In order to investigate the secretion mechanism of denervated submandibular gland（SMG） and artificially regulate the secretion of transferred SMG,serial studies on the secretion function of normal and transferred SM...In order to investigate the secretion mechanism of denervated submandibular gland（SMG） and artificially regulate the secretion of transferred SMG,serial studies on the secretion function of normal and transferred SMG have been performed. The results showed that functional α 1A- and α 1B-adrenoceptors（AR） were expressed in human SMG, and might contribute to the regulation of saliva synthesis and secretion. Both β1- and β2-AR were expressed in rabbit SMG. β1-AR was the predominant subtype and might play an important role in regulating saliva and α-amylase secretion. Vanilloid receptor1（VR1） mRNA and protein were detected in rabbit SMG. Capsaicin could induce a significant increase in secretion of rabbit SMG via activitation of VR1. On the rabbit model of microvascular transfer of SMG, phenylephrine（10 -7 mol/L）was infused into SMG through the Wharton’s duct. The secretion of transferred SMG was significantly increased without significant changes of cardiovascular function. The effective mechanism of phenylephrine might involve the increased expression of α1-AR, translocation of AQP5 from cytoplasm to apical membrane, activation of signal molecules related to cell proliferation, and moderate the atrophy of the gland. These results provided a experimental basis for deeply understanding of secretion mechanism of normal and transferred SMG, and effective regulation of secretion of the transferred SMG.展开更多
小儿复发性腮腺炎(Recurrent parotitisin children or Juvenile recurrent parotitis简称 JRP),临床上并不少见,它不等同于流行性腮腺炎,一般来说,病毒感染人体后,人体将获得终身免疫,不会再感染此型病毒。但病毒性腮腺炎除流腮病毒外...小儿复发性腮腺炎(Recurrent parotitisin children or Juvenile recurrent parotitis简称 JRP),临床上并不少见,它不等同于流行性腮腺炎,一般来说,病毒感染人体后,人体将获得终身免疫,不会再感染此型病毒。但病毒性腮腺炎除流腮病毒外,尚有柯萨奇病毒,流感病毒,疱疹病毒,EB 病毒等同样可引起腮腺感染,腮腺炎的病原体除上述病毒性外,尚有细菌性感染以链球菌为主,可导致反复感染。小儿复发性腮腺炎之所以常见。展开更多
文摘In order to investigate the secretion mechanism of denervated submandibular gland（SMG） and artificially regulate the secretion of transferred SMG,serial studies on the secretion function of normal and transferred SMG have been performed. The results showed that functional α 1A- and α 1B-adrenoceptors（AR） were expressed in human SMG, and might contribute to the regulation of saliva synthesis and secretion. Both β1- and β2-AR were expressed in rabbit SMG. β1-AR was the predominant subtype and might play an important role in regulating saliva and α-amylase secretion. Vanilloid receptor1（VR1） mRNA and protein were detected in rabbit SMG. Capsaicin could induce a significant increase in secretion of rabbit SMG via activitation of VR1. On the rabbit model of microvascular transfer of SMG, phenylephrine（10 -7 mol/L）was infused into SMG through the Wharton’s duct. The secretion of transferred SMG was significantly increased without significant changes of cardiovascular function. The effective mechanism of phenylephrine might involve the increased expression of α1-AR, translocation of AQP5 from cytoplasm to apical membrane, activation of signal molecules related to cell proliferation, and moderate the atrophy of the gland. These results provided a experimental basis for deeply understanding of secretion mechanism of normal and transferred SMG, and effective regulation of secretion of the transferred SMG.
文摘小儿复发性腮腺炎(Recurrent parotitisin children or Juvenile recurrent parotitis简称 JRP),临床上并不少见,它不等同于流行性腮腺炎,一般来说,病毒感染人体后,人体将获得终身免疫,不会再感染此型病毒。但病毒性腮腺炎除流腮病毒外,尚有柯萨奇病毒,流感病毒,疱疹病毒,EB 病毒等同样可引起腮腺感染,腮腺炎的病原体除上述病毒性外,尚有细菌性感染以链球菌为主,可导致反复感染。小儿复发性腮腺炎之所以常见。
