为研究CD8^+T细胞的功能异常机制,对功能异常状态CD8^+T细胞和3种正常CD8^+T细胞亚型[中央记忆CD8^+T细胞(HCM)、效应记忆CD8^+T细胞(HEM)和naive CD8^+T细胞(HW)]的ATAC-seq(Assay for transposase accessible chromatin with high-thr...为研究CD8^+T细胞的功能异常机制,对功能异常状态CD8^+T细胞和3种正常CD8^+T细胞亚型[中央记忆CD8^+T细胞(HCM)、效应记忆CD8^+T细胞(HEM)和naive CD8^+T细胞(HW)]的ATAC-seq(Assay for transposase accessible chromatin with high-throughput sequencing)数据进行基因调控网络比较,结果表明,3种正常CD8^+T细胞特异表达的基因参与维持相应T细胞正常功能的信号通路,功能异常CD8^+T细胞特异的基因参与癌症相关通路。转录因子调控网络比较分析发现功能异常CD8^+T细胞GMEB2转录因子表达关闭。细胞表面受体调控网络比较分析发现功能异常CD8^+T细胞CD7和P4HB受体的表达关闭。采用基因调控网络的数据进行比较分析,发现CD8^+T细胞功能异常机制可能与GMEB2转录因子、CD7和P4HB受体表达关闭有关,这为抗病育种寻找特定基因提供新思路。展开更多
3 Brief explanation of the programs The No.3 program demostrates a sorting process, its sorting key word is character string. It needs to create a string file before it runs. The length of each string is ramdom, lengt...3 Brief explanation of the programs The No.3 program demostrates a sorting process, its sorting key word is character string. It needs to create a string file before it runs. The length of each string is ramdom, length maximum is 20, a string consists of 26 lower letters a..z. The No.2 program and No.1 program demostrate repectively a sorting process too, their sorting key words are integer展开更多
文摘为研究CD8^+T细胞的功能异常机制,对功能异常状态CD8^+T细胞和3种正常CD8^+T细胞亚型[中央记忆CD8^+T细胞(HCM)、效应记忆CD8^+T细胞(HEM)和naive CD8^+T细胞(HW)]的ATAC-seq(Assay for transposase accessible chromatin with high-throughput sequencing)数据进行基因调控网络比较,结果表明,3种正常CD8^+T细胞特异表达的基因参与维持相应T细胞正常功能的信号通路,功能异常CD8^+T细胞特异的基因参与癌症相关通路。转录因子调控网络比较分析发现功能异常CD8^+T细胞GMEB2转录因子表达关闭。细胞表面受体调控网络比较分析发现功能异常CD8^+T细胞CD7和P4HB受体的表达关闭。采用基因调控网络的数据进行比较分析,发现CD8^+T细胞功能异常机制可能与GMEB2转录因子、CD7和P4HB受体表达关闭有关,这为抗病育种寻找特定基因提供新思路。
文摘3 Brief explanation of the programs The No.3 program demostrates a sorting process, its sorting key word is character string. It needs to create a string file before it runs. The length of each string is ramdom, length maximum is 20, a string consists of 26 lower letters a..z. The No.2 program and No.1 program demostrate repectively a sorting process too, their sorting key words are integer
