A rare sesquiterpene of hawkteasesquioid A(1),featuring a novel 5/6/5 tricyclic system containing a 6,5-spiroketal motif,was isolated from the bark of Litsea coreana Lévl.var.lanuginosa(hawk tea).The structure of...A rare sesquiterpene of hawkteasesquioid A(1),featuring a novel 5/6/5 tricyclic system containing a 6,5-spiroketal motif,was isolated from the bark of Litsea coreana Lévl.var.lanuginosa(hawk tea).The structure of this compound was elucidated based on the high-resolution electrospray ionization mass spectrometry(HRESIMS),one-dimensional(1D)and two-dimensional(2D)nuclear magnetic resonance(NMR)spectroscopy,and single-crystal X-ray diffraction data.The cytotoxicity of this compound was assessed on the A549,HT-29,and SW1990 cell lines.展开更多
采用ZORBAX SB-C18(250 mm×9.4 mm I.D.,5μm)色谱柱为固定相,SC-CO2/甲醇为流动相,考察了超临界流体色谱分离提纯烟草萃取物中茄尼醇的工艺条件、流动相流速和改性剂含量对分离度的影响,以及温度和压力对茄尼醇容量因子、茄尼醇...采用ZORBAX SB-C18(250 mm×9.4 mm I.D.,5μm)色谱柱为固定相,SC-CO2/甲醇为流动相,考察了超临界流体色谱分离提纯烟草萃取物中茄尼醇的工艺条件、流动相流速和改性剂含量对分离度的影响,以及温度和压力对茄尼醇容量因子、茄尼醇与相邻色谱峰组分分离度和选择性因子的影响。通过采用选定SFC分离工艺条件,茄尼醇产品纯度达到94.9%。展开更多
文摘A rare sesquiterpene of hawkteasesquioid A(1),featuring a novel 5/6/5 tricyclic system containing a 6,5-spiroketal motif,was isolated from the bark of Litsea coreana Lévl.var.lanuginosa(hawk tea).The structure of this compound was elucidated based on the high-resolution electrospray ionization mass spectrometry(HRESIMS),one-dimensional(1D)and two-dimensional(2D)nuclear magnetic resonance(NMR)spectroscopy,and single-crystal X-ray diffraction data.The cytotoxicity of this compound was assessed on the A549,HT-29,and SW1990 cell lines.
文摘采用ZORBAX SB-C18(250 mm×9.4 mm I.D.,5μm)色谱柱为固定相,SC-CO2/甲醇为流动相,考察了超临界流体色谱分离提纯烟草萃取物中茄尼醇的工艺条件、流动相流速和改性剂含量对分离度的影响,以及温度和压力对茄尼醇容量因子、茄尼醇与相邻色谱峰组分分离度和选择性因子的影响。通过采用选定SFC分离工艺条件,茄尼醇产品纯度达到94.9%。
