OBJECTIVE:To establish an in vitro model of radiation-induced lung injury using rat lung alveolar macrophages(NR8383).METHODS:Using a medical electronic linear accelerator,cells were irradiated with either 0 Gy or 6 G...OBJECTIVE:To establish an in vitro model of radiation-induced lung injury using rat lung alveolar macrophages(NR8383).METHODS:Using a medical electronic linear accelerator,cells were irradiated with either 0 Gy or 6 Gy X-rays.At 6,12,24,30 and 48 h,the DNA damage index(8-OHd G)and lipid damage index(MDA)were measured in the two groups.We also determined the levels of tumor necrosis factor-alpha(TNF-α),interleukin-6(IL-6)and transforming growth factor-β(TGF-β).RESULTS:The levels of 8-OHd G and MDA in the 6 Gy irradiation group were higher than those in the0 Gy group at 6,12,24,30 and 48 h after irradiation.The levels reached the highest value-6 h after irradiation,and then gradually decreased.The levels of the inflammatory factors TNF-α,TGF-βand IL-6 were higher in the 6 Gy irradiation group than those in the 0 Gy group at 6,12,24,30 and 48 h after irradiation.CONCLUSION:Six Gy X-ray irradiated NR8383 cells can be used to establish an in-vitro model of radiation-induced lung injury.The levels of 8-OHd G,MDA,TNF-α,TGF-βand IL-6 can be used as effective evaluation indicators.展开更多
高水平的军机飞行员岗位能力对于完成作战任务、保障飞行安全具有十分重要的意义。但是,目前关于军机飞行员岗位能力的影响因素及作用机制的研究却十分匮乏。为了构建军机飞行员岗位能力的影响因素指标体系,研究招募了30名合格军机飞行...高水平的军机飞行员岗位能力对于完成作战任务、保障飞行安全具有十分重要的意义。但是,目前关于军机飞行员岗位能力的影响因素及作用机制的研究却十分匮乏。为了构建军机飞行员岗位能力的影响因素指标体系,研究招募了30名合格军机飞行员以完成影响因素及其相互影响矩阵的调查,并综合应用决策试验与评估-综合对抗解释结构建模(decision making trial and evaluation-total adversarial interpretive structure modeling,DEMATEL-TAISM)方法进行分析。结果表明:①军机飞行员岗位能力影响因素指标体系由13项关键因素组成,可分成基础能力训练、理论知识训练、飞行训练和改换装训练这4类一级指标;②多任务/场景切换的操控能力、基本飞行操控能力、特情处置驾驶操控能力、战术基础理论、自我管理技能、职业体能是6个至关重要的影响因素,前三者的中心度(与其他因素的关联)最高,后三者的原因度(对其他因素的影响)最大;③对于军机飞行员岗位能力的生成,自我管理技能、职业体能和战术基础理论是最根本原因,空中战术能力、飞行后讲评和改装飞行驾驶技术是最直接原因。研究结果可进一步应用于军机飞行员岗位能力评估系统的开发。展开更多
2025年北美放射学会(Radiological Society of North America,RSNA)年会心脏影像学领域呈现了丰富的学术内容,共收录近160篇摘要,主要围绕人工智能在心脏影像中的应用,心血管CT与MRI成像技术临床应用以及影像组学相关研究。本文旨在综...2025年北美放射学会(Radiological Society of North America,RSNA)年会心脏影像学领域呈现了丰富的学术内容,共收录近160篇摘要,主要围绕人工智能在心脏影像中的应用,心血管CT与MRI成像技术临床应用以及影像组学相关研究。本文旨在综述这些领域的最新进展,为心脏影像学研究者与临床医生提供前沿的学术动态和科研参考方向。展开更多
基金Supported by the National Natural Science Foundation of China the Mechanism Underlying Nourishing Yin,Clearing Lung and Activating Blood Circulation to Regulate AMPK Mediated Autophagy in Radiation-induced Lung Injury(No.81673754)。
文摘OBJECTIVE:To establish an in vitro model of radiation-induced lung injury using rat lung alveolar macrophages(NR8383).METHODS:Using a medical electronic linear accelerator,cells were irradiated with either 0 Gy or 6 Gy X-rays.At 6,12,24,30 and 48 h,the DNA damage index(8-OHd G)and lipid damage index(MDA)were measured in the two groups.We also determined the levels of tumor necrosis factor-alpha(TNF-α),interleukin-6(IL-6)and transforming growth factor-β(TGF-β).RESULTS:The levels of 8-OHd G and MDA in the 6 Gy irradiation group were higher than those in the0 Gy group at 6,12,24,30 and 48 h after irradiation.The levels reached the highest value-6 h after irradiation,and then gradually decreased.The levels of the inflammatory factors TNF-α,TGF-βand IL-6 were higher in the 6 Gy irradiation group than those in the 0 Gy group at 6,12,24,30 and 48 h after irradiation.CONCLUSION:Six Gy X-ray irradiated NR8383 cells can be used to establish an in-vitro model of radiation-induced lung injury.The levels of 8-OHd G,MDA,TNF-α,TGF-βand IL-6 can be used as effective evaluation indicators.
文摘高水平的军机飞行员岗位能力对于完成作战任务、保障飞行安全具有十分重要的意义。但是,目前关于军机飞行员岗位能力的影响因素及作用机制的研究却十分匮乏。为了构建军机飞行员岗位能力的影响因素指标体系,研究招募了30名合格军机飞行员以完成影响因素及其相互影响矩阵的调查,并综合应用决策试验与评估-综合对抗解释结构建模(decision making trial and evaluation-total adversarial interpretive structure modeling,DEMATEL-TAISM)方法进行分析。结果表明:①军机飞行员岗位能力影响因素指标体系由13项关键因素组成,可分成基础能力训练、理论知识训练、飞行训练和改换装训练这4类一级指标;②多任务/场景切换的操控能力、基本飞行操控能力、特情处置驾驶操控能力、战术基础理论、自我管理技能、职业体能是6个至关重要的影响因素,前三者的中心度(与其他因素的关联)最高,后三者的原因度(对其他因素的影响)最大;③对于军机飞行员岗位能力的生成,自我管理技能、职业体能和战术基础理论是最根本原因,空中战术能力、飞行后讲评和改装飞行驾驶技术是最直接原因。研究结果可进一步应用于军机飞行员岗位能力评估系统的开发。
文摘2025年北美放射学会(Radiological Society of North America,RSNA)年会心脏影像学领域呈现了丰富的学术内容,共收录近160篇摘要,主要围绕人工智能在心脏影像中的应用,心血管CT与MRI成像技术临床应用以及影像组学相关研究。本文旨在综述这些领域的最新进展,为心脏影像学研究者与临床医生提供前沿的学术动态和科研参考方向。
