AIM:To report and analyze cases of sterile intraocular inflammation(IOI)following intravitreal faricimab injections in patients treated for neovascular age-related macular degeneration(nAMD)and diabetic macular edema(...AIM:To report and analyze cases of sterile intraocular inflammation(IOI)following intravitreal faricimab injections in patients treated for neovascular age-related macular degeneration(nAMD)and diabetic macular edema(DME).METHODS:This double-center case series included nine eyes of six patients who developed uveitis after faricimab therapy.Comprehensive clinical evaluation was performed,including slit-lamp examination,intraocular pressure(IOP)measurement,fluorescein and indocyanine green angiography(ICGA),and laboratory tests.Inflammatory responses were treated with topical or systemic corticosteroids,and patients were monitored for visual acuity and inflammatory activity.RESULTS:The incidence of IOI was 0.8%per patient(Innsbruck)and 0.23%(Czechia),with inflammation typically occurring between the third and sixth injection(mean interval:10d post-injection).Inflammator y presentations ranged from anterior uveitis to posterior segment involvement.One notable case demonstrated novel choroidal hypofluorescent lesions on angiography,suggesting deeper ocular involvement.The mean patient age was 76y;five of six affected patients were female.All cases responded to local and systemic corticosteroids,with full recovery of initial visual acuity.CONCLUSION:Sterile IOI after faricimab appears to be a rare but relevant adverse event.Although the incidence falls within expected ranges for anti-vascular endothelial growth factor(anti-VEGF)agents,the observed choroidal involvement represents a potentially new safety signal.Prompt diagnosis and corticosteroid therapy are effective in all cases.Our findings support the need for vigilant post-marketing surveillance and further studies to better understand the underlying mechanisms and risk factors of faricimab-associated inflammation.展开更多
Growth hormone-releasing hormone(GHRH)is a hypothalamic releasing hormone that plays a crucial physiological role in regulating the synthesis and release of anterior pituitary hormones.In recent years,studies have fou...Growth hormone-releasing hormone(GHRH)is a hypothalamic releasing hormone that plays a crucial physiological role in regulating the synthesis and release of anterior pituitary hormones.In recent years,studies have found that GHRH possesses functions like antiinflammation,promoting cell proliferation,and facilitating cell migration.It participates in regulating the development of uveitis and diabetic retinopathy.Additionally,it also has an impact on the development of retinal ganglion cells by modulating the inflammatory response and mediating the immune response.Given the important roles of GHRH in ophthalmic diseases,elucidating the molecular regulation of the GHRH-GHRH receptor(GHRHR)signal and the innovative development of intervention pathways that directly or indirectly target GHRH serve as strong evidence of how basic research guides innovation and translation.In this review,research reports on GHRH in ophthalmic diseases including retinal diseases and uveitis were summarized and analyzed.展开更多
目的:本文旨在分析病毒感染后引起的葡萄膜炎患者的临床特点及治疗方案。方法:收治1例经房水病原微生物宏基因组检测出病毒的葡萄膜炎患者,结合该患者情况及相关文献进行讨论与治疗。结果:患者经人免疫球蛋白及静脉激素冲击治疗后葡萄...目的:本文旨在分析病毒感染后引起的葡萄膜炎患者的临床特点及治疗方案。方法:收治1例经房水病原微生物宏基因组检测出病毒的葡萄膜炎患者,结合该患者情况及相关文献进行讨论与治疗。结果:患者经人免疫球蛋白及静脉激素冲击治疗后葡萄膜炎的症状迅速缓解,病情好转后出院。随访2个月,病情稳定,视力恢复良好。结论:葡萄膜炎是眼科常见的致盲性眼病,病毒感染是其重要原因。对于其引起的葡萄膜炎病人要做到早期明确诊断、个性化治疗以提升患者视力,改善疾病预后。Objective: This paper aims to analyze the clinical characteristics and treatment plans of patients with uveitis caused by viral infection. Methods: One patient with uveitis, in whom viruses were detected by metagenomic testing of the aqueous humor for pathogenic microorganisms, was admitted and treated. The patient’s condition was discussed in combination with relevant literature. Results: After treatment with human immunoglobulin and intravenous corticosteroid pulse therapy, the symptoms of uveitis in the patient rapidly relieved, and the patient was discharged after the condition improved. After 2 months of follow-up, the condition was stable, and the visual acuity recovered well. Conclusion: Uveitis is a common blinding eye disease in ophthalmology, and viral infection is an important cause of it. For patients with uveitis caused by viral infection, early and definite diagnosis and personalized treatment should be carried out to improve the visual function of patients and the prognosis of the disease.展开更多
文摘AIM:To report and analyze cases of sterile intraocular inflammation(IOI)following intravitreal faricimab injections in patients treated for neovascular age-related macular degeneration(nAMD)and diabetic macular edema(DME).METHODS:This double-center case series included nine eyes of six patients who developed uveitis after faricimab therapy.Comprehensive clinical evaluation was performed,including slit-lamp examination,intraocular pressure(IOP)measurement,fluorescein and indocyanine green angiography(ICGA),and laboratory tests.Inflammatory responses were treated with topical or systemic corticosteroids,and patients were monitored for visual acuity and inflammatory activity.RESULTS:The incidence of IOI was 0.8%per patient(Innsbruck)and 0.23%(Czechia),with inflammation typically occurring between the third and sixth injection(mean interval:10d post-injection).Inflammator y presentations ranged from anterior uveitis to posterior segment involvement.One notable case demonstrated novel choroidal hypofluorescent lesions on angiography,suggesting deeper ocular involvement.The mean patient age was 76y;five of six affected patients were female.All cases responded to local and systemic corticosteroids,with full recovery of initial visual acuity.CONCLUSION:Sterile IOI after faricimab appears to be a rare but relevant adverse event.Although the incidence falls within expected ranges for anti-vascular endothelial growth factor(anti-VEGF)agents,the observed choroidal involvement represents a potentially new safety signal.Prompt diagnosis and corticosteroid therapy are effective in all cases.Our findings support the need for vigilant post-marketing surveillance and further studies to better understand the underlying mechanisms and risk factors of faricimab-associated inflammation.
基金Supported by Central Government Guidance Funds for Local Science and Technology Development 2024(No.STKJ2024074).
文摘Growth hormone-releasing hormone(GHRH)is a hypothalamic releasing hormone that plays a crucial physiological role in regulating the synthesis and release of anterior pituitary hormones.In recent years,studies have found that GHRH possesses functions like antiinflammation,promoting cell proliferation,and facilitating cell migration.It participates in regulating the development of uveitis and diabetic retinopathy.Additionally,it also has an impact on the development of retinal ganglion cells by modulating the inflammatory response and mediating the immune response.Given the important roles of GHRH in ophthalmic diseases,elucidating the molecular regulation of the GHRH-GHRH receptor(GHRHR)signal and the innovative development of intervention pathways that directly or indirectly target GHRH serve as strong evidence of how basic research guides innovation and translation.In this review,research reports on GHRH in ophthalmic diseases including retinal diseases and uveitis were summarized and analyzed.
文摘目的:本文旨在分析病毒感染后引起的葡萄膜炎患者的临床特点及治疗方案。方法:收治1例经房水病原微生物宏基因组检测出病毒的葡萄膜炎患者,结合该患者情况及相关文献进行讨论与治疗。结果:患者经人免疫球蛋白及静脉激素冲击治疗后葡萄膜炎的症状迅速缓解,病情好转后出院。随访2个月,病情稳定,视力恢复良好。结论:葡萄膜炎是眼科常见的致盲性眼病,病毒感染是其重要原因。对于其引起的葡萄膜炎病人要做到早期明确诊断、个性化治疗以提升患者视力,改善疾病预后。Objective: This paper aims to analyze the clinical characteristics and treatment plans of patients with uveitis caused by viral infection. Methods: One patient with uveitis, in whom viruses were detected by metagenomic testing of the aqueous humor for pathogenic microorganisms, was admitted and treated. The patient’s condition was discussed in combination with relevant literature. Results: After treatment with human immunoglobulin and intravenous corticosteroid pulse therapy, the symptoms of uveitis in the patient rapidly relieved, and the patient was discharged after the condition improved. After 2 months of follow-up, the condition was stable, and the visual acuity recovered well. Conclusion: Uveitis is a common blinding eye disease in ophthalmology, and viral infection is an important cause of it. For patients with uveitis caused by viral infection, early and definite diagnosis and personalized treatment should be carried out to improve the visual function of patients and the prognosis of the disease.
