Transfection of cDNA in 3'untranslated region of human nuclear factor for interleukin-6(NF-IL6 3'UTR)induced tumor suppression in a human hepatoma cell line.cDNA array analysis was used to reveal changes in ge...Transfection of cDNA in 3'untranslated region of human nuclear factor for interleukin-6(NF-IL6 3'UTR)induced tumor suppression in a human hepatoma cell line.cDNA array analysis was used to reveal changes in gene expression profile leading to tumor suppression The results indicate that this suppression was not due to activation of dsRNA-dependent protein kinase,nor to inactivation ofoncogenes; rather,all the changes in expression of known genes,induced by NF-IL6 3'UTR cDNA may be ascribed to the suppression of cellular malignancy.Therefore,our results imply that this 3'untranslated region may have played role of a regulator of gene expression profile.展开更多
基金supported by the National Natural Science Foundation of China grant(No.39970172)by the Creation Foundation from Shanghai Intsitutes for Biological Sciences.
文摘Transfection of cDNA in 3'untranslated region of human nuclear factor for interleukin-6(NF-IL6 3'UTR)induced tumor suppression in a human hepatoma cell line.cDNA array analysis was used to reveal changes in gene expression profile leading to tumor suppression The results indicate that this suppression was not due to activation of dsRNA-dependent protein kinase,nor to inactivation ofoncogenes; rather,all the changes in expression of known genes,induced by NF-IL6 3'UTR cDNA may be ascribed to the suppression of cellular malignancy.Therefore,our results imply that this 3'untranslated region may have played role of a regulator of gene expression profile.
