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Unraveling the missing heritability of amyotrophic lateral sclerosis:Should we focus more on copy number variations?
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作者 Maria Guarnaccia Valentina La Cognata +2 位作者 Giulia Gentile Giovanna Morello Sebastiano Cavallaro 《Neural Regeneration Research》 2026年第5期1997-1998,共2页
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the progressive degeneration of upper and lower motor neurons in the brainstem and spinal cord,leading to muscle weakness,para... Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the progressive degeneration of upper and lower motor neurons in the brainstem and spinal cord,leading to muscle weakness,paralysis,and respiratory failure (Morgan and Orrell,2016). 展开更多
关键词 degeneration upper lower motor neurons unraveling neurodegenerative disorder missing heritability amyotrophic lateral sclerosis copy number variations
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Origin of Sexy Prime Numbers, Origin of Cousin Prime Numbers, Equations from Supposedly Prime Numbers, Origin of the Mersenne Number, Origin of the Fermat Number
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作者 Mady Ndiaye 《Advances in Pure Mathematics》 2024年第5期321-332,共12页
We have found through calculations that the differences between the closest supposed prime numbers other than 2 and 3 defined in the articles are: 2;4: and 6. For those whose difference is equal to 6, we showed their ... We have found through calculations that the differences between the closest supposed prime numbers other than 2 and 3 defined in the articles are: 2;4: and 6. For those whose difference is equal to 6, we showed their origin then we classified them into two categories according to their classes, we showed in which context two prime numbers which differ from 6 are called sexy and in what context they are said real sexy prime. For those whose difference is equal to 4, we showed their origin then we showed that two prime numbers which differ from 4, that is to say two cousin prime numbers, are successive. We made an observation on the supposed prime numbers then we established two pairs of equations from this observation and deduced the origin of the Mersenne number and that of the Fermat number. 展开更多
关键词 Cousin Prime numbers Sexy Prime numbers Real Sexy Prime numbers Equations from Supposed Prime numbers Mersenne number Fermat number Supposed Prime numbers Prime numbers
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Mersenne Numbers, Recursive Generation of Natural Numbers, and Counting the Number of Prime Numbers 被引量:1
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作者 Ramon Carbó-Dorca 《Applied Mathematics》 2022年第6期538-543,共6页
A simple recursive algorithm to generate the set of natural numbers, based on Mersenne numbers: M<sub>N</sub> = 2<sup>N</sup> – 1, is used to count the number of prime numbers within the preci... A simple recursive algorithm to generate the set of natural numbers, based on Mersenne numbers: M<sub>N</sub> = 2<sup>N</sup> – 1, is used to count the number of prime numbers within the precise Mersenne natural number intervals: [0;M<sub>N</sub>]. This permits the formulation of an extended twin prime conjecture. Moreover, it is found that the prime numbers subsets contained in Mersenne intervals have cardinalities strongly correlated with the corresponding Mersenne numbers. 展开更多
关键词 Mersenne numbers Recursive Generation of Natural numbers Mersenne Natural number Intervals Counting the number of Prime numbers in Mersenne Natural Intervals Correlation between Prime number Set Cardinalities and Mersenne numbers Extended Twin Prime number Conjecture
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广义Z-numbers证据下考虑专家影响力和评价值一致性的应急决策方法
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作者 张磊 韩可可 叶鑫 《中国管理科学》 北大核心 2025年第6期160-170,共11页
复杂不确定情景下突发事件应急决策呈现多属性群决策的特征,且在决策信息不确定的情形下,信息的可靠度会影响决策结果。本文提出一种广义Z-numbers证据下考虑专家影响力和评价值一致性的应急决策方法。首先,基于广义Z-numbers对应急决... 复杂不确定情景下突发事件应急决策呈现多属性群决策的特征,且在决策信息不确定的情形下,信息的可靠度会影响决策结果。本文提出一种广义Z-numbers证据下考虑专家影响力和评价值一致性的应急决策方法。首先,基于广义Z-numbers对应急决策问题建模,并构建信任网络分析专家影响力,提出融合专家影响力和评价可靠度的评价值权重分析方法;其次,根据犹豫模糊评价值的交集分析专家的评价值一致性情形,提出不同一致性情形下的证据生成方法,进而利用D-S证据理论融合多证据信息进行备选应对方案的优选决策;最后,以传染性疾病医疗废物处置装置的决策为例,分析验证了所提方法的有效性和决策结果的可信性。 展开更多
关键词 应急决策 广义Z-numbers D-S证据理论 专家影响力 一致性
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A New Fuzzy Number Similarity Measure Based on Quadratic-Mean Operator for Handling Fuzzy Recommendation Problems
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作者 Shijay Chen 《Journal of Computer and Communications》 2025年第1期108-124,共17页
This study presents a new approach that advances the algorithm of similarity measures between generalized fuzzy numbers. Following a brief introduction to some properties of the proposed method, a comparative analysis... This study presents a new approach that advances the algorithm of similarity measures between generalized fuzzy numbers. Following a brief introduction to some properties of the proposed method, a comparative analysis based on 36 sets of generalized fuzzy numbers was performed, in which the degree of similarity of the fuzzy numbers was calculated with the proposed method and seven methods established by previous studies in the literature. The results of the analytical comparison show that the proposed similarity outperforms the existing methods by overcoming their drawbacks and yielding accurate outcomes in all calculations of similarity measures under consideration. Finally, in a numerical example that involves recommending cars to customers based on a nine-member linguistic term set, the proposed similarity measure proves to be competent in addressing fuzzy number recommendation problems. 展开更多
关键词 Quadratic-Mean Operator Generalized Fuzzy numbers Similarity Measures Fuzzy number Recommendation
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Genome-Wide Association Study of Brown Rice Weight Identifies an RNA-Binding Protein Antagonistically Regulating Grain Weight and Panicle Number
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作者 ZHOU Lin JIANG Hong +11 位作者 HUANG Long LI Ziang YAO Zhonghao LI Linhan JI Kangwei LI Yijie TANG Haijuan CHENG Jinping BAO Yongmei HUANG Ji ZHANG Hongsheng CHEN Sunlu 《Rice science》 2025年第4期525-536,I0050-I0065,共28页
Rice grain yield is primarily determined by three key agronomic traits:panicle number,grain number per panicle,and grain weight(GW).However,the inherent tradeoffs among these yield components remain a persistent chall... Rice grain yield is primarily determined by three key agronomic traits:panicle number,grain number per panicle,and grain weight(GW).However,the inherent tradeoffs among these yield components remain a persistent challenge in rice breeding programs.Notably,compared with GW,brown rice weight(BRW)provides a more direct metric associated with actual grain yield potential.In this study,we conducted a two-year replicated genome-wide association study to elucidate the genetic architecture of BRW and identify new loci regulating GW.Among seven consistently detected loci across experimental replicates,four were not co-localized with previously reported genes associated with BRW or GW traits.BRW1.1,one of the four newly identified loci,was found to encode a novel RNA-binding protein.Functional characterization revealed that BRW1.1 acts as a negative regulator of BRW,potentially through modulating mRNA translation processes.Intriguingly,through integrated analysis of mutant phenotypes and haplotype variations,we demonstrated that BRW1.1 mediates the physiological tradeoff between GW and panicle number.This study not only delineates the genetic determinants of BRW but also identifies BRW1.1 as a promising molecular target for breaking the yield component tradeoff in precision rice breeding. 展开更多
关键词 genome-wide association study brown rice weight RNA-binding protein TRADEOFF grain weight panicle number grain number rice yield
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Changes in source contribution to particle number concentrations during the 2022 COVID-19Lockdown on southern edge of North China Plain
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作者 Zeyu Gao Nan Zhang +6 位作者 Guotao Zhang Dawei Niu Wen Yang Xinhua Wang Shengli Wang Bin Han Zhipeng Bai 《Journal of Environmental Sciences》 2025年第12期447-460,共14页
The COVID-19 lockdown was a typical example of extreme emission reduction,providing an opportunity to study the impact of lockdown measures on air pollution.Particle number concentrations(PNC)originate from direct emi... The COVID-19 lockdown was a typical example of extreme emission reduction,providing an opportunity to study the impact of lockdown measures on air pollution.Particle number concentrations(PNC)originate from direct emissions or through new particle formation events.However,their variations during the lockdown period are under investigation.This study focuses on Luohe,a city on the southern edge of the North China Plain,analyzing the changes in PNC and its sources before,during,and after the COVID-19 lockdown.From March 25^(th)to May 31^(st),2022,real-time PNC measurements were conducted using a Scanning Mobility Particle Sizer for particle size.Results showed an 11.2%decrease in PNC during the lockdown compared to pre-lockdown and a 3.6%decrease compared to post-lockdown,indicating reduced local emissions and weakened regional transportation during the lockdown.Positive Matrix Factorization analysis identified six sources contributing to the total PNC,including photochemical nucleation,aged photochemical nucleation,gasoline vehicle emissions,diesel vehicle emissions,coal and biomass combustion,and secondary aerosols.The significant changes in source emissions indicate a substantially reduced traffic volume after the implementation of lockdown measures(2644.8#/cm^(3),2202.2#/cm^(3),2792.7#/cm^(3)).Concurrently,photochemical nucleation(310.1#/cm^(3),306.3#/cm^(3),393.1#/cm^(3))and photochemical nucleation aging(592.8#/cm^(3),744.1#/cm^(3),810.7#/cm^(3))exhibited increasing trends,while coal/biomass combustion(1656.6#/cm^(3),1586.2#/cm^(3),980.0#/cm^(3))and secondary sources(999.4#/cm^(3),791.1#/cm^(3),804.1#/cm^(3))showed decreasing trends.In summary,the contributions of traffic emissions to PNC highlight the potential for targeted traffic management strategies to improve urban air quality. 展开更多
关键词 Particle number concentration Particle number size distribution Source apportionment Epidemic lockdown
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Infinite Number of Twin Primes
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作者 S. N. Baibekov A. A. Durmagambetov 《Advances in Pure Mathematics》 2016年第13期954-971,共18页
This work is devoted to the theory of prime numbers. Firstly it introduced the concept of matrix primes, which can help to generate a sequence of prime numbers. Then it proposed a number of theorems, which together wi... This work is devoted to the theory of prime numbers. Firstly it introduced the concept of matrix primes, which can help to generate a sequence of prime numbers. Then it proposed a number of theorems, which together with theorem of Dirichlet, Siegel and Euler allow to prove the infinity of twin primes. 展开更多
关键词 Prime numbers Twin Primes Composite numbers Natural numbers ALGORITHMS Arithmetic Progression Prime numbers Matrix Special Factorial Generation of Prime numbers
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On the Expression of Composite Natural Numbers as Tensorial Products of Prime Natural Powers Vectors
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作者 Debraj Nath Ramon Carbó-Dorca 《Journal of Applied Mathematics and Physics》 2023年第6期1728-1736,共9页
This study describes how one can construct sets of composite natural numbers as tensorial products of the vectors created with the natural powers of prime numbers.
关键词 Composite Natural numbers Prime numbers Prime numbers Powers Vectors of Prime numbers Powers Tensors Holding the Composite Natural numbers
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Preliminary Identification of a Prime Number Other Than 2 and 3, the Origin of Twin Prime Numbers, the Structure of the Chain of Prime Numbers and the Set of Prime Numbers Less Than a Given Integer
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作者 Mady Ndiaye 《Advances in Pure Mathematics》 2024年第1期30-48,共19页
The application of the Euclidean division theorem for the positive integers allowed us to establish a set which contains all the prime numbers and this set we called it set of supposedly prime numbers and we noted it ... The application of the Euclidean division theorem for the positive integers allowed us to establish a set which contains all the prime numbers and this set we called it set of supposedly prime numbers and we noted it E<sub>sp</sub>. We subsequently established from the previous set the set of non-prime numbers (the set of numbers belonging to this set and which are not prime) denoted E<sub>np</sub>. We then extracted from the set of supposedly prime numbers the numbers which are not prime and the set of remaining number constitutes the set of prime numbers denoted E<sub>p</sub>. We have deduced from the previous set, the set of prime numbers between two natural numbers. We have explained during our demonstrations the origin of the twin prime numbers and the structure of the chain of prime numbers. 展开更多
关键词 Supposedly Prime numbers Non-Prime numbers Prime numbers Prime numbers Less Than a Given Integer Prime numbers between Two Given Integers
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Generalizations of Euler Numbers and Euler Numbers of Higher Order 被引量:5
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作者 LUOQiu-ming QIFeng 《Chinese Quarterly Journal of Mathematics》 CSCD 北大核心 2005年第1期54-58,共5页
The purpose of this paper is to define the generalized Euler numbers and the generalized Euler numbers of higher order, their recursion formula and some properties were established, accordingly Euler numbers and Euler... The purpose of this paper is to define the generalized Euler numbers and the generalized Euler numbers of higher order, their recursion formula and some properties were established, accordingly Euler numbers and Euler numbers of higher order were extended. 展开更多
关键词 Euler numbers higher order Euler numbers generalized Euler numbers generalized higher order Euler numbers recursion formula
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Structured condition numbers and statistical condition estimation for the LDU factorization 被引量:1
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作者 Mahvish Samar Aamir Farooq MU Chun-lai 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2020年第3期332-348,共17页
In this article, we consider the structured condition numbers for LDU, factorization by using the modified matrix-vector approach and the differential calculus, which can be represented by sets of parameters. By setti... In this article, we consider the structured condition numbers for LDU, factorization by using the modified matrix-vector approach and the differential calculus, which can be represented by sets of parameters. By setting the specific norms and weight parameters, we present the expressions of the structured normwise, mixed, componentwise condition numbers and the corresponding results for unstructured ones. In addition, we investigate the statistical estimation of condition numbers of LDU factorization using the probabilistic spectral norm estimator and the small-sample statistical condition estimation method, and devise three algorithms. Finally, we compare the structured condition numbers with the corresponding unstructured ones in numerical experiments. 展开更多
关键词 LDU factorization Structured condition number Normwise condition number Mixed condition number Componentwise condition number
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Single-nucleotide polymorphisms and copy number variations drive adaptive evolution to freezing stress in a subtropical evergreen broadleaved tree:Hexaploid wild Camellia oleifera 被引量:1
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作者 Haoxing Xie Kaifeng Xing +3 位作者 Jun Zhou Yao Zhao Jian Zhang Jun Rong 《Plant Diversity》 2025年第2期214-228,共15页
Subtropical evergreen broad-leaved trees are usually vulnerable to freezing stress,while hexaploid wild Camellia oleifera shows strong freezing tolerance.As a valuable genetic resource of woody oil crop C.oleifera,wil... Subtropical evergreen broad-leaved trees are usually vulnerable to freezing stress,while hexaploid wild Camellia oleifera shows strong freezing tolerance.As a valuable genetic resource of woody oil crop C.oleifera,wild C.oleifera can serve as a case for studying the molecular bases of adaptive evolution to freezing stress.Here,47 wild C.oleifera from 11 natural distribution sites in China and 4 relative species of C.oleifera were selected for genome sequencing.“Min Temperature of Coldest Month”(BIO6)had the highest comprehensive contribution to wild C.oleifera distribution.The population genetic structure of wild C.oleifera could be divided into two groups:in cold winter(BIO6≤0℃)and warm winter(BIO6>0℃)areas.Wild C.oleifera in cold winter areas might have experienced stronger selection pressures and population bottlenecks with lower N_(e) than those in warm winter areas.155 singlenucleotide polymorphisms(SNPs)were significantly correlated with the key bioclimatic variables(106 SNPs significantly correlated with BIO6).Twenty key SNPs and 15 key copy number variation regions(CNVRs)were found with genotype differentiation>50%between the two groups of wild C.oleifera.Key SNPs in cis-regulatory elements might affect the expression of key genes associated with freezing tolerance,and they were also found within a CNVR suggesting interactions between them.Some key CNVRs in the exon regions were closely related to the differentially expressed genes under freezing stress.The findings suggest that rich SNPs and CNVRs in polyploid trees may contribute to the adaptive evolution to freezing stress. 展开更多
关键词 Adaptive evolution Camellia oleifera Copy number variations Freezing stress POLYPLOID Single-nucleotide polymorphisms
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A low Mach number asymptotic analysis of dissipation-reducing methods for curing shock instability 被引量:1
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作者 Hongping GUO Xun WANG Zhijun SHEN 《Applied Mathematics and Mechanics(English Edition)》 2025年第4期723-744,共22页
We are intrigued by the issues of shock instability,with a particular emphasis on numerical schemes that address the carbuncle phenomenon by reducing dissipation rather than increasing it.For a specific class of plana... We are intrigued by the issues of shock instability,with a particular emphasis on numerical schemes that address the carbuncle phenomenon by reducing dissipation rather than increasing it.For a specific class of planar flow fields where the transverse direction exhibits vanishing but non-zero velocity components,such as a disturbed onedimensional(1D)steady shock wave,we conduct a formal asymptotic analysis for the Euler system and associated numerical methods.This analysis aims to illustrate the discrepancies among various low-dissipative numerical algorithms.Furthermore,a numerical stability analysis of steady shock is undertaken to identify the key factors underlying shock-stable algorithms.To verify the stability mechanism,a consistent,low-dissipation,and shock-stable HLLC-type Riemann solver is presented. 展开更多
关键词 Riemann solver numerical shock instability low Mach number HLLC
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基于T-球形模糊Z-number的扩展TODIM方法及应用
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作者 程玮玲 毛军军 张胜 《武汉理工大学学报(信息与管理工程版)》 2025年第1期65-72,共8页
Z-number作为一种表达不确定信息的方法,其核心在于处理信息的模糊性和概率不确定性。然而,当前关于Z-number的研究相对有限,许多研究未能充分揭示其性质。T-球形模糊Z-number为表示数据的随机性和模糊性提供了新的视角。首先,引入了T-... Z-number作为一种表达不确定信息的方法,其核心在于处理信息的模糊性和概率不确定性。然而,当前关于Z-number的研究相对有限,许多研究未能充分揭示其性质。T-球形模糊Z-number为表示数据的随机性和模糊性提供了新的视角。首先,引入了T-球形模糊Z-number,利用T-球形模糊数和相应可靠性度量的组合表示数据信息,可以很好地体现决策数据的模糊性和适用性。其次,提出了T-球形模糊Z-number的运算法则和聚合算子,并基于所提出的聚合算子和TODIM方法,提出了两种算法来处理T-球形模糊Z-number形式的不确定信息。最后,以安徽省4个城市数字经济的评估问题为实例进行对比分析,论证了所提出算法的实用性和有效性。 展开更多
关键词 T-球形模糊 Z-number TODIM 多属性决策 数字经济评估
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Star-quadrilateral Ramsey Number and Beyond
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作者 CHEN Yaojun ZHANG Xuemei ZHANG Yanbo 《数学进展》 北大核心 2025年第2期292-314,共23页
For k given graphs H_(1),...,H_(k) with k≥2,the k-color Ramsey number R(H_(1),...,H_(k)) represents the minimum integer N with the following property:if the edges of the complete graph K_(N) are colored with k colors... For k given graphs H_(1),...,H_(k) with k≥2,the k-color Ramsey number R(H_(1),...,H_(k)) represents the minimum integer N with the following property:if the edges of the complete graph K_(N) are colored with k colors,then there exists some i with 1≤i≤k such that K_(N) has a subgraph in color i isomorphic to H_(i).Let C_(m) be a cycle of length m and K_(1,n) a star of order n+1.In this paper,we systematically introduce the latest research progress on star-quadrilateral Ramsey numbers and provide an overview of Ramsey numbers concerning quadrilaterals,including multicolor cases. 展开更多
关键词 multicolor Ramsey number polarity graph QUADRILATERAL STAR WHEEL BOOK
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Health Phys.Abstracts,Volume 128,Number 1
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《辐射防护》 北大核心 2025年第2期191-196,共6页
TENORM Regulation in the United States of America post-West Virginia vs.EPA Spenser Lynn,Charles Wilson,Emily Caffrey1(1.University of Alabama at Birmingham,School of Health Professions,Clinical and Diagnostic Science... TENORM Regulation in the United States of America post-West Virginia vs.EPA Spenser Lynn,Charles Wilson,Emily Caffrey1(1.University of Alabama at Birmingham,School of Health Professions,Clinical and Diagnostic Sciences,Health Physics Program,1720 University Blvd,Birmingham,AL 35294)Abstract:The regulation of technologically enhanced naturally occurring radioactive materials(TENORM)in the United States of America consists of fragmentary rules split between the federal and state governments. 展开更多
关键词 ABSTRACTS number naturally
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Asymptotic Probability of Record Numbers in Random Walks
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作者 PENG Wenjie LI Yuqiang 《应用概率统计》 北大核心 2025年第1期17-27,共11页
In this paper,large deviations principle(LDP)and moderate deviations principle(MDP)of record numbers in random walks are studied under certain conditions.The results show that the rate functions of LDP and MDP are dif... In this paper,large deviations principle(LDP)and moderate deviations principle(MDP)of record numbers in random walks are studied under certain conditions.The results show that the rate functions of LDP and MDP are different from those of weak record numbers,which are interesting complements of the conclusions by Li and Yao[1]. 展开更多
关键词 random walk record number large deviation moderate deviation
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The Crossing Number of Two Classes of Join Graphs
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作者 LU Shengxiang WANG Shu WANG Jing 《数学进展》 北大核心 2025年第5期983-991,共9页
Determining the crossing number of a given graph is NP-complete. The cycle of length m is denoted by Cm = v1v2…vmv1. G^((1))_(m) (m ≥ 5) is the graph obtained from Cm by adding two edges v1v3 and vlvl+2 (3 ≤ l ≤ m... Determining the crossing number of a given graph is NP-complete. The cycle of length m is denoted by Cm = v1v2…vmv1. G^((1))_(m) (m ≥ 5) is the graph obtained from Cm by adding two edges v1v3 and vlvl+2 (3 ≤ l ≤ m−2), G^((2))m (m ≥ 4) is the graph obtained from Cm by adding two edges v1v3 and v2v4. The famous Zarankiewicz’s conjecture on the crossing number of the complete bipartite graph Km,n states that cr(Km,n)=Z(m,n)=[m/2][m-1/2][n/2[n-1/2].Based on Zarankiewicz’s conjecture, a natural problem is to study the change in the crossingnumber of the graphs obtained from the complete bipartite graph by adding certain edge sets.If Zarankiewicz’s conjecture is true, this paper proves that cr(G^((1))_(m)+Kn)=Z(m,n)+2[n/2] and cr(G^((2))_(m)+Kn)=Z(m,n)+n. 展开更多
关键词 crossing number DRAWING join graph
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On the Turán Number of k_(1)P_(ι)∪k_(2)S_(ι-1)
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作者 FANG Tao YUAN Xiying 《数学进展》 北大核心 2025年第4期687-695,共9页
The Turan number of a graph H,denoted by ex(n,H),is the maximum number of edges in any graph on n vertices containing no H as a subgraph.Let P_(ι)denote the path onιvertices,S_(ι-1)denote the star onιvertices and ... The Turan number of a graph H,denoted by ex(n,H),is the maximum number of edges in any graph on n vertices containing no H as a subgraph.Let P_(ι)denote the path onιvertices,S_(ι-1)denote the star onιvertices and k_(1)P_(ι)∪k_(2)S_(ι-1)denote the path-star forest with disjoint union of k_(1)copies of P_(ι)and k_(2)copies of S_(ι-1).In 2022,[Graphs Combin.,2022,38(3):Paper No.84,16 pp.] raised a conjecture about the Turan number of k_(1)P_(2ι)∪k_(2)S_(2ι-1).In this paper,we determine the Turan numbers of P_(ι)∪kS_(ι-1)and k_(1)P_(2ι)∪k_(2)S_(2ι-1)for n appropriately large,which implies the above conjecture.The corresponding extremal graphs are also completely characterized. 展开更多
关键词 Turan number path-star forest extremal graph
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