Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health..Topics...Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health..Topics may include but not limited to:nutriology,bio-chemistry,microbiology,immunology and toxicology.展开更多
L-茶氨酸(L-Theanine,LTA)是茶叶中独特的游离氨基酸,是茶汤鲜爽味的主要来源,具有多种生物活性,属于新食品原料。本文基于Citespace和VOSviewer对Web of Science核心数据库和中国知网数据库,对2014~2024年LTA相关文献进行可视化分析,...L-茶氨酸(L-Theanine,LTA)是茶叶中独特的游离氨基酸,是茶汤鲜爽味的主要来源,具有多种生物活性,属于新食品原料。本文基于Citespace和VOSviewer对Web of Science核心数据库和中国知网数据库,对2014~2024年LTA相关文献进行可视化分析,其中关键词密度和贡献图谱结果显示LTA相关研究集中在茶叶类型、胁迫反应、LTA的生物活性等方面。因此,本文综述了茶叶LTA含量的影响因素,并重点阐述LTA生物活性作用机制,包括抗氧化、抗热应激、抗抑郁、调节代谢、抗癌、调节免疫、调节肠道菌群、保护神经系统、保护肝脏和保护肠道的作用机制,发现LTA主要通过调控核因子κB(Nuclear factor kappa B,NF-κB)、c-Jun氨基末端激酶(c-Jun N-terminal kinase,JNK)、信号传导及转录激活因子(Signal transducer and activator of transcription,STAT)和丝裂原活化蛋白激酶(Mitogen-activated protein kinase,MAPK)等信号通路发挥生物活性功能,并总结了当前LTA在食品产业中的实际应用。本文可为LTA的研究和发展提供方向,并为开发LTA功能性食品提供一定的参考。展开更多
Aging is a complex biological process characterized by nine hallmarks,including genomic instability,mitochondrial dysfunction,and chronic inflammation,which collectively drive the progression of age-related chronic no...Aging is a complex biological process characterized by nine hallmarks,including genomic instability,mitochondrial dysfunction,and chronic inflammation,which collectively drive the progression of age-related chronic non-communicable diseases.Phytonutrients,a class of bioactive secondary metabolites abundant in plants,have emerged as a promising research focus for intervening in the aging process due to their multifaceted biological activities.This review systematically elaborates on the molecular mechanisms,key signaling pathways,specifically SIRT1,Nrf2/ARE,and AMPK/mTOR,and the synergistic anti-aging effects of four typical phytonutrient categories:polyphenols(e.g.,resveratrol,quercetin),carotenoids(e.g.,lycopene,astaxanthin),sulfur compounds(e.g.,α-lipoic acid,ergothioneine),and phytoestrogens(e.g.,soybean isoflavones).The evidence indicates that these compounds combat aging through a multidimensional network involving direct antioxidant actions,free radical scavenging,metal chelation,promotion of autophagy,and modulation of inflammatory and epigenetic pathways.Crucially,the review highlights that synergistic interactions between different phytonutrients can significantly enhance their efficacy beyond the effect of any single compound.The aim is to consolidate the anti-aging evidence of phytonutrients and address the current translational challenges,such as bioavailability and a lack of robust human trials,thereby providing a comprehensive theoretical framework for developing effective,diet-centered strategies to promote healthy aging and reduce the global burden of non-communicable diseases.展开更多
文摘Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health..Topics may include but not limited to:nutriology,bio-chemistry,microbiology,immunology and toxicology.
文摘L-茶氨酸(L-Theanine,LTA)是茶叶中独特的游离氨基酸,是茶汤鲜爽味的主要来源,具有多种生物活性,属于新食品原料。本文基于Citespace和VOSviewer对Web of Science核心数据库和中国知网数据库,对2014~2024年LTA相关文献进行可视化分析,其中关键词密度和贡献图谱结果显示LTA相关研究集中在茶叶类型、胁迫反应、LTA的生物活性等方面。因此,本文综述了茶叶LTA含量的影响因素,并重点阐述LTA生物活性作用机制,包括抗氧化、抗热应激、抗抑郁、调节代谢、抗癌、调节免疫、调节肠道菌群、保护神经系统、保护肝脏和保护肠道的作用机制,发现LTA主要通过调控核因子κB(Nuclear factor kappa B,NF-κB)、c-Jun氨基末端激酶(c-Jun N-terminal kinase,JNK)、信号传导及转录激活因子(Signal transducer and activator of transcription,STAT)和丝裂原活化蛋白激酶(Mitogen-activated protein kinase,MAPK)等信号通路发挥生物活性功能,并总结了当前LTA在食品产业中的实际应用。本文可为LTA的研究和发展提供方向,并为开发LTA功能性食品提供一定的参考。
基金supported by the Shanghai Sailing Program(No.21YF1418500)the Shanghai Chenguang Program(No.21CGA70)+1 种基金the three-year action plan for strengthening the construction of the public health system in Shanghai(No.GWVI-11.2-YQ12)Additionally,we would like to thank the Shanghai Oriental Talents Program-Youth Project(Education Platform)for its support of this study.
文摘Aging is a complex biological process characterized by nine hallmarks,including genomic instability,mitochondrial dysfunction,and chronic inflammation,which collectively drive the progression of age-related chronic non-communicable diseases.Phytonutrients,a class of bioactive secondary metabolites abundant in plants,have emerged as a promising research focus for intervening in the aging process due to their multifaceted biological activities.This review systematically elaborates on the molecular mechanisms,key signaling pathways,specifically SIRT1,Nrf2/ARE,and AMPK/mTOR,and the synergistic anti-aging effects of four typical phytonutrient categories:polyphenols(e.g.,resveratrol,quercetin),carotenoids(e.g.,lycopene,astaxanthin),sulfur compounds(e.g.,α-lipoic acid,ergothioneine),and phytoestrogens(e.g.,soybean isoflavones).The evidence indicates that these compounds combat aging through a multidimensional network involving direct antioxidant actions,free radical scavenging,metal chelation,promotion of autophagy,and modulation of inflammatory and epigenetic pathways.Crucially,the review highlights that synergistic interactions between different phytonutrients can significantly enhance their efficacy beyond the effect of any single compound.The aim is to consolidate the anti-aging evidence of phytonutrients and address the current translational challenges,such as bioavailability and a lack of robust human trials,thereby providing a comprehensive theoretical framework for developing effective,diet-centered strategies to promote healthy aging and reduce the global burden of non-communicable diseases.
