Semantic representation of evidence-based medical guidelines provides the support for the data inter-operability and has been found many applications in the medical domain. In this paper, we describe a semantic repres...Semantic representation of evidence-based medical guidelines provides the support for the data inter-operability and has been found many applications in the medical domain. In this paper, we describe a semantic representation approach of evidence-based medical guidelines, which is based on the Semantic Web Technology standards. We discuss several use cases of that semantic representation of evidence-based medical guideline, and show that they are potentially useful for medical applications.展开更多
Polyhydroxyalkanoates （PHAs） are a class of biopolyesters that are synthesized intracellularly by microorganisms, mainly by different genera of eubacteria. These biopolymers have diverse physical and chemical proper...Polyhydroxyalkanoates （PHAs） are a class of biopolyesters that are synthesized intracellularly by microorganisms, mainly by different genera of eubacteria. These biopolymers have diverse physical and chemical properties that also classify them as biodegradable in nature and make them compatible to living systems. In the last two decades or so, PHAs have emerged as potential useful materials in the medical field for different applications owing to their unique properties. The lower acidity and bioactivity of PHAs confer them with minimal risk compared to other biopolymers such as poly-lactic acid （PLA） and poly-glycolic acid （PGA）. Therefore, the versatility of PHAs in terms of their non-toxic degradation products, biocompatibility, desired surface modifications, wide range of physical and chemical properties, cellular growth support, and attachment without carcinogenic effects have enabled their use as in vivo implants such as sutures, adhesion barriers, and valves to guide tissue repair and in regeneration devices such as cardiovascular patches, articular cartilage repair scaffolds, bone graft substitutes, and nerve guides. Here, we briefly describe some of the most recent innovative research involving the use of PHAs in medical applications. Microbial production of PHAs also provides the opportunity to develop PHAs with more unique monomer compositions economically through metabolic engineering approaches. At present, it is generally established that the PHA monomer composition and surface modifications influence cell responses.PHA synthesis by bacteria does not require the use of a catalyst （used in the synthesis of other polymers）, which further promotes the biocompatibility of PHA-derived polymers.展开更多
基金Supported by the European Commission under the 7th Framework EURECA Project(FP7-ICT-2011-7,288048)the Key Projects of National Social Science Foundation of China(11ZD&189)the Natural Science Foundation of Hubei Province(2014CFB247)
文摘Semantic representation of evidence-based medical guidelines provides the support for the data inter-operability and has been found many applications in the medical domain. In this paper, we describe a semantic representation approach of evidence-based medical guidelines, which is based on the Semantic Web Technology standards. We discuss several use cases of that semantic representation of evidence-based medical guideline, and show that they are potentially useful for medical applications.
文摘Polyhydroxyalkanoates （PHAs） are a class of biopolyesters that are synthesized intracellularly by microorganisms, mainly by different genera of eubacteria. These biopolymers have diverse physical and chemical properties that also classify them as biodegradable in nature and make them compatible to living systems. In the last two decades or so, PHAs have emerged as potential useful materials in the medical field for different applications owing to their unique properties. The lower acidity and bioactivity of PHAs confer them with minimal risk compared to other biopolymers such as poly-lactic acid （PLA） and poly-glycolic acid （PGA）. Therefore, the versatility of PHAs in terms of their non-toxic degradation products, biocompatibility, desired surface modifications, wide range of physical and chemical properties, cellular growth support, and attachment without carcinogenic effects have enabled their use as in vivo implants such as sutures, adhesion barriers, and valves to guide tissue repair and in regeneration devices such as cardiovascular patches, articular cartilage repair scaffolds, bone graft substitutes, and nerve guides. Here, we briefly describe some of the most recent innovative research involving the use of PHAs in medical applications. Microbial production of PHAs also provides the opportunity to develop PHAs with more unique monomer compositions economically through metabolic engineering approaches. At present, it is generally established that the PHA monomer composition and surface modifications influence cell responses.PHA synthesis by bacteria does not require the use of a catalyst （used in the synthesis of other polymers）, which further promotes the biocompatibility of PHA-derived polymers.
