目的:观察射频加热联合放疗治疗颈部淋巴结转移癌的临床疗效,以期为此类患者的诊疗提供参考。方法:分析2015年至2016年在我院接受治疗的颈部淋巴结转移癌患者的临床资料。依据治疗方案不同将患者分为观察组(射频热疗+放疗)41例及对照组...目的:观察射频加热联合放疗治疗颈部淋巴结转移癌的临床疗效,以期为此类患者的诊疗提供参考。方法:分析2015年至2016年在我院接受治疗的颈部淋巴结转移癌患者的临床资料。依据治疗方案不同将患者分为观察组(射频热疗+放疗)41例及对照组(放疗)40例。对比两组短期治疗有效率、肿瘤标志物改变及治疗后复发情况。结果:观察组患者治疗有效率显著高于对照组患者(χ~2=4.313,P=0.038)。治疗后,两组患者外周血CEA、CYFRA21-1及SCC-Ag水平均显著降低(P<0.05),但观察组患者低于对照组(P<0.05)。观察组患者治疗后6个月颈部淋巴结转移癌复发率显著低于对照组(4.88%,2/41 vs 19.44%,7/36;Log-rank χ~2=3.995,P=0.046)。结论:在颈部淋巴结转移癌的放射治疗中,联合使用射频加热治疗可显著提高疗效,值得临床推广。展开更多
Sleepiness affects normal social life, which attracts more and more attention. Circadian phenotypes contribute to obvious individual differences in susceptibility to sleepiness. We aimed to identify candidate single n...Sleepiness affects normal social life, which attracts more and more attention. Circadian phenotypes contribute to obvious individual differences in susceptibility to sleepiness. We aimed to identify candidate single nucleotide polymorphisms（SNPs） which may cause circadian phenotypes, elucidate the potential mechanisms, and generate corresponding SNP-gene-pathways. A genome-wide association studies（GWAS） dataset of circadian phenotypes was utilized in the study. Then, the Identify Candidate Causal SNPs and Pathways analysis was employed to the GWAS dataset after quality control filters. Furthermore, genotype-phenotype association analysis was performed with HapMap database. Four SNPs in three different genes were determined to correlate with usual weekday bedtime,totally providing seven hypothetical mechanisms. Eleven SNPs in six genes were identified to correlate with usual weekday sleep duration, which provided six hypothetical pathways. Our results demonstrated that fifteen candidate SNPs in eight genes played vital roles in six hypothetical pathways implicated in usual weekday bedtime and six potential pathways involved in usual weekday sleep duration.展开更多
文摘目的:观察射频加热联合放疗治疗颈部淋巴结转移癌的临床疗效,以期为此类患者的诊疗提供参考。方法:分析2015年至2016年在我院接受治疗的颈部淋巴结转移癌患者的临床资料。依据治疗方案不同将患者分为观察组(射频热疗+放疗)41例及对照组(放疗)40例。对比两组短期治疗有效率、肿瘤标志物改变及治疗后复发情况。结果:观察组患者治疗有效率显著高于对照组患者(χ~2=4.313,P=0.038)。治疗后,两组患者外周血CEA、CYFRA21-1及SCC-Ag水平均显著降低(P<0.05),但观察组患者低于对照组(P<0.05)。观察组患者治疗后6个月颈部淋巴结转移癌复发率显著低于对照组(4.88%,2/41 vs 19.44%,7/36;Log-rank χ~2=3.995,P=0.046)。结论:在颈部淋巴结转移癌的放射治疗中,联合使用射频加热治疗可显著提高疗效,值得临床推广。
基金supported by the National Natural Science Foundation of China (No.81470457 and No.81700297)
文摘Sleepiness affects normal social life, which attracts more and more attention. Circadian phenotypes contribute to obvious individual differences in susceptibility to sleepiness. We aimed to identify candidate single nucleotide polymorphisms（SNPs） which may cause circadian phenotypes, elucidate the potential mechanisms, and generate corresponding SNP-gene-pathways. A genome-wide association studies（GWAS） dataset of circadian phenotypes was utilized in the study. Then, the Identify Candidate Causal SNPs and Pathways analysis was employed to the GWAS dataset after quality control filters. Furthermore, genotype-phenotype association analysis was performed with HapMap database. Four SNPs in three different genes were determined to correlate with usual weekday bedtime,totally providing seven hypothetical mechanisms. Eleven SNPs in six genes were identified to correlate with usual weekday sleep duration, which provided six hypothetical pathways. Our results demonstrated that fifteen candidate SNPs in eight genes played vital roles in six hypothetical pathways implicated in usual weekday bedtime and six potential pathways involved in usual weekday sleep duration.
