The use of microneedles(MNs)has been established as an effective transdermal drug delivery strategy that has been extensively deployed for treating various diseases,including skin diseases.MNs can surpass the constrai...The use of microneedles(MNs)has been established as an effective transdermal drug delivery strategy that has been extensively deployed for treating various diseases,including skin diseases.MNs can surpass the constraints of conventional drug delivery methods by their superior safety and efficacy through precise targeting,while simultaneously enabling painless delivery.Currently,MNs are increasingly used as carriers for drug delivery,with the loading of insoluble drugs to improve their treatment efficiency or combining with bioactive substances for the construction of an efficient drug delivery system to maximize the effects of bioactive substances.The methods used for preparation MNs are diverse,enabling them to meet the requirements of most applications.The emergence of MNs has addressed the shortcomings associated with insoluble drugs,expanded the applications of bioactive substances,and improved their use in clinical practice.This review summarizes current information on the application of MNs in a variety of skin diseases,such as psoriasis,vitiligo,alopecia,hypertrophic scarring,atopic dermatitis,melanoma,acne,and skin infections.The current clinical applications and future opportunities for MNs in the treatment of skin diseases are also discussed.Despite substantial progress in the clinical application of MNs as delivery vectors,issues such as low drug loading and poor mechanical strength during MNs preparation remain the main challenges.Therefore,clinical implementation of MNs-based therapies remains limited,highlighting key opportunities for future research.展开更多
文摘目的:探究自体富血小板血浆(Platelet rich plasma,PRP)注射联合自体表皮移植及白芍总苷治疗稳定期白癜风的疗效及对美学效果的影响。方法:回顾性分析2020年6月-2023年1月衡水市第二人民医院收治的205例稳定期白癜风患者的临床资料,按治疗方法及入院时间的不同分成对照组(100例,2020年6月-2021年9月)和实验组(105例,2021年10月-2023年1月)。对照组予以自体表皮移植术联合白芍总苷治疗,在此基础上实验组予以PRP注射治疗,时长为3个月。比较两组疗效、白斑改善情况[白癜风面积评分指数(Vitiligo area score index,VASI)、色素积分]、皮肤病生活质量指数(Dermatology life quality index,DLQI)、美学效果、免疫功能(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))、氧化应激指标[超氧化物歧化酶(SOD)、丙二醛(MDA)、过氧化氢酶(CAT)]、不良反应发生率和复发率的差异。结果:治疗后,实验组的总有效率高于对照组(P<0.05);治疗3个月及随访6个月后,两组DLQI评分均较治疗前降低,且实验组低于对照组(P<0.05),随访6个月后实验组的美学效果评分高于对照组(P<0.05);两组CD4^(+)、CD4^(+)/CD8^(+)、SOD、CAT水平均较治疗前升高,CD8^(+)、MDA水平均较治疗前降低,且实验组变化幅度优于对照组(P<0.05);两组VASI评分均治疗前降低,色素沉着积分较治疗前升高,且实验组变化幅度优于对照组(P<0.05);治疗期间两组不良反应发生率差异无统计学意义(P>0.05);随访6个月后实验组的疾病复发率低于对照组(P<0.05)。结论:PRP注射、自体表皮移植术联合白芍总苷治疗稳定性期白癜风患者的疗效显著,能有效提高免疫功能,减轻氧化应激反应,促进白斑消退,改善生活质量及美学效果,降低疾病复发率,且安全性高。
基金supported through grants from the Key Fields of Biomedicine and Health Foundation of Colleges and Universities in Guangdong Province(2022ZDZX2017)the National Natural Science Foundation of China(82104354)+1 种基金the Guangdong Basic and Applied Basic Research Foundation(2022A1515012154)the funding grants from University of Macao and the University of Macao Development Foundation(MYRG2023-GRG00184-ICMS-UMDF and MYRG2024-GRG00271-ICMS-UMDF).
文摘The use of microneedles(MNs)has been established as an effective transdermal drug delivery strategy that has been extensively deployed for treating various diseases,including skin diseases.MNs can surpass the constraints of conventional drug delivery methods by their superior safety and efficacy through precise targeting,while simultaneously enabling painless delivery.Currently,MNs are increasingly used as carriers for drug delivery,with the loading of insoluble drugs to improve their treatment efficiency or combining with bioactive substances for the construction of an efficient drug delivery system to maximize the effects of bioactive substances.The methods used for preparation MNs are diverse,enabling them to meet the requirements of most applications.The emergence of MNs has addressed the shortcomings associated with insoluble drugs,expanded the applications of bioactive substances,and improved their use in clinical practice.This review summarizes current information on the application of MNs in a variety of skin diseases,such as psoriasis,vitiligo,alopecia,hypertrophic scarring,atopic dermatitis,melanoma,acne,and skin infections.The current clinical applications and future opportunities for MNs in the treatment of skin diseases are also discussed.Despite substantial progress in the clinical application of MNs as delivery vectors,issues such as low drug loading and poor mechanical strength during MNs preparation remain the main challenges.Therefore,clinical implementation of MNs-based therapies remains limited,highlighting key opportunities for future research.
