Objective:To investigate the clinical efficacy of levofloxacin combined with ambroxol in the treatment of elderly patients with chronic obstructive pulmonary disease(COPD)and pulmonary infection.Methods:A total of 80 ...Objective:To investigate the clinical efficacy of levofloxacin combined with ambroxol in the treatment of elderly patients with chronic obstructive pulmonary disease(COPD)and pulmonary infection.Methods:A total of 80 elderly COPD patients with pulmonary infection,treated between December 2022 and November 2023,were randomly divided into a control group and an observation group,with 40 cases in each group.The control group was treated with levofloxacin hydrochloride,while the observation group received ambroxol hydrochloride injection in addition to the treatment in the control group.Laboratory indices(white blood cell count,procalcitonin,C-reactive protein,and apolipoprotein E levels),imaging-based pulmonary lesion absorption time,hospital stay,and incidence of adverse reactions were compared between the two groups.Results:After treatment,the biochemical indices of the observation group were significantly lower than those of the control group,with highly significant differences(P<0.001).Compared to the control group,the imaging-based pulmonary lesion absorption time and hospital stay of the observation group were significantly shorter(P<0.001).Additionally,the incidence of adverse reactions in the observation group was significantly lower than in the control group(P<0.05).Conclusion:Levofloxacin combined with ambroxol demonstrates advantages in improving biochemical indices,shortening imaging-based pulmonary lesion absorption time and hospital stay,and reducing adverse reaction rates in elderly COPD patients with pulmonary infection.It holds significant clinical application value.展开更多
Cancer patients in China navigate a complex and uneven insurance landscape,making plan choice critical for equitable financial protection.This study conducts a structured narrative review(2010-2025)of the Web of Scien...Cancer patients in China navigate a complex and uneven insurance landscape,making plan choice critical for equitable financial protection.This study conducts a structured narrative review(2010-2025)of the Web of Science,PubMed,CNKI,and Wanfang databases,focusing on empirical research on insurance plan choice,enrollment,or switching among cancer patients and their households in China.Two reviewers independently screened studies and extracted information on key determinants and identification strategies.The evidence converges on five main determinants:insurance literacy,health knowledge,prior coverage,financial capability,and policy promotion intensity(PPI).However,most studies are cross-sectional and descriptive,with inconsistent operationalization of determinants,weak or absent mediation tests for PPI,and limited coverage of rural,elderly,and low-literacy populations.Building on these gaps,we synthesize an evidence map,propose an operational PPI index,and highlight quasi-experimental opportunities(such as staggered NRDL updates and variation in local publicity efforts)to identify mechanisms and inform more inclusive,patient-centered insurance design in China.展开更多
Objective:To construct an evidence-based practice plan for perioperative nutritional optimization in esophageal cancer patients.Methods:By systematically searching relevant guidelines at home and abroad,two experts in...Objective:To construct an evidence-based practice plan for perioperative nutritional optimization in esophageal cancer patients.Methods:By systematically searching relevant guidelines at home and abroad,two experts independently assessed the quality of the guidelines,extracted valuable evidence and recommendations,and initially formed a draft nursing program.Subsequently,an expert panel was organized to conduct a detailed discussion to review the practicality and effectiveness of the recommendations one by one,and the program was finally revised and improved.Results:The protocol covered four stages of patients’admission,preoperative,postoperative,and discharge,involving specific contents such as nutritional assessment,risk screening,dysphagia assessment,nutritional therapy,enteral and parenteral nutritional support,symptom management,and health education.The program included a total of 61 entries,with 33 class A recommendations and 28 class B recommendations.Conclusion:The constructed perioperative nutritional care program for esophageal cancer patients is scientific and practical,and can provide practical guidance for clinical care.展开更多
Thrombotic thrombocytopenic purpura(TTP)is a rare and life-threatening form of thrombotic microangiopathy,primarily caused by a deficiency of ADAMTS-13 activity.Immune-related adverse events(irAEs)are autoimmune toxic...Thrombotic thrombocytopenic purpura(TTP)is a rare and life-threatening form of thrombotic microangiopathy,primarily caused by a deficiency of ADAMTS-13 activity.Immune-related adverse events(irAEs)are autoimmune toxicities mediated by the use of immune checkpoint inhibitors(ICIs).Here,the study reports a case of thrombotic thrombocytopenic purpura that developed in a patient with renal cell carcinoma and vertebral metastasis following combined treatment with Toripalimab and Pazopanib.The patient received Toripalimab in combination with Pazopanib after undergoing radical nephrectomy for right renal cell carcinoma.Five days later,a generalized erythematous rash appeared,partly confluent,accompanied by congestion and swelling of both palpebral and bulbar conjunctiva.Based on the clinical presentation and laboratory results showing thrombocytopenia and hemolytic anemia,the diagnosis of TTP was established.The condition was considered an adverse effect associated with the combination therapy of Toripalimab and Pazopanib.Plasma exchange and high-dose intravenous immunoglobulin therapy were promptly initiated.The treatment regimen was subsequently modified to Axitinib combined with radiotherapy,leading to a gradual recovery of platelet counts.This report highlights the potential risk of TTP associated with combined ICI and TKI therapy,and underscores the importance of early recognition and timely management of this potentially fatal complication.展开更多
Objective:To investigate the clinical efficacy of Modified Gegen Qinlian Decoction combined with probiotics(Clostridium butyricum live capsules)in treating radiation enteritis(RE)in tumor patients,as well as its regul...Objective:To investigate the clinical efficacy of Modified Gegen Qinlian Decoction combined with probiotics(Clostridium butyricum live capsules)in treating radiation enteritis(RE)in tumor patients,as well as its regulatory effect on the structure of intestinal flora,providing clinical evidence for the integrated traditional Chinese and Western medicine treatment of radiation enteritis.Methods:A total of 40 patients with radiation enteritis admitted to the Oncology Department of Linfen Central Hospital from September 2023 to December 2024 were selected and divided into an observation group and a control group according to the random number table method,with 20 cases in each group.The control group was treated with Clostridium butyricum live capsules,while the observation group was treated with Modified Gegen Qinlian Decoction in addition to the treatment given to the control group.Both groups received a 4-week treatment course.Intestinal function indicators and changes in intestinal flora structure were compared between the two groups before and after treatment,and clinical efficacy was evaluated.Results:After 4 weeks of treatment,the total effective rate in the observation group versus the control group was(95.00%vs 65.00%),with a statistically significant difference(P<0.05).The fecal formation rate in the observation group(85.00%vs 60.00%)was significantly higher than that in the control group,and the defecation frequency(2.15±0.42 vs 3.85±0.65)times/day was significantly lower than that in the control group,with statistically significant differences(P<0.05).After treatment,the quantities of Bifidobacterium(6.85±0.72 L vs 5.23±0.61 L)gCFU/g and Lactobacillus(6.52±0.68 L vs 4.98±0.57 L)gCFU/g in the observation group were significantly higher than those in the control group,while the quantities of Escherichia coli(4.12±0.53 L vs 5.67±0.65 L)gCFU/g and Staphylococcus(3.85±0.48 L vs 5.23±0.59 L)gCFU/g were significantly lower than those in the control group,with statistically significant differences(P<0.05).Conclusion:Clinical studies have confirmed that the synergistic treatment of radiation enteritis with Modified Gegen Qinlian Decoction and probiotics can significantly improve patients’clinical symptoms and restore the balance of intestinal flora,providing an effective regimen for clinical treatment.展开更多
Objective:To analyze the clinical efficacy and safety of toripalimab combined with the GC chemotherapy regimen in the treatment of advanced urothelial carcinoma.Methods:A retrospective study was conducted on 102 patie...Objective:To analyze the clinical efficacy and safety of toripalimab combined with the GC chemotherapy regimen in the treatment of advanced urothelial carcinoma.Methods:A retrospective study was conducted on 102 patients with advanced urothelial carcinoma treated at our hospital between March 2021 and August 2024.Based on treatment regimens,patients were divided into a chemotherapy group(n=52)and a combination group(n=50).The chemotherapy group received the GC chemotherapy regimen,while the combination group received GC chemotherapy combined with toripalimab.Both groups underwent 4-6 cycles of treatment based on patient tolerance.Clinical efficacy,immune-related factor levels,survival outcomes,and safety were observed and compared.Results:The disease control rate(DCR)and overall response rate(ORR)in the combination group were slightly higher than those in the chemotherapy group,but the differences were not statistically significant(P>0.05).After treatment,levels of IFN-γand IL-2 increased significantly,while VEGF levels decreased significantly in both groups(P<0.05),with superior outcomes observed in the combination group(P<0.05).Follow-up analysis showed progression-free survival(PFS)and median overall survival(OS)in the chemotherapy group were 5.19 and 10.15 months,respectively,compared to 8.24 and 18.23 months in the combination group,with statistically significant differences(P<0.05).During treatment,the incidence of adverse reactions such as rash,immune-related pneumonia,and immune-related diarrhea was higher in the combination group than in the chemotherapy group(P<0.05).However,the incidence of gastrointestinal reactions,fever,and leukopenia did not differ significantly between the two groups(P>0.05).Conclusion:The use of toripalimab combined with the GC chemotherapy regimen for advanced urothelial carcinoma can effectively improve clinical outcomes and extend patient survival,with good overall safety.However,attention should be given to preventing adverse reactions such as rash and pneumonia during treatment.展开更多
Ovarian cancer ranks as the deadliest malignancy among female reproductive system cancers,posing a significant threat to women’s health.Around seven out of ten patients are diagnosed only after reaching progressive d...Ovarian cancer ranks as the deadliest malignancy among female reproductive system cancers,posing a significant threat to women’s health.Around seven out of ten patients are diagnosed only after reaching progressive disease phases,a phenomenon closely linked to three key factors:the disease’s hidden onset location,lack of early symptoms,and absence of reliable early diagnostic methods.Therefore,identifying early diagnostic biomarkers and therapeutic targets is critical.Exosomes participate in various phases of ovarian tumorigenesis,including transforming normal cells into cancerous cells,immune regulation,invasion,metastasis,drug resistance,and angiogenesis,making them promising biomarkers for early ovarian cancer detection.This review summarizes current research on exosomal long non-coding RNAs(lncRNAs),miRNAs,and related proteins in ovarian cancer diagnosis.Exosome-based biomarkers have shown potential advantages,including high sensitivity,specificity,stability,and non-invasive accessibility.The study concludes that while exosomes hold significant diagnostic potential for ovarian cancer,additional investigations are required to standardize detection methods,validate clinical applicability,and elucidate underlying molecular mechanisms.展开更多
Objective:To evaluate the use of infrared thermography technology for objective and quantitative syndrome differentiation and treatment in traditional Chinese medicine(TCM),specifically in patients with Chaihu Guizhi ...Objective:To evaluate the use of infrared thermography technology for objective and quantitative syndrome differentiation and treatment in traditional Chinese medicine(TCM),specifically in patients with Chaihu Guizhi Ganjiang Decoction syndrome.Methods:Data were collected from over 100 patients diagnosed with Chaihu Guizhi Ganjiang Decoction syndrome at Professor Li Leyu’s endocrinology clinic,Zhongshan Hospital of Traditional Chinese Medicine,Guangdong Province,between April 2021 and April 2022.Body surface temperature data were obtained using the MTI-EXPRO-2013-B infrared thermography system.Principal component analysis(PCA)was applied to differentiate temperature distribution characteristics between genders,and a neural network prediction model was constructed for syndrome diagnosis.Results:Infrared thermography effectively captured surface temperature characteristics of patients with Chaihu Guizhi Ganjiang Decoction syndrome.PCA identified one principal component with a variance explanation rate of 73.953%for females and two principal components with a cumulative variance explanation rate of 77.627%for males.The neural network model demonstrated high predictive performance,with an area under the ROC curve of 0.9743 for the training set and 0.9889 for the validation set.Sensitivity was 1,specificity 0.8636,precision 0.8846,accuracy 0.9333,and the F1 score 0.9388.Conclusion:Infrared thermography provides an innovative,objective,and quantitative method for syndrome differentiation and treatment in TCM.It represents a significant advancement in transitioning from traditional empirical approaches to modern,visualized,and precise diagnosis and treatment.This study underscores the potential of integrating advanced technologies in TCM for enhanced clinical application and modernization.展开更多
The global incidence of breast cancer remains high and is increasing annually in some regions.Despite the variety of current treatments for breast cancer,the preventive and therapeutic effects are still limited due to...The global incidence of breast cancer remains high and is increasing annually in some regions.Despite the variety of current treatments for breast cancer,the preventive and therapeutic effects are still limited due to the highly heterogeneous nature and complex biological mechanisms of breast cancer.In recent years,tea consumption has emerged as a research focus due to its possible anti-cancer properties.Numerous preclinical studies have demonstrated that regular tea intake could potentially curb the progression of breast cancer by influencing various biological mechanisms,including signaling pathways,cell cycle regulation,and immune system responses,among others.Nonetheless,the findings from epidemiological studies show considerable variability,and the connection between tea drinking and both the risk and outlook for breast cancer is shaped by numerous elements.These include the specific type of tea consumed,the quantity consumed,individual genetic variations,and environmental influences.This article summarizes the current research findings and delves into the connection between tea consumption and the risk as well as the prognosis of breast cancer among different regional populations.Meanwhile,it expounds on the potential molecular biological mechanisms behind it.The aim is to offer a theoretical foundation for the personalized prevention and treatment of breast cancer.展开更多
This article systematically reviews the application of biomimetic nanotechnology in targeted therapy for triple-negative breast cancer(TNBC).TNBC poses significant challenges for conventional treatments due to the lac...This article systematically reviews the application of biomimetic nanotechnology in targeted therapy for triple-negative breast cancer(TNBC).TNBC poses significant challenges for conventional treatments due to the lack of defined therapeutic targets,chemotherapy resistance,and a complex immunosuppressive microenvironment.Biomimetic nanotechnology,by mimicking the functional properties of biological structures(e.g.,cell membranes,exosomes),has significantly enhanced drug delivery efficiency,targeting precision,and anti-tumor immune responses.This review focuses on the design strategies of biomimetic nanocarriers(including cell membrane-coated nanoparticles,engineered exosomes,and biomimetic synthetic materials)and their innovative applications in TNBC therapy:(1)Targeted delivery systems that overcome tumor barriers and reduce systemic toxicity;(2)Photothermal therapy combined with immunomodulation for precise treatment and immune activation;(3)Tumor microenvironment regulation(e.g.,vascular normalization,pH neutralization,immunosuppression reversal).Studies demonstrate that biomimetic nanotechnology significantly improves TNBC treatment efficacy through multimodal synergistic mechanisms(e.g.,chemo-photothermal-immunotherapy).However,challenges such as scalable production,long-term safety,and personalized adaptation remain for clinical translation.Future research should integrate artificial intelligence for optimized design and dynamic imaging technologies to advance biomimetic nanomedicines toward clinical applications.展开更多
This review systematically elucidates the core mechanisms and research advancements regarding the role of autophagy in immune evasion in Renal Cell Carcinoma(RCC).Accumulating evidence indicates that autophagy exhibit...This review systematically elucidates the core mechanisms and research advancements regarding the role of autophagy in immune evasion in Renal Cell Carcinoma(RCC).Accumulating evidence indicates that autophagy exhibits a typical“context-dependent”dual role in RCC pathogenesis:it may suppress tumorigenesis in early stages,while primarily promoting cell survival and immunosuppressive functions within the established tumor microenvironment(TME).Autophagy facilitates immune escape through multi-dimensional mechanisms,including the precise regulation of PD-L1 stability,degradation of MHC-I molecules and the antigenic peptide pool,remodeling of the metabolic microenvironment,induction of T cell exhaustion,and enhancement of immunosuppressive cell functions.Therapeutically,combining autophagy inhibitors with immune checkpoint inhibitors has demonstrated significant synergistic effects in preclinical studies,and several clinical trials have provided preliminary validation of its safety and efficacy.Future research should focus on integrating multi-omics technologies and advanced disease models to deeply elucidate the autophagy regulatory network,explore its crosstalk with other cell death pathways such as pyroptosis and ferroptosis,and promote the development of personalized treatment strategies based on precise stratification of autophagy activity,thereby offering new avenues to overcome immunotherapy resistance in RCC.展开更多
As a severe neurological disease,cerebral hemorrhage is dangerous and progresses rapidly,with high disability and fatality rates.Its occurrence seriously harms patients’lives and health,and also causes a heavy social...As a severe neurological disease,cerebral hemorrhage is dangerous and progresses rapidly,with high disability and fatality rates.Its occurrence seriously harms patients’lives and health,and also causes a heavy social burden.Timely diagnosis and treatment of cerebral hemorrhage are essential for improving patients’prognosis.This article reviews the research progress in emergency treatment for patients with cerebral hemorrhage,providing a basis for diagnosis and treatment.展开更多
Background:Hepatocellular carcinoma(HCC)is one of the most prevalent malignant tumors worldwide,and endocrine,metabolic,and immune factors influence its occurrence and progression.Hypothyroidism(HT)is a common endocri...Background:Hepatocellular carcinoma(HCC)is one of the most prevalent malignant tumors worldwide,and endocrine,metabolic,and immune factors influence its occurrence and progression.Hypothyroidism(HT)is a common endocrine disorder that may affect cancer risk;however,its relationship with HCC remains unclear.Objective:This study aimed to investigate the potential molecular and immune mechanisms underlying the association between HT and HCC,with a focus on the regulatory effects of HT-related genetic variants on the hepatic tumor immune microenvironment.Methods:Single-nucleotide polymorphisms(SNPs)associated with HT and HCC identified through Mendelian randomization were functionally annotated using the Ensembl Genome Browser and mapped to candidate genes.Functional enrichment and pathway analyses were performed with Metascape.Differentially expressed target genes between HCC and normal liver tissues were screened using GEPIA2,and their protein expression levels were validated in the Human Protein Atlas(HPA)database.The association between target gene expression and immune cell infiltration was further evaluated using TIMER2.0.Results:A total of 68 candidate genes were analyzed.Enrichment analysis revealed that these genes are involved in IFN-γ-mediated immune responses,PI3K/AKT and RAC1 signaling pathways,and other immune regulatory processes.Among them,HLA-DQA1,HLA-DPB1,HLA-DQA2,and PVT1 showed significant differential expression in HCC.HLA-DQA1,HLA-DPB1,and HLA-DQA2 were positively correlated with CD8⁺T cells,regulatory T cells(Tregs),and M2 macrophages,suggesting that these genes may exert bidirectional effects on antitumor immunity and immunosuppression.PVT1 may influence the immune microenvironment by regulating myeloid cell recruitment and extracellular matrix remodeling.Conclusion:HLA-DQA1,HLA-DPB1,HLA-DQA2,and PVT1 may reduce the risk of HCC by enhancing IFN-γ-mediated antitumor immunity and modulating key signaling pathways,while also contributing to immune microenvironment remodeling.These findings provide mechanistic insights into the protective effects of HT on HCC and suggest potential targets for immunotherapeutic strategies.展开更多
Objective:To explore factors influencing decision regret among colorectal cancer patients undergoing intestinal ostomy.Methods:A questionnaire survey was conducted among 102 colorectal cancer patients who underwent in...Objective:To explore factors influencing decision regret among colorectal cancer patients undergoing intestinal ostomy.Methods:A questionnaire survey was conducted among 102 colorectal cancer patients who underwent intestinal ostomy surgery and visited the ostomy clinic at a tertiary hospital in Baoding from July to September 2025.The Chinese version of the Ostomy Adaptation Inventory(OAI-20),Decision Regret Scale(DRS),Decision Conflict Scale(DCS),and Functional Assessment of Cancer Therapy-Colorectal(FACT-C)were used to measure patients’adaptation to stoma,decision regret,decision conflict,and quality of life.The Shared Decision-Making Questionnaire(SDM-Q-9)assessed patient involvement in ostomy surgery decisions,while the SSUK-8 evaluated social support.Additional items explored perceptions related to decision-making,participation,and outcomes.Results:Among 134 eligible patients attending the clinic,120 participated in the questionnaire,with 102 completing all items.Stoma patients reported an average decision regret score of 60.83(SD 28.43),an average coping ability score of 54.26(SD 26.69),an average decision conflict score of 62.55(SD 25.95),and a quality of life score of 56.93(SD 27.46).In the multiple regression analysis,decision regret was associated with decision conflict,poor patient coping ability,low quality of life,and low social support.Conclusion:Decision regret is prevalent among Chinese CRC patients following ostomy surgery.Compared with similar studies in other regions,Chinese CRC patients exhibit a higher rate of regret.This may be related to lower patient involvement in decision-making,generally poorer quality of life,and heavier economic burdens.展开更多
Triple-negative breast cancer(TNBC)is marked by its high degree of malignancy and challenging treatment outcomes.While Western medicine predominantly relies on chemotherapy,issues such as drug resistance and toxic sid...Triple-negative breast cancer(TNBC)is marked by its high degree of malignancy and challenging treatment outcomes.While Western medicine predominantly relies on chemotherapy,issues such as drug resistance and toxic side effects remain prevalent.Drawing on the traditional Chinese medicine(TCM)principle of“treating the same disease with different methods,”Bian devises individualized therapeutic strategies tailored to the unique syndrome patterns of TNBC patients,adhering to the core tenets of“treatment based on syndrome differentiation”and“simultaneous regulation of the liver and spleen.”Through an analysis of clinical cases involving TNBC patients,this paper summarizes Bian’s clinical experience,which emphasizes foundational approaches such as strengthening the body’s resistance and soothing the liver to regulate qi,combined with personalized therapies including clearing heat and draining dampness,pacifying the liver and subduing yang,and resolving phlegm to unblock collaterals.The study highlights a diagnostic model of“multiple prescriptions for one disease,tailored to individual conditions,”providing valuable insights for the personalized TCM treatment of TNBC.展开更多
Objective:To utilize the VigiAccess database for data mining to analyze the characteristics of adverse reactions induced by mirogabalin,providing critical information for clinical medication use.Method:This study anal...Objective:To utilize the VigiAccess database for data mining to analyze the characteristics of adverse reactions induced by mirogabalin,providing critical information for clinical medication use.Method:This study analyzed data from the VigiAccess database,filtering out adverse reaction reports where mirogabalin was identified as the Primary Suspect Drug(PS).Reporting Odds Ratio(ROR),Proportional Reporting Ratio(PRR),Bayesian Confidence Propagation Neural Network(BCPNN),and Empirical Bayes Geometric Mean(EBGM)methods were employed as data mining algorithms for pharmacovigilance and adverse event monitoring.These methods identify potential drug-adverse event association signals by analyzing the relationship between drug use and adverse event reporting.ROR and PRR focus on calculating reporting ratios,while BCPNN and EBGM use neural networks and empirical Bayes models,respectively,to enhance the accuracy and reliability of signal detection.Results:A total of 734 adverse reaction reports associated with mirogabalin were obtained.The results showed that females reported the highest number of adverse reactions,accounting for 59.67%,while males accounted for 38.83%.In terms of age distribution,the highest number of reports came from individuals over 75 years old,accounting for 33.79%.Adverse reactions mainly involved the nervous system(33.45%),general diseases and reactions at the site of administration(11.62%),and gastrointestinal disorders(10.74%).The most common adverse reactions included dizziness(11.62%),somnolence(8.27%),renal dysfunction(2.90%),and edema(2.82%).Signal intensity analysis revealed that certain adverse reactions(such as renal dysfunction,rhabdomyolysis,and drug-induced liver injury)had significant signal strength,suggesting a strong association with mirogabalin.Conclusion:This study,through signal mining of the VigiAccess database,reveals the characteristics of mirogabalin’s adverse reactions in the real world,particularly in the nervous system and renal function.These findings provide important reference information for clinicians,aiding in the optimization of the safe use of mirogabalin.Future research should further validate the causal relationships of these signals and explore individualized treatment strategies to reduce the incidence of adverse reactions and improve patient outcomes.展开更多
To investigate the targets and mechanism of Hedysarum Multijugum Maxim(HMM)in treatment of bladder cancer(BC).Based on Traditional Chinese Medicine Systems Pharmacology(TCMSP)and gene databases,active substances and p...To investigate the targets and mechanism of Hedysarum Multijugum Maxim(HMM)in treatment of bladder cancer(BC).Based on Traditional Chinese Medicine Systems Pharmacology(TCMSP)and gene databases,active substances and potential targets of HMM were screened,and the HMM-active substances-targets-BC(HATB)regulatory network and PPI network were constructed.Hub targets were screened by Cytoscape.The main active substances and Hub targets were molecularly docked with AutoDock and visualized by PyMOL.12 Hub targets were screened.Molecular docking showed that active substances mainly acted on MAPK14,MAPK1 and CCND1.The bindings of calycosin to MAPK14,formononetin to MAPK14,and calycosin to CCND1 were stable.展开更多
Renal cell carcinoma(RCC),which accounts for about 90 percent of kidney cancers,has a distinct metabolic reprogramming profile characterized by increased aerobic glycolysis(Warburg effect),abnormal accumulation of lip...Renal cell carcinoma(RCC),which accounts for about 90 percent of kidney cancers,has a distinct metabolic reprogramming profile characterized by increased aerobic glycolysis(Warburg effect),abnormal accumulation of lipids,and impaired mitochondrial function.Recent advances in high-throughput proteomic and metabolomic technologies have revolutionized our understanding of the pathophysiology of RCC,allowing for the systematic identification of disease-specific molecular signatures,elucidation of drug resistance mechanisms,and possible targets for intervention.The review focuses on the use of proteomic and metabolomic technologies in renal cell carcinoma and the research progress on related biomarkers,and is expected to provide useful information for the early detection and treatment of RCC.展开更多
Primary of Unknown Origin Cancer(CUP)is a metastatic tumor whose origin remains undetermined.The reason for this ambiguity in identifying the primary site remains unclear,possibly due to the tumor being too small or g...Primary of Unknown Origin Cancer(CUP)is a metastatic tumor whose origin remains undetermined.The reason for this ambiguity in identifying the primary site remains unclear,possibly due to the tumor being too small or growing too slowly,or because the immune system has destroyed the tiny primary lesion.Most CUP patients receive only localized treatment or empirical systemic chemotherapy,leading to poor prognosis and shorter average overall survival.There is currently insufficient evidence-based medical support for the diagnosis and treatment of CUP.This study retrospectively analyzed clinical characteristics,diagnostic methods,treatment approaches,and prognostic outcomes of newly diagnosed CUP patients treated in our department.The findings aim to provide clinical guidance for diagnosis and treatment of CUP,with the goal of reducing diagnostic delays and improving patient outcomes.展开更多
Objective:This study aimed to prepare doxorubicin hydrochloride liposomes and explore their application value in patients with liver cancer.Methods:Doxorubicin hydrochloride liposomes were prepared using the ammonium ...Objective:This study aimed to prepare doxorubicin hydrochloride liposomes and explore their application value in patients with liver cancer.Methods:Doxorubicin hydrochloride liposomes were prepared using the ammonium sulfate gradient method.Doxorubicin,as a broad-spectrum antitumor drug,has significant toxic and side effects after toxicological investigation.After preparing DOX-Lip,single-factor analysis was used to analyze the effects of solution pH,number of ultrafiltration,oil-water ratio,incubation temperature,and time on the encapsulation efficiency of doxorubicin hydrochloride liposomes.The process was optimized through orthogonal experiments and then applied clinically.110 patients with liver cancer were selected as the research subjects to verify the drug’s effectiveness.Results:The results of this study showed that under optimal process conditions,the prepared doxorubicin hydrochloride liposomes were evenly distributed,similar to spherical shapes,with an average particle size of 85–87 mm and a Zeta potential of 15–16 mV,indicating good encapsulation efficiency.The application of these liposomes to clinical treatment of liver cancer demonstrated good therapeutic effects and could effectively promote favorable patient prognosis.Conclusion:The doxorubicin hydrochloride liposomes prepared through process optimization exhibit strong stability and pronounced sustained-release characteristics,providing a solid foundation for the treatment of liver cancer.展开更多
文摘Objective:To investigate the clinical efficacy of levofloxacin combined with ambroxol in the treatment of elderly patients with chronic obstructive pulmonary disease(COPD)and pulmonary infection.Methods:A total of 80 elderly COPD patients with pulmonary infection,treated between December 2022 and November 2023,were randomly divided into a control group and an observation group,with 40 cases in each group.The control group was treated with levofloxacin hydrochloride,while the observation group received ambroxol hydrochloride injection in addition to the treatment in the control group.Laboratory indices(white blood cell count,procalcitonin,C-reactive protein,and apolipoprotein E levels),imaging-based pulmonary lesion absorption time,hospital stay,and incidence of adverse reactions were compared between the two groups.Results:After treatment,the biochemical indices of the observation group were significantly lower than those of the control group,with highly significant differences(P<0.001).Compared to the control group,the imaging-based pulmonary lesion absorption time and hospital stay of the observation group were significantly shorter(P<0.001).Additionally,the incidence of adverse reactions in the observation group was significantly lower than in the control group(P<0.05).Conclusion:Levofloxacin combined with ambroxol demonstrates advantages in improving biochemical indices,shortening imaging-based pulmonary lesion absorption time and hospital stay,and reducing adverse reaction rates in elderly COPD patients with pulmonary infection.It holds significant clinical application value.
文摘Cancer patients in China navigate a complex and uneven insurance landscape,making plan choice critical for equitable financial protection.This study conducts a structured narrative review(2010-2025)of the Web of Science,PubMed,CNKI,and Wanfang databases,focusing on empirical research on insurance plan choice,enrollment,or switching among cancer patients and their households in China.Two reviewers independently screened studies and extracted information on key determinants and identification strategies.The evidence converges on five main determinants:insurance literacy,health knowledge,prior coverage,financial capability,and policy promotion intensity(PPI).However,most studies are cross-sectional and descriptive,with inconsistent operationalization of determinants,weak or absent mediation tests for PPI,and limited coverage of rural,elderly,and low-literacy populations.Building on these gaps,we synthesize an evidence map,propose an operational PPI index,and highlight quasi-experimental opportunities(such as staggered NRDL updates and variation in local publicity efforts)to identify mechanisms and inform more inclusive,patient-centered insurance design in China.
文摘Objective:To construct an evidence-based practice plan for perioperative nutritional optimization in esophageal cancer patients.Methods:By systematically searching relevant guidelines at home and abroad,two experts independently assessed the quality of the guidelines,extracted valuable evidence and recommendations,and initially formed a draft nursing program.Subsequently,an expert panel was organized to conduct a detailed discussion to review the practicality and effectiveness of the recommendations one by one,and the program was finally revised and improved.Results:The protocol covered four stages of patients’admission,preoperative,postoperative,and discharge,involving specific contents such as nutritional assessment,risk screening,dysphagia assessment,nutritional therapy,enteral and parenteral nutritional support,symptom management,and health education.The program included a total of 61 entries,with 33 class A recommendations and 28 class B recommendations.Conclusion:The constructed perioperative nutritional care program for esophageal cancer patients is scientific and practical,and can provide practical guidance for clinical care.
基金Natural Science Foundation of Gansu Province(Project No.:24JRRA615)Outstanding Talent Recruitment Program and the Doctoral Start-up Fund of Gansu Provincial Central Hospital(Project No.:GMCCH2024-2-6)。
文摘Thrombotic thrombocytopenic purpura(TTP)is a rare and life-threatening form of thrombotic microangiopathy,primarily caused by a deficiency of ADAMTS-13 activity.Immune-related adverse events(irAEs)are autoimmune toxicities mediated by the use of immune checkpoint inhibitors(ICIs).Here,the study reports a case of thrombotic thrombocytopenic purpura that developed in a patient with renal cell carcinoma and vertebral metastasis following combined treatment with Toripalimab and Pazopanib.The patient received Toripalimab in combination with Pazopanib after undergoing radical nephrectomy for right renal cell carcinoma.Five days later,a generalized erythematous rash appeared,partly confluent,accompanied by congestion and swelling of both palpebral and bulbar conjunctiva.Based on the clinical presentation and laboratory results showing thrombocytopenia and hemolytic anemia,the diagnosis of TTP was established.The condition was considered an adverse effect associated with the combination therapy of Toripalimab and Pazopanib.Plasma exchange and high-dose intravenous immunoglobulin therapy were promptly initiated.The treatment regimen was subsequently modified to Axitinib combined with radiotherapy,leading to a gradual recovery of platelet counts.This report highlights the potential risk of TTP associated with combined ICI and TKI therapy,and underscores the importance of early recognition and timely management of this potentially fatal complication.
基金Four“batches”innovation project of invigorating medicine through science and technology of Shanxi province(Project No.:2023XM059)。
文摘Objective:To investigate the clinical efficacy of Modified Gegen Qinlian Decoction combined with probiotics(Clostridium butyricum live capsules)in treating radiation enteritis(RE)in tumor patients,as well as its regulatory effect on the structure of intestinal flora,providing clinical evidence for the integrated traditional Chinese and Western medicine treatment of radiation enteritis.Methods:A total of 40 patients with radiation enteritis admitted to the Oncology Department of Linfen Central Hospital from September 2023 to December 2024 were selected and divided into an observation group and a control group according to the random number table method,with 20 cases in each group.The control group was treated with Clostridium butyricum live capsules,while the observation group was treated with Modified Gegen Qinlian Decoction in addition to the treatment given to the control group.Both groups received a 4-week treatment course.Intestinal function indicators and changes in intestinal flora structure were compared between the two groups before and after treatment,and clinical efficacy was evaluated.Results:After 4 weeks of treatment,the total effective rate in the observation group versus the control group was(95.00%vs 65.00%),with a statistically significant difference(P<0.05).The fecal formation rate in the observation group(85.00%vs 60.00%)was significantly higher than that in the control group,and the defecation frequency(2.15±0.42 vs 3.85±0.65)times/day was significantly lower than that in the control group,with statistically significant differences(P<0.05).After treatment,the quantities of Bifidobacterium(6.85±0.72 L vs 5.23±0.61 L)gCFU/g and Lactobacillus(6.52±0.68 L vs 4.98±0.57 L)gCFU/g in the observation group were significantly higher than those in the control group,while the quantities of Escherichia coli(4.12±0.53 L vs 5.67±0.65 L)gCFU/g and Staphylococcus(3.85±0.48 L vs 5.23±0.59 L)gCFU/g were significantly lower than those in the control group,with statistically significant differences(P<0.05).Conclusion:Clinical studies have confirmed that the synergistic treatment of radiation enteritis with Modified Gegen Qinlian Decoction and probiotics can significantly improve patients’clinical symptoms and restore the balance of intestinal flora,providing an effective regimen for clinical treatment.
文摘Objective:To analyze the clinical efficacy and safety of toripalimab combined with the GC chemotherapy regimen in the treatment of advanced urothelial carcinoma.Methods:A retrospective study was conducted on 102 patients with advanced urothelial carcinoma treated at our hospital between March 2021 and August 2024.Based on treatment regimens,patients were divided into a chemotherapy group(n=52)and a combination group(n=50).The chemotherapy group received the GC chemotherapy regimen,while the combination group received GC chemotherapy combined with toripalimab.Both groups underwent 4-6 cycles of treatment based on patient tolerance.Clinical efficacy,immune-related factor levels,survival outcomes,and safety were observed and compared.Results:The disease control rate(DCR)and overall response rate(ORR)in the combination group were slightly higher than those in the chemotherapy group,but the differences were not statistically significant(P>0.05).After treatment,levels of IFN-γand IL-2 increased significantly,while VEGF levels decreased significantly in both groups(P<0.05),with superior outcomes observed in the combination group(P<0.05).Follow-up analysis showed progression-free survival(PFS)and median overall survival(OS)in the chemotherapy group were 5.19 and 10.15 months,respectively,compared to 8.24 and 18.23 months in the combination group,with statistically significant differences(P<0.05).During treatment,the incidence of adverse reactions such as rash,immune-related pneumonia,and immune-related diarrhea was higher in the combination group than in the chemotherapy group(P<0.05).However,the incidence of gastrointestinal reactions,fever,and leukopenia did not differ significantly between the two groups(P>0.05).Conclusion:The use of toripalimab combined with the GC chemotherapy regimen for advanced urothelial carcinoma can effectively improve clinical outcomes and extend patient survival,with good overall safety.However,attention should be given to preventing adverse reactions such as rash and pneumonia during treatment.
文摘Ovarian cancer ranks as the deadliest malignancy among female reproductive system cancers,posing a significant threat to women’s health.Around seven out of ten patients are diagnosed only after reaching progressive disease phases,a phenomenon closely linked to three key factors:the disease’s hidden onset location,lack of early symptoms,and absence of reliable early diagnostic methods.Therefore,identifying early diagnostic biomarkers and therapeutic targets is critical.Exosomes participate in various phases of ovarian tumorigenesis,including transforming normal cells into cancerous cells,immune regulation,invasion,metastasis,drug resistance,and angiogenesis,making them promising biomarkers for early ovarian cancer detection.This review summarizes current research on exosomal long non-coding RNAs(lncRNAs),miRNAs,and related proteins in ovarian cancer diagnosis.Exosome-based biomarkers have shown potential advantages,including high sensitivity,specificity,stability,and non-invasive accessibility.The study concludes that while exosomes hold significant diagnostic potential for ovarian cancer,additional investigations are required to standardize detection methods,validate clinical applicability,and elucidate underlying molecular mechanisms.
基金Zhongshan Science and Technology Bureau Project“The Application of Infrared Thermography in the Syndrome Differentiation of Chaihu Guizhi Ganjiang Decoction”(Project No.2021B1066)Zhongshan Science and Technology Bureau Project“Exploring the Diagnostic Approach of the TCM Syndrome Type‘Chaihu Guizhi Ganjiang Decoction’Based on Infrared Thermal Imaging Systems and Digital Modeling Methods of Ancient and Modern Literature”(Project No.2022B1131)。
文摘Objective:To evaluate the use of infrared thermography technology for objective and quantitative syndrome differentiation and treatment in traditional Chinese medicine(TCM),specifically in patients with Chaihu Guizhi Ganjiang Decoction syndrome.Methods:Data were collected from over 100 patients diagnosed with Chaihu Guizhi Ganjiang Decoction syndrome at Professor Li Leyu’s endocrinology clinic,Zhongshan Hospital of Traditional Chinese Medicine,Guangdong Province,between April 2021 and April 2022.Body surface temperature data were obtained using the MTI-EXPRO-2013-B infrared thermography system.Principal component analysis(PCA)was applied to differentiate temperature distribution characteristics between genders,and a neural network prediction model was constructed for syndrome diagnosis.Results:Infrared thermography effectively captured surface temperature characteristics of patients with Chaihu Guizhi Ganjiang Decoction syndrome.PCA identified one principal component with a variance explanation rate of 73.953%for females and two principal components with a cumulative variance explanation rate of 77.627%for males.The neural network model demonstrated high predictive performance,with an area under the ROC curve of 0.9743 for the training set and 0.9889 for the validation set.Sensitivity was 1,specificity 0.8636,precision 0.8846,accuracy 0.9333,and the F1 score 0.9388.Conclusion:Infrared thermography provides an innovative,objective,and quantitative method for syndrome differentiation and treatment in TCM.It represents a significant advancement in transitioning from traditional empirical approaches to modern,visualized,and precise diagnosis and treatment.This study underscores the potential of integrating advanced technologies in TCM for enhanced clinical application and modernization.
文摘The global incidence of breast cancer remains high and is increasing annually in some regions.Despite the variety of current treatments for breast cancer,the preventive and therapeutic effects are still limited due to the highly heterogeneous nature and complex biological mechanisms of breast cancer.In recent years,tea consumption has emerged as a research focus due to its possible anti-cancer properties.Numerous preclinical studies have demonstrated that regular tea intake could potentially curb the progression of breast cancer by influencing various biological mechanisms,including signaling pathways,cell cycle regulation,and immune system responses,among others.Nonetheless,the findings from epidemiological studies show considerable variability,and the connection between tea drinking and both the risk and outlook for breast cancer is shaped by numerous elements.These include the specific type of tea consumed,the quantity consumed,individual genetic variations,and environmental influences.This article summarizes the current research findings and delves into the connection between tea consumption and the risk as well as the prognosis of breast cancer among different regional populations.Meanwhile,it expounds on the potential molecular biological mechanisms behind it.The aim is to offer a theoretical foundation for the personalized prevention and treatment of breast cancer.
文摘This article systematically reviews the application of biomimetic nanotechnology in targeted therapy for triple-negative breast cancer(TNBC).TNBC poses significant challenges for conventional treatments due to the lack of defined therapeutic targets,chemotherapy resistance,and a complex immunosuppressive microenvironment.Biomimetic nanotechnology,by mimicking the functional properties of biological structures(e.g.,cell membranes,exosomes),has significantly enhanced drug delivery efficiency,targeting precision,and anti-tumor immune responses.This review focuses on the design strategies of biomimetic nanocarriers(including cell membrane-coated nanoparticles,engineered exosomes,and biomimetic synthetic materials)and their innovative applications in TNBC therapy:(1)Targeted delivery systems that overcome tumor barriers and reduce systemic toxicity;(2)Photothermal therapy combined with immunomodulation for precise treatment and immune activation;(3)Tumor microenvironment regulation(e.g.,vascular normalization,pH neutralization,immunosuppression reversal).Studies demonstrate that biomimetic nanotechnology significantly improves TNBC treatment efficacy through multimodal synergistic mechanisms(e.g.,chemo-photothermal-immunotherapy).However,challenges such as scalable production,long-term safety,and personalized adaptation remain for clinical translation.Future research should integrate artificial intelligence for optimized design and dynamic imaging technologies to advance biomimetic nanomedicines toward clinical applications.
基金National Natural Science Foundation of China(Project No.:82205126)Scientific Research Project of Guangdong Provincial Administration of Traditional Chinese Medicine(Project No.:20251104)+2 种基金Guangdong Famous Traditional Chinese Medicine Studio(Jianxing Xie)Fourth batch of famous traditional Chinese medicine masterapprentice program in Guangdong Province in 2024(Jianxing Xie)Young and Middle-aged Key Talent Training Project of The First Affiliated Hospital of Guangzhou University of Chinese Medicine(Project No.:09005650043)。
文摘This review systematically elucidates the core mechanisms and research advancements regarding the role of autophagy in immune evasion in Renal Cell Carcinoma(RCC).Accumulating evidence indicates that autophagy exhibits a typical“context-dependent”dual role in RCC pathogenesis:it may suppress tumorigenesis in early stages,while primarily promoting cell survival and immunosuppressive functions within the established tumor microenvironment(TME).Autophagy facilitates immune escape through multi-dimensional mechanisms,including the precise regulation of PD-L1 stability,degradation of MHC-I molecules and the antigenic peptide pool,remodeling of the metabolic microenvironment,induction of T cell exhaustion,and enhancement of immunosuppressive cell functions.Therapeutically,combining autophagy inhibitors with immune checkpoint inhibitors has demonstrated significant synergistic effects in preclinical studies,and several clinical trials have provided preliminary validation of its safety and efficacy.Future research should focus on integrating multi-omics technologies and advanced disease models to deeply elucidate the autophagy regulatory network,explore its crosstalk with other cell death pathways such as pyroptosis and ferroptosis,and promote the development of personalized treatment strategies based on precise stratification of autophagy activity,thereby offering new avenues to overcome immunotherapy resistance in RCC.
文摘As a severe neurological disease,cerebral hemorrhage is dangerous and progresses rapidly,with high disability and fatality rates.Its occurrence seriously harms patients’lives and health,and also causes a heavy social burden.Timely diagnosis and treatment of cerebral hemorrhage are essential for improving patients’prognosis.This article reviews the research progress in emergency treatment for patients with cerebral hemorrhage,providing a basis for diagnosis and treatment.
文摘Background:Hepatocellular carcinoma(HCC)is one of the most prevalent malignant tumors worldwide,and endocrine,metabolic,and immune factors influence its occurrence and progression.Hypothyroidism(HT)is a common endocrine disorder that may affect cancer risk;however,its relationship with HCC remains unclear.Objective:This study aimed to investigate the potential molecular and immune mechanisms underlying the association between HT and HCC,with a focus on the regulatory effects of HT-related genetic variants on the hepatic tumor immune microenvironment.Methods:Single-nucleotide polymorphisms(SNPs)associated with HT and HCC identified through Mendelian randomization were functionally annotated using the Ensembl Genome Browser and mapped to candidate genes.Functional enrichment and pathway analyses were performed with Metascape.Differentially expressed target genes between HCC and normal liver tissues were screened using GEPIA2,and their protein expression levels were validated in the Human Protein Atlas(HPA)database.The association between target gene expression and immune cell infiltration was further evaluated using TIMER2.0.Results:A total of 68 candidate genes were analyzed.Enrichment analysis revealed that these genes are involved in IFN-γ-mediated immune responses,PI3K/AKT and RAC1 signaling pathways,and other immune regulatory processes.Among them,HLA-DQA1,HLA-DPB1,HLA-DQA2,and PVT1 showed significant differential expression in HCC.HLA-DQA1,HLA-DPB1,and HLA-DQA2 were positively correlated with CD8⁺T cells,regulatory T cells(Tregs),and M2 macrophages,suggesting that these genes may exert bidirectional effects on antitumor immunity and immunosuppression.PVT1 may influence the immune microenvironment by regulating myeloid cell recruitment and extracellular matrix remodeling.Conclusion:HLA-DQA1,HLA-DPB1,HLA-DQA2,and PVT1 may reduce the risk of HCC by enhancing IFN-γ-mediated antitumor immunity and modulating key signaling pathways,while also contributing to immune microenvironment remodeling.These findings provide mechanistic insights into the protective effects of HT on HCC and suggest potential targets for immunotherapeutic strategies.
文摘Objective:To explore factors influencing decision regret among colorectal cancer patients undergoing intestinal ostomy.Methods:A questionnaire survey was conducted among 102 colorectal cancer patients who underwent intestinal ostomy surgery and visited the ostomy clinic at a tertiary hospital in Baoding from July to September 2025.The Chinese version of the Ostomy Adaptation Inventory(OAI-20),Decision Regret Scale(DRS),Decision Conflict Scale(DCS),and Functional Assessment of Cancer Therapy-Colorectal(FACT-C)were used to measure patients’adaptation to stoma,decision regret,decision conflict,and quality of life.The Shared Decision-Making Questionnaire(SDM-Q-9)assessed patient involvement in ostomy surgery decisions,while the SSUK-8 evaluated social support.Additional items explored perceptions related to decision-making,participation,and outcomes.Results:Among 134 eligible patients attending the clinic,120 participated in the questionnaire,with 102 completing all items.Stoma patients reported an average decision regret score of 60.83(SD 28.43),an average coping ability score of 54.26(SD 26.69),an average decision conflict score of 62.55(SD 25.95),and a quality of life score of 56.93(SD 27.46).In the multiple regression analysis,decision regret was associated with decision conflict,poor patient coping ability,low quality of life,and low social support.Conclusion:Decision regret is prevalent among Chinese CRC patients following ostomy surgery.Compared with similar studies in other regions,Chinese CRC patients exhibit a higher rate of regret.This may be related to lower patient involvement in decision-making,generally poorer quality of life,and heavier economic burdens.
文摘Triple-negative breast cancer(TNBC)is marked by its high degree of malignancy and challenging treatment outcomes.While Western medicine predominantly relies on chemotherapy,issues such as drug resistance and toxic side effects remain prevalent.Drawing on the traditional Chinese medicine(TCM)principle of“treating the same disease with different methods,”Bian devises individualized therapeutic strategies tailored to the unique syndrome patterns of TNBC patients,adhering to the core tenets of“treatment based on syndrome differentiation”and“simultaneous regulation of the liver and spleen.”Through an analysis of clinical cases involving TNBC patients,this paper summarizes Bian’s clinical experience,which emphasizes foundational approaches such as strengthening the body’s resistance and soothing the liver to regulate qi,combined with personalized therapies including clearing heat and draining dampness,pacifying the liver and subduing yang,and resolving phlegm to unblock collaterals.The study highlights a diagnostic model of“multiple prescriptions for one disease,tailored to individual conditions,”providing valuable insights for the personalized TCM treatment of TNBC.
基金Hubei Provincial Natural Science Foundation Innovation and Development Joint Fund Project(2025AFD278)Three Gorges University Scientific Fund Project(2022kj008)Three Gorges University Special Scientific Fund Project(2023kjzx001)。
文摘Objective:To utilize the VigiAccess database for data mining to analyze the characteristics of adverse reactions induced by mirogabalin,providing critical information for clinical medication use.Method:This study analyzed data from the VigiAccess database,filtering out adverse reaction reports where mirogabalin was identified as the Primary Suspect Drug(PS).Reporting Odds Ratio(ROR),Proportional Reporting Ratio(PRR),Bayesian Confidence Propagation Neural Network(BCPNN),and Empirical Bayes Geometric Mean(EBGM)methods were employed as data mining algorithms for pharmacovigilance and adverse event monitoring.These methods identify potential drug-adverse event association signals by analyzing the relationship between drug use and adverse event reporting.ROR and PRR focus on calculating reporting ratios,while BCPNN and EBGM use neural networks and empirical Bayes models,respectively,to enhance the accuracy and reliability of signal detection.Results:A total of 734 adverse reaction reports associated with mirogabalin were obtained.The results showed that females reported the highest number of adverse reactions,accounting for 59.67%,while males accounted for 38.83%.In terms of age distribution,the highest number of reports came from individuals over 75 years old,accounting for 33.79%.Adverse reactions mainly involved the nervous system(33.45%),general diseases and reactions at the site of administration(11.62%),and gastrointestinal disorders(10.74%).The most common adverse reactions included dizziness(11.62%),somnolence(8.27%),renal dysfunction(2.90%),and edema(2.82%).Signal intensity analysis revealed that certain adverse reactions(such as renal dysfunction,rhabdomyolysis,and drug-induced liver injury)had significant signal strength,suggesting a strong association with mirogabalin.Conclusion:This study,through signal mining of the VigiAccess database,reveals the characteristics of mirogabalin’s adverse reactions in the real world,particularly in the nervous system and renal function.These findings provide important reference information for clinicians,aiding in the optimization of the safe use of mirogabalin.Future research should further validate the causal relationships of these signals and explore individualized treatment strategies to reduce the incidence of adverse reactions and improve patient outcomes.
基金2025 Open Experimental Special Fund of Beijing Institute of Technology, “Applications and Practices of R Language in Bioinformatics”。
文摘To investigate the targets and mechanism of Hedysarum Multijugum Maxim(HMM)in treatment of bladder cancer(BC).Based on Traditional Chinese Medicine Systems Pharmacology(TCMSP)and gene databases,active substances and potential targets of HMM were screened,and the HMM-active substances-targets-BC(HATB)regulatory network and PPI network were constructed.Hub targets were screened by Cytoscape.The main active substances and Hub targets were molecularly docked with AutoDock and visualized by PyMOL.12 Hub targets were screened.Molecular docking showed that active substances mainly acted on MAPK14,MAPK1 and CCND1.The bindings of calycosin to MAPK14,formononetin to MAPK14,and calycosin to CCND1 were stable.
基金National Natural Science Foundation of China(3236016631760321).
文摘Renal cell carcinoma(RCC),which accounts for about 90 percent of kidney cancers,has a distinct metabolic reprogramming profile characterized by increased aerobic glycolysis(Warburg effect),abnormal accumulation of lipids,and impaired mitochondrial function.Recent advances in high-throughput proteomic and metabolomic technologies have revolutionized our understanding of the pathophysiology of RCC,allowing for the systematic identification of disease-specific molecular signatures,elucidation of drug resistance mechanisms,and possible targets for intervention.The review focuses on the use of proteomic and metabolomic technologies in renal cell carcinoma and the research progress on related biomarkers,and is expected to provide useful information for the early detection and treatment of RCC.
文摘Primary of Unknown Origin Cancer(CUP)is a metastatic tumor whose origin remains undetermined.The reason for this ambiguity in identifying the primary site remains unclear,possibly due to the tumor being too small or growing too slowly,or because the immune system has destroyed the tiny primary lesion.Most CUP patients receive only localized treatment or empirical systemic chemotherapy,leading to poor prognosis and shorter average overall survival.There is currently insufficient evidence-based medical support for the diagnosis and treatment of CUP.This study retrospectively analyzed clinical characteristics,diagnostic methods,treatment approaches,and prognostic outcomes of newly diagnosed CUP patients treated in our department.The findings aim to provide clinical guidance for diagnosis and treatment of CUP,with the goal of reducing diagnostic delays and improving patient outcomes.
文摘Objective:This study aimed to prepare doxorubicin hydrochloride liposomes and explore their application value in patients with liver cancer.Methods:Doxorubicin hydrochloride liposomes were prepared using the ammonium sulfate gradient method.Doxorubicin,as a broad-spectrum antitumor drug,has significant toxic and side effects after toxicological investigation.After preparing DOX-Lip,single-factor analysis was used to analyze the effects of solution pH,number of ultrafiltration,oil-water ratio,incubation temperature,and time on the encapsulation efficiency of doxorubicin hydrochloride liposomes.The process was optimized through orthogonal experiments and then applied clinically.110 patients with liver cancer were selected as the research subjects to verify the drug’s effectiveness.Results:The results of this study showed that under optimal process conditions,the prepared doxorubicin hydrochloride liposomes were evenly distributed,similar to spherical shapes,with an average particle size of 85–87 mm and a Zeta potential of 15–16 mV,indicating good encapsulation efficiency.The application of these liposomes to clinical treatment of liver cancer demonstrated good therapeutic effects and could effectively promote favorable patient prognosis.Conclusion:The doxorubicin hydrochloride liposomes prepared through process optimization exhibit strong stability and pronounced sustained-release characteristics,providing a solid foundation for the treatment of liver cancer.
