In order to reveal the effect of 2-hydroxy-3-naphthyl hydroxamic acid(H205)on the flotation behavior and action mechanism of bastnaesite,single-mineral flotation experiments of bastnaesite were conducted.The flotation...In order to reveal the effect of 2-hydroxy-3-naphthyl hydroxamic acid(H205)on the flotation behavior and action mechanism of bastnaesite,single-mineral flotation experiments of bastnaesite were conducted.The flotation recovery of bastnaesites can be achieved more than 90%when the aeration rate is 40 mL/min,the rotational speed is 200 r/min,the H205 dosage is 120 mg/L,and the pulp pH ranges from 7 to 9.The action mechanism of H205 on the surface of bastnaesite was studied by simultaneous thermogravimetry and differential scanning calorimetry(TG-DSC),Zeta potential measurements,Fourier transform-infrared spectra(FT-IR)and X-ray photoelectron spectroscopy(XPS).These analysis results show that under suitable flotation conditions,H205 has an obvious adsorption phenomenon on the surface of bastnaesite.The adsorption involves electrostatic interactions and chemical interactions,namely H205 has a strong collecting ability of bastnaesite due to the synergism of electrostatic adsorption and chemical adsorption.This study systematically reveals the flotation behavior and adsorption mechanism of H205 on the surface of bastnaesite,and provides useful theoretical guidance for efficient flotation separation of bastnaesite.展开更多
Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregati...Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug resveratrol.In this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced neuropathology.Our results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein expression.Notably,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by D30.Considering the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.展开更多
Cancer represents a significant disease that profoundly impacts human health and longevity.Projections indicate a 47%increase in the global cancer burden by 2040 compared to 2020,accompanied by a further rise in the a...Cancer represents a significant disease that profoundly impacts human health and longevity.Projections indicate a 47%increase in the global cancer burden by 2040 compared to 2020,accompanied by a further rise in the associated economic burden.Consequently,there is an urgent need to discover and develop new alternative drugs to mitigate the global impact of cancer.Natural products(NPs)play a crucial role in the identification and development of anticancer therapeutics.This study identified ustusolate E(UE)and its analog 11α-hydroxy-ustusolate E(HUE)from strain Aspergillus calidoustus TJ403-EL05,and examined their antitumor activities and mechanisms of action.The findings demonstrate that both compounds significantly inhibited the proliferation and colony formation of AGS(human gastric cancer cells)and 786-O(human renal clear cell carcinoma cells),induced irreversible DNA damage,blocked the cell cycle at the G_(2)/M phase,and further induced apoptosis in tumor cells.To the best of the authors’knowledge,this is the first report on the anticancer effects of UE and HUE and their underlying mechanisms.The present study suggests that HUE and UE could serve as lead compounds for the development of novel anticancer drugs.展开更多
Solar biomass conversion has garnered significant research attention,but the rapid recombination of electrons and holes in photocatalysts hinders efficiency.To enhance this process,researchers aim to develop S-scheme ...Solar biomass conversion has garnered significant research attention,but the rapid recombination of electrons and holes in photocatalysts hinders efficiency.To enhance this process,researchers aim to develop S-scheme heterojunction photocatalysts with optimized band structures that enable effective electron-hole separation,thereby improving overall efficiency.Herein,chemical-bonded SnIn_(4)S_(8)/WO_(3)S-scheme heterostructure photocatalyst was constructed via in-situ hydrothermal strategy for sunlight-driven catalytic selective oxidization of 5-hydroxymethylfurrural(HMF)into valuable 2,5-dimethylfuran(DFF).X-ray photoelectron spectroscopy(XPS)results prove the formation of a W-S chemical bond in the composites,which will likely enhance the efficient transport of photogenerated charges.The optimal SnIn_(4)S_(8)/WO_(3)exhibited an excellent HMF conversion rate(89%)and DFF yield(68%)after 2 h.The S-scheme charge transfer pathway in the SnIn_(4)S_(8)/WO_(3)composite structure was verified through density functional theory(DFT)calculations and supported by partial in situ experimental results.This study demonstrates that the S-scheme heterostructure based on SnIn_(4)S_(8)offers innovative insights for advancing photocatalytic biomass conversion.展开更多
The biomass electrochemical oxidation coupled with hydrogen evolution reaction has received widespread attention due to its carbon-neutral and sustainable properties.The electrosynthesis of 2,5-furanodicarboxylic acid...The biomass electrochemical oxidation coupled with hydrogen evolution reaction has received widespread attention due to its carbon-neutral and sustainable properties.The electrosynthesis of 2,5-furanodicarboxylic acid(FDCA)from 5-hydroxymethylfurfural(HMF)oxidation is one of the most promising means for the production of bioplastic monomers.In this work,we constructed a novel P-doped Ni_(3)S_(2)and Ni heterojunction on nickel foam(P-Ni_(3)S_(2)/Ni/NF)using electrodeposition methods and thermal sulfuration techniques as a bifunctional catalyst for the simultaneous anodic oxidation of HMF to FDCA(HMFOR)and the cathodic hydrogen evolution reaction(HER).On one hand,the synergistic promotion of P doping and the heterojunction of Ni_(3)S_(2)and Ni accelerated electron transfer,and on the other hand,the structure of three-dimensional microsphere stacking on NF surface to form macropores enhances the exposure of catalytically active sites.The prepared P-Ni_(3)S_(2)/Ni/NF exhibited remarkable performance with high HMF conversion(99.2%),FDCA yield(98.1%),and Faraday efficiency(98.8%),and excellent stability with good product selectivity for 7 consecutive cycles,which stands at a higher level than majority of previously published electrocatalysts.Furthermore,P-Ni_(3)S_(2)/Ni/NF also shows a significant response in HER.By using HMFOR and HER as the anodic reaction and cathodic reaction,respectively,the biomass upgrading and hydrogen production can be carried out simultaneously.The synthesized P-Ni_(3)S_(2)/Ni/NF only need a voltage of 1.31V to achieve a current density of 10mA/cm^(2)in a two-electrode system of HMFOR and HER,which is much lower than that of 1.48 V in OER and HER process,thus potentially reducing the cost of this process.展开更多
Listeria monocytogenes(LM)is a dangerous foodborne pathogen for humans.One emerging and validated method of indirectly assessing LM in food is detecting 3-hydroxy-2-butanone(3H2B)gas.In this study,the synthesis of 3-(...Listeria monocytogenes(LM)is a dangerous foodborne pathogen for humans.One emerging and validated method of indirectly assessing LM in food is detecting 3-hydroxy-2-butanone(3H2B)gas.In this study,the synthesis of 3-(2-aminoethylamino)propyltrimethoxysilane(AAPTMS)functionalized hierarchical hollow TiO_(2)nanospheres was achieved via precise controlling of solvothermal reaction temperature and post-grafting route.The sensors based on as-prepared materials exhibited excellent sensitivity(480 Hz@50 ppm),low detection limit(100 ppb),and outstanding selectivity.Moreover,the evaluation of LM with high sensitivity and specificity was achieved using the sensors.Such stable three-dimensional spheres,whose distinctive hierarchical and hollow nanostructure simultaneously improved both sensitivity and response/recovery speed dramatically,were spontaneously assembled by nanosheets.Meanwhile,the moderate loadings of AAPTMS significantly improved the selectivity of sensors.Then,the gas-sensing mechanism was explored by utilizing thermodynamic investigation,Gaussian 16 software,and in situ diffuse reflectance infrared transform spectroscopy,illustrating the weak chemisorption between the-NHgroup and 3H2B molecules.These portable sensors are promising for real-time assessment of LM at room temperature,which will make a magnificent contribution to food safety.展开更多
Objectives:Ovarian cancer(OC)is a highly heterogeneous disease characterized by high metastatic potential and frequent recurrence.3β-hydroxysterolΔ24-reductase(DHCR24)is closely associated with the progression of va...Objectives:Ovarian cancer(OC)is a highly heterogeneous disease characterized by high metastatic potential and frequent recurrence.3β-hydroxysterolΔ24-reductase(DHCR24)is closely associated with the progression of various malignant tumors,but its role in OC remains unexplored.This study is the first to systematically investigate the function of DHCR24 in OC and elucidate its mechanism in promoting OC progression,providing novel theoretical insights for targeted therapy.Methods:The expression of DHCR24 was evaluated in tissues using bioinformatics and clinical data;the impact of DHCR24 on the malignant behavior of OC was assessed through in vivo and in vitro experiments;and the mechanism by which DHCR24 functions in OC was preliminarily explored using sequencing and rescue experiments.Statistical analysis was conducted using the chi-square test,t-test,and oneway ANOVA.Results:Database,clinical data,and immunohistochemical(IHC)analyses demonstrated that DHCR24 is upregulated in OC and correlates with poor outcomes.In vitro experiments indicated that DHCR24 promotes proliferation,migration,invasion,and epithelial-mesenchymal transition in OC cells.The addition of a DHCR24 inhibitor suppressed the malignant behavior of OC cells.The nude mouse tumor formation experiment demonstrated that inhibiting DHCR24 suppresses the in vivo growth of OC cells.Further experiments showed that DHCR24 promotes the malignant behavior of OC cells,correlating with the regulation of the transforming growth factor beta(TGF-β)signaling pathway.All the above experiments showed statistical significance.Conclusion:DHCR24 contributes to ovarian cancer progression by upregulating the TGF-β1 pathway,highlighting its potential as a therapeutic target in ovarian cancer.展开更多
[目的]3-(3′,4′-次甲二氧苯基)-N-正丙基丙烯酰胺是具有广谱抑菌活性的化合物,将其研制成优良环保剂型悬浮剂,可为实现田间应用提供技术依据。[方法]采用湿法研磨制备了12种不同配方的悬浮剂,通过质量指标检测确定最佳配方,测定其表...[目的]3-(3′,4′-次甲二氧苯基)-N-正丙基丙烯酰胺是具有广谱抑菌活性的化合物,将其研制成优良环保剂型悬浮剂,可为实现田间应用提供技术依据。[方法]采用湿法研磨制备了12种不同配方的悬浮剂,通过质量指标检测确定最佳配方,测定其表面张力及其在黄瓜叶面的动态接触角,并开展了防治黄瓜白粉病田间药效试验。[结果]最佳配方为3-(3′,4′-次甲二氧苯基)-N-正丙基丙烯酰胺40%(折百)、S043%、D4252%、W071%、乙二醇3%、硅酸镁铝0.4%、黄原胶0.12%、B150.12%、消泡剂X600.3%、水补足。此悬浮剂在有效成分0.27 g a.i./L时的表面张力以及在黄瓜叶面的动态接触角均小于对照药剂40%苯醚甲环唑SC,表明其具有良好的润湿性能。在有效成分0.27 g a.i./L下的防效为88.38%,与对照药剂25%嘧菌酯SC 0.20 g a.i./L相当,且对黄瓜安全。[结论]制备悬浮剂为类白色均匀悬浮液,流动性好,粒径合格,悬浮率稳定在98.5%左右,pH为4.09,黏度为452 mPa·s,入水分散性合格,热储、低温及冻融稳定性良好,未出现沉淀,各项指标均达标,对黄瓜白粉病防效优良,具有良好的开发应用前景。展开更多
基金Project supported by the Natural Science Foundation Innovation Group Project of Hubei Province(2023AFA044)the National Natural Science Foundation of China(52222405)+1 种基金the Science and Technology Research Project of Education Department of Hubei Province(Q20221505)the China Postdoctoral Science(2023M731041)。
文摘In order to reveal the effect of 2-hydroxy-3-naphthyl hydroxamic acid(H205)on the flotation behavior and action mechanism of bastnaesite,single-mineral flotation experiments of bastnaesite were conducted.The flotation recovery of bastnaesites can be achieved more than 90%when the aeration rate is 40 mL/min,the rotational speed is 200 r/min,the H205 dosage is 120 mg/L,and the pulp pH ranges from 7 to 9.The action mechanism of H205 on the surface of bastnaesite was studied by simultaneous thermogravimetry and differential scanning calorimetry(TG-DSC),Zeta potential measurements,Fourier transform-infrared spectra(FT-IR)and X-ray photoelectron spectroscopy(XPS).These analysis results show that under suitable flotation conditions,H205 has an obvious adsorption phenomenon on the surface of bastnaesite.The adsorption involves electrostatic interactions and chemical interactions,namely H205 has a strong collecting ability of bastnaesite due to the synergism of electrostatic adsorption and chemical adsorption.This study systematically reveals the flotation behavior and adsorption mechanism of H205 on the surface of bastnaesite,and provides useful theoretical guidance for efficient flotation separation of bastnaesite.
基金supported by the Research Foundation for Talented Scholars of Fujian Medical University,No.XRCZX2018014(to DZ)Startup Fund for Scientific Research,Fujian Medical University,No.2019QH1017(to CW)the Natural Science Foundation of Fujian Province,China,Nos.2021J01693(to DZ),2021J02032(to ZCY)。
文摘Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug resveratrol.In this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced neuropathology.Our results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein expression.Notably,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by D30.Considering the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.
基金supported by the Program for Changjiang Scholars of the Ministry of Education of the People’s Republic of China (No. T2016088)the National Natural Science Foundation for Distinguished Young Scholars (No. 81725021)+4 种基金the National Key R&D Program of China (No. 2021YFA0910500)the Science and Technology Major Project of Hubei Province (No.2021ACA012)the Innovative Research Groups of the National Natural Science Foundation of China (No. 81721005)the Academic Frontier Youth Team of HUST (No. 2017QYTD19)the Fundamental Research Funds for the Central Universities (No.2172019kfy XJJS166)
文摘Cancer represents a significant disease that profoundly impacts human health and longevity.Projections indicate a 47%increase in the global cancer burden by 2040 compared to 2020,accompanied by a further rise in the associated economic burden.Consequently,there is an urgent need to discover and develop new alternative drugs to mitigate the global impact of cancer.Natural products(NPs)play a crucial role in the identification and development of anticancer therapeutics.This study identified ustusolate E(UE)and its analog 11α-hydroxy-ustusolate E(HUE)from strain Aspergillus calidoustus TJ403-EL05,and examined their antitumor activities and mechanisms of action.The findings demonstrate that both compounds significantly inhibited the proliferation and colony formation of AGS(human gastric cancer cells)and 786-O(human renal clear cell carcinoma cells),induced irreversible DNA damage,blocked the cell cycle at the G_(2)/M phase,and further induced apoptosis in tumor cells.To the best of the authors’knowledge,this is the first report on the anticancer effects of UE and HUE and their underlying mechanisms.The present study suggests that HUE and UE could serve as lead compounds for the development of novel anticancer drugs.
基金the Canada First Research Excellence Fund(CFREF)Natural Sciences and Engineering Research Council of Canada-Discovery Grant(10040079)for their fundingthe financial support from the China Scholarship Council。
文摘Solar biomass conversion has garnered significant research attention,but the rapid recombination of electrons and holes in photocatalysts hinders efficiency.To enhance this process,researchers aim to develop S-scheme heterojunction photocatalysts with optimized band structures that enable effective electron-hole separation,thereby improving overall efficiency.Herein,chemical-bonded SnIn_(4)S_(8)/WO_(3)S-scheme heterostructure photocatalyst was constructed via in-situ hydrothermal strategy for sunlight-driven catalytic selective oxidization of 5-hydroxymethylfurrural(HMF)into valuable 2,5-dimethylfuran(DFF).X-ray photoelectron spectroscopy(XPS)results prove the formation of a W-S chemical bond in the composites,which will likely enhance the efficient transport of photogenerated charges.The optimal SnIn_(4)S_(8)/WO_(3)exhibited an excellent HMF conversion rate(89%)and DFF yield(68%)after 2 h.The S-scheme charge transfer pathway in the SnIn_(4)S_(8)/WO_(3)composite structure was verified through density functional theory(DFT)calculations and supported by partial in situ experimental results.This study demonstrates that the S-scheme heterostructure based on SnIn_(4)S_(8)offers innovative insights for advancing photocatalytic biomass conversion.
基金financially supported by Natural Science Foundation of Shandong Province(No.ZR2024QB415)。
文摘The biomass electrochemical oxidation coupled with hydrogen evolution reaction has received widespread attention due to its carbon-neutral and sustainable properties.The electrosynthesis of 2,5-furanodicarboxylic acid(FDCA)from 5-hydroxymethylfurfural(HMF)oxidation is one of the most promising means for the production of bioplastic monomers.In this work,we constructed a novel P-doped Ni_(3)S_(2)and Ni heterojunction on nickel foam(P-Ni_(3)S_(2)/Ni/NF)using electrodeposition methods and thermal sulfuration techniques as a bifunctional catalyst for the simultaneous anodic oxidation of HMF to FDCA(HMFOR)and the cathodic hydrogen evolution reaction(HER).On one hand,the synergistic promotion of P doping and the heterojunction of Ni_(3)S_(2)and Ni accelerated electron transfer,and on the other hand,the structure of three-dimensional microsphere stacking on NF surface to form macropores enhances the exposure of catalytically active sites.The prepared P-Ni_(3)S_(2)/Ni/NF exhibited remarkable performance with high HMF conversion(99.2%),FDCA yield(98.1%),and Faraday efficiency(98.8%),and excellent stability with good product selectivity for 7 consecutive cycles,which stands at a higher level than majority of previously published electrocatalysts.Furthermore,P-Ni_(3)S_(2)/Ni/NF also shows a significant response in HER.By using HMFOR and HER as the anodic reaction and cathodic reaction,respectively,the biomass upgrading and hydrogen production can be carried out simultaneously.The synthesized P-Ni_(3)S_(2)/Ni/NF only need a voltage of 1.31V to achieve a current density of 10mA/cm^(2)in a two-electrode system of HMFOR and HER,which is much lower than that of 1.48 V in OER and HER process,thus potentially reducing the cost of this process.
基金supported by the National Natural Science Foundation of China(No.32272399)the Shanghai Natural Science Foundation(No.21ZR1427500).
文摘Listeria monocytogenes(LM)is a dangerous foodborne pathogen for humans.One emerging and validated method of indirectly assessing LM in food is detecting 3-hydroxy-2-butanone(3H2B)gas.In this study,the synthesis of 3-(2-aminoethylamino)propyltrimethoxysilane(AAPTMS)functionalized hierarchical hollow TiO_(2)nanospheres was achieved via precise controlling of solvothermal reaction temperature and post-grafting route.The sensors based on as-prepared materials exhibited excellent sensitivity(480 Hz@50 ppm),low detection limit(100 ppb),and outstanding selectivity.Moreover,the evaluation of LM with high sensitivity and specificity was achieved using the sensors.Such stable three-dimensional spheres,whose distinctive hierarchical and hollow nanostructure simultaneously improved both sensitivity and response/recovery speed dramatically,were spontaneously assembled by nanosheets.Meanwhile,the moderate loadings of AAPTMS significantly improved the selectivity of sensors.Then,the gas-sensing mechanism was explored by utilizing thermodynamic investigation,Gaussian 16 software,and in situ diffuse reflectance infrared transform spectroscopy,illustrating the weak chemisorption between the-NHgroup and 3H2B molecules.These portable sensors are promising for real-time assessment of LM at room temperature,which will make a magnificent contribution to food safety.
文摘Objectives:Ovarian cancer(OC)is a highly heterogeneous disease characterized by high metastatic potential and frequent recurrence.3β-hydroxysterolΔ24-reductase(DHCR24)is closely associated with the progression of various malignant tumors,but its role in OC remains unexplored.This study is the first to systematically investigate the function of DHCR24 in OC and elucidate its mechanism in promoting OC progression,providing novel theoretical insights for targeted therapy.Methods:The expression of DHCR24 was evaluated in tissues using bioinformatics and clinical data;the impact of DHCR24 on the malignant behavior of OC was assessed through in vivo and in vitro experiments;and the mechanism by which DHCR24 functions in OC was preliminarily explored using sequencing and rescue experiments.Statistical analysis was conducted using the chi-square test,t-test,and oneway ANOVA.Results:Database,clinical data,and immunohistochemical(IHC)analyses demonstrated that DHCR24 is upregulated in OC and correlates with poor outcomes.In vitro experiments indicated that DHCR24 promotes proliferation,migration,invasion,and epithelial-mesenchymal transition in OC cells.The addition of a DHCR24 inhibitor suppressed the malignant behavior of OC cells.The nude mouse tumor formation experiment demonstrated that inhibiting DHCR24 suppresses the in vivo growth of OC cells.Further experiments showed that DHCR24 promotes the malignant behavior of OC cells,correlating with the regulation of the transforming growth factor beta(TGF-β)signaling pathway.All the above experiments showed statistical significance.Conclusion:DHCR24 contributes to ovarian cancer progression by upregulating the TGF-β1 pathway,highlighting its potential as a therapeutic target in ovarian cancer.
文摘[目的]3-(3′,4′-次甲二氧苯基)-N-正丙基丙烯酰胺是具有广谱抑菌活性的化合物,将其研制成优良环保剂型悬浮剂,可为实现田间应用提供技术依据。[方法]采用湿法研磨制备了12种不同配方的悬浮剂,通过质量指标检测确定最佳配方,测定其表面张力及其在黄瓜叶面的动态接触角,并开展了防治黄瓜白粉病田间药效试验。[结果]最佳配方为3-(3′,4′-次甲二氧苯基)-N-正丙基丙烯酰胺40%(折百)、S043%、D4252%、W071%、乙二醇3%、硅酸镁铝0.4%、黄原胶0.12%、B150.12%、消泡剂X600.3%、水补足。此悬浮剂在有效成分0.27 g a.i./L时的表面张力以及在黄瓜叶面的动态接触角均小于对照药剂40%苯醚甲环唑SC,表明其具有良好的润湿性能。在有效成分0.27 g a.i./L下的防效为88.38%,与对照药剂25%嘧菌酯SC 0.20 g a.i./L相当,且对黄瓜安全。[结论]制备悬浮剂为类白色均匀悬浮液,流动性好,粒径合格,悬浮率稳定在98.5%左右,pH为4.09,黏度为452 mPa·s,入水分散性合格,热储、低温及冻融稳定性良好,未出现沉淀,各项指标均达标,对黄瓜白粉病防效优良,具有良好的开发应用前景。
基金国家自然科学基金联合基金项目(U21A20485)浙江省高等教育“十四五”本科教育教学改革项目(jg20220019)+3 种基金浙江省产学合作协同育人项目(202018)浙江大学2023年度本科教学创新实践项目重点项目(202309)浙江省基础公益研究计划项目(LGG22F030008)浙江大学第一批AI For Education系列实证教学研究项目(202402)。
