one intervention every second day) with each intervention lasting15 min. There was a break for 10 d between courses. SUA and ALP were analyzed using an automatic biochemical analyzer and XOD was analyzed using immunofluorescence.RESULTS: Compared with the blank group, SUA and XOD levels in the model group were significantly higher and the renal index significantly improved. Compared with the model group, SUA and XOD levels in the three treatment groups decreased and the renal index significantly improved.When the three treatment groups were compared,the Mu-acupoint group showed the greatest decreases in SUA and XOD levels, followed by the Yuan-acupoint group. There was no significant difference in kidney index among the three treatment groups. There was no significant difference in ALP levels among the groups.CONCLUSION: The three treatments showed significantly reduced SUA and XOD levels compared with the control groups, possibly suggesting reduced renal damage.展开更多
With a rapidly increasing demand and widespread use of radiotherapy treatment, the subject area of in-vivo real time dose rate dosimeters has become a significant area of study. An embedded structure fiber-optic radia...With a rapidly increasing demand and widespread use of radiotherapy treatment, the subject area of in-vivo real time dose rate dosimeters has become a significant area of study. An embedded structure fiber-optic radiation dosimeter has proved to be a promising candidate to fulfil this role because of its high SNR (signal-to-noise ratio) and excellent light conversion efficiency. In this paper, the properties of this kind of dosimeter with respect to different SSD (Source to Surface Distance) and beam field size in a clinical Linac are studied. The characteristics of the dosimeter were evaluated by the sensor’s output intensity response in these conditions.展开更多
Background: Rivaroxaban is a directly acting, oral anti-coagulant (factor Xa inhibitor) which is used to treat and prevent the formation of blood clots. A common side effect of this drug is an increase in bleeding ten...Background: Rivaroxaban is a directly acting, oral anti-coagulant (factor Xa inhibitor) which is used to treat and prevent the formation of blood clots. A common side effect of this drug is an increase in bleeding tendencies, which can potentially lead to macroscopic hematuria. However, it is important to note that macroscopic hematuria can appear in several other conditions including urological malignancies. The Case: We report a case of a 69-year-old male patient with a history of myocardial infarction undergoing long term Rivaroxaban therapy, presenting with macroscopic hematuria and frequent urination. The clinical history and presenting symptoms were consistent with the side effects of prolonged use of Rivaroxaban, but further investigations revealed the presence of a tumor in the bladder which was instead found to be the cause of macroscopic hematuria. The conclusion: Although macroscopic hematuria is a very common side effect of Rivaroxaban therapy, it is important to consider other conditions which can present with the same symptoms.展开更多
基金Supported by Central Universities Fundamental Research Funds Project(Graduate Programs)from the Beijing University of Chinese Medicine:Experiment Research on the Effects of Acupuncturing Shu,Yuan,and Mu Acupoints in a Rat Model of Gout and Hyperuricemia(No.2015-JYB-XS127)
文摘OBJECTIVE: To investigate the effects of needling the Shu, Yuan, and Mu acupoints on serum uric acid(SUA), xanthine oxidase(XOD), and alkaline phosphatase(ALP) levels and the kidney index in a rat model of gout and hyperuricemia.METHODS: Fifty rats were randomly divided into five groups: blank, model, Shu-acupoint, Yuan-acupoint, and Mu-acupoint groups. A rat model of hyperuricemia was developed by intragastric administration of adenine and ethambutol. This experiment last for 90 d in total. Treatment groups underwent 3 courses of acupuncture. Each course involved a total of 10 interventions(one intervention every second day) with each intervention lasting15 min. There was a break for 10 d between courses. SUA and ALP were analyzed using an automatic biochemical analyzer and XOD was analyzed using immunofluorescence.RESULTS: Compared with the blank group, SUA and XOD levels in the model group were significantly higher and the renal index significantly improved. Compared with the model group, SUA and XOD levels in the three treatment groups decreased and the renal index significantly improved.When the three treatment groups were compared,the Mu-acupoint group showed the greatest decreases in SUA and XOD levels, followed by the Yuan-acupoint group. There was no significant difference in kidney index among the three treatment groups. There was no significant difference in ALP levels among the groups.CONCLUSION: The three treatments showed significantly reduced SUA and XOD levels compared with the control groups, possibly suggesting reduced renal damage.
文摘With a rapidly increasing demand and widespread use of radiotherapy treatment, the subject area of in-vivo real time dose rate dosimeters has become a significant area of study. An embedded structure fiber-optic radiation dosimeter has proved to be a promising candidate to fulfil this role because of its high SNR (signal-to-noise ratio) and excellent light conversion efficiency. In this paper, the properties of this kind of dosimeter with respect to different SSD (Source to Surface Distance) and beam field size in a clinical Linac are studied. The characteristics of the dosimeter were evaluated by the sensor’s output intensity response in these conditions.
文摘Background: Rivaroxaban is a directly acting, oral anti-coagulant (factor Xa inhibitor) which is used to treat and prevent the formation of blood clots. A common side effect of this drug is an increase in bleeding tendencies, which can potentially lead to macroscopic hematuria. However, it is important to note that macroscopic hematuria can appear in several other conditions including urological malignancies. The Case: We report a case of a 69-year-old male patient with a history of myocardial infarction undergoing long term Rivaroxaban therapy, presenting with macroscopic hematuria and frequent urination. The clinical history and presenting symptoms were consistent with the side effects of prolonged use of Rivaroxaban, but further investigations revealed the presence of a tumor in the bladder which was instead found to be the cause of macroscopic hematuria. The conclusion: Although macroscopic hematuria is a very common side effect of Rivaroxaban therapy, it is important to consider other conditions which can present with the same symptoms.
