AIM:To report and analyze cases of sterile intraocular inflammation(IOI)following intravitreal faricimab injections in patients treated for neovascular age-related macular degeneration(nAMD)and diabetic macular edema(...AIM:To report and analyze cases of sterile intraocular inflammation(IOI)following intravitreal faricimab injections in patients treated for neovascular age-related macular degeneration(nAMD)and diabetic macular edema(DME).METHODS:This double-center case series included nine eyes of six patients who developed uveitis after faricimab therapy.Comprehensive clinical evaluation was performed,including slit-lamp examination,intraocular pressure(IOP)measurement,fluorescein and indocyanine green angiography(ICGA),and laboratory tests.Inflammatory responses were treated with topical or systemic corticosteroids,and patients were monitored for visual acuity and inflammatory activity.RESULTS:The incidence of IOI was 0.8%per patient(Innsbruck)and 0.23%(Czechia),with inflammation typically occurring between the third and sixth injection(mean interval:10d post-injection).Inflammator y presentations ranged from anterior uveitis to posterior segment involvement.One notable case demonstrated novel choroidal hypofluorescent lesions on angiography,suggesting deeper ocular involvement.The mean patient age was 76y;five of six affected patients were female.All cases responded to local and systemic corticosteroids,with full recovery of initial visual acuity.CONCLUSION:Sterile IOI after faricimab appears to be a rare but relevant adverse event.Although the incidence falls within expected ranges for anti-vascular endothelial growth factor(anti-VEGF)agents,the observed choroidal involvement represents a potentially new safety signal.Prompt diagnosis and corticosteroid therapy are effective in all cases.Our findings support the need for vigilant post-marketing surveillance and further studies to better understand the underlying mechanisms and risk factors of faricimab-associated inflammation.展开更多
Growth hormone-releasing hormone(GHRH)is a hypothalamic releasing hormone that plays a crucial physiological role in regulating the synthesis and release of anterior pituitary hormones.In recent years,studies have fou...Growth hormone-releasing hormone(GHRH)is a hypothalamic releasing hormone that plays a crucial physiological role in regulating the synthesis and release of anterior pituitary hormones.In recent years,studies have found that GHRH possesses functions like antiinflammation,promoting cell proliferation,and facilitating cell migration.It participates in regulating the development of uveitis and diabetic retinopathy.Additionally,it also has an impact on the development of retinal ganglion cells by modulating the inflammatory response and mediating the immune response.Given the important roles of GHRH in ophthalmic diseases,elucidating the molecular regulation of the GHRH-GHRH receptor(GHRHR)signal and the innovative development of intervention pathways that directly or indirectly target GHRH serve as strong evidence of how basic research guides innovation and translation.In this review,research reports on GHRH in ophthalmic diseases including retinal diseases and uveitis were summarized and analyzed.展开更多
AIM:To assess the current research status and emerging trends of the choriocapillaris(CC)by bibliometric analysis.METHODS:Publications spanning from January 2013 to May 2023 were retrieved on June 27th,2023,using the ...AIM:To assess the current research status and emerging trends of the choriocapillaris(CC)by bibliometric analysis.METHODS:Publications spanning from January 2013 to May 2023 were retrieved on June 27th,2023,using the Web of Science Core Collection.Bibliometric and visualized analyses were performed employing the bibliometrix,CiteSpace and VOSviewer.RESULTS:A total of 1563 papers met the inclusion criteria,and a publication growth trend was observed.The United States was the leading country in the CC field.Retina and Investigative Ophthalmology&Visual Science stood out as highly impactful and prolific journals.Research topics in the CC field encompassed choroidal neovascularization,choroidal thickness,central serous chorioretinopathy,agerelated macular degeneration,myopia,choroidal vascularity index,and diabetic retinopathy,based on the co-citation analysis.The keyword“high myopia”experienced a burst lasting until 2023.CONCLUSION:In the past decade,research in the field of CC has flourished due to recent advancements in choroidal imaging;with focus shifting towards elucidating its role in various diseases.This will provide novel insights into managing chorioretinal diseases and vision-preserving interventions.展开更多
文摘AIM:To report and analyze cases of sterile intraocular inflammation(IOI)following intravitreal faricimab injections in patients treated for neovascular age-related macular degeneration(nAMD)and diabetic macular edema(DME).METHODS:This double-center case series included nine eyes of six patients who developed uveitis after faricimab therapy.Comprehensive clinical evaluation was performed,including slit-lamp examination,intraocular pressure(IOP)measurement,fluorescein and indocyanine green angiography(ICGA),and laboratory tests.Inflammatory responses were treated with topical or systemic corticosteroids,and patients were monitored for visual acuity and inflammatory activity.RESULTS:The incidence of IOI was 0.8%per patient(Innsbruck)and 0.23%(Czechia),with inflammation typically occurring between the third and sixth injection(mean interval:10d post-injection).Inflammator y presentations ranged from anterior uveitis to posterior segment involvement.One notable case demonstrated novel choroidal hypofluorescent lesions on angiography,suggesting deeper ocular involvement.The mean patient age was 76y;five of six affected patients were female.All cases responded to local and systemic corticosteroids,with full recovery of initial visual acuity.CONCLUSION:Sterile IOI after faricimab appears to be a rare but relevant adverse event.Although the incidence falls within expected ranges for anti-vascular endothelial growth factor(anti-VEGF)agents,the observed choroidal involvement represents a potentially new safety signal.Prompt diagnosis and corticosteroid therapy are effective in all cases.Our findings support the need for vigilant post-marketing surveillance and further studies to better understand the underlying mechanisms and risk factors of faricimab-associated inflammation.
基金Supported by Central Government Guidance Funds for Local Science and Technology Development 2024(No.STKJ2024074).
文摘Growth hormone-releasing hormone(GHRH)is a hypothalamic releasing hormone that plays a crucial physiological role in regulating the synthesis and release of anterior pituitary hormones.In recent years,studies have found that GHRH possesses functions like antiinflammation,promoting cell proliferation,and facilitating cell migration.It participates in regulating the development of uveitis and diabetic retinopathy.Additionally,it also has an impact on the development of retinal ganglion cells by modulating the inflammatory response and mediating the immune response.Given the important roles of GHRH in ophthalmic diseases,elucidating the molecular regulation of the GHRH-GHRH receptor(GHRHR)signal and the innovative development of intervention pathways that directly or indirectly target GHRH serve as strong evidence of how basic research guides innovation and translation.In this review,research reports on GHRH in ophthalmic diseases including retinal diseases and uveitis were summarized and analyzed.
文摘AIM:To assess the current research status and emerging trends of the choriocapillaris(CC)by bibliometric analysis.METHODS:Publications spanning from January 2013 to May 2023 were retrieved on June 27th,2023,using the Web of Science Core Collection.Bibliometric and visualized analyses were performed employing the bibliometrix,CiteSpace and VOSviewer.RESULTS:A total of 1563 papers met the inclusion criteria,and a publication growth trend was observed.The United States was the leading country in the CC field.Retina and Investigative Ophthalmology&Visual Science stood out as highly impactful and prolific journals.Research topics in the CC field encompassed choroidal neovascularization,choroidal thickness,central serous chorioretinopathy,agerelated macular degeneration,myopia,choroidal vascularity index,and diabetic retinopathy,based on the co-citation analysis.The keyword“high myopia”experienced a burst lasting until 2023.CONCLUSION:In the past decade,research in the field of CC has flourished due to recent advancements in choroidal imaging;with focus shifting towards elucidating its role in various diseases.This will provide novel insights into managing chorioretinal diseases and vision-preserving interventions.
