AIM:To ascertain the pattern of ocular morbidity in a population of primary school children in rural Kenya as it is a prerequisite for planning effective preventive and therapeutic strategies.METHODS:A cross-sectional...AIM:To ascertain the pattern of ocular morbidity in a population of primary school children in rural Kenya as it is a prerequisite for planning effective preventive and therapeutic strategies.METHODS:A cross-sectional survey of ocular symptoms and clinical eye examinations were performed in a sample of 35 rural primary schools in the semi-arid region of Kajiado West sub-county in S.W.Kenya,amongst a seminomadic tribe(Maasai).Students in Grades 1-8 were included.Visual acuity was measured using the Snellen“tumbling E”chart at 6 m.Children with symptoms of refractive error underwent non-cycloplegic refraction.RESULTS:A total of 2036 children(1084 males)between the ages of 4-20y were examined.Conjunctival actinic changes were present in 22%(442/2036).Nine cases were seen with a potential squamous carcinoma.No overt classical ocular signs of vitamin A deficiency were noted,although 181(8.9%)children complained of nyctalopia.Three hundred thirty-six(16.5%)children had a visual acuity worse than 6/12 in either eye,were unable to read N10 near text at 40 cm or had symptoms suggestive of refractive error.Refractive data led to an estimate of hyperopia of+1.00 D or more in 3.9%and of myopia of-0.50 D or more in either eye in 3.0%of the study population.CONCLUSION:Solar exposure-and dust-related conjunctival pathology is common.As this may develop into potentially sight-or even life-threatening conditions,it warrants further study,and preventive strategies may be needed.Complaints of nyctalopia were common and could suggest vitamin A deficiency.The prevalence of refractive errors is low in this rural African population.展开更多
目的:评估WINROP、ROPScore和PW-ROP模型检测早产儿视网膜病变(ROP)的预测效能,为传统筛查标准提供参考。方法:选择2019年1月至2021年12月于温州医科大学附属第二医院育英儿童医院新生儿科住院,符合孕周≤32周和(或)出生体质量≤1500 g ...目的:评估WINROP、ROPScore和PW-ROP模型检测早产儿视网膜病变(ROP)的预测效能,为传统筛查标准提供参考。方法:选择2019年1月至2021年12月于温州医科大学附属第二医院育英儿童医院新生儿科住院,符合孕周≤32周和(或)出生体质量≤1500 g ROP标准,进行过ROP眼底筛查且结果明确的患儿共352例。收集患儿出生体质量、孕周、出生后每周体质量、吸氧、输血等相关信息。分别将符合算法要求的患儿进行算法计算,得出WINROP、ROPScore和PW-ROP模型的预测结果。结果:282例患儿纳入WINROP模型,352例纳入PW-ROP模型,155例纳入ROPScore模型。在ROP患儿的筛查中,WINROP模型的灵敏度和特异度均较低;PW-ROP模型的灵敏度与特异度均较高;ROPScore模型的灵敏度较高,但特异度相对较低。各模型AUC的成对DeLong检验显示,严重ROP患儿中,PW-ROP模型(AUC=0.830,95%CI=0.755~0.905)和ROPScore模型(AUC=0.717,95%CI=0.606~0.827)的预测价值高于WINROP模型(AUC=0.582,95%CI=0.473~0.691),差异有统计学意义(P<0.001);任何阶段ROP患儿中,PW-ROP模型(AUC=0.853,95%CI=0.811~0.895)和ROPScore模型(AUC=0.861,95%CI=0.617~1.000)的预测价值也高于WINROP(AUC=0.705,95%CI=0.653~0.758),差异有统计学意义(P<0.001);而PW-ROP模型与ROPScore模型的AUC差异无统计学意义(P>0.05)。结论:PW-ROP模型与ROPScore模型在新生儿中对所有ROP具有较高的预测效能,且其预测性能优于WINROP模型。PW-ROP模型与ROPScore模型的预测性能无显著差异。展开更多
基金Supported by Vision International Eye Missions-USA,“One Drop for All”,Italy,and Private Donors in the Netherlands.
文摘AIM:To ascertain the pattern of ocular morbidity in a population of primary school children in rural Kenya as it is a prerequisite for planning effective preventive and therapeutic strategies.METHODS:A cross-sectional survey of ocular symptoms and clinical eye examinations were performed in a sample of 35 rural primary schools in the semi-arid region of Kajiado West sub-county in S.W.Kenya,amongst a seminomadic tribe(Maasai).Students in Grades 1-8 were included.Visual acuity was measured using the Snellen“tumbling E”chart at 6 m.Children with symptoms of refractive error underwent non-cycloplegic refraction.RESULTS:A total of 2036 children(1084 males)between the ages of 4-20y were examined.Conjunctival actinic changes were present in 22%(442/2036).Nine cases were seen with a potential squamous carcinoma.No overt classical ocular signs of vitamin A deficiency were noted,although 181(8.9%)children complained of nyctalopia.Three hundred thirty-six(16.5%)children had a visual acuity worse than 6/12 in either eye,were unable to read N10 near text at 40 cm or had symptoms suggestive of refractive error.Refractive data led to an estimate of hyperopia of+1.00 D or more in 3.9%and of myopia of-0.50 D or more in either eye in 3.0%of the study population.CONCLUSION:Solar exposure-and dust-related conjunctival pathology is common.As this may develop into potentially sight-or even life-threatening conditions,it warrants further study,and preventive strategies may be needed.Complaints of nyctalopia were common and could suggest vitamin A deficiency.The prevalence of refractive errors is low in this rural African population.
文摘目的:评估WINROP、ROPScore和PW-ROP模型检测早产儿视网膜病变(ROP)的预测效能,为传统筛查标准提供参考。方法:选择2019年1月至2021年12月于温州医科大学附属第二医院育英儿童医院新生儿科住院,符合孕周≤32周和(或)出生体质量≤1500 g ROP标准,进行过ROP眼底筛查且结果明确的患儿共352例。收集患儿出生体质量、孕周、出生后每周体质量、吸氧、输血等相关信息。分别将符合算法要求的患儿进行算法计算,得出WINROP、ROPScore和PW-ROP模型的预测结果。结果:282例患儿纳入WINROP模型,352例纳入PW-ROP模型,155例纳入ROPScore模型。在ROP患儿的筛查中,WINROP模型的灵敏度和特异度均较低;PW-ROP模型的灵敏度与特异度均较高;ROPScore模型的灵敏度较高,但特异度相对较低。各模型AUC的成对DeLong检验显示,严重ROP患儿中,PW-ROP模型(AUC=0.830,95%CI=0.755~0.905)和ROPScore模型(AUC=0.717,95%CI=0.606~0.827)的预测价值高于WINROP模型(AUC=0.582,95%CI=0.473~0.691),差异有统计学意义(P<0.001);任何阶段ROP患儿中,PW-ROP模型(AUC=0.853,95%CI=0.811~0.895)和ROPScore模型(AUC=0.861,95%CI=0.617~1.000)的预测价值也高于WINROP(AUC=0.705,95%CI=0.653~0.758),差异有统计学意义(P<0.001);而PW-ROP模型与ROPScore模型的AUC差异无统计学意义(P>0.05)。结论:PW-ROP模型与ROPScore模型在新生儿中对所有ROP具有较高的预测效能,且其预测性能优于WINROP模型。PW-ROP模型与ROPScore模型的预测性能无显著差异。
