Background: Mycoplasma pneumoniae (MP) is the primary causative agent of community-acquired pneumonia, which has increasingly become resistant to macrolides, complicating treatment regimens, especially with the co-inf...Background: Mycoplasma pneumoniae (MP) is the primary causative agent of community-acquired pneumonia, which has increasingly become resistant to macrolides, complicating treatment regimens, especially with the co-infection factor. Its worldwide prevalence has fluctuated due to the influence of the COVID-19 pandemic. The study investigated co-infection patterns in children diagnosed with Mycoplasma pneumoniae pneumonia (MPP). Methods: From June 2022 to December 2023, we retrospectively analyzed the clinical data for hospitalized children with Mycoplasma pneumoniae pneumonia in Wuhan, China. We collected data on age, sex, clinical information, and pathogenic results. We also collected sputum or bronchoalveolar lavage fluid (BALF) samples to test respiratory pathogens and macrolide resistance using targeted microbial next-generation sequencing (tNGS). We analyzed the data using SPSS. Results: The study involved 417 patients diagnosed with MPP, of whom 86.33% had co-infections. Co-infections were notably linked to lobar pneumonia, prominent imaging shadows and higher macrolide resistance rate. Key bacterial pathogens were Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, rhinoviruses, and human adenoviruses (HADV). In MPP cases, Candida albicans was the fungal pathogen related to co-infections. The co-infection with HADV and human bocavirus 1 (HBoV1) correlated with prolonged fever, whereas Bordetella pertussis was linked to prolonged cough. In contrast, Candida albicans exhibited a weaker association with diffuse large-area infiltration on chest imaging, and its co-infection was less likely to result in severe disease. Conclusion: These results offer valuable insight into Mycoplasma pneumoniae pneumonia in children, highlighting the impact of co-infections on the disease’s clinical outcomes.展开更多
A 60-year-old female with post-concussion syndrome (PCS) presented with persistent cognitive deficits and functional limitations following a slip and fall. She underwent a multimodal therapeutic protocol including hyp...A 60-year-old female with post-concussion syndrome (PCS) presented with persistent cognitive deficits and functional limitations following a slip and fall. She underwent a multimodal therapeutic protocol including hyperbaric therapy (HBT), photobiomodulation (PBM), and molecular hydrogen (MH) therapy over 10 sessions. Pre- and post-treatment assessments demonstrated significant improvements in cognitive function and neurophysiological markers, as evidenced by WAVi EEG and Trail Making Test (TMT) results. This case highlights the potential of a non-invasive, multimodal therapeutic approach to address persistent post-concussion symptoms, an area with limited effective interventions. Findings suggest that integrating these therapies into standard rehabilitation protocols may enhance recovery trajectories, particularly for patients with persistent cognitive symptoms. This case report explores the clinical course, treatment efficacy, and the potential for combining these therapies in addressing complex neurological recovery.展开更多
This case report examines the impact of mild hyperbaric oxygen therapy (mHBOT) on cognitive function and symptom relief in a 35-year-old male presenting with concussive symptoms (CS) following a motor vehicle accident...This case report examines the impact of mild hyperbaric oxygen therapy (mHBOT) on cognitive function and symptom relief in a 35-year-old male presenting with concussive symptoms (CS) following a motor vehicle accident (MVA). The patient underwent 10 mHBOT sessions over five weeks (40 minutes per session at 1.5 ATA with 32% oxygen). Post-treatment assessments revealed significant improvements, including an increase in P300 voltage from 4.2 µV to 9.2 µV, aligning with the normative range of 8 - 21 µV. Electroencephalogram (EEG) analysis demonstrated enhanced alpha and theta band activity, reflecting improved cognitive processing and attentional regulation. Clinically, the patient reported reduced headache severity, improved sleep quality, and decreased pain intensity. These findings suggest that mHBOT may support neuroplasticity, mitigate inflammation, and restore cognitive function in patients with CS. Further research, including randomized controlled trials (RCTs), is warranted to validate mHBOT’s efficacy and explore its long-term benefits in traumatic brain injury (TBI) rehabilitation.展开更多
目的分析伏诺拉生(VPZ)治疗消化性溃疡(PU)和内镜黏膜下剥离术(ESD)术后溃疡的安全性与有效性,为临床实践、医疗决策提供循证药学证据。方法计算机检索中国知网、万方、维普、中国生物医学文献数据库、PubMed、Embase、Web of Science、...目的分析伏诺拉生(VPZ)治疗消化性溃疡(PU)和内镜黏膜下剥离术(ESD)术后溃疡的安全性与有效性,为临床实践、医疗决策提供循证药学证据。方法计算机检索中国知网、万方、维普、中国生物医学文献数据库、PubMed、Embase、Web of Science、the Cochrane Library等数据库,获取VPZ治疗PU和ESD术后溃疡相关的Meta分析/系统评价。由2名研究者独立进行文献筛选、数据提取、文献质量评估、文献重叠程度评估,采用伞形评价分析方法;当纳入的文献高度重叠时,对所有相关原始研究数据重新进行Meta分析。结果共纳入17项Meta分析,质量从高质量到极低质量不等;所有涉及的结局指标,在纳入的相关Meta分析中均存在非常高的重叠水平(校正覆盖面积为22.22%~100%)。治疗ESD术后溃疡时,与质子泵抑制剂(PPI)比较,VPZ可显著提高ESD术后4周的溃疡愈合率[RR=1.27,95%CI(1.03,1.56),Z=2.21,P=0.027]和溃疡收缩率[MD=0.08,95%CI(0.00,0.16),Z=2.09,P=0.037],显著降低具有PU病史患者的溃疡复发率[RR=0.49,95%CI(0.32,0.73),Z=3.49,P=0.001];VPZ组延迟出血率较兰索拉唑亚组显著降低[RR=0.47,95%CI(0.25,0.90),Z=2.28,P=0.02]。治疗PU时,十二指肠溃疡亚组中,VPZ的不良事件发生率明显高于PPI[RR=1.13,95%CI(1.02,1.26),Z=2.38,P=0.017]。结论对于ESD术后溃疡,VPZ的治疗效果优于PPI,且可以降低具有PU病史患者的溃疡复发率,但在治疗十二指肠溃疡的安全性方面并不具有优势。展开更多
探究了不同碳纤维/玄武岩纤维(carbon fiber/basalt fiber,CF/BF)配比的混杂层合板在弹道冲击及冲击后压缩(compression after impact,CAI)性能方面的表现,结果表明,玄武岩纤维显著提升了混杂层合板的能量吸收能力。采用C扫描、电子显...探究了不同碳纤维/玄武岩纤维(carbon fiber/basalt fiber,CF/BF)配比的混杂层合板在弹道冲击及冲击后压缩(compression after impact,CAI)性能方面的表现,结果表明,玄武岩纤维显著提升了混杂层合板的能量吸收能力。采用C扫描、电子显微镜和扫描电镜分析了材料的损伤机制,揭示了材料性能提升的内在机理。另一方面,混杂层合板的初始压缩强度随玄武岩纤维含量的增加而下降。在混杂层合板的能量吸收能力增强与初始压缩强度下降的共同作用下,CAI测试中受损层合板的残余压缩强度呈局部波动趋势。研究结果可为轻量化、高抗冲击复合材料的结构设计提供指导。展开更多
南海中央海盆海底扩张活动结束之后,出现了频繁的岩浆活动。由于海盆被海水覆盖,针对活跃的岩浆活动开展实测调查非常困难。本文利用二维地震剖面资料,结合拖网样品资料及有关钻探资料的研究成果,在建立岩浆活动与沉积作用关系模型的基...南海中央海盆海底扩张活动结束之后,出现了频繁的岩浆活动。由于海盆被海水覆盖,针对活跃的岩浆活动开展实测调查非常困难。本文利用二维地震剖面资料,结合拖网样品资料及有关钻探资料的研究成果,在建立岩浆活动与沉积作用关系模型的基础上,通过解释地震剖面反射特征和地震相特征,较全面地分析了南海中央海盆扩张期后岩浆活动的特征与期次。结果表明,南海中央海盆的岩浆活动具有脉动期,形成大量的海底山和岩浆底辟,即以多期次间隙性喷发和浅层侵入为特征。南海中央海盆后扩张期的岩浆活动主要有4个期次,其中11.6、7.5、5.3 Ma 3个期次的分析结果与岩石样品的测年结果吻合,而且进一步确定1.6 Ma左右的岩浆活动时间较长,一直延续至近代,分布范围广;2.6~1.6 Ma期间曾被认为是南海中央海盆岩浆活动静默期,本研究首次发现岩浆活动的踪迹;这一时期既有一次性活动形成的岩浆底辟和海底火山,也有通过多次火山活动而形成的规模较大的岩浆底辟和海底火山。展开更多
文摘Background: Mycoplasma pneumoniae (MP) is the primary causative agent of community-acquired pneumonia, which has increasingly become resistant to macrolides, complicating treatment regimens, especially with the co-infection factor. Its worldwide prevalence has fluctuated due to the influence of the COVID-19 pandemic. The study investigated co-infection patterns in children diagnosed with Mycoplasma pneumoniae pneumonia (MPP). Methods: From June 2022 to December 2023, we retrospectively analyzed the clinical data for hospitalized children with Mycoplasma pneumoniae pneumonia in Wuhan, China. We collected data on age, sex, clinical information, and pathogenic results. We also collected sputum or bronchoalveolar lavage fluid (BALF) samples to test respiratory pathogens and macrolide resistance using targeted microbial next-generation sequencing (tNGS). We analyzed the data using SPSS. Results: The study involved 417 patients diagnosed with MPP, of whom 86.33% had co-infections. Co-infections were notably linked to lobar pneumonia, prominent imaging shadows and higher macrolide resistance rate. Key bacterial pathogens were Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, rhinoviruses, and human adenoviruses (HADV). In MPP cases, Candida albicans was the fungal pathogen related to co-infections. The co-infection with HADV and human bocavirus 1 (HBoV1) correlated with prolonged fever, whereas Bordetella pertussis was linked to prolonged cough. In contrast, Candida albicans exhibited a weaker association with diffuse large-area infiltration on chest imaging, and its co-infection was less likely to result in severe disease. Conclusion: These results offer valuable insight into Mycoplasma pneumoniae pneumonia in children, highlighting the impact of co-infections on the disease’s clinical outcomes.
文摘A 60-year-old female with post-concussion syndrome (PCS) presented with persistent cognitive deficits and functional limitations following a slip and fall. She underwent a multimodal therapeutic protocol including hyperbaric therapy (HBT), photobiomodulation (PBM), and molecular hydrogen (MH) therapy over 10 sessions. Pre- and post-treatment assessments demonstrated significant improvements in cognitive function and neurophysiological markers, as evidenced by WAVi EEG and Trail Making Test (TMT) results. This case highlights the potential of a non-invasive, multimodal therapeutic approach to address persistent post-concussion symptoms, an area with limited effective interventions. Findings suggest that integrating these therapies into standard rehabilitation protocols may enhance recovery trajectories, particularly for patients with persistent cognitive symptoms. This case report explores the clinical course, treatment efficacy, and the potential for combining these therapies in addressing complex neurological recovery.
文摘This case report examines the impact of mild hyperbaric oxygen therapy (mHBOT) on cognitive function and symptom relief in a 35-year-old male presenting with concussive symptoms (CS) following a motor vehicle accident (MVA). The patient underwent 10 mHBOT sessions over five weeks (40 minutes per session at 1.5 ATA with 32% oxygen). Post-treatment assessments revealed significant improvements, including an increase in P300 voltage from 4.2 µV to 9.2 µV, aligning with the normative range of 8 - 21 µV. Electroencephalogram (EEG) analysis demonstrated enhanced alpha and theta band activity, reflecting improved cognitive processing and attentional regulation. Clinically, the patient reported reduced headache severity, improved sleep quality, and decreased pain intensity. These findings suggest that mHBOT may support neuroplasticity, mitigate inflammation, and restore cognitive function in patients with CS. Further research, including randomized controlled trials (RCTs), is warranted to validate mHBOT’s efficacy and explore its long-term benefits in traumatic brain injury (TBI) rehabilitation.
文摘目的分析伏诺拉生(VPZ)治疗消化性溃疡(PU)和内镜黏膜下剥离术(ESD)术后溃疡的安全性与有效性,为临床实践、医疗决策提供循证药学证据。方法计算机检索中国知网、万方、维普、中国生物医学文献数据库、PubMed、Embase、Web of Science、the Cochrane Library等数据库,获取VPZ治疗PU和ESD术后溃疡相关的Meta分析/系统评价。由2名研究者独立进行文献筛选、数据提取、文献质量评估、文献重叠程度评估,采用伞形评价分析方法;当纳入的文献高度重叠时,对所有相关原始研究数据重新进行Meta分析。结果共纳入17项Meta分析,质量从高质量到极低质量不等;所有涉及的结局指标,在纳入的相关Meta分析中均存在非常高的重叠水平(校正覆盖面积为22.22%~100%)。治疗ESD术后溃疡时,与质子泵抑制剂(PPI)比较,VPZ可显著提高ESD术后4周的溃疡愈合率[RR=1.27,95%CI(1.03,1.56),Z=2.21,P=0.027]和溃疡收缩率[MD=0.08,95%CI(0.00,0.16),Z=2.09,P=0.037],显著降低具有PU病史患者的溃疡复发率[RR=0.49,95%CI(0.32,0.73),Z=3.49,P=0.001];VPZ组延迟出血率较兰索拉唑亚组显著降低[RR=0.47,95%CI(0.25,0.90),Z=2.28,P=0.02]。治疗PU时,十二指肠溃疡亚组中,VPZ的不良事件发生率明显高于PPI[RR=1.13,95%CI(1.02,1.26),Z=2.38,P=0.017]。结论对于ESD术后溃疡,VPZ的治疗效果优于PPI,且可以降低具有PU病史患者的溃疡复发率,但在治疗十二指肠溃疡的安全性方面并不具有优势。
文摘探究了不同碳纤维/玄武岩纤维(carbon fiber/basalt fiber,CF/BF)配比的混杂层合板在弹道冲击及冲击后压缩(compression after impact,CAI)性能方面的表现,结果表明,玄武岩纤维显著提升了混杂层合板的能量吸收能力。采用C扫描、电子显微镜和扫描电镜分析了材料的损伤机制,揭示了材料性能提升的内在机理。另一方面,混杂层合板的初始压缩强度随玄武岩纤维含量的增加而下降。在混杂层合板的能量吸收能力增强与初始压缩强度下降的共同作用下,CAI测试中受损层合板的残余压缩强度呈局部波动趋势。研究结果可为轻量化、高抗冲击复合材料的结构设计提供指导。
文摘南海中央海盆海底扩张活动结束之后,出现了频繁的岩浆活动。由于海盆被海水覆盖,针对活跃的岩浆活动开展实测调查非常困难。本文利用二维地震剖面资料,结合拖网样品资料及有关钻探资料的研究成果,在建立岩浆活动与沉积作用关系模型的基础上,通过解释地震剖面反射特征和地震相特征,较全面地分析了南海中央海盆扩张期后岩浆活动的特征与期次。结果表明,南海中央海盆的岩浆活动具有脉动期,形成大量的海底山和岩浆底辟,即以多期次间隙性喷发和浅层侵入为特征。南海中央海盆后扩张期的岩浆活动主要有4个期次,其中11.6、7.5、5.3 Ma 3个期次的分析结果与岩石样品的测年结果吻合,而且进一步确定1.6 Ma左右的岩浆活动时间较长,一直延续至近代,分布范围广;2.6~1.6 Ma期间曾被认为是南海中央海盆岩浆活动静默期,本研究首次发现岩浆活动的踪迹;这一时期既有一次性活动形成的岩浆底辟和海底火山,也有通过多次火山活动而形成的规模较大的岩浆底辟和海底火山。
