Microplastic contamination has emerged as a threat in transplantation,with evidence of its presence in human tissues and potential to compromise grafts.Transplant recipients,vulnerable due to immunosuppression and sur...Microplastic contamination has emerged as a threat in transplantation,with evidence of its presence in human tissues and potential to compromise grafts.Transplant recipients,vulnerable due to immunosuppression and surgical exposure,face risk from microplastics via airborne particles,surgical materials,and organ preservation systems.These particles trigger inflammation,oxidative stress,and immune dysregulation—pathways critical in rejection.Microplastics support biofilm formation,potentially facilitating antimicrobial resistance in clinical settings.Despite this risk,transplant-specific research is lacking.We urge action through environmental controls,material substitutions,and procedural modifications,alongside research targeting exposure pathways,biological impact,and mitigation strategies.Transplantation has historically led medical innovation and must do so in confronting this environmental challenge.Leadership from global transplant societies is essential to protect recipients and ensure safe procedures.展开更多
Iron oxide nanoparticles(IONPs)have wide applications in the biomedical field due to their outstanding physical and chemical properties.However,the potential adverse effects and relatedmechanisms of IONPs in human org...Iron oxide nanoparticles(IONPs)have wide applications in the biomedical field due to their outstanding physical and chemical properties.However,the potential adverse effects and relatedmechanisms of IONPs in human organs,especially the lung,are still largely ignored.In this study,we found that group-modified IONPs(carboxylated,aminated and silica coated)induce slight lung cell damage(in terms of the cell cycle,reactive oxygen species(ROS)production,cell membrane integrity and DNA damage)at a sublethal dosage.However,aminated IONPs could release more iron ions in the lysosome than the other two types of IONPs,but the abnormally elevated iron ion concentration did not induce ferroptosis.In-triguingly,amino-modified IONPs aggravated the accumulation of intracellular peroxides induced by the ferroptosis activator RSL3 and thus caused ferroptosis in vitro,and the coadministration of amino-modified IONPs and RSL3 induced more severe lung injury in vivo.Therefore,our data revealed that the surface functionalization of IONPs plays an important role in determining their potential pulmonary toxicity,as surface modification influences their degradation behavior.These results provide guidance for the design of future IONPs and the corresponding safety evaluations and predictions.展开更多
文摘Microplastic contamination has emerged as a threat in transplantation,with evidence of its presence in human tissues and potential to compromise grafts.Transplant recipients,vulnerable due to immunosuppression and surgical exposure,face risk from microplastics via airborne particles,surgical materials,and organ preservation systems.These particles trigger inflammation,oxidative stress,and immune dysregulation—pathways critical in rejection.Microplastics support biofilm formation,potentially facilitating antimicrobial resistance in clinical settings.Despite this risk,transplant-specific research is lacking.We urge action through environmental controls,material substitutions,and procedural modifications,alongside research targeting exposure pathways,biological impact,and mitigation strategies.Transplantation has historically led medical innovation and must do so in confronting this environmental challenge.Leadership from global transplant societies is essential to protect recipients and ensure safe procedures.
基金supported by the National Natural Science Foundation of China(Nos.22076212 and 22222611)the Youth Innovation Promotion Association of CAS(No.2021040).
文摘Iron oxide nanoparticles(IONPs)have wide applications in the biomedical field due to their outstanding physical and chemical properties.However,the potential adverse effects and relatedmechanisms of IONPs in human organs,especially the lung,are still largely ignored.In this study,we found that group-modified IONPs(carboxylated,aminated and silica coated)induce slight lung cell damage(in terms of the cell cycle,reactive oxygen species(ROS)production,cell membrane integrity and DNA damage)at a sublethal dosage.However,aminated IONPs could release more iron ions in the lysosome than the other two types of IONPs,but the abnormally elevated iron ion concentration did not induce ferroptosis.In-triguingly,amino-modified IONPs aggravated the accumulation of intracellular peroxides induced by the ferroptosis activator RSL3 and thus caused ferroptosis in vitro,and the coadministration of amino-modified IONPs and RSL3 induced more severe lung injury in vivo.Therefore,our data revealed that the surface functionalization of IONPs plays an important role in determining their potential pulmonary toxicity,as surface modification influences their degradation behavior.These results provide guidance for the design of future IONPs and the corresponding safety evaluations and predictions.
