目的通过孟德尔随机化(Mendelian randomization,MR),探索免疫细胞表型与梅尼埃病(Meniere's disease,MD)易感性之间的关系。方法利用在线的全基因组关联研究(genome-wide association study,GWAS)数据库中的731种免疫表型和MD的GWA...目的通过孟德尔随机化(Mendelian randomization,MR),探索免疫细胞表型与梅尼埃病(Meniere's disease,MD)易感性之间的关系。方法利用在线的全基因组关联研究(genome-wide association study,GWAS)数据库中的731种免疫表型和MD的GWAS数据进行两样本MR研究。逆方差加权为主要分析方法,与免疫表型相关的单核苷酸多态性作为暴露因素。使用敏感性分析校正来检验MR假设。此外,通过反向MR验证了免疫细胞表型和MD之间反向因果关系。结果共确定了33种免疫细胞表型与MD的因果关系,其中包含B细胞组11种、Treg组5种、TBNK组4种、成熟阶段的T细胞组7种、髓系细胞组2种和常规树突状细胞组4种。有20种表型对MD有潜在保护作用,其余13种表型则是危险因素。结论MR分析表明免疫细胞与MD密切相关,部分有保护作用,部分是危险因素。展开更多
Background:The masseter vestibular evoked myogenic potential(mVEMP) is a novel test that has been explored in various brainstem lesions. However, it has not yet been studied in individuals with definite Meniere's ...Background:The masseter vestibular evoked myogenic potential(mVEMP) is a novel test that has been explored in various brainstem lesions. However, it has not yet been studied in individuals with definite Meniere's disease. Therefore, the current study aimed to investigate m VEMP responses in individuals with definite Meniere's disease and compare them with those of a reference group.Method:The present study investigated narrowband Claus Elberling chirp-evoked m VEMP responses in 22 ears diagnosed with definite Meniere's disease and 22 ears with hearing sensitivity ≤ 15 dB HL across three stimulation frequencies.Results:m VEMP responses in participants with definite Meniere's disease varied from normal to reduced or absent across three octave frequencies. These individuals exhibited significantly reduced P11-N21 peak-to-peak amplitudes compared to those in the reference group. Although a frequency tuning shift toward 1000 Hz was observed, the inter-frequency amplitude ratio of m VEMP was not found to be a sensitive parameter for detecting individuals with definite Meniere's disease. Additionally, no association was found between the degree of hearing loss or the duration of the disease and m VEMP responses. Conclusion: Participants with definite Meniere's disease exhibited reduced P11-N21 amplitude and a tuning shift toward 1000 Hz. These findings suggest the involvement of the vestibulo-trigeminal reflex pathway in this condition.展开更多
文摘目的通过孟德尔随机化(Mendelian randomization,MR),探索免疫细胞表型与梅尼埃病(Meniere's disease,MD)易感性之间的关系。方法利用在线的全基因组关联研究(genome-wide association study,GWAS)数据库中的731种免疫表型和MD的GWAS数据进行两样本MR研究。逆方差加权为主要分析方法,与免疫表型相关的单核苷酸多态性作为暴露因素。使用敏感性分析校正来检验MR假设。此外,通过反向MR验证了免疫细胞表型和MD之间反向因果关系。结果共确定了33种免疫细胞表型与MD的因果关系,其中包含B细胞组11种、Treg组5种、TBNK组4种、成熟阶段的T细胞组7种、髓系细胞组2种和常规树突状细胞组4种。有20种表型对MD有潜在保护作用,其余13种表型则是危险因素。结论MR分析表明免疫细胞与MD密切相关,部分有保护作用,部分是危险因素。
文摘Background:The masseter vestibular evoked myogenic potential(mVEMP) is a novel test that has been explored in various brainstem lesions. However, it has not yet been studied in individuals with definite Meniere's disease. Therefore, the current study aimed to investigate m VEMP responses in individuals with definite Meniere's disease and compare them with those of a reference group.Method:The present study investigated narrowband Claus Elberling chirp-evoked m VEMP responses in 22 ears diagnosed with definite Meniere's disease and 22 ears with hearing sensitivity ≤ 15 dB HL across three stimulation frequencies.Results:m VEMP responses in participants with definite Meniere's disease varied from normal to reduced or absent across three octave frequencies. These individuals exhibited significantly reduced P11-N21 peak-to-peak amplitudes compared to those in the reference group. Although a frequency tuning shift toward 1000 Hz was observed, the inter-frequency amplitude ratio of m VEMP was not found to be a sensitive parameter for detecting individuals with definite Meniere's disease. Additionally, no association was found between the degree of hearing loss or the duration of the disease and m VEMP responses. Conclusion: Participants with definite Meniere's disease exhibited reduced P11-N21 amplitude and a tuning shift toward 1000 Hz. These findings suggest the involvement of the vestibulo-trigeminal reflex pathway in this condition.
