目的探究耐药肺结核合并咽炎患者多重耐药α-溶血性链球菌分子流行病学调查并构建风险模型。方法选择2019年3月-2022年1月在我院接受治疗的耐药肺结核合并咽炎患者150例为研究对象。采用PhoenixTM-100全自动细菌检测分析系统进行药敏试...目的探究耐药肺结核合并咽炎患者多重耐药α-溶血性链球菌分子流行病学调查并构建风险模型。方法选择2019年3月-2022年1月在我院接受治疗的耐药肺结核合并咽炎患者150例为研究对象。采用PhoenixTM-100全自动细菌检测分析系统进行药敏试验。依据脉冲场凝胶电泳(Pulsed field gel electrophoresis,PFGE)和多点位序列分析(Multilocus sequence type,MLST)技术对其中92例多重耐药草绿色链球菌(Viridans Group Streptococcus,VGS)感染患者进行分子流行病学调查。根据是否发生多重耐药感染将患者分为感染组(n=92)和非感染组(n=58),多因素Logistic分析多重耐药VGS感染的独立影响因素并构建简易评分模型划分感染风险等级并进行验证。结果药敏结果显示,VGS对亚胺培南、厄他培南的敏感性高,敏感率为100%;PFGE分型和MLST分型结果显示,92株多重耐药VGS菌株可分为5种PFGE克隆型和15种ST型;多因素Logistic分析结果表明,年龄、呕吐、腹泻、降钙素原、中性粒细胞、白细胞是导致耐药肺结核合并咽炎患者感染多重耐药VGS菌株的独立危险因素(P<0.05);年龄、白细胞、中性粒细胞和降钙素原与多重耐药VGS感染风险关联密切;简易评分模型结果显示其预测效能较好。结论年龄、降钙素原、中性粒细胞、白细胞是感染多重耐药VGS菌株关联最大的独立危险因素,为临床筛查和预防有多重耐药VGS感染风险的耐药肺结核合并咽炎患者提供了理论基础。展开更多
AIM: To study the treatment effect of chronic pharyngitis using radiofrenquency and compound iodine glycerin. METHODS: If the patients were diagnosed as chronic simple pharyngitis and atrophic pharyngitis or pharyngit...AIM: To study the treatment effect of chronic pharyngitis using radiofrenquency and compound iodine glycerin. METHODS: If the patients were diagnosed as chronic simple pharyngitis and atrophic pharyngitis or pharyngitis sicca,they were treated with smearing compound iodine glycerin on the back wall of pharynx, combining with general treatment. If the patients were diagnosed as chronic hypertrophic pharyngitis, they were treated with radiofrenquency, combining with general treatment. The control groups were only treated with general treatment. RESULTS: Half a month post treatment, 268 cases were recovered (82.0%) among 327 patients; 56 cases were better (17.1%). In the control groups, 62 cases were healed (62.0%). The effect of the treatment using radiofrenquency or compound iodine glycerin is significantly better than that in the control groups (P<0.0001). CONCLUSION: Treatment of chronic simple pharyngitis and atrophic pharyngitis or pharyngitis sicca with smearing compound iodine glycerin on the back wall of pharynx, and the treatment of chronic hypertrophic pharyngitis using radiofrenquency are more effective than routine method. Their advantages are local treatment, accurate localization, simple process, short therapy duration, no bleeding and pain, higher cure rate.展开更多
文摘目的探究耐药肺结核合并咽炎患者多重耐药α-溶血性链球菌分子流行病学调查并构建风险模型。方法选择2019年3月-2022年1月在我院接受治疗的耐药肺结核合并咽炎患者150例为研究对象。采用PhoenixTM-100全自动细菌检测分析系统进行药敏试验。依据脉冲场凝胶电泳(Pulsed field gel electrophoresis,PFGE)和多点位序列分析(Multilocus sequence type,MLST)技术对其中92例多重耐药草绿色链球菌(Viridans Group Streptococcus,VGS)感染患者进行分子流行病学调查。根据是否发生多重耐药感染将患者分为感染组(n=92)和非感染组(n=58),多因素Logistic分析多重耐药VGS感染的独立影响因素并构建简易评分模型划分感染风险等级并进行验证。结果药敏结果显示,VGS对亚胺培南、厄他培南的敏感性高,敏感率为100%;PFGE分型和MLST分型结果显示,92株多重耐药VGS菌株可分为5种PFGE克隆型和15种ST型;多因素Logistic分析结果表明,年龄、呕吐、腹泻、降钙素原、中性粒细胞、白细胞是导致耐药肺结核合并咽炎患者感染多重耐药VGS菌株的独立危险因素(P<0.05);年龄、白细胞、中性粒细胞和降钙素原与多重耐药VGS感染风险关联密切;简易评分模型结果显示其预测效能较好。结论年龄、降钙素原、中性粒细胞、白细胞是感染多重耐药VGS菌株关联最大的独立危险因素,为临床筛查和预防有多重耐药VGS感染风险的耐药肺结核合并咽炎患者提供了理论基础。
文摘AIM: To study the treatment effect of chronic pharyngitis using radiofrenquency and compound iodine glycerin. METHODS: If the patients were diagnosed as chronic simple pharyngitis and atrophic pharyngitis or pharyngitis sicca,they were treated with smearing compound iodine glycerin on the back wall of pharynx, combining with general treatment. If the patients were diagnosed as chronic hypertrophic pharyngitis, they were treated with radiofrenquency, combining with general treatment. The control groups were only treated with general treatment. RESULTS: Half a month post treatment, 268 cases were recovered (82.0%) among 327 patients; 56 cases were better (17.1%). In the control groups, 62 cases were healed (62.0%). The effect of the treatment using radiofrenquency or compound iodine glycerin is significantly better than that in the control groups (P<0.0001). CONCLUSION: Treatment of chronic simple pharyngitis and atrophic pharyngitis or pharyngitis sicca with smearing compound iodine glycerin on the back wall of pharynx, and the treatment of chronic hypertrophic pharyngitis using radiofrenquency are more effective than routine method. Their advantages are local treatment, accurate localization, simple process, short therapy duration, no bleeding and pain, higher cure rate.
