BNCT is finally becoming ＂a new option against cancer＂. The difficulties for its development progress of that firstly is to improve the performance of boron compounds, secondly, it is the requirements of quantificat...BNCT is finally becoming ＂a new option against cancer＂. The difficulties for its development progress of that firstly is to improve the performance of boron compounds, secondly, it is the requirements of quantification and accuracy upon radiation dosimetry evaluation in clinical trials. Furthermore, that is long anticipation on hospital base neutron sources. It includes dedicated new NCT reactor, accelerator based neutron sources, and isotope source facilities. In ad- dition to reactors, so far, the technology of other types of sources for clinical trials is not yet completely proven. The In- Hospital Neutron lrradiator specially designed for NCT, based on the MNSR successfully developed by China, can be installed inside or near the hospital and operated directly by doctors. The Irradiator has two neutron beams for respective treatment of the shallow and deep tumors. It is expected to initiate operation in the end of this year. It would provide a safe, low cost, and effective treatment tool for the NCT routine application in near future.展开更多
Boron Neutron Capture Therapy （BNCT） has been under investigation for some time and several applications to terminal brain cancer patients have been made at different institution in the US （MIT, Mass General Hospit...Boron Neutron Capture Therapy （BNCT） has been under investigation for some time and several applications to terminal brain cancer patients have been made at different institution in the US （MIT, Mass General Hospital, Japan, the Netherland, Sweden, Finland, and others. All together about 300 patients were treated. Using the very large neutron capture cross section by 10B, one taps the tumor with a compound containing Boron. This is followed by bombarding the tumor with termal neutrons which splits the boron nucleus into an alpha particle and 6Li. These charged particles lose their energy within the size of the tumor and thus destroy it. The Gadolinium Neutron Capture Therapy （GNCT） is similar to BNCT, with the advantage that 157Gd has a huge neutron capture cross section （about 120 Mb compared to the neutron ＋ boron cross section of about 4 Kb）. In this talk I give a description of the physics of these therapies and discuss their future.展开更多
文摘BNCT is finally becoming ＂a new option against cancer＂. The difficulties for its development progress of that firstly is to improve the performance of boron compounds, secondly, it is the requirements of quantification and accuracy upon radiation dosimetry evaluation in clinical trials. Furthermore, that is long anticipation on hospital base neutron sources. It includes dedicated new NCT reactor, accelerator based neutron sources, and isotope source facilities. In ad- dition to reactors, so far, the technology of other types of sources for clinical trials is not yet completely proven. The In- Hospital Neutron lrradiator specially designed for NCT, based on the MNSR successfully developed by China, can be installed inside or near the hospital and operated directly by doctors. The Irradiator has two neutron beams for respective treatment of the shallow and deep tumors. It is expected to initiate operation in the end of this year. It would provide a safe, low cost, and effective treatment tool for the NCT routine application in near future.
文摘Boron Neutron Capture Therapy （BNCT） has been under investigation for some time and several applications to terminal brain cancer patients have been made at different institution in the US （MIT, Mass General Hospital, Japan, the Netherland, Sweden, Finland, and others. All together about 300 patients were treated. Using the very large neutron capture cross section by 10B, one taps the tumor with a compound containing Boron. This is followed by bombarding the tumor with termal neutrons which splits the boron nucleus into an alpha particle and 6Li. These charged particles lose their energy within the size of the tumor and thus destroy it. The Gadolinium Neutron Capture Therapy （GNCT） is similar to BNCT, with the advantage that 157Gd has a huge neutron capture cross section （about 120 Mb compared to the neutron ＋ boron cross section of about 4 Kb）. In this talk I give a description of the physics of these therapies and discuss their future.
