目的探讨阿卡波糖、吡格列酮二甲双胍片联合治疗对2型糖尿病(T2DM)患者血清单核细胞趋化蛋白-1(MCP-1)、胰岛素样生长因子1(IGF-1)、肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)水平的影响和临床疗效。方法选取2022年5月至2024年5月...目的探讨阿卡波糖、吡格列酮二甲双胍片联合治疗对2型糖尿病(T2DM)患者血清单核细胞趋化蛋白-1(MCP-1)、胰岛素样生长因子1(IGF-1)、肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)水平的影响和临床疗效。方法选取2022年5月至2024年5月泰安市妇幼保健院收治的136例T2DM患者为研究对象,按照随机数字表法分为联合组与常规组,各68例。常规组采用吡格列酮二甲双胍进行口服治疗,联合组则在常规治疗的基础上口服阿卡波糖进行治疗。比较2组治疗前后血糖、胰岛素相关指标、MCP-1、IGF-1、炎症因子水平,比较2组不良反应发生率、总有效率。结果2组治疗前空腹血糖(FPG)、餐后2 h血糖(2 h PG)、空腹胰岛素(FINS)、IGF-1、MCP-1、TNF-α、IL-6水平及胰岛素抵抗指数(HOMA-IR)比较,差异均无统计学意义(P>0.05)。治疗后,2组FPG、2 h PG、FINS、MCP-1、TNF-α、IL-6水平及HOMA-IR均明显降低,且联合组明显低于常规组,差异均有统计学意义(P<0.05)。治疗后,2组IGF-1水平升高,且联合组明显高于常规组,差异均有统计学意义(P<0.05)。联合组与常规组在治疗过程中不良反应总发生率分别为17.65%、13.24%,差异无统计学意义(χ^(2)=0.507,P=0.477)。联合组与常规组总有效率分别为94.12%、80.88%,联合组高于常规组,差异有统计学意义(χ^(2)=5.445,P=0.020)。结论阿卡波糖与吡格列酮二甲双胍片联合治疗T2DM患者,能较有效降低血糖和胰岛素抵抗,抑制血清MCP-1及炎症因子水平,提高IGF-1水平及疗效。展开更多
目的:系统评价瑞格列奈对比格列美脲分别联合二甲双胍治疗2型糖尿病的有效性和安全性,为临床提供循证依据。方法:计算机检索中国期刊全文数据库、中文科技期刊数据库、万方数据库、Pub Med、Embase、Medline、Cochrane图书馆,收集瑞格...目的:系统评价瑞格列奈对比格列美脲分别联合二甲双胍治疗2型糖尿病的有效性和安全性,为临床提供循证依据。方法:计算机检索中国期刊全文数据库、中文科技期刊数据库、万方数据库、Pub Med、Embase、Medline、Cochrane图书馆,收集瑞格列奈联合二甲双胍(试验组)对比格列美脲联合二甲双胍(对照组)治疗2型糖尿病疗效[糖化血红蛋白(Hb A1c)、空腹血糖(FPG)、餐后2 h血糖(2 h PG)水平]和安全性(不良反应发生率、低血糖反应发生率、胃肠道反应发生率)的随机对照试验(RCT),对符合纳入标准的文献进行资料提取,并采用Cochrane系统评价手册5.1.0进行质量评价后,采用Rev Man 5.2统计软件进行Meta分析。结果:共纳入12项RCT,合计957例患者。Meta分析结果显示,试验组患者2 h PG降低程度显著低于对照组,差异有统计学意义[MD=-0.70,95%CI(-1.02,-0.38),P<0.001];两组患者Hb A1c降低水平[MD=0.00,95%CI(-0.24,0.25),P=0.98]、FPG降低水平[MD=0.10,95%CI(-0.17,0.36),P=0.47]、不良反应发生率[OR=0.54,95%CI(0.28,1.06),P=0.07]、低血糖反应发生率[OR=0.52,95%CI(0.13,2.06),P=0.35]和胃肠道反应发生率[OR=0.60,95%CI(0.15,2.41),P=0.47]比较,差异均无统计学意义。结论:瑞格列奈联合二甲双胍降低2 h PG效果优于格列美脲联合二甲双胍,安全性相当。展开更多
A new spectrophotometric method for the determination of trace heparin has been studied. The method was based on the discoloration reaction between heparin and bisphenylnaphthylmethane dyes such as victoria blue 4R(VB...A new spectrophotometric method for the determination of trace heparin has been studied. The method was based on the discoloration reaction between heparin and bisphenylnaphthylmethane dyes such as victoria blue 4R(VB4R), victoria blue B(VBB) and night blue(NB) in weak acid medium. The reduction in absorbance was directly proportional to the concentration of heparin. The linear ranges of heparin were from 0 to 2.4 μg/mL for all systems. The molar absorptivities( ε ) of the three systems were between 2.11×10 6 and 2.66×10 6 L·mol -1 ·cm -1 and the sensitivity of VB4R system was the highest. Taking VB4R system for an example, the effects of some coexisting substances on the determination of heparin have been investigated and the results showed that the method had a good selectivity. The method has been applied to determination of the heparin samples with satisfactory results.展开更多
文摘目的探讨阿卡波糖、吡格列酮二甲双胍片联合治疗对2型糖尿病(T2DM)患者血清单核细胞趋化蛋白-1(MCP-1)、胰岛素样生长因子1(IGF-1)、肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)水平的影响和临床疗效。方法选取2022年5月至2024年5月泰安市妇幼保健院收治的136例T2DM患者为研究对象,按照随机数字表法分为联合组与常规组,各68例。常规组采用吡格列酮二甲双胍进行口服治疗,联合组则在常规治疗的基础上口服阿卡波糖进行治疗。比较2组治疗前后血糖、胰岛素相关指标、MCP-1、IGF-1、炎症因子水平,比较2组不良反应发生率、总有效率。结果2组治疗前空腹血糖(FPG)、餐后2 h血糖(2 h PG)、空腹胰岛素(FINS)、IGF-1、MCP-1、TNF-α、IL-6水平及胰岛素抵抗指数(HOMA-IR)比较,差异均无统计学意义(P>0.05)。治疗后,2组FPG、2 h PG、FINS、MCP-1、TNF-α、IL-6水平及HOMA-IR均明显降低,且联合组明显低于常规组,差异均有统计学意义(P<0.05)。治疗后,2组IGF-1水平升高,且联合组明显高于常规组,差异均有统计学意义(P<0.05)。联合组与常规组在治疗过程中不良反应总发生率分别为17.65%、13.24%,差异无统计学意义(χ^(2)=0.507,P=0.477)。联合组与常规组总有效率分别为94.12%、80.88%,联合组高于常规组,差异有统计学意义(χ^(2)=5.445,P=0.020)。结论阿卡波糖与吡格列酮二甲双胍片联合治疗T2DM患者,能较有效降低血糖和胰岛素抵抗,抑制血清MCP-1及炎症因子水平,提高IGF-1水平及疗效。
文摘目的:系统评价瑞格列奈对比格列美脲分别联合二甲双胍治疗2型糖尿病的有效性和安全性,为临床提供循证依据。方法:计算机检索中国期刊全文数据库、中文科技期刊数据库、万方数据库、Pub Med、Embase、Medline、Cochrane图书馆,收集瑞格列奈联合二甲双胍(试验组)对比格列美脲联合二甲双胍(对照组)治疗2型糖尿病疗效[糖化血红蛋白(Hb A1c)、空腹血糖(FPG)、餐后2 h血糖(2 h PG)水平]和安全性(不良反应发生率、低血糖反应发生率、胃肠道反应发生率)的随机对照试验(RCT),对符合纳入标准的文献进行资料提取,并采用Cochrane系统评价手册5.1.0进行质量评价后,采用Rev Man 5.2统计软件进行Meta分析。结果:共纳入12项RCT,合计957例患者。Meta分析结果显示,试验组患者2 h PG降低程度显著低于对照组,差异有统计学意义[MD=-0.70,95%CI(-1.02,-0.38),P<0.001];两组患者Hb A1c降低水平[MD=0.00,95%CI(-0.24,0.25),P=0.98]、FPG降低水平[MD=0.10,95%CI(-0.17,0.36),P=0.47]、不良反应发生率[OR=0.54,95%CI(0.28,1.06),P=0.07]、低血糖反应发生率[OR=0.52,95%CI(0.13,2.06),P=0.35]和胃肠道反应发生率[OR=0.60,95%CI(0.15,2.41),P=0.47]比较,差异均无统计学意义。结论:瑞格列奈联合二甲双胍降低2 h PG效果优于格列美脲联合二甲双胍,安全性相当。
文摘A new spectrophotometric method for the determination of trace heparin has been studied. The method was based on the discoloration reaction between heparin and bisphenylnaphthylmethane dyes such as victoria blue 4R(VB4R), victoria blue B(VBB) and night blue(NB) in weak acid medium. The reduction in absorbance was directly proportional to the concentration of heparin. The linear ranges of heparin were from 0 to 2.4 μg/mL for all systems. The molar absorptivities( ε ) of the three systems were between 2.11×10 6 and 2.66×10 6 L·mol -1 ·cm -1 and the sensitivity of VB4R system was the highest. Taking VB4R system for an example, the effects of some coexisting substances on the determination of heparin have been investigated and the results showed that the method had a good selectivity. The method has been applied to determination of the heparin samples with satisfactory results.
