A 16‐year‐old male teenager with no prior medical history suddenly experienced right upper limb weakness.The weakness persisted for 2 weeks,followed by a headache and unstable walking.On physical examination,the pat...A 16‐year‐old male teenager with no prior medical history suddenly experienced right upper limb weakness.The weakness persisted for 2 weeks,followed by a headache and unstable walking.On physical examination,the patient exhibited decreased verbal fluency,a shallow right nasolabial fold,and tongue movement to the right side.Reduced muscle strength with normal muscle tension was observed in the right limb.On laboratory examination,lymphocytes were decreased,and neutrophils were slightly increased.The patient underwent brain CT,MRI,and whole‐body ^(18)F‐fluorodeoxyglucose PET/CT.Intra-cranial biopsy was performed to confirm the pathology(Figure 1).The final pathological diagnosis was the Rosai-Dorfman disease,characterized by abnormal hyperplasia of the sinuses combined with an accumulation of histiocytes in the lymph nodes.Although extranodal involvement has been reported,primary infiltration of the central nervous system is extremely rare,particularly in the brain parenchyma.展开更多
目的采用智能眼动仪快速评估老年人群的认知功能,并分析认知功能与情绪和运动功能的相关性。方法2023年6月到2023年8月在北京市某社区招募60~80岁的老年人共160名,其中男49名(30.6%),女111名(69.4%),年龄(68.6±4.5)岁。收集被调查...目的采用智能眼动仪快速评估老年人群的认知功能,并分析认知功能与情绪和运动功能的相关性。方法2023年6月到2023年8月在北京市某社区招募60~80岁的老年人共160名,其中男49名(30.6%),女111名(69.4%),年龄(68.6±4.5)岁。收集被调查者的性别、年龄、教育程度等基本信息,应用智能眼动仪进行眼动检查评估认知功能,利用9项患者健康问卷(9-item patient health questionnaire,PHQ-9)评估抑郁症状,并通过“起立-行走”计时测试(time up and go test,TUG)评估其运动功能。根据眼动仪检查结果将被调查者分为认知障碍高风险组(综合评分<60分)和低风险组(综合评分≥60分),比较两组人群资料的差异,并分析认知功能与运动功能及抑郁的相关性。结果160名被调查者中存在认知障碍高风险者9名(5.6%),低风险者151名(94.4%)。认知障碍高风险组完成TUG的时间较低风险组更长(P=0.005),运动功能异常者占比更高(P=0.025)。老年人完成TUG时间与认知功能综合评分(r=-0.183,P=0.021)及记忆力评分(r=-0.180,P=0.023)呈负相关。PHQ-9评分与认知功能评分无相关。结论智能眼动仪对于社区老年人群认知功能的快速评估具有一定应用价值。社区老年人群发生认知障碍的风险可能与其运动能力下降具有相关性。展开更多
快进展型中枢性性早熟(rapidly progressive central precocious puberty,RP-CPP)是性发育异常的常见类型,发病后可诱使患儿骨骺提前闭合,干预不及时可能影响患儿成年后身高,甚至导致患儿出现相应心理问题[1-2]。RP-CPP的病理机制主要...快进展型中枢性性早熟(rapidly progressive central precocious puberty,RP-CPP)是性发育异常的常见类型,发病后可诱使患儿骨骺提前闭合,干预不及时可能影响患儿成年后身高,甚至导致患儿出现相应心理问题[1-2]。RP-CPP的病理机制主要涉及下丘脑-垂体-性腺轴的提前激活和快速发展[3]。血清胰岛素样生长因子-1(insulin like growth factor-1,IGF-1)可调控生殖系统发育及生长发育,或能成为RP-CPP发病的预警指标[4]。黄体生成素(luteinizing hormone,LH)、促卵泡生成素(follicle stimulating hormone,FSH)通过协同作用、负反馈机制共同维持生殖系统的正常生理功能,下丘脑-垂体-性腺轴启动后可能使LH、FSH水平发生波动[5]。因此,本研究通过分析血清IGF-1与LH/FSH的交互作用,并探讨其对RPCPP的影响,现报道如下。展开更多
文摘A 16‐year‐old male teenager with no prior medical history suddenly experienced right upper limb weakness.The weakness persisted for 2 weeks,followed by a headache and unstable walking.On physical examination,the patient exhibited decreased verbal fluency,a shallow right nasolabial fold,and tongue movement to the right side.Reduced muscle strength with normal muscle tension was observed in the right limb.On laboratory examination,lymphocytes were decreased,and neutrophils were slightly increased.The patient underwent brain CT,MRI,and whole‐body ^(18)F‐fluorodeoxyglucose PET/CT.Intra-cranial biopsy was performed to confirm the pathology(Figure 1).The final pathological diagnosis was the Rosai-Dorfman disease,characterized by abnormal hyperplasia of the sinuses combined with an accumulation of histiocytes in the lymph nodes.Although extranodal involvement has been reported,primary infiltration of the central nervous system is extremely rare,particularly in the brain parenchyma.
文摘目的采用智能眼动仪快速评估老年人群的认知功能,并分析认知功能与情绪和运动功能的相关性。方法2023年6月到2023年8月在北京市某社区招募60~80岁的老年人共160名,其中男49名(30.6%),女111名(69.4%),年龄(68.6±4.5)岁。收集被调查者的性别、年龄、教育程度等基本信息,应用智能眼动仪进行眼动检查评估认知功能,利用9项患者健康问卷(9-item patient health questionnaire,PHQ-9)评估抑郁症状,并通过“起立-行走”计时测试(time up and go test,TUG)评估其运动功能。根据眼动仪检查结果将被调查者分为认知障碍高风险组(综合评分<60分)和低风险组(综合评分≥60分),比较两组人群资料的差异,并分析认知功能与运动功能及抑郁的相关性。结果160名被调查者中存在认知障碍高风险者9名(5.6%),低风险者151名(94.4%)。认知障碍高风险组完成TUG的时间较低风险组更长(P=0.005),运动功能异常者占比更高(P=0.025)。老年人完成TUG时间与认知功能综合评分(r=-0.183,P=0.021)及记忆力评分(r=-0.180,P=0.023)呈负相关。PHQ-9评分与认知功能评分无相关。结论智能眼动仪对于社区老年人群认知功能的快速评估具有一定应用价值。社区老年人群发生认知障碍的风险可能与其运动能力下降具有相关性。
