Nocardia is an aerobic,gram-positive,and opportunistic bacillus widely distributed in the environment.Nocardia cyriacigeorgica(N.cyriacigeorgica) was first isolated in 2001 from a chronic bronchitis patient,^([1]) and...Nocardia is an aerobic,gram-positive,and opportunistic bacillus widely distributed in the environment.Nocardia cyriacigeorgica(N.cyriacigeorgica) was first isolated in 2001 from a chronic bronchitis patient,^([1]) and has since been reported as an emerging clinically relevant pathogen worldwide.The diagnosis of nocardial infections remains challenging due to nonspecific symptoms and low culture sensitivity,resulting in high mortality.^([2]) Herein,we report a case of N.cyriacigeorgica brain abscess in an immunosuppressed patient who was successfully treated with antibiotics and surgery.展开更多
A large body of evidence has highlighted the role of non-coding RNAs in neurodevelopment and neuroinflammation.This evidence has led to increasing speculation that non-coding RNAs may be involved in the pathophysiolog...A large body of evidence has highlighted the role of non-coding RNAs in neurodevelopment and neuroinflammation.This evidence has led to increasing speculation that non-coding RNAs may be involved in the pathophysiological mechanisms underlying hydrocephalus,one of the most common neurological conditions worldwide.In this review,we first outline the basic concepts and incidence of hydrocephalus along with the limitations of existing treatments for this condition.Then,we outline the definition,classification,and biological role of non-coding RNAs.Subsequently,we analyze the roles of non-coding RNAs in the formation of hydrocephalus in detail.Specifically,we have focused on the potential significance of non-coding RNAs in the pathophysiology of hydrocephalus,including glymphatic pathways,neuroinflammatory processes,and neurological dysplasia,on the basis of the existing evidence.Lastly,we review the potential of non-coding RNAs as biomarkers of hydrocephalus and for the creation of innovative treatments.展开更多
基金funded by grants from Guangdong Basic and Applied Basic Research Foundation (2025A1515011901)Natural Science Foundation of Guangdong Province (2024A1515012228)。
文摘Nocardia is an aerobic,gram-positive,and opportunistic bacillus widely distributed in the environment.Nocardia cyriacigeorgica(N.cyriacigeorgica) was first isolated in 2001 from a chronic bronchitis patient,^([1]) and has since been reported as an emerging clinically relevant pathogen worldwide.The diagnosis of nocardial infections remains challenging due to nonspecific symptoms and low culture sensitivity,resulting in high mortality.^([2]) Herein,we report a case of N.cyriacigeorgica brain abscess in an immunosuppressed patient who was successfully treated with antibiotics and surgery.
基金supported by the National Natural Science Foundation of China,Nos.82171347,82371362the Natural Science Foundation of Hunan Province,No.2022JJ30971the Scientific Research Project of Hunan Provincial Health Commission of China,No.202204040024(all to GX).
文摘A large body of evidence has highlighted the role of non-coding RNAs in neurodevelopment and neuroinflammation.This evidence has led to increasing speculation that non-coding RNAs may be involved in the pathophysiological mechanisms underlying hydrocephalus,one of the most common neurological conditions worldwide.In this review,we first outline the basic concepts and incidence of hydrocephalus along with the limitations of existing treatments for this condition.Then,we outline the definition,classification,and biological role of non-coding RNAs.Subsequently,we analyze the roles of non-coding RNAs in the formation of hydrocephalus in detail.Specifically,we have focused on the potential significance of non-coding RNAs in the pathophysiology of hydrocephalus,including glymphatic pathways,neuroinflammatory processes,and neurological dysplasia,on the basis of the existing evidence.Lastly,we review the potential of non-coding RNAs as biomarkers of hydrocephalus and for the creation of innovative treatments.
