氨铂(Am-DACHP),化学名为氨基丙二酸-1,2-二氨基环已烷合铂(Ⅱ)(1),是顺铂的衍生物,属第二代铂配合物抗癌药。氨铂化学稳定性好,水溶性大,动物实验表明,其抗 L 1210白血病和 B_(16)黑色素瘤的活性优于顺铂,且肾脏毒性低,与顺铂又无交叉...氨铂(Am-DACHP),化学名为氨基丙二酸-1,2-二氨基环已烷合铂(Ⅱ)(1),是顺铂的衍生物,属第二代铂配合物抗癌药。氨铂化学稳定性好,水溶性大,动物实验表明,其抗 L 1210白血病和 B_(16)黑色素瘤的活性优于顺铂,且肾脏毒性低,与顺铂又无交叉耐药性。展开更多
The adsorption isotherm and adsorption reaction kinetics of carboxymethyl chitosan(CMCS) for Fe 2+ have been studied. The results showed that CMCS appeared a good adsorbent for Fe 2+ in solution with pH 6~8 and the ad...The adsorption isotherm and adsorption reaction kinetics of carboxymethyl chitosan(CMCS) for Fe 2+ have been studied. The results showed that CMCS appeared a good adsorbent for Fe 2+ in solution with pH 6~8 and the adsorption capacity of CMCS increased with the increase in its carboxyl groups. The adsorption isotherm of CMCS for Fe 2+ at 20 ℃ was fitted good for the Langmuir equation.展开更多
合成了[PtAX_2](其中 A 为顺式-1.3-环戊二胺;X=Cl,Br,I,Ac—Cl,NO_3,1/2Mal,1/2Ox,1/2SO_4,1/2C_3H_6(COO_2)和[PtA(OH)_2X′2](X′=Cl,Ac—Cl)共十一种未知化合物,并用红外光谱,热失重差热等方法进行了表征,测定了它们在水和乙酸乙酯...合成了[PtAX_2](其中 A 为顺式-1.3-环戊二胺;X=Cl,Br,I,Ac—Cl,NO_3,1/2Mal,1/2Ox,1/2SO_4,1/2C_3H_6(COO_2)和[PtA(OH)_2X′2](X′=Cl,Ac—Cl)共十一种未知化合物,并用红外光谱,热失重差热等方法进行了表征,测定了它们在水和乙酸乙酯中的溶解度及对小鼠S-180肉瘤和 L-1210白血病的押制能力,发现[Pt A(Ac-Cl_2]对小鼠 S-180肉瘤有强烈的抑制作用。对配合物的抗癌活性与其脂溶性和水溶性关系进行了讨论。展开更多
文摘The adsorption isotherm and adsorption reaction kinetics of carboxymethyl chitosan(CMCS) for Fe 2+ have been studied. The results showed that CMCS appeared a good adsorbent for Fe 2+ in solution with pH 6~8 and the adsorption capacity of CMCS increased with the increase in its carboxyl groups. The adsorption isotherm of CMCS for Fe 2+ at 20 ℃ was fitted good for the Langmuir equation.
