In this article,we show the existence,uniqueness and stability of bounded solutions to the following quasilinear problems with mean curvature operator(φ'(x′(t)))′=f(t,x),t≥t_(0),lim_(t→∞)x(t)=ψ_(0),lim_(t→...In this article,we show the existence,uniqueness and stability of bounded solutions to the following quasilinear problems with mean curvature operator(φ'(x′(t)))′=f(t,x),t≥t_(0),lim_(t→∞)x(t)=ψ_(0),lim_(t→∞)x′(t)e^(t)=0,where t_(0) and ψ_(0) are real constants,φ(s)=s/√1−s^(2),s∈R with s∈(−1,1),f:[t_(0),∞)×R→R satisfies the Lipschitz or Osgood-type conditions.展开更多
Accurate and rapid recognition of weathering degree(WD)and groundwater condition(GC)is essential for evaluating rock mass quality and conducting stability analyses in underground engineering.Conventional WD and GC rec...Accurate and rapid recognition of weathering degree(WD)and groundwater condition(GC)is essential for evaluating rock mass quality and conducting stability analyses in underground engineering.Conventional WD and GC recognition methods often rely on subjective evaluation by field experts,supplemented by field sampling and laboratory testing.These methods are frequently complex and timeconsuming,making it challenging to meet the rapidly evolving demands of underground engineering.Therefore,this study proposes a rock non-geometric parameter classification network(RNPC-net)to rapidly achieve the recognition and mapping ofWD and GC of tunnel faces.The hybrid feature extraction module(HFEM)in RNPC-net can fully extract,fuse,and utilize multi-scale features of images,enhancing the network's classification performance.Moreover,the designed adaptive weighting auxiliary classifier(AC)helps the network learn features more efficiently.Experimental results show that RNPC-net achieved classification accuracies of 0.8756 and 0.8710 for WD and GC,respectively,representing an improvement of approximately 2%e10%compared to other methods.Both quantitative and qualitative experiments confirm the effectiveness and superiority of RNPC-net.Furthermore,for WD and GC mapping,RNPC-net outperformed other methods by achieving the highest mean intersection over union(mIOU)across most tunnel faces.The mapping results closely align with measurements provided by field experts.The application of WD and GC mapping results to the rock mass rating(RMR)system achieved a transition from conventional qualitative to quantitative evaluation.This advancement enables more accurate and reliable rock mass quality evaluations,particularly under critical conditions of RMR.展开更多
Background:Therapeutic responses of breast cancer vary among patients and lead to drug resistance and recurrence due to the heterogeneity.Current preclinical models,however,are inadequate for predicting individual pat...Background:Therapeutic responses of breast cancer vary among patients and lead to drug resistance and recurrence due to the heterogeneity.Current preclinical models,however,are inadequate for predicting individual patient responses towards different drugs.This study aimed to investigate the patient-derived breast cancer culture models for drug sensitivity evaluations.Methods:Tumor and adjacent tissues from female breast cancer patients were collected during surgery.Patient-derived breast cancer cells were cultured using the conditional reprogramming technique to establish 2D models.The obtained patient-derived conditional reprogramming breast cancer(CRBC)cells were subsequently embedded in alginate-gelatin methacryloyl hydrogel microspheres to form 3D culture models.Comparisons between 2D and 3D models were made using immunohistochemistry(tumor markers),MTS assays(cell viability),flow cytometry(apoptosis),transwell assays(migration),and Western blotting(protein expression).Drug sensitivity tests were conducted to evaluate patient-specific responses to anti-cancer agents.Results:2D and 3D culture models were successfully established using samples from eight patients.The 3D models retained histological and marker characteristics of the original tumors.Compared to 2D cultures,3D models exhibited increased apoptosis,enhanced drug resistance,elevated stem cell marker expression,and greater migration ability—features more reflective of in vivo tumor behavior.Conclusion:Patient-derived 3D CRBC models effectively mimic the in vivo tumor microenvironment and demonstrate stronger resistance to anti-cancer drugs than 2D models.These hydrogel-based models offer a cost-effective and clinically relevant platform for drug screening and personalized breast cancer treatment.展开更多
Estimating the properties of foam-conditioned clay soils is important for both conditioning and recycling goals in earth pressure balance(EPB)shield tunneling.In this study,the vacuum dewatering behaviors of foam-cond...Estimating the properties of foam-conditioned clay soils is important for both conditioning and recycling goals in earth pressure balance(EPB)shield tunneling.In this study,the vacuum dewatering behaviors of foam-conditioned clay soils were investigated,with their potential use as an alternative means to assess foam optimization being examined.A series of laboratory and fieldtests was conducted,including vacuum dewatering tests that considered the effects of filtrationtime and pressure,vane shear tests,and improved cone pullout tests under different gravimetric water content(w)and foam injection ratio(FIR)conditions.It was found that the filtrate loss(FL),which characterizes dewaterability,was increased by extended vacuum filtrationtime and elevated pressure.While increases in w and FIR enhanced FL,reductions were observed in the undrained shear strength(cu),tangential adhesion stress(Fs),and normal adhesion stress(Fn).Furthermore,a linear decrease in FL with increasing mechanical indices(cu,Fs,and Fn)was demonstrated by both laboratory and fielddata fittingresults,regardless of w,FIR,and dewatering conditions.This study provides novel insights into the understanding of vacuum dewatering mechanisms in foam-conditioned clay soils,while a simple approach is proposed for evaluating foam conditioning effectiveness in EPB shield tunneling applications.展开更多
The real-time and accurate calculation of electricity indirect carbon emissions is not only the critical component for quantifying the carbon emission levels of the power system but also an effective mean to guide ele...The real-time and accurate calculation of electricity indirect carbon emissions is not only the critical component for quantifying the carbon emission levels of the power system but also an effective mean to guide electricity users in carbon reduction and promote power industry low-carbon transformation.Fundamentally,calculating indirect carbon emissions involves allocating direct carbon emission data from the power source side,indicating that accurate indirect emission results rely on the precise measurement of power source emissions.However,existing research on indirect carbon emissions in large-scale power systems rarely accounts for variations in carbon emission characteristics under different operating conditions of power sources,such as rated/non-rated operating conditions and ramping up/down conditions,making it difficult to reflect source-side and load-side carbon emission information variation during providing ancillary services.Quadratic and exponential functions are proposed to characterize the energy consumption profiles of coal-fired and gas-fired power generation,respectively,to construct a refined carbon emission model for power sources.By leveraging the theory of power system carbon flow,we analyze how variable operating conditions of power sources impact indirect carbon emissions.Case studies demonstrate that changes in power source emissions under variable conditions have a significant effect on the indirect carbon emissions of power grids.展开更多
To the Editor,Artificial intelligence(AI)usage has been increasing.Many fields have implemented the use of AI and Large LanguageModels(LLMs),especially in medicine.Furthermore,manypatients have increasingly been using...To the Editor,Artificial intelligence(AI)usage has been increasing.Many fields have implemented the use of AI and Large LanguageModels(LLMs),especially in medicine.Furthermore,manypatients have increasingly been using AI;often,they will prompt AI with questions before even stepping into a physi-cian's office.The question lies in whether the information produced by AI is reliable and if this information is concise and easy to read across all patient populations.展开更多
Ti(C,N)-Mo_(2)C-Ni cermet as alternative materials was explored for use in alkaline conditions,replacing the WC-Co cemented carbides,since Co is classified as a potentially carcinogenic substance and there is potentia...Ti(C,N)-Mo_(2)C-Ni cermet as alternative materials was explored for use in alkaline conditions,replacing the WC-Co cemented carbides,since Co is classified as a potentially carcinogenic substance and there is potential hazard of“hard metal disease”under the exposure to cobalt dust.The changes in microstructure,corrosion rate and volumetric loss rate of the two materials were compared under electrochemical corrosion and erosion-corrosion in alkaline environment.The results demonstrates that Ti(C,N)-Mo_(2)C-Ni cermet undergoes passivation when exposed to electrochemical corrosion of NaOH solution,resulting in a significant increase in oxygen content on the corroded surface.The corrosion rate of cermet is approximately one order of magnitude lower than that of the cemented carbide.Under the erosion-corrosion of an alkaline sand-water mixture,both the cermet and cemented carbide experience a gradual increase in volumetric loss rate with prolonging the erosion time.During erosion,the rim phase in cermet is fragile,so cracks easily penetrate it while the core phase remains intact.The medium-grained cemented carbide commonly demonstrates transgranular fracture mode,while in the fine-grained cemented carbide,cracks tend to propagate along phase boundaries.The erosive wear and damage caused by sand particles play a predominant role in the erosion-corrosion process of alkaline sand-water mixtures.This process represents an accelerated destructive phenomenon influenced and intensified by the combined effects of corrosion and erosion.It is confirmed that using cermet as an alternative anti-wear material to cemented carbides is feasible under alkaline conditions,and even better.展开更多
基金Supported by the National Natural Science Foundation of China(Grant Nos.12361040,12061064)the National Science Foundation of Gansu Province(Grant No.22JR5RA264)State Scholarship Fund(Grant No.20230862021).
文摘In this article,we show the existence,uniqueness and stability of bounded solutions to the following quasilinear problems with mean curvature operator(φ'(x′(t)))′=f(t,x),t≥t_(0),lim_(t→∞)x(t)=ψ_(0),lim_(t→∞)x′(t)e^(t)=0,where t_(0) and ψ_(0) are real constants,φ(s)=s/√1−s^(2),s∈R with s∈(−1,1),f:[t_(0),∞)×R→R satisfies the Lipschitz or Osgood-type conditions.
基金supported by the National Natural Science Foundation of China(Grant Nos.42077242 and 42171407)the Graduate Innovation Fund of Jilin University.
文摘Accurate and rapid recognition of weathering degree(WD)and groundwater condition(GC)is essential for evaluating rock mass quality and conducting stability analyses in underground engineering.Conventional WD and GC recognition methods often rely on subjective evaluation by field experts,supplemented by field sampling and laboratory testing.These methods are frequently complex and timeconsuming,making it challenging to meet the rapidly evolving demands of underground engineering.Therefore,this study proposes a rock non-geometric parameter classification network(RNPC-net)to rapidly achieve the recognition and mapping ofWD and GC of tunnel faces.The hybrid feature extraction module(HFEM)in RNPC-net can fully extract,fuse,and utilize multi-scale features of images,enhancing the network's classification performance.Moreover,the designed adaptive weighting auxiliary classifier(AC)helps the network learn features more efficiently.Experimental results show that RNPC-net achieved classification accuracies of 0.8756 and 0.8710 for WD and GC,respectively,representing an improvement of approximately 2%e10%compared to other methods.Both quantitative and qualitative experiments confirm the effectiveness and superiority of RNPC-net.Furthermore,for WD and GC mapping,RNPC-net outperformed other methods by achieving the highest mean intersection over union(mIOU)across most tunnel faces.The mapping results closely align with measurements provided by field experts.The application of WD and GC mapping results to the rock mass rating(RMR)system achieved a transition from conventional qualitative to quantitative evaluation.This advancement enables more accurate and reliable rock mass quality evaluations,particularly under critical conditions of RMR.
基金supported by the Natural Science Foundation of Guangdong Province(No.2021B1515120053)Guangdong Basic and Applied Basic Research Foundation(Grant No.2024A1515140166).
文摘Background:Therapeutic responses of breast cancer vary among patients and lead to drug resistance and recurrence due to the heterogeneity.Current preclinical models,however,are inadequate for predicting individual patient responses towards different drugs.This study aimed to investigate the patient-derived breast cancer culture models for drug sensitivity evaluations.Methods:Tumor and adjacent tissues from female breast cancer patients were collected during surgery.Patient-derived breast cancer cells were cultured using the conditional reprogramming technique to establish 2D models.The obtained patient-derived conditional reprogramming breast cancer(CRBC)cells were subsequently embedded in alginate-gelatin methacryloyl hydrogel microspheres to form 3D culture models.Comparisons between 2D and 3D models were made using immunohistochemistry(tumor markers),MTS assays(cell viability),flow cytometry(apoptosis),transwell assays(migration),and Western blotting(protein expression).Drug sensitivity tests were conducted to evaluate patient-specific responses to anti-cancer agents.Results:2D and 3D culture models were successfully established using samples from eight patients.The 3D models retained histological and marker characteristics of the original tumors.Compared to 2D cultures,3D models exhibited increased apoptosis,enhanced drug resistance,elevated stem cell marker expression,and greater migration ability—features more reflective of in vivo tumor behavior.Conclusion:Patient-derived 3D CRBC models effectively mimic the in vivo tumor microenvironment and demonstrate stronger resistance to anti-cancer drugs than 2D models.These hydrogel-based models offer a cost-effective and clinically relevant platform for drug screening and personalized breast cancer treatment.
基金supported by the National Youth Top-notch Talent Support Program of China(Grant No.00389335)the National Natural Science Foundation of China(Grant No.52378392)the“Foal Eagle Program”Youth Top-notch Talent Project of Fujian Province(Grant No.00387088).
文摘Estimating the properties of foam-conditioned clay soils is important for both conditioning and recycling goals in earth pressure balance(EPB)shield tunneling.In this study,the vacuum dewatering behaviors of foam-conditioned clay soils were investigated,with their potential use as an alternative means to assess foam optimization being examined.A series of laboratory and fieldtests was conducted,including vacuum dewatering tests that considered the effects of filtrationtime and pressure,vane shear tests,and improved cone pullout tests under different gravimetric water content(w)and foam injection ratio(FIR)conditions.It was found that the filtrate loss(FL),which characterizes dewaterability,was increased by extended vacuum filtrationtime and elevated pressure.While increases in w and FIR enhanced FL,reductions were observed in the undrained shear strength(cu),tangential adhesion stress(Fs),and normal adhesion stress(Fn).Furthermore,a linear decrease in FL with increasing mechanical indices(cu,Fs,and Fn)was demonstrated by both laboratory and fielddata fittingresults,regardless of w,FIR,and dewatering conditions.This study provides novel insights into the understanding of vacuum dewatering mechanisms in foam-conditioned clay soils,while a simple approach is proposed for evaluating foam conditioning effectiveness in EPB shield tunneling applications.
基金supported by the Science and Technology Project of China Southern Power Grid Co.,Ltd.(ZBKTM20232244)the Project of National Natural of Science Foundation of China(52477103).
文摘The real-time and accurate calculation of electricity indirect carbon emissions is not only the critical component for quantifying the carbon emission levels of the power system but also an effective mean to guide electricity users in carbon reduction and promote power industry low-carbon transformation.Fundamentally,calculating indirect carbon emissions involves allocating direct carbon emission data from the power source side,indicating that accurate indirect emission results rely on the precise measurement of power source emissions.However,existing research on indirect carbon emissions in large-scale power systems rarely accounts for variations in carbon emission characteristics under different operating conditions of power sources,such as rated/non-rated operating conditions and ramping up/down conditions,making it difficult to reflect source-side and load-side carbon emission information variation during providing ancillary services.Quadratic and exponential functions are proposed to characterize the energy consumption profiles of coal-fired and gas-fired power generation,respectively,to construct a refined carbon emission model for power sources.By leveraging the theory of power system carbon flow,we analyze how variable operating conditions of power sources impact indirect carbon emissions.Case studies demonstrate that changes in power source emissions under variable conditions have a significant effect on the indirect carbon emissions of power grids.
文摘To the Editor,Artificial intelligence(AI)usage has been increasing.Many fields have implemented the use of AI and Large LanguageModels(LLMs),especially in medicine.Furthermore,manypatients have increasingly been using AI;often,they will prompt AI with questions before even stepping into a physi-cian's office.The question lies in whether the information produced by AI is reliable and if this information is concise and easy to read across all patient populations.
基金Chongqing Light Alloy Materials and Processing Engineering Technology Research Center Open Fund Project(GCZX201903)Yunnan Province Major Science and Technology Special Project Plan(202302AA310038)Sichuan University-Suining Municipal-University Cooperation Project(2023CDSN-12)。
文摘Ti(C,N)-Mo_(2)C-Ni cermet as alternative materials was explored for use in alkaline conditions,replacing the WC-Co cemented carbides,since Co is classified as a potentially carcinogenic substance and there is potential hazard of“hard metal disease”under the exposure to cobalt dust.The changes in microstructure,corrosion rate and volumetric loss rate of the two materials were compared under electrochemical corrosion and erosion-corrosion in alkaline environment.The results demonstrates that Ti(C,N)-Mo_(2)C-Ni cermet undergoes passivation when exposed to electrochemical corrosion of NaOH solution,resulting in a significant increase in oxygen content on the corroded surface.The corrosion rate of cermet is approximately one order of magnitude lower than that of the cemented carbide.Under the erosion-corrosion of an alkaline sand-water mixture,both the cermet and cemented carbide experience a gradual increase in volumetric loss rate with prolonging the erosion time.During erosion,the rim phase in cermet is fragile,so cracks easily penetrate it while the core phase remains intact.The medium-grained cemented carbide commonly demonstrates transgranular fracture mode,while in the fine-grained cemented carbide,cracks tend to propagate along phase boundaries.The erosive wear and damage caused by sand particles play a predominant role in the erosion-corrosion process of alkaline sand-water mixtures.This process represents an accelerated destructive phenomenon influenced and intensified by the combined effects of corrosion and erosion.It is confirmed that using cermet as an alternative anti-wear material to cemented carbides is feasible under alkaline conditions,and even better.
