A new isoflavone was obstained from the medicinal herb Amorpha fruticosa. It was elucidated asbenzopyran- 12-one, 1,4,10,11 - tetrahydro-6′-[8′-（hydroxymethy1）etheny1]-2,3-dimethoxy-8′-O-β-glucopyranosy1-O-α-D-...A new isoflavone was obstained from the medicinal herb Amorpha fruticosa. It was elucidated asbenzopyran- 12-one, 1,4,10,11 - tetrahydro-6′-[8′-（hydroxymethy1）etheny1]-2,3-dimethoxy-8′-O-β-glucopyranosy1-O-α-D-arabinoside by spectroscopic methods including UV, IR, 1D NMR and 2D NMR techniques. And the activity against acetaminophen-induced hepatotoxicity of this compound was also studied, and found this compound can protect liver obviously from hepatotoxicity induced by acetaminophen （AAP）. ？2009 Ting Guo Kang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.展开更多
Three compounds were isolated from the tissue culture cells of Daphne giraldii cullus, their structures were identified as daphneolone （1）, S-（＋）-1-（4-hydroxy-3-methoxyphenyl）-3-hydroxy-5-phenyl-l-pentanone （2...Three compounds were isolated from the tissue culture cells of Daphne giraldii cullus, their structures were identified as daphneolone （1）, S-（＋）-1-（4-hydroxy-3-methoxyphenyl）-3-hydroxy-5-phenyl-l-pentanone （2）, S-（＋）-1-（4-methoxyphenyl）-3- hydroxy-5-phenyl-l-pentanone （3）, and among them, 2 was a new compound, 3 was a novel natural product.展开更多
One new sesquiterpene lactone,1 α,8 α,9 α-trihydroxyeudesman-3（4）,7（11）-dien-8 β,12-olide（1） and two new phenylpropanoidsubstituted catechin glycosides,glabraoside C（2） and glabraoside D（3） were isolated...One new sesquiterpene lactone,1 α,8 α,9 α-trihydroxyeudesman-3（4）,7（11）-dien-8 β,12-olide（1） and two new phenylpropanoidsubstituted catechin glycosides,glabraoside C（2） and glabraoside D（3） were isolated from the whole plant of Sarcandra glabra. Their structures were established by the analyses of spectral and chemical evidences.展开更多
A new pterocarpan glycoside, （-）-maackiain 3-O-6＇-O-acrylyl-β-D-galactopyranoside（1） was isolated from the whole parts of Caragana jubata（pall.） Poir., together with three known pterocarpan glycosides, （-）-m...A new pterocarpan glycoside, （-）-maackiain 3-O-6＇-O-acrylyl-β-D-galactopyranoside（1） was isolated from the whole parts of Caragana jubata（pall.） Poir., together with three known pterocarpan glycosides, （-）-maackiain 3-O-6＇-O-acetyl-β-D-glucopyranoside（2）, （-）-maackiain 3-O-β-D-glucopyranoside（3） and （-）-maackiain 3-O-β-D-galactopyranoside（4）. All the compounds were isolated from the title plant for the first time. The structure of the new compound was established on the basis of detailed 1D, 2D NMR and circular dichroism spectroscopic analyses. All the compounds were evaluated for their cytotoxic activities against three tumor cell lines, A549, HL-60 and P388.展开更多
Two new compounds. corialins A （1） and B （2） were isolated from Coriaria nepulensis Wall. These new compounds were established as 7-hydroxy-3-[2,3-acetonidc-（3-methylhutane）] coumarin （1） and 3-O-β-D-glucopyr...Two new compounds. corialins A （1） and B （2） were isolated from Coriaria nepulensis Wall. These new compounds were established as 7-hydroxy-3-[2,3-acetonidc-（3-methylhutane）] coumarin （1） and 3-O-β-D-glucopyranosyl-3,4,5-1rihydroxy-1-（3- methyl-2-butenyl）-benzene （2）. on the basis of ID and 2D NMR techniques.展开更多
From the oligotrophic culture of a soft coral-associated actinomycetes strain, Streptomyces sp. OUCMDZ-1703, we isolated and identified two new chlorinated polyketides that we named strepchloritides A and B （1 and 2...From the oligotrophic culture of a soft coral-associated actinomycetes strain, Streptomyces sp. OUCMDZ-1703, we isolated and identified two new chlorinated polyketides that we named strepchloritides A and B （1 and 2）, three thiazole derivatives known as watasemycin A （3）, pulicatin G （4） and aerugine （5）, along with pyrrole- 2-carboxamide, furan-2-carboxamide and 1-（3,5-dihydroxyphenyl）ethanone. The new structures of 1 and 2 were determined by spectroscopic studies such as 1D- and 2D-NMR and MS analyses, while the known compounds were identified by comparison of the NMR data with those in literatures. The results showed that actinomycete strain OUCMDZ-1703 could use the relative high ratio of chlorine in the oligotrophic medium to synthesize chlorinated natural products. New compounds 1 and 2 displayed cytotoxicity against the MCF-7 ceils with ICs0 values of 9.9 and 20.2 ~tmoloL-1, respectively. Thiazole derivatives 3 and 5 were first found to be active against three clinical strains of methicillin-resistant Staphylococcus aureus （MRSA082, MRSA111 and MRSA234） with the same MIC/MBC values of 7.81/7.81 μg·mL-1.展开更多
基金supported by the Science and Technology of Dalian(No.2008E11SF168).
文摘A new isoflavone was obstained from the medicinal herb Amorpha fruticosa. It was elucidated asbenzopyran- 12-one, 1,4,10,11 - tetrahydro-6′-[8′-（hydroxymethy1）etheny1]-2,3-dimethoxy-8′-O-β-glucopyranosy1-O-α-D-arabinoside by spectroscopic methods including UV, IR, 1D NMR and 2D NMR techniques. And the activity against acetaminophen-induced hepatotoxicity of this compound was also studied, and found this compound can protect liver obviously from hepatotoxicity induced by acetaminophen （AAP）. ？2009 Ting Guo Kang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
文摘Three compounds were isolated from the tissue culture cells of Daphne giraldii cullus, their structures were identified as daphneolone （1）, S-（＋）-1-（4-hydroxy-3-methoxyphenyl）-3-hydroxy-5-phenyl-l-pentanone （2）, S-（＋）-1-（4-methoxyphenyl）-3- hydroxy-5-phenyl-l-pentanone （3）, and among them, 2 was a new compound, 3 was a novel natural product.
基金supported by the National Natural Science Foundation of China(Nos.20772157 and 21132009)National Science and Technology Project of China(No.2011ZX09307-002-01)the Program for Changjiang Scholars and Innovative Research Team in University of Ministry of Education of China(No.IRT1007)
文摘One new sesquiterpene lactone,1 α,8 α,9 α-trihydroxyeudesman-3（4）,7（11）-dien-8 β,12-olide（1） and two new phenylpropanoidsubstituted catechin glycosides,glabraoside C（2） and glabraoside D（3） were isolated from the whole plant of Sarcandra glabra. Their structures were established by the analyses of spectral and chemical evidences.
基金Supported by the National Natural Science Foundation of China(No.30660221)the Natural Science Foundation of Qinghai Province,China(No.2006-N-554)
文摘A new pterocarpan glycoside, （-）-maackiain 3-O-6＇-O-acrylyl-β-D-galactopyranoside（1） was isolated from the whole parts of Caragana jubata（pall.） Poir., together with three known pterocarpan glycosides, （-）-maackiain 3-O-6＇-O-acetyl-β-D-glucopyranoside（2）, （-）-maackiain 3-O-β-D-glucopyranoside（3） and （-）-maackiain 3-O-β-D-galactopyranoside（4）. All the compounds were isolated from the title plant for the first time. The structure of the new compound was established on the basis of detailed 1D, 2D NMR and circular dichroism spectroscopic analyses. All the compounds were evaluated for their cytotoxic activities against three tumor cell lines, A549, HL-60 and P388.
基金supported by the Major State Basic Research Development Program of China(Nos. 2009CB522303 and 2009CB940900)the foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China(No.P2008-ZZ13)
文摘Two new compounds. corialins A （1） and B （2） were isolated from Coriaria nepulensis Wall. These new compounds were established as 7-hydroxy-3-[2,3-acetonidc-（3-methylhutane）] coumarin （1） and 3-O-β-D-glucopyranosyl-3,4,5-1rihydroxy-1-（3- methyl-2-butenyl）-benzene （2）. on the basis of ID and 2D NMR techniques.
文摘From the oligotrophic culture of a soft coral-associated actinomycetes strain, Streptomyces sp. OUCMDZ-1703, we isolated and identified two new chlorinated polyketides that we named strepchloritides A and B （1 and 2）, three thiazole derivatives known as watasemycin A （3）, pulicatin G （4） and aerugine （5）, along with pyrrole- 2-carboxamide, furan-2-carboxamide and 1-（3,5-dihydroxyphenyl）ethanone. The new structures of 1 and 2 were determined by spectroscopic studies such as 1D- and 2D-NMR and MS analyses, while the known compounds were identified by comparison of the NMR data with those in literatures. The results showed that actinomycete strain OUCMDZ-1703 could use the relative high ratio of chlorine in the oligotrophic medium to synthesize chlorinated natural products. New compounds 1 and 2 displayed cytotoxicity against the MCF-7 ceils with ICs0 values of 9.9 and 20.2 ~tmoloL-1, respectively. Thiazole derivatives 3 and 5 were first found to be active against three clinical strains of methicillin-resistant Staphylococcus aureus （MRSA082, MRSA111 and MRSA234） with the same MIC/MBC values of 7.81/7.81 μg·mL-1.
