以1,3-二溴金刚烷为起始原料,首先在Lewis酸催化作用下与苯酚发生傅-克烷基化反应生成1,3-二(4-羟苯基)金刚烷(DPAD);DPAD再经Williamson缩合反应和中和反应合成了新型金刚烷基Bola型表面活性剂1,3-二(4-(2-乙氧基磺酸钠)-苯基)金刚烷...以1,3-二溴金刚烷为起始原料,首先在Lewis酸催化作用下与苯酚发生傅-克烷基化反应生成1,3-二(4-羟苯基)金刚烷(DPAD);DPAD再经Williamson缩合反应和中和反应合成了新型金刚烷基Bola型表面活性剂1,3-二(4-(2-乙氧基磺酸钠)-苯基)金刚烷。采用IR、1 H NMR和元素分析等手段确定了各中间物及产物的结构,测试了1,3-二(4-(2-乙氧基磺酸钠)-苯基)金刚烷的表面活性。考察了关键反应步骤(Williamson缩合反应)溶剂、卤代磺烷基化试剂、反应温度、反应时间和物料比对产物收率的影响。在优化的反应条件下,1,3-二(4-(2-乙氧基磺酸钠)-苯基)金刚烷的总收率可达72%。展开更多
The methane monooxygenase of methanotrophs is capable of catalyzing propene to produce epoxypropane directly in one step,without formation of by-products except water.Compared with the chemical synthesis method for pr...The methane monooxygenase of methanotrophs is capable of catalyzing propene to produce epoxypropane directly in one step,without formation of by-products except water.Compared with the chemical synthesis method for production of epoxypropane,the biosynthesis has promising potential due to the mild reaction conditions,high selectivity and environmental friendliness.In this paper,the conditions were optimized for production of epoxypropane from propene with Methylosinus trichosporim OB3b whole cells cultivated by the traditional method,including temperatures,initial propene concentrations,sodium formate and MgCl2 concentrations,which are important factors affecting the epoxypropane biosythesis.Based on the optimization results,the performance of epoxypropane production carried out with M.trichosporium OB3b of high cell density was investigated,which was obtained by a novel rapid cultivation method developed by the authors.The final concentration of epoxypropane was almost four times of the highest productivity reported so far.展开更多
文摘以1,3-二溴金刚烷为起始原料,首先在Lewis酸催化作用下与苯酚发生傅-克烷基化反应生成1,3-二(4-羟苯基)金刚烷(DPAD);DPAD再经Williamson缩合反应和中和反应合成了新型金刚烷基Bola型表面活性剂1,3-二(4-(2-乙氧基磺酸钠)-苯基)金刚烷。采用IR、1 H NMR和元素分析等手段确定了各中间物及产物的结构,测试了1,3-二(4-(2-乙氧基磺酸钠)-苯基)金刚烷的表面活性。考察了关键反应步骤(Williamson缩合反应)溶剂、卤代磺烷基化试剂、反应温度、反应时间和物料比对产物收率的影响。在优化的反应条件下,1,3-二(4-(2-乙氧基磺酸钠)-苯基)金刚烷的总收率可达72%。
文摘The methane monooxygenase of methanotrophs is capable of catalyzing propene to produce epoxypropane directly in one step,without formation of by-products except water.Compared with the chemical synthesis method for production of epoxypropane,the biosynthesis has promising potential due to the mild reaction conditions,high selectivity and environmental friendliness.In this paper,the conditions were optimized for production of epoxypropane from propene with Methylosinus trichosporim OB3b whole cells cultivated by the traditional method,including temperatures,initial propene concentrations,sodium formate and MgCl2 concentrations,which are important factors affecting the epoxypropane biosythesis.Based on the optimization results,the performance of epoxypropane production carried out with M.trichosporium OB3b of high cell density was investigated,which was obtained by a novel rapid cultivation method developed by the authors.The final concentration of epoxypropane was almost four times of the highest productivity reported so far.
