目的:分析全球干眼的研究现状、研究热点及趋势,以期为干眼领域相关研究者提供理论依据及参考,促进该领域的进一步发展。方法:检索中国知网(CNKI)数据库、万方医学数据库、维普数据库、Web of Science核心合集数据库、PubMed数据库自建...目的:分析全球干眼的研究现状、研究热点及趋势,以期为干眼领域相关研究者提供理论依据及参考,促进该领域的进一步发展。方法:检索中国知网(CNKI)数据库、万方医学数据库、维普数据库、Web of Science核心合集数据库、PubMed数据库自建库至2025-07-10已发表的干眼相关文献,并通过CiteSpace 6.2.R3和VOSviewer软件对国家/发文机构、研究作者、高频关键词为分析节点进行可视化分析。结果:目前全球干眼的相关研究已形成各个国家相应的科研团体,发文量位于前3位的国家分别为美国(3956篇)、中国(2255篇)、日本(1053篇);全球研究机构发文量最多的是日本的庆应义塾大学(395篇),其次是美国的哈佛大学(243篇)、哈佛医学院(242篇);国内发文量位于前3位的研究机构分别为首都医科大学附属北京同仁医院(83篇)、中山大学中山眼科中心(67篇)、南昌大学第一附属医院(63篇)。中英文高频关键词及爆点关键词分析结果显示:人工智能、强脉冲光治疗、干眼动物疾病模型、病理机制及药物递送为研究热点。结论:全球干眼临床研究以人工智能诊断技术及强脉冲光治疗为研究热点及趋势;基础研究以干眼动物模型、氧化应激等病理机制及干眼新型药物研发为热点及趋势。展开更多
BACKGROUND Dry eye disease(DED)is a multifactorial ocular surface disorder with rising prevalence.It is closely related to systemic health and psychological factors,such as sleep and mood disorders,which significantly...BACKGROUND Dry eye disease(DED)is a multifactorial ocular surface disorder with rising prevalence.It is closely related to systemic health and psychological factors,such as sleep and mood disorders,which significantly impact the quality of life of patients.AIM To explore the correlations between ocular surface function,sleep quality,and anxiety/depression in patients with DED.METHODS This was a cross-sectional investigative study that included 358 patients with DED between January 2022 and January 2025.Ocular surface was assessed using the ocular surface disease index(OSDI),tear film break-up time,fluorescein staining score,and Schirmer I test.The Pittsburgh Sleep Quality Index(PSQI),Self-Rating Anxiety Scale(SAS),and Self-Rating Depression Scale(SDS)were used to evaluate sleep quality and anxiety/depression levels.Correlation and linear regression analyses were used to explore the relationships.RESULTS The mean PSQI score of the patients was 9.94±2.18;the mean SAS score was 47.30±4.90,and the mean SDS score was 50.08±5.52.These suggested a prevalence of sleep and psychological abnormalities.There was a significant correlation between the indicators of ocular surface function(OSDI,tear film break-up time,fluorescein staining,and Schirmer I test)and PSQI,SAS,and SDS scores(P<0.05).Moreover,multiple regression revealed that age≥50 years(β=1.55,P=0.029),PSQI scores(β=0.58,P<0.001),SAS scores(β=0.17,P=0.017),and SDS scores(β=0.15,P=0.019)were independent predictors of the OSDI scores.CONCLUSION Ocular surface function in patients with DED is closely related to sleep quality and anxiety/depression,emphasizing the need for holistic clinical management.展开更多
文摘目的:分析全球干眼的研究现状、研究热点及趋势,以期为干眼领域相关研究者提供理论依据及参考,促进该领域的进一步发展。方法:检索中国知网(CNKI)数据库、万方医学数据库、维普数据库、Web of Science核心合集数据库、PubMed数据库自建库至2025-07-10已发表的干眼相关文献,并通过CiteSpace 6.2.R3和VOSviewer软件对国家/发文机构、研究作者、高频关键词为分析节点进行可视化分析。结果:目前全球干眼的相关研究已形成各个国家相应的科研团体,发文量位于前3位的国家分别为美国(3956篇)、中国(2255篇)、日本(1053篇);全球研究机构发文量最多的是日本的庆应义塾大学(395篇),其次是美国的哈佛大学(243篇)、哈佛医学院(242篇);国内发文量位于前3位的研究机构分别为首都医科大学附属北京同仁医院(83篇)、中山大学中山眼科中心(67篇)、南昌大学第一附属医院(63篇)。中英文高频关键词及爆点关键词分析结果显示:人工智能、强脉冲光治疗、干眼动物疾病模型、病理机制及药物递送为研究热点。结论:全球干眼临床研究以人工智能诊断技术及强脉冲光治疗为研究热点及趋势;基础研究以干眼动物模型、氧化应激等病理机制及干眼新型药物研发为热点及趋势。
文摘BACKGROUND Dry eye disease(DED)is a multifactorial ocular surface disorder with rising prevalence.It is closely related to systemic health and psychological factors,such as sleep and mood disorders,which significantly impact the quality of life of patients.AIM To explore the correlations between ocular surface function,sleep quality,and anxiety/depression in patients with DED.METHODS This was a cross-sectional investigative study that included 358 patients with DED between January 2022 and January 2025.Ocular surface was assessed using the ocular surface disease index(OSDI),tear film break-up time,fluorescein staining score,and Schirmer I test.The Pittsburgh Sleep Quality Index(PSQI),Self-Rating Anxiety Scale(SAS),and Self-Rating Depression Scale(SDS)were used to evaluate sleep quality and anxiety/depression levels.Correlation and linear regression analyses were used to explore the relationships.RESULTS The mean PSQI score of the patients was 9.94±2.18;the mean SAS score was 47.30±4.90,and the mean SDS score was 50.08±5.52.These suggested a prevalence of sleep and psychological abnormalities.There was a significant correlation between the indicators of ocular surface function(OSDI,tear film break-up time,fluorescein staining,and Schirmer I test)and PSQI,SAS,and SDS scores(P<0.05).Moreover,multiple regression revealed that age≥50 years(β=1.55,P=0.029),PSQI scores(β=0.58,P<0.001),SAS scores(β=0.17,P=0.017),and SDS scores(β=0.15,P=0.019)were independent predictors of the OSDI scores.CONCLUSION Ocular surface function in patients with DED is closely related to sleep quality and anxiety/depression,emphasizing the need for holistic clinical management.
