Near infrared-II(NIR-II)dyes have unique advantages in biomedical applications owing to the powerful ability in penetrating biological tissues.Herein,NIR-II aza-BODIPY dye,QLD-BDP,was developed with julolidine at 1,7-...Near infrared-II(NIR-II)dyes have unique advantages in biomedical applications owing to the powerful ability in penetrating biological tissues.Herein,NIR-II aza-BODIPY dye,QLD-BDP,was developed with julolidine at 1,7-sites and p-dimethylaminophenyl group at 3,5-sites.According to X-ray analysis,QLD-BDP exhibits significant distortion,and this molecule appears a bowl shaped structure.The photothermal conversion efficiency of the self-assembled QLD-BDP nanoparticles(QLD-BDP-NPs)can reach 50.5%,with maximum emission at 998 nm by the aggregate.QLD-BDP-NPs can cause the complete destruction of 4T1multicellular spheroids(MCSs),indicating a photothermal therapy(PTT)effect.展开更多
Recent research on photothermal therapy(PTT) has sparked significant interest in the development of new organic photothermal agents(PTAs),ranging from single-molecule to aggregated levels.However,controlling aggregati...Recent research on photothermal therapy(PTT) has sparked significant interest in the development of new organic photothermal agents(PTAs),ranging from single-molecule to aggregated levels.However,controlling aggregation pathways for PTAs with ultrahigh photothermal conversion efficiency(PCE) remains a major challenge.Herein,a two-pronged approach utilizing “Haggregation” and “intramolecular motion” was employed to enhance the PCE of an acceptor-substituted squaraine dye(NSQs).The C2vmolecular symmetry of the NSQs,which possess a ground state dipole moment(μg),promotes H-dimeric aggregates through dipole-dipole counteraction.Peripheral triphenylethylene or diphenylamine groups were added to this H-dimeric nanoplatform.This was done to enhance intramolecular motions for heat generation and also to extend conjugation,which redshifted the optical absorption and balanced the blue-shift induced by H-aggregation.With this technique,an organic PTA with NIR-II absorption was developed,and its nanoparticle achieved a remarkable PCE of 86.3% under 1,064 nm laser excitation.Femtosecond transient absorption spectroscopy and quantum mechanical calculations demonstrated the accelerated internal conversion process in NIR-II PTAs for rapid heat generation.The NSQs nanoparticles exhibit superior photothermal therapeutic properties for in vivo photoacoustic imaging-guided PTT,demonstrating the potential of bottom-up design to enable synergistic engineering strategies towards efficient phototheranostic agents.展开更多
Recently,nano theranostics,by integrating diagnostic and therapeutic functions into a nano system,have provided increasing opportunities for the design of personalized medicine in cancer.Among the construction method ...Recently,nano theranostics,by integrating diagnostic and therapeutic functions into a nano system,have provided increasing opportunities for the design of personalized medicine in cancer.Among the construction method of various theranostic nano systems,the design of single component nanoparticles which are composed of organic photosensitive dyes has become a promising approach to constructing multifunctional nano-theranostic systems,thanks to its unique advantages such as defined structure,100%loading,and high repeatability.Specifically,depending on the inherent photonic imaging and therapeutic properties of the photosensitive dyes,the multifunctional purpose which integrates theranostic effects and targeting abilities can be realized via reasonable molecular modification and supramolecular assembly.In this review,recent advances in the development of nanostructured self-assemblies of porphyrins,phthalocyanines,and boron-dipyrromethanes for theranostics are summarized.Emphasis on their design consideration and theranostic applications are presented.Additionally,prospects for clinical practice and potential challenges of this rapidly growing field are also provided.展开更多
基金supported by the National Natural Science Foundation of China(Nos.22078201,U1908202)Liaoning&Shenyang Key Laboratory of Functional Dye and Pigment(Nos.2021JH13/10200018,21–104–0–23)。
文摘Near infrared-II(NIR-II)dyes have unique advantages in biomedical applications owing to the powerful ability in penetrating biological tissues.Herein,NIR-II aza-BODIPY dye,QLD-BDP,was developed with julolidine at 1,7-sites and p-dimethylaminophenyl group at 3,5-sites.According to X-ray analysis,QLD-BDP exhibits significant distortion,and this molecule appears a bowl shaped structure.The photothermal conversion efficiency of the self-assembled QLD-BDP nanoparticles(QLD-BDP-NPs)can reach 50.5%,with maximum emission at 998 nm by the aggregate.QLD-BDP-NPs can cause the complete destruction of 4T1multicellular spheroids(MCSs),indicating a photothermal therapy(PTT)effect.
基金supported by the National Natural Science Foundation of China (22063005)the Natural Science Foundation of Jiangxi Province (20212ACBA203012,20224BAB214003,20232BAB-203031)the Interdisciplinary Innovation Fund of Natural Science,Nanchang University (9167-27060003-ZD2101,9167-28220007-YB2113)。
文摘Recent research on photothermal therapy(PTT) has sparked significant interest in the development of new organic photothermal agents(PTAs),ranging from single-molecule to aggregated levels.However,controlling aggregation pathways for PTAs with ultrahigh photothermal conversion efficiency(PCE) remains a major challenge.Herein,a two-pronged approach utilizing “Haggregation” and “intramolecular motion” was employed to enhance the PCE of an acceptor-substituted squaraine dye(NSQs).The C2vmolecular symmetry of the NSQs,which possess a ground state dipole moment(μg),promotes H-dimeric aggregates through dipole-dipole counteraction.Peripheral triphenylethylene or diphenylamine groups were added to this H-dimeric nanoplatform.This was done to enhance intramolecular motions for heat generation and also to extend conjugation,which redshifted the optical absorption and balanced the blue-shift induced by H-aggregation.With this technique,an organic PTA with NIR-II absorption was developed,and its nanoparticle achieved a remarkable PCE of 86.3% under 1,064 nm laser excitation.Femtosecond transient absorption spectroscopy and quantum mechanical calculations demonstrated the accelerated internal conversion process in NIR-II PTAs for rapid heat generation.The NSQs nanoparticles exhibit superior photothermal therapeutic properties for in vivo photoacoustic imaging-guided PTT,demonstrating the potential of bottom-up design to enable synergistic engineering strategies towards efficient phototheranostic agents.
基金supported by the National Natural Science Foundation of China(Grant Nos.22078066 and 22178065)
文摘Recently,nano theranostics,by integrating diagnostic and therapeutic functions into a nano system,have provided increasing opportunities for the design of personalized medicine in cancer.Among the construction method of various theranostic nano systems,the design of single component nanoparticles which are composed of organic photosensitive dyes has become a promising approach to constructing multifunctional nano-theranostic systems,thanks to its unique advantages such as defined structure,100%loading,and high repeatability.Specifically,depending on the inherent photonic imaging and therapeutic properties of the photosensitive dyes,the multifunctional purpose which integrates theranostic effects and targeting abilities can be realized via reasonable molecular modification and supramolecular assembly.In this review,recent advances in the development of nanostructured self-assemblies of porphyrins,phthalocyanines,and boron-dipyrromethanes for theranostics are summarized.Emphasis on their design consideration and theranostic applications are presented.Additionally,prospects for clinical practice and potential challenges of this rapidly growing field are also provided.
