AIM:To compare the tear film quantity and stability parameters in keratoconus(KCN)and normal eyes using test breakup time(TBUT),noninvasive TBUT(NITBUT),and Schirmer test.METHODS:All participants(n=166),including pati...AIM:To compare the tear film quantity and stability parameters in keratoconus(KCN)and normal eyes using test breakup time(TBUT),noninvasive TBUT(NITBUT),and Schirmer test.METHODS:All participants(n=166),including patients with KCN and age-matched healthy individuals with normal corneas,were recruited from those referred to Farabi Eye Hospital,Iran,in 2023.To better account for genetic and environmental factors,the control group comprised healthy individuals who were relatives of KCN patients and had normal corneal topography.Tear quantity parameters were evaluated in the following order:NITBUT,TBUT,and Schirmer tests.RESULTS:The mean age of cases in KCN(61.7%males)and normal(63.5%males)participants was 27.54±5.44y(range 19 to 38)and 27.52±5.63y(range 20 to 38),respectively(P=0.976).NIBUT,TBUT,and Schirmer’s tests were significantly lower in KCN group compared to normal controls(all P<0.001).The mean difference for NIBUT was-7.81s(P<0.001),and for TBUT was-7.61s(P<0.001).Schirmer test values were also significantly lower in the KCN group,with a mean difference of-5.61 mm compared to normal people(P<0.001).CONCLUSION:Our findings demonstrate significant tear film impairment in KCN.The reductions in NIBUT,TBUT and Schirmer scores highlight an underlying tear film dysfunction in KCN that extends beyond the morphological changes of the cornea.展开更多
AIM:To analyze the etiologies,disease course,clinical characteristics,and surgical management patterns of nontraumatic corneal perforation in China.METHODS:This multicenter,retrospective study reviewed medical records...AIM:To analyze the etiologies,disease course,clinical characteristics,and surgical management patterns of nontraumatic corneal perforation in China.METHODS:This multicenter,retrospective study reviewed medical records from patients with non-traumatic corneal perforation treated at 16 tertiary hospitals in China from 2019 to 2021.Data collected included demographics,etiology,disease duration,perforation location,visual acuity Non-traumatic corneal perforation on admission,and surgical procedures.RESULTS:A total of 796 eyes from 791 patients were included,comprising 271 women(34.2%)and 520 men(65.7%),with a mean age of 58.4±15.6y(range,0.38-92y).Infectious keratitis was the leading cause(62.6%),followed by postoperative complications(12.8%)and autoimmune diseases(8.7%).Fungal infections were more prevalent in rural areas,while autoimmune-related perforations were more common in females.Autoimmune cases more frequently presented with a chronic disease course and better visual acuity at admission compared to infectious causes(P<0.001).Among infectious causes,viral keratitis exhibited the highest proportion of chronic cases(65.7%).Perforation location varied significantly by etiology,with infectious cases predominantly central and autoimmune cases more often peripheral or limbal(P<0.001).Overall,88.3%of eyes presented with poor visual acuity on admission.Most eyes(90.0%)required surgical intervention.Penetrating keratoplasty was the most common procedure,especially for central perforations,while lamellar keratoplasty was preferred for peripheral and autoimmune-related cases.CONCLUSION:This nationwide,multicenter study provides a comprehensive epidemiologic characterization of non-traumatic corneal perforation.Infectious keratitis was identified as the predominant etiology.Distinct patterns in disease progression,perforation location,and surgical intervention were observed across etiologic subgroups.These findings underscore the relevance of etiologystratified assessment and support the need for tailored clinical management strategies.展开更多
AIM:To evaluate the corneal biomechanical properties in patients with angioid streaks(AS),and to compare these parameters with those of healthy subjects.METHODS:A retrospective study was conducted,enrolling AS patient...AIM:To evaluate the corneal biomechanical properties in patients with angioid streaks(AS),and to compare these parameters with those of healthy subjects.METHODS:A retrospective study was conducted,enrolling AS patients and healthy participants as controls.The collected corneal tomographic parameters included flat keratometry,steep keratometry,mean keratometry,maximum keratometry,topographic cylinder value,central corneal thickness,and the total deviation value of the Belin-Ambrósio enhanced ectasia display measured with Pentacam tomography.Corvis ST was used to measure corneal biomechanical parameters,non-contact tonometry intraocular pressure(IOPnct),and biomechanically corrected intraocular pressure(bIOP).RESULTS:The study comprised 18 eyes from 10 male and 8 female AS patients with a mean age of 48.83±10.66y,and the controls included 31 eyes from 12 male and 19 female healthy participants with a mean age of 47.87±10.69y.All corneal tomographic parameters were comparable between the two groups(all P>0.05),and no corneal ectasia was observed in any AS patient.Compared with the controls,AS patients exhibited statistically significant increases in applanation 1(A1)time and stiffness parameter A1(SP-A1),along with significant decreases in applanation 2(A2)velocity,deformation amplitude(DA),DA ratio(2 mm),and Corvis biomechanical index(CBI;all P<0.05),which indicated higher corneal stiffness in AS.The IOPnct value in AS was significantly elevated,while no significant difference was found in the bIOP value compared to controls(P=0.031 and P=0.095,respectively).CONCLUSION:Eyes with AS exhibit normal corneal tomographic characteristics and increased corneal stiffness.展开更多
文摘AIM:To compare the tear film quantity and stability parameters in keratoconus(KCN)and normal eyes using test breakup time(TBUT),noninvasive TBUT(NITBUT),and Schirmer test.METHODS:All participants(n=166),including patients with KCN and age-matched healthy individuals with normal corneas,were recruited from those referred to Farabi Eye Hospital,Iran,in 2023.To better account for genetic and environmental factors,the control group comprised healthy individuals who were relatives of KCN patients and had normal corneal topography.Tear quantity parameters were evaluated in the following order:NITBUT,TBUT,and Schirmer tests.RESULTS:The mean age of cases in KCN(61.7%males)and normal(63.5%males)participants was 27.54±5.44y(range 19 to 38)and 27.52±5.63y(range 20 to 38),respectively(P=0.976).NIBUT,TBUT,and Schirmer’s tests were significantly lower in KCN group compared to normal controls(all P<0.001).The mean difference for NIBUT was-7.81s(P<0.001),and for TBUT was-7.61s(P<0.001).Schirmer test values were also significantly lower in the KCN group,with a mean difference of-5.61 mm compared to normal people(P<0.001).CONCLUSION:Our findings demonstrate significant tear film impairment in KCN.The reductions in NIBUT,TBUT and Schirmer scores highlight an underlying tear film dysfunction in KCN that extends beyond the morphological changes of the cornea.
基金Supported by the National Key R&D Program of China(No.2019YFC0840708)the Zhejiang Province Leading Geese Plan(No.2024C03206)+2 种基金the Science and Technology Plan Project of Wenzhou Municipality(No.Y20211005)the Centralized Guided Local Science and Technology Development Funds Project of China(No.ZYYD2024CG16)the Ningbo Top Medical and Health Research Program(No.2023030716).
文摘AIM:To analyze the etiologies,disease course,clinical characteristics,and surgical management patterns of nontraumatic corneal perforation in China.METHODS:This multicenter,retrospective study reviewed medical records from patients with non-traumatic corneal perforation treated at 16 tertiary hospitals in China from 2019 to 2021.Data collected included demographics,etiology,disease duration,perforation location,visual acuity Non-traumatic corneal perforation on admission,and surgical procedures.RESULTS:A total of 796 eyes from 791 patients were included,comprising 271 women(34.2%)and 520 men(65.7%),with a mean age of 58.4±15.6y(range,0.38-92y).Infectious keratitis was the leading cause(62.6%),followed by postoperative complications(12.8%)and autoimmune diseases(8.7%).Fungal infections were more prevalent in rural areas,while autoimmune-related perforations were more common in females.Autoimmune cases more frequently presented with a chronic disease course and better visual acuity at admission compared to infectious causes(P<0.001).Among infectious causes,viral keratitis exhibited the highest proportion of chronic cases(65.7%).Perforation location varied significantly by etiology,with infectious cases predominantly central and autoimmune cases more often peripheral or limbal(P<0.001).Overall,88.3%of eyes presented with poor visual acuity on admission.Most eyes(90.0%)required surgical intervention.Penetrating keratoplasty was the most common procedure,especially for central perforations,while lamellar keratoplasty was preferred for peripheral and autoimmune-related cases.CONCLUSION:This nationwide,multicenter study provides a comprehensive epidemiologic characterization of non-traumatic corneal perforation.Infectious keratitis was identified as the predominant etiology.Distinct patterns in disease progression,perforation location,and surgical intervention were observed across etiologic subgroups.These findings underscore the relevance of etiologystratified assessment and support the need for tailored clinical management strategies.
文摘AIM:To evaluate the corneal biomechanical properties in patients with angioid streaks(AS),and to compare these parameters with those of healthy subjects.METHODS:A retrospective study was conducted,enrolling AS patients and healthy participants as controls.The collected corneal tomographic parameters included flat keratometry,steep keratometry,mean keratometry,maximum keratometry,topographic cylinder value,central corneal thickness,and the total deviation value of the Belin-Ambrósio enhanced ectasia display measured with Pentacam tomography.Corvis ST was used to measure corneal biomechanical parameters,non-contact tonometry intraocular pressure(IOPnct),and biomechanically corrected intraocular pressure(bIOP).RESULTS:The study comprised 18 eyes from 10 male and 8 female AS patients with a mean age of 48.83±10.66y,and the controls included 31 eyes from 12 male and 19 female healthy participants with a mean age of 47.87±10.69y.All corneal tomographic parameters were comparable between the two groups(all P>0.05),and no corneal ectasia was observed in any AS patient.Compared with the controls,AS patients exhibited statistically significant increases in applanation 1(A1)time and stiffness parameter A1(SP-A1),along with significant decreases in applanation 2(A2)velocity,deformation amplitude(DA),DA ratio(2 mm),and Corvis biomechanical index(CBI;all P<0.05),which indicated higher corneal stiffness in AS.The IOPnct value in AS was significantly elevated,while no significant difference was found in the bIOP value compared to controls(P=0.031 and P=0.095,respectively).CONCLUSION:Eyes with AS exhibit normal corneal tomographic characteristics and increased corneal stiffness.
