吡啶作为重要的三药中间体,在各行各业具有广泛应用,但是在吡啶的生产中,烷基吡啶作为副产同时产生,吡啶收率偏低,为满足吡啶需求,企业通过提升产能解决问题,导致经常会出现烷基吡啶胀库、积压的问题,这也是困扰企业的难点。本文在醛-...吡啶作为重要的三药中间体,在各行各业具有广泛应用,但是在吡啶的生产中,烷基吡啶作为副产同时产生,吡啶收率偏低,为满足吡啶需求,企业通过提升产能解决问题,导致经常会出现烷基吡啶胀库、积压的问题,这也是困扰企业的难点。本文在醛-氨法合成吡啶的基础上,通过设计新型催化剂Ag-ZSM-5催化甲醛、乙醛、氨合成吡啶,提高吡啶合成收率。分子筛为载体,有机胺为模板剂,硅锰为骨架,过渡金属银为改性剂,制备得到Ag-ZSM-5分子筛型催化剂。催化剂Ag-ZSM-5中Ag含量0.55%,在空气流量为70 m L/min的条件下活化4 h。当催化剂床层20 cm、反应温度450℃、反应压力120 k Pa、甲醛∶乙醛∶氨气摩尔比为2∶1∶3、停留时间8 s时,吡啶收率达到68.5%。展开更多
Pyridine(Py) and 3-methylpyridine(3-MP) are crucial intermediates in chemical industrial processes.Here,we provide a simple and energy-efficient approach for the isolation of Py and 3-MP by employing crystalline cucur...Pyridine(Py) and 3-methylpyridine(3-MP) are crucial intermediates in chemical industrial processes.Here,we provide a simple and energy-efficient approach for the isolation of Py and 3-MP by employing crystalline cucurbit[6]uril(Q[6]).The crystal exhibit high selectivity for Py from the mixture of Py and 3-MP in both vapor and liquid phases,with separation purities close to 100%.The selectivity is attributed to the varying stability of the host-vip complexes after the absorption of Py or 3-MP,as revealed by the single-crystal structure analysis.ITC experimental results and DFT calculations indicate that,compared to3-MP,Q[6] has a higher binding strength and lower binding energy with Py.In addition,pyridine can be removed from the Q[6] cavity through vacuum heating or organic solvent immersion,enabling Q[6]reuse via reversible vip loading.This method offers a promising approach for high-purity Py and 3-MP separation with significant economic and environmental benefits.展开更多
文摘吡啶作为重要的三药中间体,在各行各业具有广泛应用,但是在吡啶的生产中,烷基吡啶作为副产同时产生,吡啶收率偏低,为满足吡啶需求,企业通过提升产能解决问题,导致经常会出现烷基吡啶胀库、积压的问题,这也是困扰企业的难点。本文在醛-氨法合成吡啶的基础上,通过设计新型催化剂Ag-ZSM-5催化甲醛、乙醛、氨合成吡啶,提高吡啶合成收率。分子筛为载体,有机胺为模板剂,硅锰为骨架,过渡金属银为改性剂,制备得到Ag-ZSM-5分子筛型催化剂。催化剂Ag-ZSM-5中Ag含量0.55%,在空气流量为70 m L/min的条件下活化4 h。当催化剂床层20 cm、反应温度450℃、反应压力120 k Pa、甲醛∶乙醛∶氨气摩尔比为2∶1∶3、停留时间8 s时,吡啶收率达到68.5%。
基金supported by the Guizhou Provincial Basic Research Program(Natural Science) Youth Guidance(Nos.[2024]110,[2024]378)Science and Technology Innovation Team of Natural Science Foundation of Guizhou Province(No.CXTD[2023]005)+3 种基金Science and Technology Innovation Team of Higher Education Department of Guizhou Province(No.QJJ[2023]053)Natural Science Special of Guizhou University(No.202137)Guizhou Provincial Key Laboratory Platform Project(No.ZSYS[2025]008)PhD Foundation of Guizhou University(No.[2021]83)。
文摘Pyridine(Py) and 3-methylpyridine(3-MP) are crucial intermediates in chemical industrial processes.Here,we provide a simple and energy-efficient approach for the isolation of Py and 3-MP by employing crystalline cucurbit[6]uril(Q[6]).The crystal exhibit high selectivity for Py from the mixture of Py and 3-MP in both vapor and liquid phases,with separation purities close to 100%.The selectivity is attributed to the varying stability of the host-vip complexes after the absorption of Py or 3-MP,as revealed by the single-crystal structure analysis.ITC experimental results and DFT calculations indicate that,compared to3-MP,Q[6] has a higher binding strength and lower binding energy with Py.In addition,pyridine can be removed from the Q[6] cavity through vacuum heating or organic solvent immersion,enabling Q[6]reuse via reversible vip loading.This method offers a promising approach for high-purity Py and 3-MP separation with significant economic and environmental benefits.
