急性肺损伤(ALI)是一种具有高发病率和高死亡率的严重疾病,目前缺乏有效的治疗手段。近年来,干细胞治疗因其多能性和再生能力受到广泛关注。本综述总结了不同类型干细胞(如间充质干细胞、上皮祖细胞、内皮祖细胞等)在急性肺损伤中的治...急性肺损伤(ALI)是一种具有高发病率和高死亡率的严重疾病,目前缺乏有效的治疗手段。近年来,干细胞治疗因其多能性和再生能力受到广泛关注。本综述总结了不同类型干细胞(如间充质干细胞、上皮祖细胞、内皮祖细胞等)在急性肺损伤中的治疗潜力,重点阐述了其作用机制、实验研究进展以及临床应用的挑战和未来方向。Acute lung injury (ALI) is a severe clinical condition with high morbidity and mortality rates, for which effective treatment options remain elusive. In recent years, stem cell therapy has emerged as a promising approach due to the pluripotency and regenerative capabilities of stem cells. This review explores the therapeutic potential of various stem cell types, including mesenchymal stem cells (MSCs), epithelial progenitor cells, and endothelial progenitor cells, in the context of ALI. It highlights their mechanisms of action, recent advances in experimental studies, and the challenges associated with clinical translation, while providing insights into future research directions.展开更多
In the present study, the morphological and ultrastructural characteristics of mesenchymal stem cells (MSCs) induced towards osteogenic, adipogenic, and chondrogenic lineages were investigated. The main objective of t...In the present study, the morphological and ultrastructural characteristics of mesenchymal stem cells (MSCs) induced towards osteogenic, adipogenic, and chondrogenic lineages were investigated. The main objective of this paper was to focus on the differentiation capacity of ovine [oMSCs] and equine MSCs [eMSCs]. Bone marrow [BM] MSCs were isolated from ovine and equine patients, expanded in monolayer culture and induced into osteogenic, adipogenic and chondrogenic differentiation. For chondrogenic differentiation, cells were cultured in micromass culture. Also, their ultrastructural phenotypes were studied by transmission electron microscopy [TEM]. This study was aimed to provide an indepth morphological description of BM-derived ovine and equine MSCs induced towards three lineages, it demonstrated that TEM analysis is useful in elucidating detailed structural information.展开更多
文摘急性肺损伤(ALI)是一种具有高发病率和高死亡率的严重疾病,目前缺乏有效的治疗手段。近年来,干细胞治疗因其多能性和再生能力受到广泛关注。本综述总结了不同类型干细胞(如间充质干细胞、上皮祖细胞、内皮祖细胞等)在急性肺损伤中的治疗潜力,重点阐述了其作用机制、实验研究进展以及临床应用的挑战和未来方向。Acute lung injury (ALI) is a severe clinical condition with high morbidity and mortality rates, for which effective treatment options remain elusive. In recent years, stem cell therapy has emerged as a promising approach due to the pluripotency and regenerative capabilities of stem cells. This review explores the therapeutic potential of various stem cell types, including mesenchymal stem cells (MSCs), epithelial progenitor cells, and endothelial progenitor cells, in the context of ALI. It highlights their mechanisms of action, recent advances in experimental studies, and the challenges associated with clinical translation, while providing insights into future research directions.
文摘In the present study, the morphological and ultrastructural characteristics of mesenchymal stem cells (MSCs) induced towards osteogenic, adipogenic, and chondrogenic lineages were investigated. The main objective of this paper was to focus on the differentiation capacity of ovine [oMSCs] and equine MSCs [eMSCs]. Bone marrow [BM] MSCs were isolated from ovine and equine patients, expanded in monolayer culture and induced into osteogenic, adipogenic and chondrogenic differentiation. For chondrogenic differentiation, cells were cultured in micromass culture. Also, their ultrastructural phenotypes were studied by transmission electron microscopy [TEM]. This study was aimed to provide an indepth morphological description of BM-derived ovine and equine MSCs induced towards three lineages, it demonstrated that TEM analysis is useful in elucidating detailed structural information.
